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AstraZeneca pause could slow Canada's COVID-19 vaccine rollout – CTV News

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TORONTO —
Concerns over blood clots in patients who have received the AstraZeneca vaccine may further slow the vaccine rollout in Canada.

Provinces are reconsidering their rollout plans in light of new guidelines from NACI to avoid use of the AstraZeneca vaccine in people under the age of 55. NACI’s updated guidelines comes after 31 people in Germany developed blood clots after receiving the AstraZeneca vaccine, nine of them died.

In Germany, 2.7 million people have received the AstraZeneca vaccine, this puts the chance of getting a blood clot at about one in 100,000, as opposed toaone in a million chance,according to the World Health Organization (WHO). The European Medicines Agency shared similar data, with 25 people out of 20 million developing blood clots. 

“The odds of dying in a car crash are one in 100, to put that in perspective,” Rodney Russell, professor of virology and immunology at Memorial University of Newfoundland, told CTVNews.ca in a phone interview on Tuesday.

“It still puts it in the same range as dying by getting hit by lightning, but it sounds a lot worse,” he said.

The general adult population has a one in 1,000 chance of developing a blood clot in a given year. This is 100 times more likely than the risk associated with the AstraZeneca vaccine.

While the rare cases of blood clots are concerning, Russell is also worried about what this may do for Canada’s vaccine rollout. Canada is set to receive 1.5 million doses of the vaccine by April 4.

“The key to getting back to normal is for everyone to get vaccinated,” he said.

He said that reports saying that people aren’t showing up to get their vaccines indicates that there’s already a high rate of hesitancy among Canadians.

Pfizer and Moderna vaccines came out of the gate with 95 per cent efficacy rates, a number that was much higher than anticipated, he said. When AstraZeneca released their data with a lower efficacy, people began to prefer one over the other.

He said it’s important that people understand that each vaccine will have the same end result: preparing the body to create an immune response to the SARS-CoV-2 spike protein.

“It’s the protein at the end of the assembly line that gets seen by the immune system,” he said.

While the Pfizer and Moderna vaccines, which use mRNA technology, have a higher efficacy than the AstraZeneca vaccine, which uses viral vector technology, they all target the same protein.

The mRNA vaccines use molecules called mRNA to tell the body how to make the SARS-CoV-2 spike protein, while viral vector vaccines use genetically modified virus to deliver the instructions on making the spike protein, according to Health Canada. According to the CDC, viral vector vaccines have been studied since the 1970s and most recently two viral vector vaccines have been used in Ebola outbreaks. They say that mRNA vaccines are newer with Pfizer and Moderna being the first of their kind approved in Canada and the U.S..

Russell said that it’s unfortunate that the efficacy of the various vaccines have been focused on, leading to the public to label Pfizer and Moderna as good and AstraZeneca as bad. Real-world data has allowed AstraZeneca to increase the efficacy data from 62 per cent to 76 per cent.

The news of lower efficacy was followed by Health Canada’s approval of the vaccine for use in people under age 65, an age determined by a lack of data, not safety issues, he said.

“Don’t forget, this is the vaccine that they mistakenly gave half doses in the phase three trial,” he added.

Since day one, AstraZeneca seems to be followed by bad news that Pfizer and Moderna have so far been able to avoid, and extra precautions are being taken to ensure the safety of the new vaccines.

“We’re trying to show how careful we’re being, but by doing that, then we’re pausing every week for different reasons, at some point people start to think ‘well this is garbage and shouldn’t be put in our bodies because every week there’s a new problem with it,’” he said.

If given the chance, Russell said he’d get the AstraZeneca vaccine today.

“I’d rather be vaccinated and watching for side effects than not know when I’m ever going to get a vaccine,” he said. “You still have 17 million people who’ve been vaccinated and not had any trouble.”

And there’s the trouble. Russell, like many Canadians, doesn’t know when he’ll be able to get the vaccine. He thinks it will be late summer, but in light of the latest data on AstraZeneca, it could be even later.

He said that a day or two of pauses may not cause a backlog, but if the pauses last for weeks it will cause delays and backlogs. Not to mention the potential for doses to expire and go to waste.

Canada’s rollout plan relies heavily on the use of AstraZeneca. The country has 20 million doses of the AstraZeneca vaccine on order.

“It has to increase hesitancy, which is going to slow down acquisition of herd immunity,” Russell said. “And it’s vaccines that are going to get us there.”

The data surrounding AstraZeneca has cast doubt on the vaccine since the start. It’s efficacy wasn’t as high, the third phase of the trial used incorrect dosing, it wasn’t approved for use in those over age 65, and then it was. For the general public, this may be a cause for doubt in the approval process, but it shouldn’t be,said CTV News medical specialist, Dr. Marla Shapiro.

