Scientists in Europe have reportedly found a link between the AstraZeneca-Oxford COVID-19 vaccine and extremely rare but potentially fatal blood clots, but Canadian public health officials have so far provided no update on guidance for the shot.
News broke on Friday that researchers in Germany and Norway said they had found a mechanism that could cause the AstraZeneca-Oxford vaccine to create the blood clots in very rare circumstances, in addition to identifying a possible treatment for it.
The finding comes after the European Medicines Agency (EMA) investigated 25 cases of the rare blood clots out of about 20 million AstraZeneca shots given and concluded on Thursday that the benefits from the vaccine far outweigh its possible risks, although a definitive link could not be ruled out.
The EMA said there was no increased risk from blood clots and that because the AstraZeneca-Oxford vaccine is effective in preventing COVID-19, which itself causes blood clots, the shot could actually reduce the risk of them overall.
But not all blood clots are the same, and 18 of the cases in Europe were of an extremely rare type called cerebral venous sinus thrombosis (CVST) — where veins that drain blood from the brain are obstructed and can potentially cause fatal bleeding.
Most of the incidents occurred within 14 days of receiving the AstraZeneca shot, and the majority were in women under the age of 55. It’s worth noting that this type of blood clot is much more common in women, particularly during and after pregnancy and while on birth control.
Canada’s Chief Public Health Officer Dr. Theresa Tam says the benefits of the AstraZeneca COVID-19 vaccine outweigh the rare risks. 1:53
Three of the seven patients in Germany who were recently vaccinated with the AstraZeneca-Oxford shot that had this rare brain blood clot have died.
In its investigative document, the EMA said it would expect to see just 1.35 cases of CVST in the time period it looked at — but instead its researchers saw 12.
Germany and Italy resumed vaccinations with the shot on Friday, but France opted to vaccinate only those over 55 with the AstraZeneca vaccine after discovering three cases of CVST. Denmark, Sweden and Norway decided to hold off on using the vaccine until at least next week, citing the need for more time to investigate.
Findings ‘need to be investigated’
“You cannot brush adverse effects under the rug. They always need to be investigated, and I think we have to look at this in a careful and critical manner,” said Dr. Isaac Bogoch, an infectious diseases physician and member of Ontario’s COVID-19 vaccine task force.
“We don’t have all the information yet and we’ll learn more about this — and I imagine we’ll see some updated guidance on who should get this vaccine and perhaps who shouldn’t be getting this vaccine.”
Health Canada released a statement on Thursday saying the benefits of the AstraZeneca-Oxford vaccine outweighed the risks and that the vaccine does not increase the “overall risk of blood clots,” but it provided no update on Friday when pressed for more comment on the evolving situation.
“As the vaccine rollout continues in Canada, Health Canada will continue to monitor the use of all COVID-19 vaccines closely,” the statement read.
“Health Canada will examine and assess any new safety concerns, and should a safety signal be confirmed, the department will take appropriate action.”
Researchers in Norway reported identifying the mechanism early Friday, saying it was due to a “powerful immune response” from the vaccine.
The AstraZeneca vaccine is prepared at the local vaccination centre in Hagen, Germany. Germany and Italy resumed vaccinations with the shot on Friday, the day after the European Medicines Agency found there was no increased risk of blood clots from the vaccine. (Kai Pfaffenbach/Reuters)
German researchers corroborated that finding, adding they had found a typical intravenous immunoglobulin treatment that can be offered to patients in hospitals if this rare type of blood clot occurs, but they said it wouldn’t work as a preventive measure.
“Of course you can’t completely undo a complication,” Dr. Andreas Greinacher, a professor of transfusion medicine at the Greifswald University Clinic, said during a news conference in Germany.
“But at least now we can offer the right treatment to be able to help as quickly as possible and as efficiently as possible.”
Potential blood clot link could alter rollout in Canada
The potential link could have massive implications on the rollout of the vaccine in Canada and other countries, after use of the shot was halted in parts of Europe over safety concerns in connection with the adverse events last week.
