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Behind the Research: Western examines the brain's secrets – Western News – Western News

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Researchers at Western are at the forefront of unraveling the mysteries of the human brain, making significant contributions to understanding diseases such as Alzheimer’s and Parkinson’s.    

President Alan Shepard recently sat down with Lisa Saksida and Ravi Menon, professors at Schulich School of Medicine & Dentistry and co-scientific directors of BrainsCAN, to discuss the latest advances in neuroscience, cognition and neurocognitive disease research. 

Alan Shepard: What is BrainsCAN and how is it transforming brain research?

Lisa Saksida: BrainsCAN is a research initiative at Western with a focus on cognitive neuroscience. Cognition is how we learn, remember, think and pay attention. 

Research at BrainsCAN is all about taking that fundamental basic research about the brain – focused on cognition –  and using it to have an impact on society. This could be in the form of treatments for diseases of the brain or even educating medical students.  

Parkinson’s and Alzheimer’s are two of the major diseases we work on. But there are many, many others, including neurodevelopmental disorders like autism and ADHD. BrainsCAN is funded by the Canada First Research Excellence Fund (CFREF), which supports institutions or collaboration between institutions for programs to create impact in the real world. 

AS: Ravi, how would you explain the work you do?   

Ravi Menon: My research is really at the interface of MRI physics and neuroscience and trying to use MRI, which is just incredibly evolving. Even after 50 years, new ways of doing MRI are being discovered on a weekly basis. 

It’s a very interdisciplinary environment. Our imaging equipment is used by every faculty at Western from business to education to music. And in each case, the questions being asked are around cognition.    

AS: What is MRI and how does it help researchers understand the brain?   

RM: MRI, magnetic resonance imaging, is almost 50 years old and allows us to look at the structure and function of the brain in a non-invasive manner. The machines we have at Western are unique and state-of-the-art. We also now have a 15.2 tesla machine, the most powerful in Canada and among the most powerful MRI machines in the world.    

AS: Lisa, tell us about your lab.

LS: We are primarily focused on assessment of cognition. My colleague Tim [Bussey] and I invented a system based on touch screens that allows us to assess cognition in mouse models. Typically, the cognition tests used on a mouse are very different from what one would do with a human.So, we developed this iPad-like device where we can give mice tasks identical to the ones we would give to a human patient. If they get it wrong, they get a little signal, like the lights in the box turning on, to tell them it wasn’t the right answer.We have a similar process with human patients. We don’t tell them how to do the tasks. We just say, here are some images, interact with them and see how you do.    

AS: What does it mean to be a Canada Research Chair in your area of brain research?   

LS: The kind of work we are doing as part of BrainsCAN and the Initiative for Translational Neuroscience is all about teams. Mapping the brain from the molecular, cellular level up to animal and human behaviour is a complex task. What I love about research is being able to bring different scientists together and get them talking to each other. It’s at the boundaries between disciplines and between levels of analysis that the really exciting stuff happens.   

AS: What are the challenges Canada faces in dealing with neurodegenerative diseases?    

LS: As our population ages, we will see more individuals affected by diseases like Alzheimer’s or Parkinson’s. We really need treatments and solutions for those individuals.   

RM: In another decade, 10 to 50 per cent of the population will need assistance of some sort. Just the burden of that care, let alone any sort of treatment, is enough to bankrupt the country. Add the cost of current drugs— which aren’t very good either—and you will see that therapeutics, early diagnosis and assessment need to change. Otherwise, we are in big trouble. 

AS: Are we going to find treatments for brain diseases and disorders?   

LS: In the last decade or so, the degree to which we’ve developed our understanding of the brain has been immense. We’re developing lots of new technologies to help us understand the brain better at the molecular and cellular level. There is a great promise for developing treatments for brain disease over the next 10 or 20 years.

For example, we might find similar memory impairments in certain forms of dementia and in ADHD. So we might be treating those similar impairments rather than a disease as a whole. 

I think we’re on the cusp of starting to develop personalized treatments for brain disease, much like what has happened with cancer treatments. Not everybody who gets dementia has the same kind of dementia. There are different kinds already, but now we are trying to refine treatment for these types, at a molecular level, a genetic level, or even at the cognitive level. 

RM: The progression to find treatments will occur probably in two steps, with what we’re now learning and what we have learned over the last generation about the brain. We’re getting to the point where we can at least contemplate and in some cases effectively modify the trajectory of disease. That’s the first step. At least we can slow things down. That’s not a cure. Cure is maybe a different approach. That’s the approach Lisa just talked about: rather than treating a particular pathology, we’re actually treating a constellation of cognitive symptoms that are maybe common across a bunch of different disorders.    

AS: What do you like best about being a researcher?   

LS: I love being able to work on problems with the potential to have tremendous benefits to society.

RM: The best hours of my day are when I sit with a student talking, debating and scrawling through a problem on my whiteboard, coming up with ideas and how to test them, and sending the student off to do experiments and waiting in anticipation for the results. Sometimes your hopes are dashed and sometimes your ideas are validated, and then you go on to the next one.    

