Blood plasma proteins can better explain long Covid: Study | Canada News Media
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Blood plasma proteins can better explain long Covid: Study

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Toronto, Jul 8 (IANS): Canadian researchers have discovered unique patterns of blood plasma proteins in patients with suspected long Covid that could act as a potential drug target to improve patient outcomes.

Currently, approximately 10-20 per cent of people with a confirmed case of Covid-19 will get long Covid, and experience a wide variety of symptoms, which may include fatigue, brain fog and difficulty breathing.

Researchers from Lawson Health Research Institute and London Health Sciences Centre (LHSC) in Canada found that the proteins in blood plasma, called “the plasma proteome”, are released by cells that often play an important role in the body’s immune response to viruses.

In the paper, published in The Journal of Translational Medicine, the team studied how those proteins adapt and change in long Covid.

“Trying to understand this mechanism is quite important because it provides further insight into how patients are affected,” said Dr Michael Nicholson, Associate Scientist at Lawson.

“This paper sheds further light onto a possible mechanism which may provide insight into why some patients have certain symptoms,” he added.

For the study, blood plasma samples were collected from long Covid outpatients and analysed in comparison to acutely ill Covid-19 patients as well as compared to a group of healthy volunteers.

“We used novel technologies for this study, allowing us to analyse more than 3,000 proteins in blood plasma at the same time with multiple patients,” explains Cristiana Iosef, Research Analyst at Children’s Health Research Institute (CHRI), a programme of Lawson.

“We used a novel bioinformatic pipeline, a form of artificial intelligence (AI), to then analyse the proteins to determine the specific changes that occur in long Covid.”

By using advanced technology the researchers were able to determine unique patterns in the blood proteins. The team discovered that people with suspected long Covid have prolonged inflammation associated with changes in their immune cells and blood vessels. These changes may lead to problems in specific organs, like the brain and the heart.

“The saved blood plasma samples that we are using helped us determine the long-term responses to Covid-19; serial blood plasma samples from individuals that had a Covid-19 infection and now presumed long Covid will help us determine how proteins are changing over time,” said Dr Michael Knauer, Associate Scientist at Lawson.

Dr Douglas Fraser, Scientist and Critical Care Physician at London Health Sciences Centre (LHSC) in Canada, added that the proteins discovered could act as a potential drug target. The team is now examining potential new drug therapies with the hopes of improving outcomes for these patients.

“When we identify these signalling patterns within the blood plasma, we can then take the information and screen drug databases to better understand which drugs would be best to target the changes we identified in long Covid patients,” he said. “With this understanding, the identified drugs may be used in future long Covid clinical trials.”

 

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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