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After Omicron Variant of COVID-19, Risk of BA.2 Subvariant Is Rare, Says Study – LatestLY

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London, February 27: People infected with the highly contagious Omicron variant of Covid are less likely to contract BA.2 subvariant, according to a study.Omicron, which has rapidly spread worldwide, carries numerous mutations in key regions and is associated with increased transmissibility and immune escape.

The variant has recently been divided into three subvariants with substantial genomic differences, in particular between Omicron BA.1 and BA.2. While Omicron is on the decline, many countries in Europe and Asia have seen an increase in BA.2 cases. Maharashtra Reports 12,160 COVID-19 Cases, Including 68 Omicron Infections In A Day.

With the surge in BA.2, a large number of reinfections from earlier cases has been observed, raising the question of whether the subvariant specifically can escape the natural immunity acquired shortly after a BA.1 infection.

“We provide evidence that Omicron BA.2 reinfections do occur shortly after BA.1 infections but are rare,” said corresponding author Morten Rasmussen, from the Department of Virus and Microbiological Special Diagnostics, at Statens Serum Institut, Denmark.

While the reinfection rate appears to be low given the high number of positive SARS-CoV-2 tests during the study period, it “still highlights the need for continuous assessment of length of vaccine-induced and/or natural immunity”, Rasmussen said.

To explore, a team of several Danish and Australian researchers selected a subset of samples from more than 1,8 million cases of infections in the period from November 22, 2021, until February 11, 2022.

They selected individuals with two positive samples, more than 20 and less than 60 days apart. Omicron’s Immune Evasion Behind Rapid Spread of the COVID-19 Variant, Say Studies.

From a total of 187 reinfection cases, they identified 47 instances of BA.2 reinfections shortly after a BA.1 infection, mostly in young unvaccinated individuals with mild disease not resulting in hospitalisation or death.

Further, the study showed that Omicron BA.2 reinfections after either Delta or BA.1 initial infections, were mainly observed among young individuals below the age of 30 and the majority of these cases were not vaccinated.

This emphasises the enhanced immunity obtained by the combination of vaccination and infection compared to infection induced immunity only, Rasmussen said.

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Quebec health officials confirm 25 monkeypox cases now in province – Global News

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Quebec public health officials are reporting a total of 25 confirmed cases of monkeypox in the province as of Thursday.

Dr. Luc Boileau, interim public health director in the province, described it as a “serious outbreak” of the virus. Officials are investigating several more suspected cases.

“We had about 20 to 30 suspected cases under investigation so far,” Boileau said.

The province will also begin administering the Imvamune vaccine to close contacts of confirmed or suspected cases of monkeypox as soon as Friday. A single dose will be provided within four days of exposure to the virus.

Quebec’s Health Ministry said in a statement that a second dose of the vaccine could be administered, but only if the risk of exposure is “still present 28 days later” and “only following a decision by public health authorities.”

READ MORE: Mass vaccinations for monkeypox not needed, WHO official says

Boileau said the majority of confirmed cases in the province are tied mostly to men who have had sexual relations with other men. There has been one case in a person under 18.

Last week, Quebec recorded the first cases of the virus in the country. The first suspected cases were reported on May 12 in Montreal.

Monkeypox is a rare disease that comes from the same family of viruses that causes smallpox, which the World Health Organization declared eradicated around the globe in 1980.

The virus spreads through prolonged closed contact. It can cause fever, headache, muscle aches, exhaustion, swollen lymph nodes and lesions.

— with files from Global News’ Dan Spector and the Canadian Press

© 2022 Global News, a division of Corus Entertainment Inc.

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Quebec to start monkeypox vaccination of contacts as officials confirm 25 cases

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MONTREAL — Quebec’s interim public health director says the province could start vaccinating people against monkeypox as soon as Friday.

Dr. Luc Boileau says there are now 25 confirmed cases of the disease in the province and about 30 suspected cases are under investigation.

He says the province has received supplies of smallpox vaccine from the federal government, and it will be administered to people who have been in close contact with confirmed cases of the disease.

Dr. Caroline Quach, the chair of Quebec’s immunization committee, says the vaccine has been shown to prevent monkeypox in animal studies if it is administered within four days of an exposure and can reduce severity if it is administered up to 14 days after an exposure.

She says the disease is transmitted only through prolonged close contact.

Boileau says the majority of cases are in adult men who have been in sexual contact with people who have the disease, and there has been one case in a person under 18.

This report by The Canadian Press was first published May 26, 2022.

 

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Monkeypox Warnings Ignored; Dominant COVID Strain Emerges; Better Paxlovid Access – Medpage Today

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Warning signs of the current monkeypox outbreak may have been ignored. (STAT)

The CDC issued a monkeypox travel alert encouraging “enhanced precautions” after cases were reported in North America, Europe, and Australia.

Roche announced it has developed three PCR test kits to detect the monkeypox virus.

The U.S. has a new dominant COVID-19 strain — BA.2.12.1 — a highly contagious sublineage of the BA.2 omicron subvariant that now accounts for 57.9% of all cases, according to CDC estimates.

Washington Gov. Jay Inslee, as well as Lt. Gov.Denny Heck, both tested positive for COVID-19, as did U.S. Rep. Liz Cheney (R-Wyo.). (Seattle Times, The Hill)

As of Thursday at 8:00 a.m. EDT, the unofficial U.S. COVID toll was 83,697,199 cases and 1,004,558 deaths, increases of 218,146 and 913, respectively, compared with this time Wednesday morning.

The Biden Administration, projecting COVID infections will continue to spread during the summer travel season announced additional steps to make nirmatrelvir/ritonavir (Paxlovid) more accessible. (ABC News)

The White House also reported the launch of the first federally-supported test-to-treat COVID site.

U.K. Prime Minister Boris Johnson and other senior leaders of the government are to blame for booze-filled parties that violated the country’s COVID-19 lockdown rules, according to an investigative report. (NPR)

A mouse study suggested that maraviroc (Selzentry), a FDA-approved drug used to treat HIV, may be able to reverse middle-aged memory loss. (Nature)

The University of California system will be paying nearly $700 million to women who said they were sexually abused by a UCLA gynecologist over the course of several decades. (AP)

The parents of a 4-year-old girl spoke out about her mysterious case of pediatric hepatitis that required a liver transplant, one of 180 similar cases under investigation in the U.S. (Today)

Teva Pharmaceuticals has issued a voluntary nationwide recall of one lot of anagrelide capsules, which are used to treat thrombocythemia secondary to myeloproliferative neoplasms, due to dissolution test failure during routine stability testing.

Servier announced the FDA approved ivosidenib (Tibsovo) in combination with azacitidine for certain patients with newly diagnosed IDH1-mutated acute myeloid leukemia.

A report from the American Medical Association shows that payers are not following the prior authorization reforms agreed to in 2018. (Fierce Healthcare)

The mass shooting in Buffalo earlier this month is a reminder that millions of Americans don’t have easy access to grocery stores. (NPR)

COVID-era misinformation is leading a wave of parents to reject ordinary childhood immunizations. (New York Times)

The FDA issued guidance spelling out rules for states that want to import certain prescription drugs from Canada.

  • Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

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