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AstraZeneca’s deals to produce and supply its COVID-19 vaccine

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AstraZeneca signed a deal on Wednesday in Japan to produce the COVID-19 vaccine, Vaxzevria, that it developed with Oxford University.

AstraZeneca has signed manufacturing deals with at least 20 firms for distribution worldwide.

Here are the deals it has signed, with the most recent first:

SUPPLY DEALS

REGION/GROUP DOSES FUNDING EXPECTED FURTHER

DELIVERIES

4 Last

Mexico, million Undisclosed week of May 2021

Argentina

 

African Afreximbank had [nL1N2M10IP]

Union Dropped plans to earlier planned Ongoing

secure the to provide

vaccines for advance

members from the procurement

Serum Institute of commitment

India to avoid guarantees of

duplicating up to $2

efforts by COVAX. billion to the

manufacturers

 

COVAX

aims to deliver

600 million shots

 

 

Bahrain Undisclosed Undisclosed Received first

delivery from

Serum in January

Japan Will procure 120 Undisclosed Undisclosed

million doses from

domestic makers

Chile Had a pre-deal to Undisclosed Undisclosed

purchase 14.4

million doses but

eventually signed

to buy 4 million

Saudi Arabia 3 Undisclosed

million from Serum January 2021

 

Ecuador Allocated some Mass vaccination

Approximately 5 $200 million started in March

million overall to buy

vaccines

Germany 3 million doses Undisclosed In February

Mali Wants to buy more Over 31 billion At the end of

than 8.4 million CFA francs with March

doses financial

assistance from

GAVI

Morocco 2 million Undisclosed Received in

January

Bolivia 5 million from Undisclosed 228,000 doses

Serum arrived in March

India 110 To be

million from Serum Federal govt delivered in May,

Institute as of received doses June and July

Apr 28, according at 150 Indian

to govt rupees per dose

 

Kenya 24 million Undisclosed

Arrived in second

week of February

Peru 14 million Undisclosed Supply not due to

begin arriving

until September

Vietnam 30 million Undisclosed Unknown

Indonesia 50 million Undisclosed One

batch arrived in

April 2021

 

Malaysia 6.4 million Undisclosed Unknown

Colombia 10 million Undisclosed Unknown

Philippines 17 million, Undisclosed Due to

including a receive 2.6 mln

private sector shots in May;

agreement for 2.6 received 525,600

million doses through

COVAX

 

Thailand Previously First batch

Initially 26 approved budget expected to be {nL4N2IC2R6]

million doses, of 6 billion available in

addition under baht ($199 mid-2021 ?Status

further agreement million)

unknown

 

Bangladesh 30 million from Undisclosed

Serum Received over 9

mln doses from

Serum earlier; in

March, India gifts

1.2 mln free doses

 

Spain 31.6 million under Undisclosed Between Dec. 2020

European Union and June 2021

scheme

Switzerland 5.3 million Undisclosed Unknown

Canada Up to 20 million Undisclosed Unknown

doses

Australia “Enough” for Undisclosed Unknown

population of 25

million, free of

cost

European 300 million, 750 million Some

Union option of euros for 300 by end-2020

additional 100 million doses

million dropped

after delays

Latin Initially produce Estimated at First half 2021

America, 150 million doses, $600 million

excluding and eventually for the first

Brazil make at least 400 150 million

million doses

Japan 120 million doses Undisclosed 30 million doses

by March 2021

China Undisclosed Some

Private deal aimed by end-2020

for annual

production

capacity of at

least 100 million

doses in 2020, and

at least 200

million doses by

the end 2021

South Korea 20 million Undisclosed First

shipment was in

February

 

Russia Unknown Undisclosed Unknown

Israel Unknown Undisclosed Unknown

Brazil Initially receive $356 million Unknown

100 million doses

Serum One billion Undisclosed 400 million before

Institute of end-2020 were

India expected

previously

Epidemic 300 million $750 million, Some before end-

response with $383 from 2020

group CEPI CEPI

and Vaccine

alliance

GAVI

United 300 million $1.2 billion Was earlier

States expected by Oct.

2020

United 100 million 84 million 4 million in 2020.

Kingdom pounds Earlier about 30

million doses were

expected with

initial deliveries

by Sept/Oct. 2020.

MANUFACTURING DEALS

FIRM BASED IN DEAL VALUE FOR FURTHER

Filling the

Nipro Corp Japan Undisclosed shot into vials and

packaging it, due to

start in June 2021

 

Preparing

KM Biologics, Japan Undisclosed and bottling doses

part of Meiji

holdings

 

IDT Biologika Germany Undisclosed Contract manufacturing

expected to speed up

output of finished

COVID-19 vaccine in the

second quarter

CSL Ltd Australia Undisclosed Additional 20 million

requested by Australian

government,

approximately 30

million doses already

being manufactured

Halix B.V. Netherlands Undisclosed Commercial manufacture

of the vaccine

Siam Thailand Undisclosed Manufacture and supply

Bioscience, the vaccine in Thailand

SCG and other nations in

Southeast Asia

Albany U.S. Undisclosed Produce millions of

Molecular doses through finishing

Research services at

manufacturing plant in

Albuquerque, New Mexico

Oxford UK 15 million Unknown number of doses

Biomedica pounds to for large-scale

reserve commercial manufacture

manufacturin under expanded deal. In

g capacity, May, company said AZ

further 35 commissioned more

million batches from it for H2

pounds plus 2021

costs

payable in

certain

situations

Catalent U.S. Undisclosed Making the drug

substance at its

Maryland facility. AZ’s

second deal with firm

Foundation of Mexico Undisclosed Latin American supply

Mexican with Argentina,

billionaire excluding Brazil, could

Carlos Slim reach 250 million

mAbxience of Argentina Undisclosed Initially producing 150

the INSUD million doses for Latin

Group America, excluding

Brazil

Kangtai Bio China Undisclosed Aimed for

Annual production

capacity of at least

100 million doses in

2020, and at least 200

million doses by

end-2021

Emergent U.S. $174 million Undisclosed doses in

BioSolutions second deal with AZ.

Cut manufacturing for

AZ vaccine at its

Baltimore plant in

April

SK Bioscience South Korea Undisclosed Undiluted solutions of

the vaccine until early

2021

R-Pharm Russia Undisclosed Unknown doses

Daiichi Japan Undisclosed Unknown doses

Sankyo

Fundação Brazil $127 million About 30 million doses

Osvaldo Cruz

(Fiocruz)

Symbiosis Scotland Undisclosed Clinical trial supply

Pharmaceutica

l

Cobra U.S. Undisclosed One million doses per

Biosciences month

Catalent U.S. Undisclosed Vial filling and

packaging capacity at

its manufacturing

facility in Anagni,

Italy

Emergent U.S. $87 million 300 million doses

BioSolutions

Serum India Undisclosed One billion doses for

Institute of low and middle-income

India countries. 400 million

before end-2020 were

expected previously

Oxford UK Undisclosed Manufacturing unknown

Biomedica number of doses

Sources: Company statements, Government reports, WHO, Reuters reporting

 

(Reporting by Pushkala Aripaka and Vishwadha Chander in Bengaluru; Editing by Jason Neely and Clarence Fernandez)

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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