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Charting a safer course: Advancements in chronic pain treatment

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From left to right: Ariel Ase, PhD, Research Associate (Co-inventor IP); Philippe Séguéla, PhD, Full Professor in the Department of Neurology and Neurosurgery at McGill (Project lead); and Jonas Friard, PhD, Postdoctoral Researcher. Emilie Hackett

Chronic pain affects one in every five individuals, yet effective treatment options are far and few between. Too often, chronic pain patients are left to choose between opioids, anticonvulsants for nerve pain and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, all of which present their own negative side effects.

Canadian opioid prescriptions have risen dramatically in recent years, surpassing 20 million prescriptions written annually. Historically known for addiction risks and severe consequences like abuse and overdose, opioids are overprescribed, harmful, and often insufficient to treat pain.

Meanwhile, the over-the-counter accessibility of NSAIDs complicates efforts to mitigate potential interactions with other medications, adding to their adverse effects on the gastrointestinal and cardiovascular systems. Anticonvulsants like gabapentin, used for nerve damage pain, also come with many side effects, like swelling, rashes, seizures, and drowsiness.

Moving pain research forward

“This is the limited arsenal we have right now, and it is simply not good enough. Clinicians and patients are not satisfied with this,” says McGill neuroscience professor and pain specialist Philippe Séguéla, PhD. The Séguéla Lab, , located at the Neuro (Montreal Neurological Institute-Hospital), has studied pain receptors for nearly three decades in the hopes of finding a safer, opiate-sparing alternative to relieve pain. His team has focused on deepening their understanding of the neurobiology of pain, investigating genes, cells and circuits related to pain perception and analgesia – the inability to feel pain.

They were able to identify a class of neuronal receptors – acid-sensing ion channels (ASICs) – as promising targets for pain relief. Their findings suggested that blocking peripheral ASICs could serve as an effective alternative to addictive opioid-based drugs for pain management.

With prior collaborations in the pharmaceutical and biotechnology sectors, Séguéla was driven to leverage his expertise to help chronic pain patients. He admits he was eager to explore the translational and therapeutic potential of these findings rather than solely conducting basic research on ASICs.

“Everyone knows someone affected by chronic pain and feels helpless,” he says. “We need a real qualitative step in the way we approach pain treatment and analgesia. We shouldn’t be afraid of failing, because regardless of the outcome, basic and translational science will have progressed.”

Toward opiate-free treatment of acute and chronic pain

With support from NeuroSphere, Séguéla secured early-stage funding from adMare Bioinnovations and AmorChem in 2020 for the preclinical development of this new therapy and the creation of Neurasic Therapeutics, a biotech company.

“NeuroSphere was pivotal to the creation of Neurasic Therapeutics. The NeuroSphere team was enthusiastic and pushed us forward,” recalls Séguéla. “They came to all our pitch meetings and provided us with support and professional advice. They were very helpful in fine-tuning the message.”

In 2022, Neurasic Therapeutics obtained even more funding from HBHL, CQDM and the Louise and Alan Edwards Foundation through NeuroSphere’s Neuro-Partnerships Program. With three patents filed and past progression to drug safety testing stages, Neurasic Therapeutics is inching closer to phase one clinical trials. If successful, these ASIC blockers could offer an opioid-free solution to the treatment of acute and chronic pain, potentially revolutionizing the field of pain management.

Small part of a larger story

For now, the outlook is highly promising. “In terms of potency and efficacy in vivo, the drug is already a success. Even ahead of testing in humans, we were able to confirm the absence of gastrointestinal side effects,” explains Séguéla. “This potentially offers an interesting clinical avenue, as our drug could be used alongside NSAIDs, reducing the incidence and severity of their side effects.”

In hindsight, Séguéla paints a favourable image of his experience in the corporate side of pharmacology, which can have a positive impact on any lab in the Canadian landscape thanks to its goal-oriented approach. “I like the milestones, the concrete objectives, the precise timeline involved in biotech,” he says. “There may be less freedom and more pressure than in academia, but it is very motivating and stimulating to try to reach tangible goals for the benefit of patients.”

Encouraging researchers to take risks, Séguéla emphasizes the transformative potential of their work: “Commercialization is a very positive experience for the scientists who are willing to dive. We have nothing to lose,” he says. “Even if the venture doesn’t culminate into successful drug development, the optimization of these molecules’ selectivity and potency will at the very least generate unique scientific tools.”

