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B.C. study says vaccine protected 60% of people during unusual flu season – CTV News

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VANCOUVER —
Getting vaccinated for the flu may have prevented about six out of 10 people from becoming infected in an early Canadian flu season, says a study involving a network of family doctors who monitored patients in British Columbia, Alberta, Ontario and Quebec.

Dr. Danuta Skowronski, lead author of the study and lead epidemiologist for influenza at the BC Centre for Disease Control, said the study involved about 2,800 patients who were seen by their physicians for a flu-like illness between Nov. 1, 2019 and Feb. 1.

The current flu season was the most unusual in about five years because of an early spike in influenza B as influenza A was circulating across Canada and the northern hemisphere.

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Skowronski said the doctors are part of the Sentinel Practitioner Surveillance Network involved in helping to determine vaccine effectiveness. They took nasal swabs from patients who were at least a year old and were seen within seven days of the start of symptoms such as fever, cough and sore throat.

The study, published Thursday in Eurosurveillance, a journal on infectious disease surveillance, epidemiology, prevention and control, found about an equal number of people were sickened by influenza A and B.

“This vaccine prevented about 60 per cent of cases of influenza that would have otherwise occurred in unvaccinated cases,” Skowronski said.

She said vaccination effectiveness was estimated by comparing vaccine coverage of patients who tested negative for influenza versus those who tested positive.

The so-called test-negative method was pioneered by the BC Centre for Disease Control in 2004 and has come to be used globally in place of randomized control trials, which would require a group of unvaccinated patients, an unethical scenario given everyone should get the vaccine, Skowronski said.

“Other countries have now adopted that methodology,” she said. “Collectively, we submit our findings to the World Health Organization. Later this month the WHO will be meeting to decide whether it needs to update the vaccine strains for next season’s formulation,” she said of the virus that changes every year.

“This is good news in that the vaccine is performing better than it has in previous years,” Skowronski said of the findings, adding they highlight the fact that the public should get vaccinated annually to protect themselves against various strains of the influenza virus, especially if they have a heart or lung condition or are in contact with vulnerable people including the elderly.

“If you want to prevent a miserable illness, and influenza is a miserable illness, a vaccine will protect you against that. But that might be an individual decision. For me, it’s really a kind of double tragedy when high-risk individuals experience these severe outcomes and they could have been prevented through vaccination.”

Concerns about the novel coronavirus should create a greater appreciation for influenza vaccines, Skowronski said.

In place of no vaccine for COVID-19, people should rely on conventional public health measures used for other coronaviruses, such as washing their hands and sneezing and coughing into their elbow, she said.

However, she said knowing who will or won’t get the flu is complex and could include issues such as which influenza subtypes were prevalent around the time someone was born, giving them a lifelong immunity to those subtypes.

British Columbia, Quebec and New Brunswick are the only provinces that do not offer publicly funded vaccination for influenza for all residents but provide it in limited cases, including for pregnant women.

The Public Health Agency of Canada said an average of 12,200 people are hospitalized for the flu every year and 3,500 people die of it annually.

It says everyone aged six months and older should get immunized, and the best time for that is between October and December, before the virus begins spreading.

This report by The Canadian Press was first reported Feb. 20, 2020.

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RCMP warn about benzodiazepine-laced fentanyl tied to overdose in Alberta – Edmonton Journal

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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.

The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.

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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.

The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.

Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”

Photo of benzodiazepine-laced fentanyl seized earlier this year by Grande Prairie RCMP after a fatal overdose. edm

From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.

Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.

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CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture

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The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.

Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.

The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.

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Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.

As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.

This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.

Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.

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Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star

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Canada has seen a concerning rise in measles cases in the first months of 2024.

By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.

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