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Canada posts deadliest day of coronavirus pandemic since June as vaccine hopes rise – Global News

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Newly-identified cases of the novel coronavirus surged past the 6,000 mark in Canada again on Wednesday as the country identified its highest increase in COVID-19 deaths since early June.

The new cases, which totaled 6,302, brought Canada’s caseload to 389,436. Health authorities also reported an increase of 114 deaths, though only 80 of those fatalities occurred in the past 24 hours.

The last time cases surpassed 110 was on June 4, which saw 139 deaths reported to have been caused by the virus.

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Canada’s death toll from COVID-19 now stands at 12,325, while over 309,000 patients have since recovered and another 14.8 million tests have been administered so far.

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As Canadian communities continue to grapple with surges in COVID-19 cases, hospitalizations and deaths, Canada’s chief public health officer said the priority list of people to get the coronavirus vaccine would have to be refined further, due to the initial six million doses not being enough to inoculate them all.


Click to play video 'Coronavirus: Tam says priority list for first COVID-19 vaccinations being refined'



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Coronavirus: Tam says priority list for first COVID-19 vaccinations being refined


Coronavirus: Tam says priority list for first COVID-19 vaccinations being refined

As of now, Canada is set to receive four million doses from Pfizer and two million from Moderna within the first quarter of 2021. The amount would only be enough to vaccinate three million people, however, as a person would need two doses of the vaccine in order for it to be effective.

Tam hinted that the variety and supply of doses was expected to increase soon due to Canada having contracts for three more vaccines that are in late-state clinical trials, having said that “means we will have more flexibility as time goes on, and more and more vaccines come on board.”

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“We’re expecting that in the second quarter. Depending on the approvals of the vaccines, we will have different amounts, but that is when the supply will become more and more plentiful,” said Tam Wednesday during a virtual speech at the 2020 Canadian Immunization Conference.

Canada’s health minister also said on Wednesday that the country’s review of Pfizer’s coronavirus vaccine was “expected to be completed soon” — comments that come shortly after news of the U.K. officially approving the vaccine.

“The news that the Pfizer/BioNTech vaccine has been approved in the U.K. is encouraging. Health Canada’s review of this candidate is ongoing, and is expected to be completed soon,” said Patty Hadju.

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“Making sure a COVID-19 vaccine is safe before approving it is Health Canada’s priority, and when a vaccine is ready, Canada will be ready.”


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Coronavirus: U.K.’s Johnson stresses global co-operation following approval of Pfizer vaccine


Coronavirus: U.K.’s Johnson stresses global co-operation following approval of Pfizer vaccine

During the conference, Tam also revealed plans from the Public Health Agency of Canada to combat the increase in misinformation surrounding the COVID-19 vaccine using online webinars. According to her, the webinars would include several topics like the different types of vaccines available, how to run immunization clinics and guidance on how to use vaccines.

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“Because of the social media and its internet age, we’ve got even more of a challenge on our hands than anyone else in tackling pandemics of the past,” said Tam, who also noted the importance of Canadians knowing how vaccines are developed

The federal government also introduced a new COVID-19 spending bill Wednesday, just days after revealing the country’s economic update.

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The bill, which would effectively determine how billions of dollars in new pandemic-related aid would be spent, would follow the measures proposed in Monday’s fall economic statement.


Click to play video '‘Take this seriously’: 23-year-old suffers stroke due to COVID-19'



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‘Take this seriously’: 23-year-old suffers stroke due to COVID-19


‘Take this seriously’: 23-year-old suffers stroke due to COVID-19

Several provinces across Canada also reported surges in new coronavirus cases Wednesday, with Ontario, Alberta and Quebec all reporting over 1,500 newly reported infections.

Ontario added the highest increase of 1,723 cases, pushing its total caseload to 119,922. Another 35 deaths were also reported by the province, which now has 656 people in hospital due to COVID-19.

Alberta added 1,685 more infections on Wednesday as well as 10 additional deaths. The new data also comes amid an announcement from Premier Jason Kenney that the province expects its first doses of the coronavirus vaccine to arrive by Jan 4.

“While we can’t control when these vaccines arrive in Alberta, we can make sure that when we get them, we’re ready to roll them out as quickly as we can,” said Kenny during a press conference Wednesday afternoon. To date, Alberta has seen a total of 61,169 virus cases and 561 deaths.

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Quebec added another 43 deaths on Wednesday, of which only nine occurred within the past 24 hours. The fatalities bring the province’s death toll to 7,125, while health authorities reported an additional 1,514 cases Wednesday.

British Columbia added 830 cases as well, pushing the province’s caseload to 34,728. A total of 338 cases are considered “epi-linked,’ which are cases that show symptoms and were close contacts of confirmed infections, but were never tested.

