Antibodies in children last at least 6 mos after COVID; SK Bioscience vaccine shows promise vs Omicron | Canada News Media
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Antibodies in children last at least 6 mos after COVID; SK Bioscience vaccine shows promise vs Omicron

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The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

Antibodies in kids after COVID last 6 months or more

Most children and adolescents with COVID-19 antibodies after SARS-CoV-2 infection usually still have the antibodies in their blood more than half a year later, new data shows.

Starting in October 2020, researchers in Texas recruited 218 subjects between the ages of 5 and 19. Each provided three blood samples, at three-month intervals. More than 90% were unvaccinated when they enrolled in the study. The first blood test showed infection-related antibodies indicating recovery from COVID-19 in one-third of the children, the researchers reported online Friday in Pediatrics https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2021-055505/185412/Durability-of-SARS-CoV-2-Antibodies-From-Natural. Six months later, 96% of those with the antibodies still had them. The study was designed to detect the presence of antibodies, which are only one component of the immune system’s defenses, not the amount of antibodies. The level of protection even in those with antibodies is unclear. Researchers found no differences based on whether a child was asymptomatic, severity of symptoms, when they had the virus or due to weight or gender.

“It was the same for everyone,” Sarah Messiah of UTHealth School of Public Health Dallas, said in a statement. “Some parents… think just because their child has had COVID-19, they are now protected and don’t need to get the vaccine,” Messiah said. “We have a great tool available to give children additional protection by getting their vaccine.”

A small study published earlier this month in JAMA Network Open https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789845 suggested that most children infected with the coronavirus do not have antibodies in their blood afterward. Only 37% of children appeared to develop antibodies, compared to 76% of adults, even though viral loads were similar in the two groups, those researchers found.

Experimental SK vaccine shows promise against Omicron

A booster shot of an experimental vaccine being developed by SK Bioscience Co has shown “durable protection” against the Omicron variant in Rhesus macaques, according to new data.

The monkeys had received two initial doses of the vaccine plus a booster 6 or 12 months later. Blood samples from the boosted primates showed “remarkably high” levels of antibodies that could neutralize both the original strain of the virus and the Omicron variant that caused infections to soar, the researchers reported on Sunday on bioRxiv https://www.biorxiv.org/content/10.1101/2022.03.18.484950v1 ahead of peer review. The animals’ second-line immune defenses were also “substantial and persistent,” they said. The vaccine, called GBP510, triggers responses from the immune system by delivering copies of a key part of the spike protein from the surface of the coronavirus. The protein “subunits” are studded onto nanoparticles to resemble the virus itself. These components are supplemented with an adjuvant from GSK that boosts the immune system’s responses, explained Bali Pulendran of Stanford University in California.

“Vaccination with two doses… followed a year later by a booster shot… plus adjuvant, led to highly durable antibody responses and protection against Omicron infection, even six months later,” Pulendran said. Large late-stage trials of GBP510 in humans are underway.

AstraZeneca drug less protective vs Omicron in transplant patients

The AstraZeneca antibody shots given to prevent COVID-19 in high-risk children and adults with weakened immune systems do not adequately protect organ transplant recipients from the Omicron variant, researchers found.

The drug, Evusheld, did protect against the Delta variant in kidney transplant recipients, and lab test results released on Monday show Evusheld can neutralize Omicron in mice, including the highly contagious BA.2 version. But among 416 kidney recipients treated with Evusheld after Omicron became the predominant variant, 9.4% developed symptomatic breakthrough infections, with one-in-three of those patients requiring hospitalization, researchers reported on Saturday on medRxiv https://www.medrxiv.org/content/10.1101/2022.03.19.22272575v1 ahead of peer review. Two patients died of COVID-19. In lab experiments, the researchers exposed the BA.1 version of Omicron that caused the massive winter surge to blood samples from 15 Evusheld-treated patients. None of the samples could neutralize the virus.

The U.S. Food and Drug Administration recently advised https://www.fda.gov/drugs/drug-safety-and-availability/fda-authorizes-revisions-evusheld-dosing that higher doses of Evusheld are likely needed to prevent Omicron infections, and that patients who received the originally approved shots should receive booster doses. The researchers said kidney transplant recipients “should be advised to maintain sanitary protection measures and undergo vaccine boosters.”