AS: Tell me more about working with students and teaching.  

RM: Students bring techniques to our labs that they’ve learned in undergraduate summer jobs that didn’t exist when we were going to school. Like machine learning or a lot of electrical engineering approaches. I don’t know how these techniques work and the students do. They are constantly infusing our research with state-of-the-art ideas. 

You only get that when you interact with the students and turn them on to the problems that they might want to address. They may want to do research, or motivate somebody to become a doctor, or a venture capitalist who will fund a new drug for underprivileged kids in a resource-constrained part of the world. You just never know where that’s going to go. And you have to interact with students to get that. 

LS: Students bring in so much energy and fresh perspectives. My lab members understand the technology they’re using much better than I do. Seeing their approach and eagerness is very motivating for me.Working with them at all levels helps to keep me on my game and is incredibly inspiring. 

The conversation has been edited for clarity and length.Watch it here.

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Here’s how Helene and other storms dumped a whopping 40 trillion gallons of rain on the South

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More than 40 trillion gallons of rain drenched the Southeast United States in the last week from Hurricane Helene and a run-of-the-mill rainstorm that sloshed in ahead of it — an unheard of amount of water that has stunned experts.

That’s enough to fill the Dallas Cowboys’ stadium 51,000 times, or Lake Tahoe just once. If it was concentrated just on the state of North Carolina that much water would be 3.5 feet deep (more than 1 meter). It’s enough to fill more than 60 million Olympic-size swimming pools.

“That’s an astronomical amount of precipitation,” said Ed Clark, head of the National Oceanic and Atmospheric Administration’s National Water Center in Tuscaloosa, Alabama. “I have not seen something in my 25 years of working at the weather service that is this geographically large of an extent and the sheer volume of water that fell from the sky.”

The flood damage from the rain is apocalyptic, meteorologists said. More than 100 people are dead, according to officials.

Private meteorologist Ryan Maue, a former NOAA chief scientist, calculated the amount of rain, using precipitation measurements made in 2.5-mile-by-2.5 mile grids as measured by satellites and ground observations. He came up with 40 trillion gallons through Sunday for the eastern United States, with 20 trillion gallons of that hitting just Georgia, Tennessee, the Carolinas and Florida from Hurricane Helene.

Clark did the calculations independently and said the 40 trillion gallon figure (151 trillion liters) is about right and, if anything, conservative. Maue said maybe 1 to 2 trillion more gallons of rain had fallen, much if it in Virginia, since his calculations.

Clark, who spends much of his work on issues of shrinking western water supplies, said to put the amount of rain in perspective, it’s more than twice the combined amount of water stored by two key Colorado River basin reservoirs: Lake Powell and Lake Mead.

Several meteorologists said this was a combination of two, maybe three storm systems. Before Helene struck, rain had fallen heavily for days because a low pressure system had “cut off” from the jet stream — which moves weather systems along west to east — and stalled over the Southeast. That funneled plenty of warm water from the Gulf of Mexico. And a storm that fell just short of named status parked along North Carolina’s Atlantic coast, dumping as much as 20 inches of rain, said North Carolina state climatologist Kathie Dello.

Then add Helene, one of the largest storms in the last couple decades and one that held plenty of rain because it was young and moved fast before it hit the Appalachians, said University of Albany hurricane expert Kristen Corbosiero.

“It was not just a perfect storm, but it was a combination of multiple storms that that led to the enormous amount of rain,” Maue said. “That collected at high elevation, we’re talking 3,000 to 6000 feet. And when you drop trillions of gallons on a mountain, that has to go down.”

The fact that these storms hit the mountains made everything worse, and not just because of runoff. The interaction between the mountains and the storm systems wrings more moisture out of the air, Clark, Maue and Corbosiero said.

North Carolina weather officials said their top measurement total was 31.33 inches in the tiny town of Busick. Mount Mitchell also got more than 2 feet of rainfall.

Before 2017’s Hurricane Harvey, “I said to our colleagues, you know, I never thought in my career that we would measure rainfall in feet,” Clark said. “And after Harvey, Florence, the more isolated events in eastern Kentucky, portions of South Dakota. We’re seeing events year in and year out where we are measuring rainfall in feet.”

Storms are getting wetter as the climate change s, said Corbosiero and Dello. A basic law of physics says the air holds nearly 4% more moisture for every degree Fahrenheit warmer (7% for every degree Celsius) and the world has warmed more than 2 degrees (1.2 degrees Celsius) since pre-industrial times.

Corbosiero said meteorologists are vigorously debating how much of Helene is due to worsening climate change and how much is random.

For Dello, the “fingerprints of climate change” were clear.

“We’ve seen tropical storm impacts in western North Carolina. But these storms are wetter and these storms are warmer. And there would have been a time when a tropical storm would have been heading toward North Carolina and would have caused some rain and some damage, but not apocalyptic destruction. ”

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Follow AP’s climate coverage at https://apnews.com/hub/climate

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Follow Seth Borenstein on Twitter at @borenbears

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Associated Press climate and environmental coverage receives support from several private foundations. See more about AP’s climate initiative here. The AP is solely responsible for all content.

