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Canada building facilities to make vaccines for COVID-19 and other viruses – CBC.ca

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In the initial sprint to create a vaccine for COVID-19, Pfizer and Moderna crossed the finish line first. But for Canadian researchers who continue to work away at coronavirus vaccines and therapeutics, there are still big potential wins ahead.

While priority groups are already being inoculated against the virus thanks to vaccine shipments arriving from Europe, researchers like Volker Gerdts, CEO of Saskatoon’s Vaccine and Infectious Disease Organization (VIDO), have their sights set on Canada’s long game.

“It is important for us, for Canadians, to have long-term access to made-in-Canada vaccines,” he said.

Gerdts’ team was among the first out of the gate with promising COVID-19 research, but did not have the manufacturing capability to create vaccine components needed to keep its momentum going. It was a temporary setback that shed light on essential gaps in Canadian infrastructure. With new funding from multiple levels of government, the team has started building what it needs to create human vaccines in-house well into the future.

It’s a long-term strategy being pursued from the very top. According to Innovation, Science and Economic Development Canada, “When this pandemic began, Canada had no flexible, large-scale biomanufacturing capacity suitable for a COVID-19 vaccine.”

Spurred by the urgent need for COVID-19 vaccines and with hundreds of millions of dollars in new federal funding, several teams are now building the infrastructure Canada needs to take advanced vaccine research and make it into a product within the country’s borders.

Scaffolding outside the lab at the University of Saskatchewan is a sign of the ongoing renovations there. After they’re completed next fall, the upgrades could allow researchers to make up to 40 million doses of the VIDO team’s COVID-19 vaccines each year.

Workers in Saskatoon are expanding the Vaccine and Infectious Disease Organization (VIDO) facility at the University of Saskatchewan. (CBC)

Crucially, Gerdts said, the facility will be “open to all Canadians, and in fact all international groups that are looking for it” to pilot promising developments.

“For the country to be better prepared, we need to have this capacity,” he added.

Other projects are also underway to achieve this goal. One of the largest involves Quebec-based biopharmaceutical company Medicago, which has experience developing rapid responses to emerging viruses, such as Ebola and H1N1. The company has received $173 million in federal funding to move ahead with its COVID-19 vaccine research, and to establish a large-scale Canadian manufacturing facility in Quebec City.

Its aim is “to first develop new technologies to react rapidly, but also to be able to protect our own citizens,” said Nathalie Charland, a senior director with Medicago.

Nathalie Charland, a senior director with Medicago, says the company hopes to be able to produce anywhere between 500 million and 1 billion doses of vaccine per year by 2023 at its new plant being built in Quebec City. (Medicago)

The company’s plant-based COVID-19 vaccine candidate is now in Phase 2 clinical trials. If things go according to plan, there will be 80 million doses by the end of this year, produced at facilities in Canada and the U.S.

By the end of 2023, Medicago expects to be making vaccines from start to finish in the new manufacturing plant in the eastern part of Quebec City.

“We hope to be able to produce anywhere between 500 million and 1 billion doses per year,” Charland said.

That’s enough to help the Canadian population with ongoing vaccine needs, but also the world, which Charland points out will require billions of doses to overcome the COVID-19 pandemic.

A researcher at Medicago works on a vaccine. If things go according to plan, there will be 80 million doses of its vaccine by the end of this year, produced at facilities in Canada and the U.S. (Medicago)

‘We need to reverse that trend’

Canada has been a global leader in vaccine development before. In the middle of the last century, public labs in Ontario and Quebec provided the ability to produce them here at home. Toronto’s Connaught Laboratories played a key role in developing the polio vaccine in the 1950s, for example.

However, through privatization and globalization, “we lost that capacity,” said Scott Halperin, director of the Canadian Centre for Vaccinology at Dalhousie University in Halifax.

Now, Halperin said, “we need to reverse that trend.”

Vaccine independence is important, he said, because relying on relationships with other countries to secure supplies of vaccines doesn’t always work.