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Saskatchewan announced 237 cases and Manitoba another 277, bringing their total case figures to 8,982 and 17,384, respectively.

In Atlantic Canada, New Brunswick added another six cases while Newfoundland and Labrador reported just one. Nova Scotia reported an increase of 17 cases Wednesday, pushing its total infections to 1,332.

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The Yukon added one more cases on Wednesday, while Nunavut added another 11. The Northwest Territories did not report any additional cases.


Click to play video 'Looking at widely praised coronavirus messages  from around the world'



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Looking at widely praised coronavirus messages from around the world


Looking at widely praised coronavirus messages from around the world

Nunavut’s government also lifted its two-week lockdown on Wednesday everywhere except for the coastal town of Arviat, of which saw all 11 new cases reported by the province. To date, Nunavut has seen 193 cases of the novel coronavirus — the highest among Canada’s territories.

Cases of the coronavirus have since surpassed 64.4 million according to a tally kept by Johns Hopkins University. A total of 1,491,000 people have also succumbed to the virus, with the United States, Brazil and India leading in both cases and deaths.

With files from Global News’ Emerald Bensadoun and The Canadian Press

© 2020 Global News, a division of Corus Entertainment Inc.

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Made-in-Canada coronavirus vaccine starts human clinical trials – CBC.ca

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A made-in-Canada vaccine to protect against COVID-19 began human clinical trials Tuesday in Toronto, says the biotechnology company that developed the vaccine.

Toronto-based Providence Therapeutics said three shots will be given to 60 adult volunteers at a clinical trial site in Toronto in the first phase of the trial on Tuesday. 

Fifteen of those volunteers will receive a placebo, and 45 will get the vaccine, called PTX-COVID19-B.

Brad Sorenson, the company’s CEO, said it’s the first time a vaccine designed and manufactured in Canada has begun clinical trials. The company has purchased a site in Calgary to mass produce the vaccine. 

Vaccines are designed to trigger an immune response in the body. Providence’s product is an mRNA vaccine and is similar to the Moderna coronavirus shot being given to people across Canada.

Quebec-based pharmaceutical Medicago began clinical trials last July of its coronavirus vaccine that is based on another technology. Unlike Providence, a large portion of Medicago’s vaccine doses will be manufactured outside the country, in North Carolina.

A vial is shown in this handout image provided by Providence Therapeutics. The company says it is the first fully made-in-Canada coronavirus vaccine to reach clinical trials in this country. (Providence Therapeutics/The Canadian Press)

Medicago’s vaccine is currently in Phase 3 clinical trials — the last stage before it can apply for approval from Health Canada and other regulators to market the product. 

Sorenson said Providence designed and built its vaccine last March.

“We reached out to the Canadian government in April and said, ‘Hey, you’ve heard of Moderna. We’re doing the exact same thing,’ ” Sorenson said in an interview.

“We went from concept into the clinic in under a year without the same level of support as our peers had.”

Purchased Calgary site

The federal government provided financial sponsorship and support for the early phase clinical trial through the National Research Council of Canada’s Industrial Research Assistance Program. 

Currently, Canada lacks the capacity to manufacture the millions of doses of coronavirus vaccines needed to immunize people outside of a clinical trial setting. It’s why the federal government struck deals with Pfizer-BioNTech and Moderna — both manufactured abroad — to obtain the vaccines being rolled out across Canada.

While the company was developing the vaccine in pre-clinical studies, Sorenson said it also started to build the infrastructure to manufacture the vaccine in Canada as well.

A typical vaccination station is seen at the COVID-19 vaccination clinic at the Health Sciences Centre in Winnipeg on Dec. 14. Currently, Canada lacks the capacity to manufacture the millions of doses of coronavirus vaccines needed to immunize people outside of a clinical trial setting. (John Woods/The Canadian Press)

The company purchased a 20,000-square-foot facility in Calgary that includes 12,000 square feet of lab space to mass produce the vaccine. The facility will be up and running in two months, Sorensen said. 

Pending regulatory approval, a larger Phase 2 trial with adults over 65, youths under 18 and pregnant people could start in May, Sorenson said.

Initial focus was cancer research

If the vaccine proves safe and effective in clinical trials and Health Canada approves it, the goal is to have it ready for the global market by January 2022.

Several other Canadian vaccine candidates are poised to start clinical trials in Canada, including one from Saskatoon-based VIDO-Intervac that’s currently recruiting volunteers for a Phase 1 clinical trial in Halifax.