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‘Big Sam’: Paleontologists unearth giant skull of Pachyrhinosaurus in Alberta

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It’s a dinosaur that roamed Alberta’s badlands more than 70 million years ago, sporting a big, bumpy, bony head the size of a baby elephant.

On Wednesday, paleontologists near Grande Prairie pulled its 272-kilogram skull from the ground.

They call it “Big Sam.”

The adult Pachyrhinosaurus is the second plant-eating dinosaur to be unearthed from a dense bonebed belonging to a herd that died together on the edge of a valley that now sits 450 kilometres northwest of Edmonton.

It didn’t die alone.

“We have hundreds of juvenile bones in the bonebed, so we know that there are many babies and some adults among all of the big adults,” Emily Bamforth, a paleontologist with the nearby Philip J. Currie Dinosaur Museum, said in an interview on the way to the dig site.

She described the horned Pachyrhinosaurus as “the smaller, older cousin of the triceratops.”

“This species of dinosaur is endemic to the Grand Prairie area, so it’s found here and nowhere else in the world. They are … kind of about the size of an Indian elephant and a rhino,” she added.

The head alone, she said, is about the size of a baby elephant.

The discovery was a long time coming.

The bonebed was first discovered by a high school teacher out for a walk about 50 years ago. It took the teacher a decade to get anyone from southern Alberta to come to take a look.

“At the time, sort of in the ’70s and ’80s, paleontology in northern Alberta was virtually unknown,” said Bamforth.

When paleontogists eventually got to the site, Bamforth said, they learned “it’s actually one of the densest dinosaur bonebeds in North America.”

“It contains about 100 to 300 bones per square metre,” she said.

Paleontologists have been at the site sporadically ever since, combing through bones belonging to turtles, dinosaurs and lizards. Sixteen years ago, they discovered a large skull of an approximately 30-year-old Pachyrhinosaurus, which is now at the museum.

About a year ago, they found the second adult: Big Sam.

Bamforth said both dinosaurs are believed to have been the elders in the herd.

“Their distinguishing feature is that, instead of having a horn on their nose like a triceratops, they had this big, bony bump called a boss. And they have big, bony bumps over their eyes as well,” she said.

“It makes them look a little strange. It’s the one dinosaur that if you find it, it’s the only possible thing it can be.”

The genders of the two adults are unknown.

Bamforth said the extraction was difficult because Big Sam was intertwined in a cluster of about 300 other bones.

The skull was found upside down, “as if the animal was lying on its back,” but was well preserved, she said.

She said the excavation process involved putting plaster on the skull and wooden planks around if for stability. From there, it was lifted out — very carefully — with a crane, and was to be shipped on a trolley to the museum for study.

“I have extracted skulls in the past. This is probably the biggest one I’ve ever done though,” said Bamforth.

“It’s pretty exciting.”

This report by The Canadian Press was first published Sept. 25, 2024.

The Canadian Press. All rights reserved.

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The ancient jar smashed by a 4-year-old is back on display at an Israeli museum after repair

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TEL AVIV, Israel (AP) — A rare Bronze-Era jar accidentally smashed by a 4-year-old visiting a museum was back on display Wednesday after restoration experts were able to carefully piece the artifact back together.

Last month, a family from northern Israel was visiting the museum when their youngest son tipped over the jar, which smashed into pieces.

Alex Geller, the boy’s father, said his son — the youngest of three — is exceptionally curious, and that the moment he heard the crash, “please let that not be my child” was the first thought that raced through his head.

The jar has been on display at the Hecht Museum in Haifa for 35 years. It was one of the only containers of its size and from that period still complete when it was discovered.

The Bronze Age jar is one of many artifacts exhibited out in the open, part of the Hecht Museum’s vision of letting visitors explore history without glass barriers, said Inbal Rivlin, the director of the museum, which is associated with Haifa University in northern Israel.

It was likely used to hold wine or oil, and dates back to between 2200 and 1500 B.C.

Rivlin and the museum decided to turn the moment, which captured international attention, into a teaching moment, inviting the Geller family back for a special visit and hands-on activity to illustrate the restoration process.

Rivlin added that the incident provided a welcome distraction from the ongoing war in Gaza. “Well, he’s just a kid. So I think that somehow it touches the heart of the people in Israel and around the world,“ said Rivlin.

Roee Shafir, a restoration expert at the museum, said the repairs would be fairly simple, as the pieces were from a single, complete jar. Archaeologists often face the more daunting task of sifting through piles of shards from multiple objects and trying to piece them together.

Experts used 3D technology, hi-resolution videos, and special glue to painstakingly reconstruct the large jar.

Less than two weeks after it broke, the jar went back on display at the museum. The gluing process left small hairline cracks, and a few pieces are missing, but the jar’s impressive size remains.

The only noticeable difference in the exhibit was a new sign reading “please don’t touch.”

The Canadian Press. All rights reserved.

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