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The Canadian Press

The Latest: Johnson & Johnson: 1-dose vaccine prevents virus

New Brunswick, N.J. — Johnson & Johnson says its vaccine appears to protect against COVID-19 with just one shot. It’s not as strong as some two-shot rivals but still potentially helpful for a world in dire need of more doses. Results released Friday show the single-shot vaccine was 66% effective overall at preventing moderate to severe illness, and much more protective against the most serious symptoms. These are preliminary findings from a study of 44,000 volunteers that is ongoing. Researchers tracked illnesses starting 28 days after vaccination – about the time when, if participants were getting a two-dose variety instead, they would have needed another shot. After day 28, no one who got vaccinated needed hospitalization or died regardless of whether they were exposed to “regular COVID or these particularly nasty variants,” Dr. Mathai Mammen, global research chief for J&J’s Janssen Pharmaceutical unit, told The Associated Press. When the vaccinated did become infected, they had a milder illness. The vaccine worked better in the U.S. compared to South Africa, where it was up against a tougher, mutated virus. The company says it will file an application for emergency use soon in the U.S., and then abroad. It expects to have some ready to ship as soon as authorities give the green light and supply 100 million doses to the U.S. by June. ___ THE VIRUS OUTBREAK: Johnson & Johnson 1-dose shot prevents virus, but less than some others. WHO team visits Wuhan hospital that had early coronavirus patients. The EU publishes vaccine contract, price redacted. Dubai blamed by several countries for spreading the coronavirus abroad after the city welcomed New Year’s revelers. Tanzania’s president says God has eliminated COVID-19 in the country; his own church begs to differ. Philadelphia’s problematic vaccine rollout raises larger questions. ___ Follow all of AP’s pandemic coverage at https://apnews.com/hub/coronavirus-pandemic, https://apnews.com/hub/coronavirus-vaccine and https://apnews.com/UnderstandingtheOutbreak ___ HERE’S WHAT ELSE IS HAPPENING: BERLIN — Swiss pharmaceutical company Novartis says it has signed an agreement to help production of the Pfizer-BioNTech coronavirus vaccine. Novartis says the initial agreement calls for it to take active ingredient from Germany’s BioNTech and fill it into vials at its plant in Stein, Switzerland. The vials would be sent back to BioNTech for distribution. Novartis says the plan is for it to start production during the second quarter, with the initial shipment of finished vaccines expected in the third quarter. Novartis’ announcement comes after another rival, French drugmaker Sanofi, said Wednesday it would help bottle and package the BioNTech-Pfizer vaccine at a plant in Frankfurt. ___ PARIS — Nearly two weeks after France extended its vaccine campaign to over-75-year-olds, elderly residents across Paris are flocking to vaccination centres amid concerns of a vaccine shortfall. France is expecting less than a third of planned deliveries of the AstraZeneca vaccine this quarter – 4.6 million doses instead of 15.8 million, according to French officials. Nurses at a medical centre in Paris’ residential 15th district are currently administering between 80 and 100 shots a day – a number that could drop. “Our goal here is to administer the second jab within the recommended timeframe,” said the centre’s Chief Doctor François Teboul. “The likely consequence is we will have to push back a number of first vaccinations in the weeks to come.” Delays or production problems for the Pfizer-BioNTech vaccine have caused concerns across the European Union. ___ WASHINGTON — The new director of the Centers for Disease Control says officials have “scaled up” their surveillance of new coronavirus variants in the United States. CDC Director Rochelle Walensky told ABC’s “Good Morning America” that previously “there has not been a public health infrastructure” to track such variants. Also, there weren’t resources to do “mass sequencing” of the virus across the country. She noted the coronavirus aid plan pushed by the Biden Administration includes funds to improve such tracing. However, Walensky says it was “concerning” the two South Carolina individuals who were diagnosed with the more virulent strain first identified in South Africa didn’t know each other or travel there, so the “presumption” is there’s “community spread of this strain.” ___ BRUSSELS — The European Union has made public a redacted version of the contract it agreed with the drugmaker AstraZeneca which lies at the heart of a major row over coronavirus vaccine deliveries. The EU’s executive branch, the European Commission, published the text of the advance purchasing agreement Friday after consulting the British-Swedish company. Details about the