“When I look to the immediate response and how nimble and flexible we are as data evolves, it really does tell me that we should have confidence in our advisory bodies who are monitoring and really have a very high bar of safety here and really want to make sure that we’re doing no harm,” she told CTV News Channel on Tuesday.

Anything that slows down the ability to vaccinate will result in a slower return to so-called normal life in Canada, said Russell.

It doesn’t help that different provinces are taking different approaches, leaving Canadians unsure of what to do. People will wonder why their province didn’t pause it, or wonder what their province knows that others don’t, he added.

A single voice from the government about why there is changing information could help ease some concerns.

“I do think we need a much better communication strategy, we need a single, solid voice explaining to the Canadian population where the information is coming from, why we’re responding the way we do. We need to be completely transparent,” said Shapiro.

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Virginia Democrats advance efforts to protect abortion, voting rights, marriage equality

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RICHMOND, Va. (AP) — Democrats who control both chambers of the Virginia legislature are hoping to make good on promises made on the campaign trail, including becoming the first Southern state to expand constitutional protections for abortion access.

The House Privileges and Elections Committee advanced three proposed constitutional amendments Wednesday, including a measure to protect reproductive rights. Its members also discussed measures to repeal a now-defunct state constitutional ban on same-sex marriage and ways to revise Virginia’s process to restore voting rights for people who served time for felony crimes.

“This meeting was an important next step considering the moment in history we find ourselves in,” Democratic Del. Cia Price, the committee chair, said during a news conference. “We have urgent threats to our freedoms that could impact constituents in all of the districts we serve.”

The at-times raucous meeting will pave the way for the House and Senate to take up the resolutions early next year after lawmakers tabled the measures last January. Democrats previously said the move was standard practice, given that amendments are typically introduced in odd-numbered years. But Republican Minority Leader Todd Gilbert said Wednesday the committee should not have delved into the amendments before next year’s legislative session. He said the resolutions, particularly the abortion amendment, need further vetting.

“No one who is still serving remembers it being done in this way ever,” Gilbert said after the meeting. “Certainly not for something this important. This is as big and weighty an issue as it gets.”

The Democrats’ legislative lineup comes after Republican Governor Glenn Youngkin, to the dismay of voting-rights advocates, rolled back a process to restore people’s civil rights after they completed sentences for felonies. Virginia is the only state that permanently bans anyone convicted of a felony from voting unless a governor restores their rights.

“This amendment creates a process that is bounded by transparent rules and criteria that will apply to everybody — it’s not left to the discretion of a single individual,” Del. Elizabeth Bennett-Parker, the patron of the voting rights resolution, which passed along party lines, said at the news conference.

Though Democrats have sparred with the governor over their legislative agenda, constitutional amendments put forth by lawmakers do not require his signature, allowing the Democrat-led House and Senate to bypass Youngkin’s blessing.

Instead, the General Assembly must pass proposed amendments twice in at least two years, with a legislative election sandwiched between each statehouse session. After that, the public can vote by referendum on the issues. The cumbersome process will likely hinge upon the success of all three amendments on Democrats’ ability to preserve their edge in the House and Senate, where they hold razor-thin majorities.

It’s not the first time lawmakers have attempted to champion the three amendments. Republicans in a House subcommittee killed a constitutional amendment to restore voting rights in 2022, a year after the measure passed in a Democrat-led House. The same subcommittee also struck down legislation supporting a constitutional amendment to repeal an amendment from 2006 banning marriage equality.

On Wednesday, a bipartisan group of lawmakers voted 16-5 in favor of legislation protecting same-sex marriage, with four Republicans supporting the resolution.

“To say the least, voters enacted this (amendment) in 2006, and we have had 100,000 voters a year become of voting age since then,” said Del. Mark Sickles, who sponsored the amendment as one of the first openly gay men serving in the General Assembly. “Many people have changed their opinions of this as the years have passed.”

A constitutional amendment protecting abortion previously passed the Senate in 2023 but died in a Republican-led House. On Wednesday, the amendment passed on party lines.

If successful, the resolution proposed by House Majority Leader Charniele Herring would be part of a growing trend of reproductive rights-related ballot questions given to voters. Since 2022, 18 questions have gone before voters across the U.S., and they have sided with abortion rights advocates 14 times.

The voters have approved constitutional amendments ensuring the right to abortion until fetal viability in nine states: Arizona, California, Colorado, Maryland, Michigan, Missouri, Montana, Ohio and Vermont. Voters also passed a right-to-abortion measure in Nevada in 2024, but it must be passed again in 2026 to be added to the state constitution.