Beyond the potential of his own discovery, Séguéla is optimistic for the emerging treatment options for chronic pain. “Our adventure here is only one small part of a much larger story,” he reveals. “There are currently very interesting clinical trials happening globally, also in the process of testing novel pain targets. There are very promising advancements in the field, all driven by recent progress in the biology of pain. There is hope for chronic pain patients, now more than ever.”

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Ottawa orders TikTok’s Canadian arm to be dissolved

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The federal government is ordering the dissolution of TikTok’s Canadian business after a national security review of the Chinese company behind the social media platform, but stopped short of ordering people to stay off the app.

Industry Minister François-Philippe Champagne announced the government’s “wind up” demand Wednesday, saying it is meant to address “risks” related to ByteDance Ltd.’s establishment of TikTok Technology Canada Inc.

“The decision was based on the information and evidence collected over the course of the review and on the advice of Canada’s security and intelligence community and other government partners,” he said in a statement.

The announcement added that the government is not blocking Canadians’ access to the TikTok application or their ability to create content.

However, it urged people to “adopt good cybersecurity practices and assess the possible risks of using social media platforms and applications, including how their information is likely to be protected, managed, used and shared by foreign actors, as well as to be aware of which country’s laws apply.”

Champagne’s office did not immediately respond to a request for comment seeking details about what evidence led to the government’s dissolution demand, how long ByteDance has to comply and why the app is not being banned.

A TikTok spokesperson said in a statement that the shutdown of its Canadian offices will mean the loss of hundreds of well-paying local jobs.

“We will challenge this order in court,” the spokesperson said.

“The TikTok platform will remain available for creators to find an audience, explore new interests and for businesses to thrive.”

The federal Liberals ordered a national security review of TikTok in September 2023, but it was not public knowledge until The Canadian Press reported in March that it was investigating the company.

At the time, it said the review was based on the expansion of a business, which it said constituted the establishment of a new Canadian entity. It declined to provide any further details about what expansion it was reviewing.

A government database showed a notification of new business from TikTok in June 2023. It said Network Sense Ventures Ltd. in Toronto and Vancouver would engage in “marketing, advertising, and content/creator development activities in relation to the use of the TikTok app in Canada.”

Even before the review, ByteDance and TikTok were lightning rod for privacy and safety concerns because Chinese national security laws compel organizations in the country to assist with intelligence gathering.

Such concerns led the U.S. House of Representatives to pass a bill in March designed to ban TikTok unless its China-based owner sells its stake in the business.

Champagne’s office has maintained Canada’s review was not related to the U.S. bill, which has yet to pass.

Canada’s review was carried out through the Investment Canada Act, which allows the government to investigate any foreign investment with potential to might harm national security.

While cabinet can make investors sell parts of the business or shares, Champagne has said the act doesn’t allow him to disclose details of the review.

Wednesday’s dissolution order was made in accordance with the act.

The federal government banned TikTok from its mobile devices in February 2023 following the launch of an investigation into the company by federal and provincial privacy commissioners.

— With files from Anja Karadeglija in Ottawa

This report by The Canadian Press was first published Nov. 6, 2024.

The Canadian Press. All rights reserved.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Google’s partnership with AI startup Anthropic faces a UK competition investigation

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LONDON (AP) — Britain’s competition watchdog said Thursday it’s opening a formal investigation into Google’s partnership with artificial intelligence startup Anthropic.

The Competition and Markets Authority said it has “sufficient information” to launch an initial probe after it sought input earlier this year on whether the deal would stifle competition.

The CMA has until Dec. 19 to decide whether to approve the deal or escalate its investigation.

“Google is committed to building the most open and innovative AI ecosystem in the world,” the company said. “Anthropic is free to use multiple cloud providers and does, and we don’t demand exclusive tech rights.”

San Francisco-based Anthropic was founded in 2021 by siblings Dario and Daniela Amodei, who previously worked at ChatGPT maker OpenAI. The company has focused on increasing the safety and reliability of AI models. Google reportedly agreed last year to make a multibillion-dollar investment in Anthropic, which has a popular chatbot named Claude.

Anthropic said it’s cooperating with the regulator and will provide “the complete picture about Google’s investment and our commercial collaboration.”

“We are an independent company and none of our strategic partnerships or investor relationships diminish the independence of our corporate governance or our freedom to partner with others,” it said in a statement.

The U.K. regulator has been scrutinizing a raft of AI deals as investment money floods into the industry to capitalize on the artificial intelligence boom. Last month it cleared Anthropic’s $4 billion deal with Amazon and it has also signed off on Microsoft’s deals with two other AI startups, Inflection and Mistral.

The Canadian Press. All rights reserved.

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