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A look at the search for a COVID-19 vaccine in Canada – CBC.ca

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Thousands of scientists around the world are working on problems raised by the COVID-19 pandemic, including the search for a vaccine against the virus.

Canadian researchers are part of that search.

Here is a summary of some of the projects underway at Canadian universities:

Western University in London, Ont., is working on a COVID-19 vaccine, as well as on developing a coronavirus vaccine bank containing hundreds to thousands of potential vaccines that could be used at the start of another outbreak.

The research builds on previous work done at the school for a vaccine against the MERS virus, another coronavirus related to the one now circulating.

Researchers hope to develop ways to adapt vaccines effective against one virus to work against a related one. That would allow them to quickly produce new vaccines to fight future viral outbreaks.

Testing in animals

In Saskatoon, University of Saskatchewan scientists are trying to identify what common lab and agricultural animals can be infected with the virus to better understand which animals may pose a risk and which may be used as models for human infection.

The team will also use animals to ensure proposed vaccines don’t actually worsen the infection, as has been observed elsewhere, and to determine whether animals can be used to test safety of vaccines.

The university’s Vaccine and Infectious Disease Organization is building a pilot-scale plant on campus for vaccine development. It says it’s the first in the country to have a possible novel coronavirus vaccine for testing in animals.

Vaccine research

The University of Alberta in Edmonton is also investigating possible coronavirus vaccine candidates.

Researchers are building on previous experience to work toward developing methods for industry-scale vaccine purification.

Meanwhile, a University of Alberta cancer researcher and his biotechnology company is working on a DNA vaccine for the COVID-19 virus.

DNA-based vaccines introduce genetic material into a patient’s cells, which causes them to make bits of the virus and trick the immune system into a response. Such a vaccine is easier to manufacture at scale, offers improved stability and doesn’t need an infectious agent.

The vaccine candidates are to be tested soon in animal models before moving to human trials.

Reverse-engineering

At Laval University in Quebec City, scientists who have already had success against the Zika and MERS viruses are trying to develop a COVID-19 vaccine by reverse-engineering the genetics of the novel coronavirus.

Data is to be used to identify bodies that can neutralize the virus. The research, conducted in conjunction with biotechnology companies, is also expected to yield information on vaccine safety as well as on how the target viruses damage and travel between their human hosts.

Laval is also host to a project hoping to use nanoparticles to enhance the strength of an immune response and the speed of that response for any new vaccine.

The project is also looking for ways to induce cells to produce antibodies against the virus. The two components would be combined into a vaccine.

The approach has been used before during the SARS epidemic in 2002 and produces stable vaccines that can be stored for long periods.

Antiviral agents

In Winnipeg, a University of Manitoba team is looking at how the novel coronavirus gains entry to a healthy cell.

Researchers suspect compounds that interfere with that mechanism could be used as vaccines. They’ve found a way to target cells that present antiviral agents to the immune system and hope to use those cells to transmit the compounds they’ve developed.

University of British Columbia scientists are examining the effectiveness of previously known drugs against the novel coronavirus.

Many viruses that affect human health are related, but it’s not known if drugs developed to fight those are effective against COVID-19.

The team is assessing the most likely drugs to work and, since it’s already known they are safe, putting them into clinical trials. Work has already begun on a drug originally developed to fight HIV.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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Bizarre Sunlight Loophole Melts Belly Fat Fast!

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