Virologist Alyson Kelvin, an assistant professor at Dalhousie University and a scientist at the Canadian Centre for Vaccinology at VIDO-Intervac, is one of the many Canadian researchers involved in vaccine development and anticipating the results of clinical trials, including from Providence. 

“The mRNA vaccines produced by Pfizer and Moderna have shown to have very robust immune responses, so perhaps this is a good strategy to be backing,” Kelvin said. “Phase one clinical trials will help us determine if this mRNA vaccine is going into that same progression.”

Michael Gardam, an infectious disease physician and chief operating officer at Health PEI, said the idea of having a domestic pandemic vaccine supplier makes sense. But Canada’s plan was based on making more familiar influenza vaccines. 

 “If we’re in Phase one, Phase two trials, by the time this Canadian vaccine may be approved, the pandemic may be largely over,” said Gardam, who is not involved in vaccine development. “But the concept is a good one.”

Sorenson founded Providence Therapeutics in 2013 to focus on cancer vaccines.

Several scientists contributed to the pre-clinical research on Providence’s vaccine, including those at the lab of Dr. Mario Ostrowski, a scientist at the Keenan Research Centre for Biomedical Science and an infectious disease clinician at St. Michael’s Hospital, Dr. Anne-Claude Gingras at Mt. Sinai Hospital, Dr. Samira Mubareka and Dr. Rob Kozak at Sunnybrook Research Institute, as well as Dr. Michael Pollanen, Ontario’s chief forensic pathologist.

In August, Ostrowski, whose laboratory performed the animal trials, said results were on par with tests of vaccines from Moderna and Pfizer-BioNTech at that stage.

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Explained: What the Pfizer shortage means for Canada's vaccine rollout – CTV News

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TORONTO —
Canada won’t receive a single vial of the Pfizer-BioNTech vaccine this week due to an international shortage that has prompted finger-pointing in Ottawa and forced provinces to temporarily delay their vaccine rollouts.

For the next four weeks, Canada’s vaccine deliveries will be cut in half with up to 400,000 doses delayed, according to Maj.-Gen. Dany Fortin, who is leading the country’s vaccine rollout. Canada won’t receive any new deliveries from Pfizer this week, and only one-quarter of the previously promised delivery next week.

Pfizer advised Canada earlier this month that upgrades to its plant in Belgium would temporarily slow production and reduce doses delivered to every country except the United States, which has its own production facility. The factory is expected to return to full production on Feb. 15.

The upgrades are expected to help boost Pfizer’s annual production capacity from 1.3 billion shots in 2021 to up to 2 billion, which would be enough to cover about 13 per cent of the world’s population.

Prime Minister Justin Trudeau spoke directly to Pfizer’s CEO last week and said he was assured that, despite the slowdown, the company will fulfil its contractual promise to deliver four million doses to Canada by the end of March.

The next shipment of Canada’s second approved vaccine, from Moderna, is expected in the first week of February and will include an estimated 230,400 doses.

In the meantime, the temporary shortage has forced provinces and territories to pump the brakes on their vaccine rollout plans. Opposition parties have accused the Liberals of mishandling the vaccine rollout and pointed to other countries, including the U.S. and the U.K., where more people have received their shots.

WHAT DOES THIS MEAN FOR THE VACCINE ROLLOUT?

Federal health officials overseeing Canada’s vaccine plan insist the Pfizer delay is temporary and will not hamper the country’s long-term goal of vaccinating every Canadian by Sept. 30. Fortin said future shipments and “a rapid scale-up of deliveries in the upcoming weeks” will make up for the current shortage.

For now, provinces have started retooling their vaccination plans to prolong the time between vaccinations and, in some cases, are turning people away from new vaccine appointments.

Ontario Premier Doug Ford called the Pfizer shortage “a massive concern” and announced that the province will no longer be able to meet its goal of vaccinating all residents and staff in long-term care homes by Feb. 15.

Ontario, Quebec, Nova Scotia, New Brunswick, Saskatchewan and British Columbia will all slow down their vaccine schedules to stretch whatever vaccine supply they have on hand. The provinces will delay second doses up to 42 days, with Quebec prolonging the wait up to 90 days.

The National Advisory Council On Immunization has advised that the wait period between first and second doses could be extended up to 42 days.

In Alberta, officials have paused new appointments for those looking to get their first vaccine. Manitoba temporarily stopped booking new appointments but is expected to resume this week.

WILL THE SHORTAGE MEAN LONG-TERM DELAYS?

The federal government insists that the country’s long-term vaccine rollout remains on track. Officials released projections last week that suggest Canada will still meet its goal of vaccinating 3 million people by the end of March, accounting for eight per cent of the entire population. A total of 36 million Canadians are expected to be vaccinated by the end of September.