“Countries and governments tend to think about their own populations first,” he said. “And they’re not necessarily going to want vaccines to leave their borders before their own population’s needs are met.”

Researchers work on a COVID-19 vaccine at Saskatoon’s Vaccine and Infectious Disease Organization (VIDO) lab. (Bonnie Allen/CBC)

Halperin also pointed out that this likely won’t be the last time Canadians require a new vaccine or therapeutic to combat a new virus. Avoiding another “mad rush” to access vaccines in that case, he said, is key.

For that reason, Volker Gerdts hopes Canada continues to support domestic vaccine research and production, even after the pandemic. With Zika, SARS, MERS and other diseases that have cropped up over the past few years, he said, future viruses are to be expected.

Beyond Canadians’ potential ongoing need for coronavirus vaccines and boosters down the road, he added, “what we really are also preparing for at the same time by doing all of this [is] the next pandemic, the next emerging disease.”

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Suspicious deaths of two N.S. men were the result of homicide, suicide: RCMP

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Nova Scotia RCMP say their investigation into two suspicious deaths earlier this month has concluded that one man died by homicide and the other by suicide.

The bodies of two men, aged 40 and 73, were found in a home in Windsor, N.S., on Sept. 3.

Police say the province’s medical examiner determined the 40-year-old man was killed and the 73-year-old man killed himself.

They say the two men were members of the same family.

No arrests or charges are anticipated, and the names of the deceased will not be released.

RCMP say they will not be releasing any further details out of respect for the family.

This report by The Canadian Press was first published Sept. 16, 2024.

The Canadian Press. All rights reserved.



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Turning the tide: Quebec premier visits Cree Nation displaced by hydro project in 70s

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For the first time in their history, members of the Cree community of Nemaska received a visit from a sitting Quebec premier on Sunday and were able to share first-hand the story of how they were displaced by a hydroelectric project in the 1970s.

François Legault was greeted in Nemaska by men and women who arrived by canoe to re-enact the founding of their new village in the Eeyou Istchee James Bay region, in northern Quebec, 47 years ago. The community was forced in the early 1970s to move from its original location because members were told it would be flooded as part of the Nottaway-Broadback-Rupert hydro project.

The reservoir was ultimately constructed elsewhere, but by then the members of the village had already left for other places, abandoning their homes and many of their belongings in the process.

George Wapachee, co-author of the book “Going Home,” said community members were “relocated for nothing.”

“We didn’t know what the rights were, or who to turn to,” he said in an interview. “That turned us into refugees and we were forced to abandon the life we knew.”

Nemaska’s story illustrates the challenges Legault’s government faces as it looks to build new dams to meet the province’s power needs, which are anticipated to double by 2050. Legault has promised that any new projects will be developed in partnership with Indigenous people and have “social acceptability,” but experts say that’s easier said than done.

François Bouffard, an associate professor of electrical engineering at McGill University, said the earlier era of hydro projects were developed without any consideration for the Indigenous inhabitants living nearby.

“We live in a much different world now,” he said. “Any kind of hydro development, no matter where in Quebec, will require true consent and partnership from Indigenous communities.” Those groups likely want to be treated as stakeholders, he added.

Securing wider social acceptability for projects that significantly change the landscape — as hydro dams often do — is also “a big ask,” he said. The government, Bouchard added, will likely focus on boosting capacity in its existing dams, or building installations that run off river flow and don’t require flooding large swaths of land to create reservoirs.

Louis Beaumier, executive director of the Trottier Energy Institute at Polytechnique Montreal, said Legault’s visit to Nemaska represents a desire for reconciliation with Indigenous people who were traumatized by the way earlier projects were carried about.

Any new projects will need the consent of local First Nations, Beaumier said, adding that its easier to get their blessing for wind power projects compared to dams, because they’re less destructive to the environment and easier around which to structure a partnership agreement.

Beaumier added that he believes it will be nearly impossible to get the public — Indigenous or not — to agree to “the destruction of a river” for a new dam, noting that in recent decades people have come to recognize rivers as the “unique, irreplaceable riches” that they are.

