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Booster may be needed for J&J shot as Delta variant spreads

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Infectious disease experts are weighing the need for booster shots of the Pfizer/BioNTech or Moderna mRNA-based vaccines for Americans who received Johnson & Johnson’s one-dose vaccine due to the increasing prevalence of the more contagious Delta coronavirus variant.

A few say they have already done so themselves, even without published data on whether combining two different vaccines is safe and effective or backing from U.S. health regulators. Canada and some European countries are already allowing people to get two different COVID-19 shots.

The debate centers on concerns over how protective the J&J shot is against the Delta variant first detected in India and now circulating widely in many countries. Delta, which has also been associated with more severe disease, could quickly become the dominant version of the virus in the United States, Centers for Disease Control and Prevention (CDC) Director Rochelle Walensky has warned.

There is no substantial data showing how protective the J&J vaccine is against the new variant. However, UK studies show that two doses of either the Pfizer/BioNTech or AstraZeneca vaccines are significantly more protective against the variant than one.

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Andy Slavitt, former senior pandemic advisor to U.S. President Joe Biden, raised the idea this week on his podcast. At least half a dozen prominent infectious disease experts said U.S. regulators need to address the issue in short order.

“There’s no doubt that the people who receive the J&J vaccine are less protected against disease,” than those who get two doses of the other shots, said Stanford professor Dr. Michael Lin. “From the principle of taking easy steps to prevent really bad outcomes, this is really a no brainer.”

The CDC is not recommending boosters, and advisors to the agency said at a public meeting this week there is not yet significant evidence of declining protection from the vaccines.

Jason Gallagher, an infectious diseases expert at Temple University’s School of Pharmacy, recently received a Pfizer dose at the Philadelphia vaccine clinic where he has been administering shots. He got the J&J vaccine in a clinical trial in November.

Gallagher said he was concerned about the UK data https://www.gov.uk/government/news/vaccines-highly-effective-against-b-1-617-2-variant-after-2-doses showing lower efficacy against the Delta variant for people who received one vaccine dose.

“While the situation has gotten so much better in the U.S., the Delta variant that’s spreading … and really quickly taking over in the U.S. looks a little more concerning in terms of the breakthrough infections with the single-dose vaccines,” he said. “So I took the plunge.”

Cases, hospitalizations and deaths have plummeted in the United States with 56% of the adult population fully vaccinated.

J&J said it is testing whether the immune response from its vaccine is capable of neutralizing the Delta variant in a laboratory setting, but no data is available yet.

Both mRNA vaccines showed efficacy rates around 95% in large U.S. trials, while J&J’s vaccine was 66% effective in preventing moderate-to-severe COVID-19 globally when more contagious variants were circulating.

Dr. Angela Rasmussen, a researcher at the University of Saskatchewan’s Vaccine and Infectious Disease Organization, said on Twitter she had gotten a dose of Pfizer’s vaccine this week after receiving J&J’s in April.

Rasmussen, who declined to be interviewed, encouraged Americans who received the J&J vaccine to talk to their doctors about a possible second shot.

“If you live in a community with overall low vaccination, I’d suggest you strongly consider doing so,” she tweeted.

Vaccine expert Dr. Peter Hotez from Baylor College of Medicine in a tweet said adding a second J&J dose or one of the mRNA vaccines might provide broader protection, “but we need data and CDC-FDA guidance.”

The U.S. National Institute of Allergy and Infectious Diseases (NIAID) is running a trial to determine the need for boosting all currently authorized shots with another dose of Moderna’s vaccine. NIAID scientist Dr. John Beigel told Reuters the agency hopes to have that data by September to help inform regulators’ decisions on boosters.

As long as case counts remain low in the United States, J&J recipients should wait for more data, he said.

If Delta variant-driven infections and hospitalizations increase significantly, he said, “then decisions might need to be made with an absence of data. But right now, I do think it’s appropriate that they wait.”

(Reporting by Michael Erman; Editing by Caroline Humer and Bill Berkrot)

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It's possible to rely on plant proteins without sacrificing training gains, new studies say – The Globe and Mail

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At the 1936 Olympics in Berlin, a scientist named Paul Schenk surveyed the eating habits of top athletes from around the world. The Canadians reported plowing through more than 800 grams of meat per day on average; the Americans were downing more than two litres of milk daily.

While there have been plenty of changes in sports nutrition since then, the belief that meat and dairy are the best fuel for building muscle persists. These days, though, a growing number of athletes are interested in reducing or eliminating their reliance on animal proteins, for environmental, ethical or health reasons. A pair of new studies bolsters the case that it’s possible to rely on plant proteins without sacrificing training gains, as long as you pick your proteins carefully.

The standard objection to plant proteins is that they don’t have the right mix of essential amino acids needed to assemble new muscle fibres. Unlike animal proteins, most plant proteins are missing or low in at least one essential amino acid.

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In particular, there’s one specific amino acid, leucine, that seems to play a special role in triggering the synthesis of new muscle. It’s particularly abundant in whey, one of the two proteins (along with casein) found in milk. That’s why whey protein is the powdered beverage of choice in gyms around the world, backed by decades of convincing research, which was often funded by the dairy industry.