Even if Canada doesn’t approve any more vaccines by the fall, estimates suggest that doses from Pfizer and Moderna will cover 13 million Canadians, or 34 per cent, by June and 36 million, or 95 per cent, by September 30.

Canada’s vaccine rollout could happen even faster if more vaccines are approved. The projections suggest that, based on all vaccines Canada has procured but have yet to be approved, as many as 23 million Canadians could be vaccinated between April and June, accounting for 61 per cent of the population. Canada could have enough doses for up to 73 million people between July on September. In such a scenario, there would be more than enough vaccines for everyone who wants one.

HOW DOES CANADA COMPARE TO OTHER COUNTRIES?

So far, 761,530 people in Canada have received at least their first shot of either the Pfizer or Moderna vaccine, accounting for roughly two per cent of the population.

In the United States, about six per cent of the population has received at least their first shot. However, the U.S. is lagging when it comes to administering available vaccines, with only about half of all shots available still undistributed.

In Israel, which secured a large stock of Pfizer vaccines from the get-go, more than 2.5 million of the country’s 9 million people have been vaccinated. Teenagers between 16 and 18 are now receiving vaccines on the condition that they receive parental permission. https://www.ctvnews.ca/world/israel-expands-vaccination-campaign-to-teens-1.5279506

Canada’s rollout is more on par with countries such as Finland, Austria, Poland, Switzerland and Estonia, all of which have vaccinated around two per cent of their populations.

Canada is hardly alone when it comes to the delays. Mexico, Saudi Arabia, Bahrain and several European countries have all begun slowing down vaccinations, and Italy has threatened to sue Pfizer.

In Ottawa, the Liberals have been criticized for how they’re managing the rollout. Some members of the opposition have called on Trudeau to ask U.S. President Joe Biden for help.

NDP House Leader Peter Julian said the Liberals need to explain the situation to Canadians.

“Why are other countries ahead?” Julian said. “That’s the question that the government will have to respond to. And we believe that the government needs to very clearly spell out their plan to accelerate the vaccine distribution across the country.”

The government says it has worked hard to secure as many doses as possible and signed multiple contracts in anticipation of multiple vaccine candidates booming available in the coming months.

With files from The Canadian Press

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Ontario working to adapt to the delay of Pfizer BioNTech vaccines: Public health officials – SooToday

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In response to the Pfizer BioNTech delay in delivering vaccines to Ontario, public health officials in this province could extend the interval between the two doses that are given to some less-vulnerable vaccine recipients. Pfizer revealed last week it had to shut down production for one week so it could scale ups European manufacturing capacity. 

Both the Pfizer BioNTech and Moderna vaccines that are provided in Ontario are double-dose vaccines, meaning the first dose is administered one day and then the follow-up second dose is delivered 21 to 28 days later.

Despite the shortage, Ontario officials told a technical briefing Monday that the plan is to accelerate the vaccines going out to long-term care homes, to high risk retirement homes and to First Nations elder care homes. 

“With uncertainty and reduced allocations we will be reallocating vaccines to 14 public health unit regions that haven’t received any vaccine yet so that they can begin to vaccinate their vulnerable populations, starting this week,” said a public health official.

She said Ontario is working on a new strategic approach. This will include a focus on areas where Ontario can reduce risk of illness and death for the most vulnerable populations. 

“We’re accelerating the vaccination of residents in long-term care homes, high-risk retirement homes and First Nations elder care homes,” she added.

Ontario is also planning to expand the time allocation between first and second dosages on the Pfizer BioNTech vaccine.

“We will be extending the interval between doses in some situations and only as needed to support the vaccinations of the most vulnerable populations. For resident groups, in long-term care, in high-risk retirement homes and elder care homes, we will be maintaining the recommended maximum interval of 21 to 27 days and for all other groups, we will expand that interval to no more than 42 days.”

The idea of expanding the time interval was taken into account during the vaccine trial studies and was proven effective with time intervals from 19 days to 42 days, the briefing was told. 

The health ministry official said this measure is supported by the World Health Organization as well as the Centers for Disease Control, based in the United States. 

The effort is also being accelerated for remote and isolated First Nations communities.

Despite the one-week delay from Pfizer, the company has stated it will live up to the contractual obligation to provide Canada with a total of four million doses of vaccine by the end of March, the briefing was told.

In response to a media question about the reliability of the Moderna vaccine delivery, the briefing was told that Moderna delivers its vaccines every three weeks, and in both instances, the vaccines from Moderna had arrived on time in Ontario. The next delivery, of about 80,000 doses, is expected on Monday February 1, 2021. There has been no indication that Moderna’s delivery schedule will be changed.

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