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Sublingual vaccine for urinary tract infections is awaiting approval by Health Canada – iHeartRadio.ca

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Canadians who experience chronic urinary tract infections may soon have another option than antibiotics — a vaccine is awaiting approval by Health Canada.

Urinary tract infections, known as UTIs, are one of the most common infections across the globe.

They cause extreme discomfort in patients, and require antibiotics in order to clear the infection. Dr. Marla Shapiro, CTV’s medical contributor, explained the two main symptoms to CTV News Channel on Friday.

“The hallmark really is that urgency, that you’ve gotta get to the washroom in time,” she said. “There can be burning either initiating the urination or at the end of it.”

There might also be blood in the urine, or it could be cloudy, and often the odour of the urine will have changed. Some sufferers of UTIs have even reported pelvic pain.

“But it’s usually that razorblade burning that women talk about,” Shapiro said.

“Because it’s so common, the idea of finding a vaccine is particularly appealing.”

Although men also contract UTIs, they are far more common among women and other people with vaginas, partly due to a shorter urethra, which makes it easier for bacteria to enter the urinary tract.

“Also varies around the time of our estrogen. If we have less estrogen, for example, in post-menopausal women, we’re more likely to see (UTIs) because of the change in the microbiome,” Shapiro said.

Between 50 and 60 per cent of women will develop more than one UTI in their lifetime, but as many as one in four women may also develop a recurrent urinary tract infection, defined as three or more UTIs in a 12-month period.

It is this condition that the new vaccine aims to tackle.

MV140 is a sublingual bacterial vaccine developed in Spain by Inmunotek, and has been approved for use there since 2010.

Since its development, it has been used for patients in several European countries through special access programs, including in the U.K., Sweden, Australia and New Zealand, among others.

Now, it is heading to Canada.

Red Leaf Medical, which owns the licence for Uromune (MV140) in Canada, filed a new drug submission with Health Canada a year ago.

Health Canada’s drug approval process can take one to two years.

“Uromune offers hope to women suffering from recurrent urinary tract infections who currently rely on multiple courses of antibiotics to treat their condition,” Charles Ko, managing director of Red Leaf Medical Inc., said in a press release at the time. “In addition to improving UTI management, Uromune has the potential to improve antibiotic stewardship and decrease the overall risk of antibiotic resistance.”

So will UTIs soon become a thing of the past?

Well, not with MV140 — the drug doesn’t provide full immunity against contracting a UTI, but does lessen the chances for those who have chronic infections. In a trial performed in Spain, described in a study published in 2022, the drug showed a 56 to 60 per cent efficacy in preventing UTIs in a nine-month study period.

A review published in the Canadian Urological Association Journal in 2020 found that Uromune had superior outcomes over other sublingual vaccines for UTIs.

Shapiro explained that this new drug doesn’t align with the typical concept of a vaccine as one or two shots that convey a lasting immunity.

It’s a sublingual vaccine, a type of vaccine which doesn’t use needles, but enters the body through tablets taken orally, or through a spray. 

“They’re made of inactivated bacteria, and the notion is that if you put (a tablet-based sublingual vaccine) under your tongue and it was daily for three months, your body would recognize these dead bacteria, mount an immune response at the level of where it should be … so that when you had an infection, you would mount your own immune response, not needing an antibiotic,” Shapiro said.

Uromune is a sublingual spray.

“It wouldn’t be a universal vaccine,” she said. “It’s something that would be used in women who are really having frequent urinary tract infections.”

For most of the population, a UTI is an uncomfortable experience that can be solved relatively quickly through antibiotics. But when a person has recurrent UTIs, the antibiotics start to become a problem.

“We worry about this because of antibiotic resistance, which we’re beginning to see, and many women end up being put on antibiotics on an ongoing basis if they have that criteria of ongoing chronic urinary tract infections,” Shapiro explained.

Antibiotic resistance occurs when bacteria learns how to fight against the antibiotics that have been developed in order to treat bacterial infections. The World Health Organization classifies it as “one of the biggest threats to global health” today, as a growing number of infections are becoming harder and harder to treat due to antibiotic resistance.

The stronger bacteria created by antibiotic resistance aren’t only a problem for the person who is being prescribed antibiotics that are no longer working — that stronger bacteria can also infect others and cause these more difficult infections to spread.

If Uromune is approved for use in Canada, it could help combat some of the antibiotic resistance that those with recurrent UTIs are at a risk of.

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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