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AstraZeneca’s COVID-19 vaccine on track despite setback, CEO says – The Globe and Mail

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The chief executive of AstraZeneca says it is not uncommon for vaccine trials to be paused because of an adverse event and he believes the company can still deliver a safe COVID-19 vaccine by the end of the year.

“If you have an event that you didn’t expect, then you stop to look at it and explore it and study it,” Pascal Soriot said Thursday during a conference sponsored by British news outlet Tortois Media. “And that’s what happened in our case, but it’s really common.”

AstraZeneca announced this week that it had halted the Phase 3 trial of a COVID-19 vaccine the company is developing with researchers at Oxford University. It is considered one of the best candidates for a viable vaccine, but the trial was stopped after a female volunteer in Britain fell ill. She developed symptoms consistent with a rare disorder called transverse myelitis, which causes inflammation of the spinal cord. The woman’s condition has been improving, and she was expected to leave hospital this week.

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Mr. Soriot said an independent safety committee was reviewing the case and it had yet to determine if the volunteer had actually developed transverse myelitis. He added that the trial won’t restart until the review is completed. The committee can either allow the trial to continue or stop the project altogether.

This was the second time the trial for the vaccine, known as AZD1222, has been halted. Mr. Soriot confirmed that another pause happened in July when a participant experienced neurological symptoms. Further examination found the participant had multiple sclerosis, which was deemed unrelated to the vaccine.

Mr. Soriot said that although transverse myelitis is rare, it had surfaced in other vaccine projects. “What is true is that you will see transverse myelitis mentioned in the product information of several other vaccines,” he said. “And the issue with vaccines is you actually vaccinate thousands and thousands of people, so you will see all sorts of issues come up that are often not related to the vaccine.”

He added that many other vaccine trials have had to stop but such developments rarely get much public attention. “The difference with other vaccine trials is the whole world is not watching them, of course, so they stop, they study and they restart. What happened here is not uncommon,” he said. “What we have here is a very special set of circumstances where the entire world becomes involved in the conduct of the clinical trial and wants to know every step of the way.”

The Phase 3 trial of AZD1222 involves 30,000 participants in Britain, the United States, Brazil and South Africa. Such trials often last several years, but AstraZeneca has been able to speed up the process by working in parallel with regulators. Usually drug companies complete their trials and then submit the data to regulators, who spend months analyzing the information. AstraZeneca has been handing over data as the trials proceed.

“We could not do this for every single vaccine or drug because the system would not be supporting it – the regulator would not have the resources,” Mr. Soriot said. He added that the vaccine will ultimately be tested on as many as 60,000 people before it is approved.

Despite the setback, Mr. Soriot said that if the trial can restart soon the company is on track to deliver the vaccine in a few months. “We could still have a vaccine by the end of this year, maybe early next year, but by the end of this year is still possible.”

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Two other vaccines in development – by Pfizer Inc. and Moderna Therapeutics – are also in Phase 3 testing and could be ready by early 2021, he said.

AstraZeneca is producing the vaccine on a non-profit basis and has lined up manufacturing partners around the world to ensure it can be delivered in all regions at roughly the same time. The company and Oxford are also working with non-profit organizations to co-ordinate distribution among developing countries and to people in refugee camps.

Medical experts said it was not uncommon for trials to stop because a participant fell ill. “A suspension such as this is not unusual for Phase 3 trials, which have tens of thousands of participants,” said Ohid Yaqub, a senior lecturer at the science policy research unit at the University of Sussex.

“Suspending the trial gives time to investigate whether the incident is related to the vaccine or is happening by coincidence. If the data and safety monitoring board decides it’s the latter, the trial will resume. Other trials will also investigate their data, too.”

U.S. top infectious disease expert, Dr. Anthony Fauci, in an online forum moderated by PBS NewsHour’s Judy Woodruff on Tuesday, said while he thinks it’s “unlikely” there will be a coronavirus vaccine by Election Day, it’s not “impossible.” Reuters

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Telus prioritizing ‘most important customers,’ avoiding ‘unprofitable’ offers: CFO

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Telus Corp. says it is avoiding offering “unprofitable” discounts as fierce competition in the Canadian telecommunications sector shows no sign of slowing down.

The company said Friday it had fewer net new customers during its third quarter compared with the same time last year, as it copes with increasingly “aggressive marketing and promotional pricing” that is prompting more customers to switch providers.

Telus said it added 347,000 net new customers, down around 14.5 per cent compared with last year. The figure includes 130,000 mobile phone subscribers and 34,000 internet customers, down 30,000 and 3,000, respectively, year-over-year.

The company reported its mobile phone churn rate — a metric measuring subscribers who cancelled their services — was 1.09 per cent in the third quarter, up from 1.03 per cent in the third quarter of 2023. That included a postpaid mobile phone churn rate of 0.90 per cent in its latest quarter.

Telus said its focus is on customer retention through its “industry-leading service and network quality, along with successful promotions and bundled offerings.”

“The customers we have are the most important customers we can get,” said chief financial officer Doug French in an interview.

“We’ve, again, just continued to focus on what matters most to our customers, from a product and customer service perspective, while not loading unprofitable customers.”

Meanwhile, Telus reported its net income attributable to common shares more than doubled during its third quarter.

The telecommunications company said it earned $280 million, up 105.9 per cent from the same three-month period in 2023. Earnings per diluted share for the quarter ended Sept. 30 was 19 cents compared with nine cents a year earlier.

It reported adjusted net income was $413 million, up 10.7 per cent year-over-year from $373 million in the same quarter last year. Operating revenue and other income for the quarter was $5.1 billion, up 1.8 per cent from the previous year.