Health officials now face the unenviable task of either adjusting the rollout or trying to restore confidence in the shot, at a time when a variant-driven third wave is unfolding and many vulnerable Canadians are vastly underprotected from COVID-19.
The National Advisory Committee on Immunization (NACI) recommended earlier this month that Canadians over 65 not receive the shot, despite emerging evidence from around the world demonstrating its ability to prevent severe COVID-19 in older adults.
But that guidance changed on Tuesday after more real-world data on the vaccine’s effectiveness was reviewed by NACI, and CBC News broke the story revealing documents on the federal government’s plans to allow those 65 and older to receive it.
Experts say that while the guidelines for the vaccine could further change and it may not be recommended for certain age groups in the future, the protection against COVID-19 provided by the AstraZeneca-Oxford shot vastly outweighs the risk of rare adverse events.
That being said, we still don’t have all of the answers, and Canadians need to be aware of potential risks moving forward — however small they may be.
Medical experts in Canada divided over findings
Dr. Michael Hill, a professor of neuroscience at the University of Calgary’s Cumming School of Medicine, said on Friday that while the finding out of Europe is interesting, he remains skeptical of the potential link.
“For now, the case prevalence is such that it could still be a coincidence,” he said. “We just do not know.”
Hill said that as new data emerges, new questions will arise until there is enough evidence to meet the criteria to either confirm or deny a causal link to the vaccine.
The World Organization’s advisory committee on vaccine saftey says the AstraZeneca COVID-19 vaccine’s benefits outweigh the risks and the shot saves lives. 1:09
“The data will evolve further over time,” he said. “Meanwhile, a very large set of randomized trial data has shown no increased major adverse events with the AstraZeneca vaccine compared to placebo.”
Dr. David Fisman, an epidemiologist at the University of Toronto’s Dalla Lana School of Public Health, said German data offered a “compelling picture” that the rare blood clots were potentially linked to the vaccine in rare cases.
“I find myself in disagreement with Health Canada’s guidance on the use of AstraZeneca,” Fisman said.
“I do think that the use of this vaccine should be suspended in Canada until we have more data. At a minimum, I do not think it should be used in women aged 20 to 50 until we know more.”
Fisman said while the messaging around the AstraZeneca shot would be “challenging,” the continued use of the vaccine in the face of the issue that he believes will become “more apparent” as surveillance increases could erode trust in COVID-19 vaccines.
“I appreciate that this is a sunk cost and is politically difficult. I appreciate that vaccines have become a political football,” he said.
“That said, I think suspension of use of [AstraZeneca-Oxford] will create short-term discomfort but is the right thing to do in the longer term.”
In a statement on Thursday, Health Canada said it ‘will continue to monitor the use of all COVID-19 vaccines closely,’ noting that the benefits of the AstraZeneca-Oxford vaccine outweigh the risks. (Hannibal Hanschke/Reuters)
Dr. David Juurlink, head of clinical pharmacology at Sunnybrook Health Sciences Centre in Toronto, said the rare events may signal a causal link with the vaccine but need to be put in context even if they are confirmed.
“If people are foregoing vaccination — AstraZeneca or otherwise — because of fear of some infinitesimally rare adverse effect, they run the risk of dying,” he said.
“I think it’s probably fair to make the claim that the countries in Europe that went against the advice of their regulator and suspended the use — that may cost some of their citizens in those countries their lives.”
VANCOUVER – Contract negotiations resume today in Vancouver in a labour dispute that has paralyzed container cargo shipping at British Columbia’s ports since Monday.
The BC Maritime Employers Association and International Longshore and Warehouse Union Local 514 are scheduled to meet for the next three days in mediated talks to try to break a deadlock in negotiations.
The union, which represents more than 700 longshore supervisors at ports, including Vancouver, Prince Rupert and Nanaimo, has been without a contract since March last year.
The latest talks come after employers locked out workers in response to what it said was “strike activity” by union members.
The start of the lockout was then followed by several days of no engagement between the two parties, prompting federal Labour Minister Steven MacKinnon to speak with leaders on both sides, asking them to restart talks.