Legault’s visit to northern Quebec came on Sept. 15, when the community gathers every year to remember the founding of the “New Nemaska,” on the shores of Lake Champion in the heart of the boreal forest, some 1,500 kilometres from Montreal. Nemaska Chief Clarence Jolly said the community invited Legault to a traditional feast on Sunday, and planned to present him with Wapachee’s book and tell him their stories.

The book, published in 2022 along with Susan Marshall, is filled with stories of Nemaska community members. Leaving behind sewing machines and hunting dogs, they were initially sent to two different villages, Wapachee said.

In their new homes, several of them were forced to live in “deplorable conditions,” and some were physically and verbally abused, he said. The new village of Nemaska was only built a few years later, in 1977.

“At this time, families were losing their children to prison-schools,” he said, in reference to the residential school system. “Imagine the burden of losing your community as well.”

Thomas Jolly, a former chief, said he was 15 years old when he was forced to leave his village with all his belongings in a single bag.

Meeting Legault was important “because have to recognize what happened and we have to talk about the repercussions that the relocation had on people,” he said, adding that those effects are still felt today.

Earlier Sunday, Legault was in the Cree community of Eastmain, where he participated in the official renaming of a hydro complex in honour of former premier Bernard Landry. At the event, Legault said he would follow the example of his late predecessor, who oversaw the signing of the historic “Paix des Braves” agreement between the Quebec government and the Cree in 2002.

He said there is “significant potential” in Eeyou Istchee James Bay, both in increasing the capacity of its large dams and in developing wind power projects.

“Obviously, we will do that with the Cree,” he said.

This report by The Canadian Press was first published Sept. 16, 2024.



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Quebec premier visits Cree community displaced by hydro project in 1970s

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NEMASKA – For the first time in their history, members of the Cree community of Nemaska received a visit from a sitting Quebec premier on Sunday and were able to share first-hand the story of how they were displaced by a hydroelectric project in the 1970s.

François Legault was greeted in Nemaska by men and women who arrived by canoe to re-enact the founding of their new village in the Eeyou Istchee James Bay region, in northern Quebec, 47 years ago. The community was forced in the early 1970s to move from their original location because they were told it would be flooded as part of the Nottaway-Broadback-Rupert hydro project.

The reservoir was ultimately constructed elsewhere, but by then the members of the village had already left for other places, abandoning their homes and many of their belongings in the process.

George Wapachee, co-author of the book “Going Home,” said community members were “relocated for nothing.”

“We didn’t know what the rights were, or who to turn to,” he said in an interview. “That turned us into refugees and we were forced to abandon the life we knew.”

The book, published in 2022 by Wapachee and Susan Marshall, is filled with stories of Cree community members. Leaving behind sewing machines and hunting dogs, they were initially sent to two different villages, 100 and 300 kilometres away, Wapachee said.

In their new homes, several of them were forced to live in “deplorable conditions,” and some were physically and verbally abused, he said. The new village of Nemaska was only built a few years later, in 1977.

“At this time, families were losing their children to prison-schools,” he said, in reference to the residential school system. “Imagine the burden of losing your community as well.”

Legault’s visit came on Sept. 15, when the community gathers every year to remember the founding of the “New Nemaska,” on the shores of Lake Champion in the heart of the boreal forest, some 1,500 kilometres from Montreal. Nemaska Chief Clarence Jolly said the community invited Legault to a traditional feast on Sunday, and planned to present him with Wapachee’s book and tell him their stories.

Thomas Jolly, a former chief, said he was 15 years old when he was forced to leave his village with all his belongings in a single bag.

Meeting Legault was important “because have to recognize what happened and we have to talk about the repercussions that the relocation had on people,” he said, adding that those effects are still felt today.

Earlier Sunday, Legault had been in the Cree community of Eastmain, where he participated in the official renaming of a hydro dam in honour of former premier Bernard Landry.

This report by The Canadian Press was first published Sept. 16, 2024.

The Canadian Press. All rights reserved.



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