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AI cell analytics app aims to supercharge biotechnology research – UBC Faculty of Medicine – UBC Faculty of Medicine

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Transformative technology developed at the Vancouver Prostate Centre (VPC) is putting cell analytics into the hands of scientists around the globe. The technology — an artificial intelligence (AI)-driven smartphone app called SnapCyte — produces data for cell growth medical research faster and at a fraction of the cost compared to current technology.

“We developed SnapCyte based on a need for affordable, basic cell analytics that can be accessed by any scientist working in a cell culture or biotechnology laboratory,” says Dr. Mads Daugaard, an associate professor of urologic sciences at UBC and senior research scientist at VPC. “This app makes commercially available affordable, high-performance laboratory technology that can be conveniently accessed on a smartphone.”

Used in the analysis of cancer cells and other diseases at a microscopic scale, the first-of-its-kind smartphone app aims to supercharge the development of novel, personalized medical treatments. Dr. Daugaard and his team at VPC, a Centre of Excellence hosted by UBC and the Vancouver Coastal Health Research Institute, developed the technology based on their own need for fast and accurate cell growth data. Now, they want to bring the breakthrough technology to researchers around the globe.

“The app returns precision data results within five minutes,” he says. “With the former technology, this process would normally take 45 minutes to an hour with the most high-end live-cell imaging and analysis platforms, or 24 hours with colorimetric assays.”

Dr. Mads Daugaard

The researchers say that SnapCyte simplifies workflows without compromising accuracy. Unlike current technology that uses duplicate samples of a cell culture with a medium/serum solution, SnapCyte can be used on experiments in the plates where the cell culture is grown. It also collects and displays cumulative cell data in growth curves to aid with monitoring cell development over time, which can be easily shared among researchers.

“We developed SnapCyte based on a need for affordable, basic cell analytics that can be accessed by any scientist working in a cell culture or biotechnology laboratory..”
Dr. Mads Daugaard

“All you have to do is take the plate with the cell culture out of an incubator for a minute and put it under a microscope where you can then snap a picture of it with your smartphone,” says Dr. Daugaard.

Scientists can also monitor cell growth in the same well or stack of plates continuously, and add nucleic acids or other substances — in a process called transfection — when optimal.

“This platform can be very helpful in drug screening,” says Dr. Daugaard. “When comparing multiple drug candidates, SnapCyte can very accurately and quickly assess how each drug acts on cancer or other cells to identify the most effective treatment.”

Bringing cell analytics within reach of labs across the globe

At a few hundred dollars per year, the app’s affordability makes the platform an accessible option for laboratories that are unable to buy costly cell analytics equipment.

“Many laboratories do not have the funding to purchase new $25,000 to $30,000 machines, or the budget to support the ongoing investment of thousands of dollars per month required to use the equipment,” says Dr. Daugaard.

SnapCyte’s cloud-based platform allows users to not only accurately measure their collective cell culture data in minutes — the big data it gathers could also provide important insights to further advance scientific research.

The app’s AI algorithm is continuously learning from the data received from its users, says Dr. Daugaard. While the data is protected, the app’s efficacy will improve over time as it learns from and shares insights with the research community.

“It is time to democratize research, and that is what we are doing here,” says Dr. Daugaard. “We are putting something on the market for a fraction of the cost that will perform at least as good as — or even better than — many other devices currently available.”

The SnapCyte App is currently undergoing final beta testing and is expected to launch worldwide early next year.

A version of this story originally appeared on the Vancouver Coastal Health Research Institute website.

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The body of a Ugandan Olympic athlete who was set on fire by her partner is received by family

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NAIROBI, Kenya (AP) — The body of Ugandan Olympic athlete Rebecca Cheptegei — who died after being set on fire by her partner in Kenya — was received Friday by family and anti-femicide crusaders, ahead of her burial a day later.

Cheptegei’s family met with dozens of activists Friday who had marched to the Moi Teaching and Referral Hospital’s morgue in the western city of Eldoret while chanting anti-femicide slogans.

She is the fourth female athlete to have been killed by her partner in Kenya in yet another case of gender-based violence in recent years.

Viola Cheptoo, the founder of Tirop Angels – an organization that was formed in honor of athlete Agnes Tirop, who was stabbed to death in 2021, said stakeholders need to ensure this is the last death of an athlete due to gender-based violence.

“We are here to say that enough is enough, we are tired of burying our sisters due to GBV,” she said.

It was a somber mood at the morgue as athletes and family members viewed Cheptegei’s body which sustained 80% of burns after she was doused with gasoline by her partner Dickson Ndiema. Ndiema sustained 30% burns on his body and later succumbed.

Ndiema and Cheptegei were said to have quarreled over a piece of land that the athlete bought in Kenya, according to a report filed by the local chief.