MacKinnon had said that the talks were “progressing at an insufficient pace, indicating a concerning absence of urgency from the parties involved” — a sentiment echoed by several business groups across Canada.
In a joint letter, more than 100 organizations, including the Canadian Chamber of Commerce, Business Council of Canada and associations representing industries from automotive and fertilizer to retail and mining, urged the government to do whatever it takes to end the work stoppage.
“While we acknowledge efforts to continue with mediation, parties have not been able to come to a negotiated agreement,” the letter says. “So, the federal government must take decisive action, using every tool at its disposal to resolve this dispute and limit the damage caused by this disruption.
“We simply cannot afford to once again put Canadian businesses at risk, which in turn puts Canadian livelihoods at risk.”
In the meantime, the union says it has filed a complaint to the Canada Industrial Relations Board against the employers, alleging the association threatened to pull existing conditions out of the last contract in direct contact with its members.
“The BCMEA is trying to undermine the union by attempting to turn members against its democratically elected leadership and bargaining committee — despite the fact that the BCMEA knows full well we received a 96 per cent mandate to take job action if needed,” union president Frank Morena said in a statement.
The employers have responded by calling the complaint “another meritless claim,” adding the final offer to the union that includes a 19.2 per cent wage increase over a four-year term remains on the table.
“The final offer has been on the table for over a week and represents a fair and balanced proposal for employees, and if accepted would end this dispute,” the employers’ statement says. “The offer does not require any concessions from the union.”
The union says the offer does not address the key issue of staffing requirement at the terminals as the port introduces more automation to cargo loading and unloading, which could potentially require fewer workers to operate than older systems.
The Port of Vancouver is the largest in Canada and has seen a number of labour disruptions, including two instances involving the rail and grain storage sectors earlier this year.
A 13-day strike by another group of workers at the port last year resulted in the disruption of a significant amount of shipping and trade.
This report by The Canadian Press was first published Nov. 9, 2024.
The Royal Canadian Legion says a new partnership with e-commerce giant Amazon is helping boost its veterans’ fund, and will hopefully expand its donor base in the digital world.
Since the Oct. 25 launch of its Amazon.ca storefront, the legion says it has received nearly 10,000 orders for poppies.
Online shoppers can order lapel poppies on Amazon in exchange for donations or buy items such as “We Remember” lawn signs, Remembrance Day pins and other accessories, with all proceeds going to the legion’s Poppy Trust Fund for Canadian veterans and their families.
Nujma Bond, the legion’s national spokesperson, said the organization sees this move as keeping up with modern purchasing habits.
“As the world around us evolves we have been looking at different ways to distribute poppies and to make it easier for people to access them,” she said in an interview.
“This is definitely a way to reach a wider number of Canadians of all ages. And certainly younger Canadians are much more active on the web, on social media in general, so we’re also engaging in that way.”
Al Plume, a member of a legion branch in Trenton, Ont., said the online store can also help with outreach to veterans who are far from home.
“For veterans that are overseas and are away, (or) can’t get to a store they can order them online, it’s Amazon.” Plume said.
Plume spent 35 years in the military with the Royal Engineers, and retired eight years ago. He said making sure veterans are looked after is his passion.
“I’ve seen the struggles that our veterans have had with Veterans Affairs … and that’s why I got involved, with making sure that the people get to them and help the veterans with their paperwork.”
But the message about the Amazon storefront didn’t appear to reach all of the legion’s locations, with volunteers at Branch 179 on Vancouver’s Commercial Drive saying they hadn’t heard about the online push.
Holly Paddon, the branch’s poppy campaign co-ordinator and bartender, said the Amazon partnership never came up in meetings with other legion volunteers and officials.
“I work at the legion, I work with the Vancouver poppy office and I go to the meetings for the Vancouver poppy campaign — which includes all the legions in Vancouver — and not once has this been mentioned,” she said.
Paddon said the initiative is a great idea, but she would like to have known more about it.
The legion also sells a larger collection of items at poppystore.ca.
This report by The Canadian Press was first published Nov. 9, 2024.