But one of the reasons whey looks so good may be that we haven’t fully explored the alternatives. A 2018 study by Luc van Loon of the University of Maastricht in the Netherlands, for example, tested nine vegetable proteins including wheat, hemp, soy, brown rice, pea and corn. To their surprise, they found that corn protein contains 13.5 per cent leucine – even more than whey.

Based on that insight, van Loon decided to pit corn against milk in a direct test of muscle protein synthesis. Volunteers consumed 30 grams of one of the proteins; a series of blood tests and muscle biopsies were collected over the next five hours to determine how much of the ingested protein was being turned into new muscle fibres. The results, which appeared in the journal Amino Acids, were straightforward: Despite all the hype about whey, there was no discernible difference between them.

A second study, this one published in Medicine & Science in Sports & Exercise by a team led by Benjamin Wall of the University of Exeter in Britain, had similar findings. Instead of corn, it used a mix of 40 per cent pea, 40 per cent brown rice and 20 per cent canola proteins. Since different plants have different amino acids profiles, mixing complementary proteins has long been suggested as a way overcoming the deficiencies of any single plant protein. Sure enough, the protein blend triggered just as much new muscle synthesis as whey.

On the surface, the message from these studies is straightforward: Plant proteins are – or at least can be – as effective as even the best animal proteins for supporting muscle growth. There are a few caveats to consider, though. One is that the studies used isolated protein powders rather than whole foods. You would need nearly nine cobs of corn to get the 30 grams of protein used in van Loon’s study, compared to just three-and-a-half cups of milk.

Another is that plants are generally harder to digest, meaning that not all the amino acids will be usable. That may not be a problem for healthy young adults consuming 30 grams of protein at once, which is enough to trigger a near-maximal muscle response. But for older people, who tend to have blunted muscle-building responses to protein, or in situations where you’re getting a smaller dose of protein, the details of protein quality may become more important.

Of course, the effectiveness of plant proteins won’t be news to notable plant-based athletes such as ultrarunner Scott Jurek or basketball star Chris Paul – but it’s encouraging to see the science finally begin to catch up.

Alex Hutchinson is the author of Endure: Mind, Body, and the Curiously Elastic Limits of Human Performance. Follow him on Threads @sweat_science.

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See how chicken farmers are trying to stop the spread of bird flu – Fox 46 Charlotte

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CLOVER, S.C. (QUEEN CITY NEWS) — Poultry farmers across the Carolinas aren’t taking any chances.  Many are turning to strict protocols as another wave of bird flu continues to threaten the chicken population across the country. 

Since 2022, it is estimated more than 90 million birds have either died from the virus or were killed to prevent further spread in the U.S. 

“We try to make them the happiest as possible. We always say a happy chicken is a tasty chicken,” owner of Eden Farms Adam Shumate said. 

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With their happiness in mid, Shumate also wants to keep his chickens alive and healthy. On his farm in Clover, he has implemented protocols to minimize a potential bird flu outbreak.  

“We want to be prepared,” he said. “We feel like the things that we can do to prevent it first is the best case because we don’t want to start from scratch with a whole new flock.”  

Because bird flu is commonly spread through bird droppings, Shumate is limiting the number of people coming into contact with his flocks. He says this would minimize the chances of someone walking onto the property with bird droppings on the bottoms of their shoes. 

On top of monitoring the chickens closely, Shumate and his staff are constantly cleaning their equipment, including what they wear on their feet.   

“We have specific shoes that are just for working with the flock and for when we are taking care of them,” Shumate said. 

Other farmers, like Holly Burrell, haven’t let a visitor step foot near her hens in Gastonia for more than two years. 

No visitors or outside cars are welcomed, and her chickens are separated in what she calls “tent cities.” 

“We don’t want to do that because we want them to live their best life,” Burrell said in a 2022 interview with Queen City News. 

Recently, health officials have detected bird flu in other animals like seals, squirrels and dolphins. 

Earlier this month, bird flu was detected in one of the state’s dairy cow herds. While concerning, state health officials say the overall risk to the general public remains low. 

“I’ve not heard of any cases, zero cases of people being affected by this virus associated with food consumption, milk consumption with egg consumption… any of these products we’re getting from farm animals is not really been associated with any human risk at this point,” said Dr. Michael Martin, director of the Veterinary Division at the N.C. Department of Agriculture and Consumer Services. 

As of March 28, at least 80 birds in North Carolina were detected with the virus. Back in York County, Shumate says it all starts with the individual farms. 

“When it comes to wildlife and things that that, there is only so much that you can do is be observant,” Shumate said. “Keep a healthy flock that way they can find off the infections that may come about.” 

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CFIA Monitoring for Avian Influenza in Canadian Dairy Cattle After US Discoveries – Morning Ag Clips –

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From the field to your inbox, the Weekend Edition of the Morning Ag Clips features stories, trends, and unique perspectives from the farming community. This laid-back edition is great for anyone looking for a fun weekend read.

Morning Ag Clips. All ag. All the time.

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