Click for a Reuters graphic https://tmsnrt.rs/3c7R3Bl on vaccines in development.

(Reporting by Nancy Lapid; Editing by Bill Berkrot)

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Whooping cough is at a decade-high level in US

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MILWAUKEE (AP) — Whooping cough is at its highest level in a decade for this time of year, U.S. health officials reported Thursday.

There have been 18,506 cases of whooping cough reported so far, the Centers for Disease Control and Prevention said. That’s the most at this point in the year since 2014, when cases topped 21,800.

The increase is not unexpected — whooping cough peaks every three to five years, health experts said. And the numbers indicate a return to levels before the coronavirus pandemic, when whooping cough and other contagious illnesses plummeted.

Still, the tally has some state health officials concerned, including those in Wisconsin, where there have been about 1,000 cases so far this year, compared to a total of 51 last year.

Nationwide, CDC has reported that kindergarten vaccination rates dipped last year and vaccine exemptions are at an all-time high. Thursday, it released state figures, showing that about 86% of kindergartners in Wisconsin got the whooping cough vaccine, compared to more than 92% nationally.

Whooping cough, also called pertussis, usually starts out like a cold, with a runny nose and other common symptoms, before turning into a prolonged cough. It is treated with antibiotics. Whooping cough used to be very common until a vaccine was introduced in the 1950s, which is now part of routine childhood vaccinations. It is in a shot along with tetanus and diphtheria vaccines. The combo shot is recommended for adults every 10 years.

“They used to call it the 100-day cough because it literally lasts for 100 days,” said Joyce Knestrick, a family nurse practitioner in Wheeling, West Virginia.

Whooping cough is usually seen mostly in infants and young children, who can develop serious complications. That’s why the vaccine is recommended during pregnancy, to pass along protection to the newborn, and for those who spend a lot of time with infants.

But public health workers say outbreaks this year are hitting older kids and teens. In Pennsylvania, most outbreaks have been in middle school, high school and college settings, an official said. Nearly all the cases in Douglas County, Nebraska, are schoolkids and teens, said Justin Frederick, deputy director of the health department.

That includes his own teenage daughter.

“It’s a horrible disease. She still wakes up — after being treated with her antibiotics — in a panic because she’s coughing so much she can’t breathe,” he said.

It’s important to get tested and treated with antibiotics early, said Dr. Kris Bryant, who specializes in pediatric infectious diseases at Norton Children’s in Louisville, Kentucky. People exposed to the bacteria can also take antibiotics to stop the spread.

“Pertussis is worth preventing,” Bryant said. “The good news is that we have safe and effective vaccines.”

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AP data journalist Kasturi Pananjady contributed to this report.

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The Associated Press Health and Science Department receives support from the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

The Canadian Press. All rights reserved.

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Scientists show how sperm and egg come together like a key in a lock

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How a sperm and egg fuse together has long been a mystery.

New research by scientists in Austria provides tantalizing clues, showing fertilization works like a lock and key across the animal kingdom, from fish to people.

“We discovered this mechanism that’s really fundamental across all vertebrates as far as we can tell,” said co-author Andrea Pauli at the Research Institute of Molecular Pathology in Vienna.

The team found that three proteins on the sperm join to form a sort of key that unlocks the egg, allowing the sperm to attach. Their findings, drawn from studies in zebrafish, mice, and human cells, show how this process has persisted over millions of years of evolution. Results were published Thursday in the journal Cell.

Scientists had previously known about two proteins, one on the surface of the sperm and another on the egg’s membrane. Working with international collaborators, Pauli’s lab used Google DeepMind’s artificial intelligence tool AlphaFold — whose developers were awarded a Nobel Prize earlier this month — to help them identify a new protein that allows the first molecular connection between sperm and egg. They also demonstrated how it functions in living things.

It wasn’t previously known how the proteins “worked together as a team in order to allow sperm and egg to recognize each other,” Pauli said.

Scientists still don’t know how the sperm actually gets inside the egg after it attaches and hope to delve into that next.

Eventually, Pauli said, such work could help other scientists understand infertility better or develop new birth control methods.

The work provides targets for the development of male contraceptives in particular, said David Greenstein, a genetics and cell biology expert at the University of Minnesota who was not involved in the study.

The latest study “also underscores the importance of this year’s Nobel Prize in chemistry,” he said in an email.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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