Mobile phone average revenue per user was $58.85 in the third quarter, a decrease of $2.09 or 3.4 per cent from a year ago. Telus said the drop was attributable to customers signing up for base rate plans with lower prices, along with a decline in overage and roaming revenues.

It said customers are increasingly adopting unlimited data and Canada-U.S. plans which provide higher and more stable ARPU on a monthly basis.

“In a tough operating environment and relative to peers, we view Q3 results that were in line to slightly better than forecast as the best of the bunch,” said RBC analyst Drew McReynolds in a note.

Scotiabank analyst Maher Yaghi added that “the telecom industry in Canada remains very challenging for all players, however, Telus has been able to face these pressures” and still deliver growth.

The Big 3 telecom providers — which also include Rogers Communications Inc. and BCE Inc. — have frequently stressed that the market has grown more competitive in recent years, especially after the closing of Quebecor Inc.’s purchase of Freedom Mobile in April 2023.

Hailed as a fourth national carrier, Quebecor has invested in enhancements to Freedom’s network while offering more affordable plans as part of a set of commitments it was mandated by Ottawa to agree to.

The cost of telephone services in September was down eight per cent compared with a year earlier, according to Statistics Canada’s most recent inflation report last month.

“I think competition has been and continues to be, I’d say, quite intense in Canada, and we’ve obviously had to just manage our business the way we see fit,” said French.

Asked how long that environment could last, he said that’s out of Telus’ hands.

“What I can control, though, is how we go to market and how we lead with our products,” he said.

“I think the conditions within the market will have to adjust accordingly over time. We’ve continued to focus on digitization, continued to bring our cost structure down to compete, irrespective of the price and the current market conditions.”

Still, Canada’s telecom regulator continues to warn providers about customers facing more charges on their cellphone and internet bills.

On Tuesday, CRTC vice-president of consumer, analytics and strategy Scott Hutton called on providers to ensure they clearly inform their customers of charges such as early cancellation fees.

That followed statements from the regulator in recent weeks cautioning against rising international roaming fees and “surprise” price increases being found on their bills.

Hutton said the CRTC plans to launch public consultations in the coming weeks that will focus “on ensuring that information is clear and consistent, making it easier to compare offers and switch services or providers.”

“The CRTC is concerned with recent trends, which suggest that Canadians may not be benefiting from the full protections of our codes,” he said.

“We will continue to monitor developments and will take further action if our codes are not being followed.”

French said any initiative to boost transparency is a step in the right direction.

“I can’t say we are perfect across the board, but what I can say is we are absolutely taking it under consideration and trying to be the best at communicating with our customers,” he said.

“I think everyone looking in the mirror would say there’s room for improvement.”

This report by The Canadian Press was first published Nov. 8, 2024.

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TC Energy cuts cost estimate for Southeast Gateway pipeline project in Mexico

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CALGARY – TC Energy Corp. has lowered the estimated cost of its Southeast Gateway pipeline project in Mexico.

It says it now expects the project to cost between US$3.9 billion and US$4.1 billion compared with its original estimate of US$4.5 billion.

The change came as the company reported a third-quarter profit attributable to common shareholders of C$1.46 billion or $1.40 per share compared with a loss of C$197 million or 19 cents per share in the same quarter last year.

Revenue for the quarter ended Sept. 30 totalled C$4.08 billion, up from C$3.94 billion in the third quarter of 2023.

TC Energy says its comparable earnings for its latest quarter amounted to C$1.03 per share compared with C$1.00 per share a year earlier.

The average analyst estimate had been for a profit of 95 cents per share, according to LSEG Data & Analytics.

This report by The Canadian Press was first published Nov. 7, 2024.

Companies in this story: (TSX:TRP)

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BCE reports Q3 loss on asset impairment charge, cuts revenue guidance

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BCE Inc. reported a loss in its latest quarter as it recorded $2.11 billion in asset impairment charges, mainly related to Bell Media’s TV and radio properties.

The company says its net loss attributable to common shareholders amounted to $1.24 billion or $1.36 per share for the quarter ended Sept. 30 compared with a profit of $640 million or 70 cents per share a year earlier.

On an adjusted basis, BCE says it earned 75 cents per share in its latest quarter compared with an adjusted profit of 81 cents per share in the same quarter last year.

“Bell’s results for the third quarter demonstrate that we are disciplined in our pursuit of profitable growth in an intensely competitive environment,” BCE chief executive Mirko Bibic said in a statement.

“Our focus this quarter, and throughout 2024, has been to attract higher-margin subscribers and reduce costs to help offset short-term revenue impacts from sustained competitive pricing pressures, slow economic growth and a media advertising market that is in transition.”

Operating revenue for the quarter totalled $5.97 billion, down from $6.08 billion in its third quarter of 2023.

BCE also said it now expects its revenue for 2024 to fall about 1.5 per cent compared with earlier guidance for an increase of zero to four per cent.

The company says the change comes as it faces lower-than-anticipated wireless product revenue and sustained pressure on wireless prices.

BCE added 33,111 net postpaid mobile phone subscribers, down 76.8 per cent from the same period last year, which was the company’s second-best performance on the metric since 2010.

It says the drop was driven by higher customer churn — a measure of subscribers who cancelled their service — amid greater competitive activity and promotional offer intensity. BCE’s monthly churn rate for the category was 1.28 per cent, up from 1.1 per cent during its previous third quarter.

The company also saw 11.6 per cent fewer gross subscriber activations “due to more targeted promotional offers and mobile device discounting compared to last year.”

Bell’s wireless mobile phone average revenue per user was $58.26, down 3.4 per cent from $60.28 in the third quarter of the prior year.

This report by The Canadian Press was first published Nov. 7, 2024.

Companies in this story: (TSX:BCE)

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