As lawmakers debated the measure, roughly 18 members spoke. Mercedes Perkins, at 38 weeks pregnant, described the importance of women making decisions about their own bodies. Rhea Simon, another Virginia resident, anecdotally described how reproductive health care shaped her life.

Then all at once, more than 50 people lined up to speak against the abortion amendment.

“Let’s do the compassionate thing and care for mothers and all unborn children,” resident Sheila Furey said.

The audience gave a collective “Amen,” followed by a round of applause.

___

Associated Press writer Geoff Mulvihill in Cherry Hill, New Jersey, contributed to this report.

___

Olivia Diaz is a corps member for The Associated Press/Report for America Statehouse News Initiative.

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Vancouver Canucks winger Joshua set for season debut after cancer treatment

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Vancouver Canucks winger Dakota Joshua is set to make his season debut Thursday after missing time for cancer treatment.

Head coach Rick Tocchet says Joshua will slot into the lineup Thursday when Vancouver (8-3-3) hosts the New York Islanders.

The 28-year-old from Dearborn, Mich., was diagnosed with testicular cancer this summer and underwent surgery in early September.

He spoke earlier this month about his recovery, saying it had been “very hard to go through” and that he was thankful for support from his friends, family, teammates and fans.

“That was a scary time but I am very thankful and just happy to be in this position still and be able to go out there and play,,” Joshua said following Thursday’s morning skate.

The cancer diagnosis followed a career season where Joshua contributed 18 goals and 14 assists across 63 regular-season games, then added four goals and four assists in the playoffs.

Now, he’s ready to focus on contributing again.

“I expect to be good, I don’t expect a grace period. I’ve been putting the work in so I expect to come out there and make an impact as soon as possible,” he said.

“I don’t know if it’s going to be perfect right from the get-go, but it’s about putting your best foot forward and working your way to a point of perfection.”

The six-foot-three, 206-pound Joshua signed a four-year, US$13-million contract extension at the end of June.

This report by The Canadian Press was first published Nov. 14, 2024.

The Canadian Press. All rights reserved.

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Trump chooses anti-vaccine activist Robert F. Kennedy Jr. as health secretary

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NEW YORK (AP) — President-elect Donald Trump says he will nominate anti-vaccine activist Robert F. Kennedy Jr. to lead the Department of Health and Human Services, putting him in charge of a massive agency that oversees everything from drug, vaccine and food safety to medical research and the social safety net programs Medicare and Medicaid.

“For too long, Americans have been crushed by the industrial food complex and drug companies who have engaged in deception, misinformation, and disinformation when it comes to Public Health,” Trump said in a post on his Truth Social site announcing the appointment. Kennedy, he said, would “Make America Great and Healthy Again!”

Kennedy, a former Democrat who ran as an independent in this year’s presidential race, abandoned his bid after striking a deal to give Trump his endorsement with a promise to have a role in health policy in the administration.

He and Trump have since become good friends, with Kennedy frequently receiving loud applause at Trump’s rallies.

The expected appointment was first reported by Politico Thursday.

A longtime vaccine skeptic, Kennedy is an attorney who has built a loyal following over several decades of people who admire his lawsuits against major pesticide and pharmaceutical companies. He has pushed for tighter regulations around the ingredients in foods.

With the Trump campaign, he worked to shore up support among young mothers in particular, with his message of making food healthier in the U.S., promising to model regulations imposed in Europe. In a nod to Trump’s original campaign slogan, he named the effort “Make America Healthy Again.”

It remains unclear how that will square with Trump’s history of deregulation of big industries, including food. Trump pushed for fewer inspections of the meat industry, for example.

Kennedy’s stance on vaccines has also made him a controversial figure among Democrats and some Republicans, raising question about his ability to get confirmed, even in a GOP-controlled Senate. Kennedy has espoused misinformation around the safety of vaccines, including pushing a totally discredited theory that childhood vaccines cause autism.

He also has said he would recommend removing fluoride from drinking water. The addition of the material has been cited as leading to improved dental health.

HHS has more than 80,000 employees across the country. It houses the Food and Drug Administration, the Centers for Disease Control and Prevention, the Medicare and Medicaid programs and the National Institutes of Health.

Kennedy’s anti-vaccine nonprofit group, Children’s Health Defense, currently has a lawsuit pending against a number of news organizations, among them The Associated Press, accusing them of violating antitrust laws by taking action to identify misinformation, including about COVID-19 and COVID-19 vaccines. Kennedy took leave from the group when he announced his run for president but is listed as one of its attorneys in the lawsuit.

__ Seitz reported from Washington.

The Canadian Press. All rights reserved.

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