Cheptegei competed in the women’s marathon at the Paris Olympics less than a month before the attack. She finished in 44th place.

Cheptegei’s father, Joseph, said that the body will make a brief stop at their home in the Endebess area before proceeding to Bukwo in eastern Uganda for a night vigil and burial on Saturday.

“We are in the final part of giving my daughter the last respect,” a visibly distraught Joseph said.

He told reporters last week that Ndiema was stalking and threatening Cheptegei and the family had informed police.

Kenya’s high rates of violence against women have prompted marches by ordinary citizens in towns and cities this year.

Four in 10 women or an estimated 41% of dating or married Kenyan women have experienced physical or sexual violence perpetrated by their current or most recent partner, according to the Kenya Demographic and Health Survey 2022.

The Canadian Press. All rights reserved.

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The ancient jar smashed by a 4-year-old is back on display at an Israeli museum after repair

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TEL AVIV, Israel (AP) — A rare Bronze-Era jar accidentally smashed by a 4-year-old visiting a museum was back on display Wednesday after restoration experts were able to carefully piece the artifact back together.

Last month, a family from northern Israel was visiting the museum when their youngest son tipped over the jar, which smashed into pieces.

Alex Geller, the boy’s father, said his son — the youngest of three — is exceptionally curious, and that the moment he heard the crash, “please let that not be my child” was the first thought that raced through his head.

The jar has been on display at the Hecht Museum in Haifa for 35 years. It was one of the only containers of its size and from that period still complete when it was discovered.

The Bronze Age jar is one of many artifacts exhibited out in the open, part of the Hecht Museum’s vision of letting visitors explore history without glass barriers, said Inbal Rivlin, the director of the museum, which is associated with Haifa University in northern Israel.

It was likely used to hold wine or oil, and dates back to between 2200 and 1500 B.C.

Rivlin and the museum decided to turn the moment, which captured international attention, into a teaching moment, inviting the Geller family back for a special visit and hands-on activity to illustrate the restoration process.

Rivlin added that the incident provided a welcome distraction from the ongoing war in Gaza. “Well, he’s just a kid. So I think that somehow it touches the heart of the people in Israel and around the world,“ said Rivlin.

Roee Shafir, a restoration expert at the museum, said the repairs would be fairly simple, as the pieces were from a single, complete jar. Archaeologists often face the more daunting task of sifting through piles of shards from multiple objects and trying to piece them together.

Experts used 3D technology, hi-resolution videos, and special glue to painstakingly reconstruct the large jar.

Less than two weeks after it broke, the jar went back on display at the museum. The gluing process left small hairline cracks, and a few pieces are missing, but the jar’s impressive size remains.

The only noticeable difference in the exhibit was a new sign reading “please don’t touch.”

The Canadian Press. All rights reserved.

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B.C. sets up a panel on bear deaths, will review conservation officer training

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VICTORIA – The British Columbia government is partnering with a bear welfare group to reduce the number of bears being euthanized in the province.

Nicholas Scapillati, executive director of Grizzly Bear Foundation, said Monday that it comes after months-long discussions with the province on how to protect bears, with the goal to give the animals a “better and second chance at life in the wild.”

Scapillati said what’s exciting about the project is that the government is open to working with outside experts and the public.

“So, they’ll be working through Indigenous knowledge and scientific understanding, bringing in the latest techniques and training expertise from leading experts,” he said in an interview.

B.C. government data show conservation officers destroyed 603 black bears and 23 grizzly bears in 2023, while 154 black bears were killed by officers in the first six months of this year.

Scapillati said the group will publish a report with recommendations by next spring, while an independent oversight committee will be set up to review all bear encounters with conservation officers to provide advice to the government.

Environment Minister George Heyman said in a statement that they are looking for new ways to ensure conservation officers “have the trust of the communities they serve,” and the panel will make recommendations to enhance officer training and improve policies.

Lesley Fox, with the wildlife protection group The Fur-Bearers, said they’ve been calling for such a committee for decades.

“This move demonstrates the government is listening,” said Fox. “I suspect, because of the impending election, their listening skills are potentially a little sharper than they normally are.”

Fox said the partnership came from “a place of long frustration” as provincial conservation officers kill more than 500 black bears every year on average, and the public is “no longer tolerating this kind of approach.”

“I think that the conservation officer service and the B.C. government are aware they need to change, and certainly the public has been asking for it,” said Fox.

Fox said there’s a lot of optimism about the new partnership, but, as with any government, there will likely be a lot of red tape to get through.

“I think speed is going to be important, whether or not the committee has the ability to make change and make change relatively quickly without having to study an issue to death, ” said Fox.

This report by The Canadian Press was first published Sept. 9, 2024.

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