price of the vaccine were notably redacted. The U.K. is thought to be paying far more for the vaccine than the 27-nation bloc. Earlier this week, the EU lashed out at the drugmaker after it said it would not be able to deliver the 80 million doses that it hoped to provide and could only supply 31 million. The advance purchasing agreement was signed before any vaccine existed. European authorities are expected to approve the AstraZeneca vaccine later Friday, but questions remain over how effective it is among people over 65. ___ ROME — Italy’s virus czar says pharmaceutical company Moderna officially advised the government Friday that it would reduce a planned upcoming vaccine delivery to Italy by 20%, fueling increasing outrage in Italy as such delays have forced the country to drastically slow down its vaccine campaign. Domenico Arcuri expressed “stupor, concern and discomfort” at Moderna’s decision, noting that it came after both Pfizer and AstraZeneca announced similar delays in scheduled deliveries. The Italian government has formally advised Pfizer it is weighing legal action. Arcuri said Moderna told the government its Feb. 8 deliveries would be 132,000 doses instead of a planned 166,000. The reduced deliveries have meant that Italy’s plan to start vaccinating Italians over age 80 on a mass scale have been delayed by several weeks, and reduced by more than half the number of shots administered each day. Italy concentrated the first weeks of its vaccine campaign on health care workers, with about 1 million of the 1.7 million doses administered so far going to doctors and nurses. ___ MADRID — Spain’s health minister says that between 5 and 10% of all confirmed coronavirus infections are believed to be derived from a mutation seen as responsible for the high contagion rates seen first in the United Kingdom and later in other countries. Appearing Friday at a Congress of Deputies health commission, Carolina Darias said that so far confirmed cases of the new variant in Spain stand at 350 but that experts’ analysis showed that up to 10% of new infections could be attributed to it. “The following weeks are crucial to see if this variant takes over … like has happened in other countries,” Darias told lawmakers. On Thursday Spain logged nearly 35,000 new cases of the virus and 515 confirmed deaths, although the 14-day rate of infection per 100,000 residents dropped slightly for the first time in nearly a month. Authorities say that an abrupt decline would be needed for overwhelmed hospitals to free up space before any effects of the new variant increases contagion and hospitalizations again. ___ BELGRADE, Serbia — Serbia has received an additional 40,000 doses of the Sputnik V vaccine from Russia, further boosting its so far successful coronavirus vaccination campaign when compared with the rest of the Balkans. While its neighbours have struggled to secure the shots, Serbia has embarked on one of the fastest vaccine rollouts in Europe with some 400,000 people getting jabs so far in the country of 7 million. One million doses of Chinese Sinopharm vaccines arrived in Serbia earlier this month as well as thousands of doses of the Pfizer and Sputnik V shots. Serbian officials say all the vaccine shipments which have arrived have been directly negotiated with either Russia and China, or with the Pfizer producers in the U.S. They say that so far no vaccines have been delivered by the global Covax system aimed at providing affordable shots to poor and middle-income countries. Serbia is also negotiating the domestic production of the Russian Sputnik V vaccine. The Russian and Chinese vaccines have not been approved by the European Union drug regulators. ___ AMSTERDAM — The European Medicines Agency says no new side effects linked to the coronavirus vaccine made by BioNTech and Pfizer were identified in the regulator’s first safety update on COVID-19 vaccines. In a statement published Friday, the European regulator said its expert committee assessed reports of people who died after getting the vaccine and said their review “did not suggest a safety concern.” Earlier this month, Norwegian officials amended their vaccination advice to say that doctors should assess frail and severely ill elderly people to decide if they should be immunized. The EMA concluded that safety data collected on the Pfizer vaccine are “consistent with the known safety profile of the vaccine” and noted that severe allergic reactions are a known, rare side effect. It said the frequency of such allergic reactions was about 11 cases per million doses in the U.S. but that there was no comparable European estimate yet. The EMA authorized the Pfizer vaccine on December 21 and granted it a conditional license; Pfizer and BioNTech must submit safety reports every month in line with a heightened monitoring process. The agency said “there are no recommended changes regarding the use of the vaccine.” ___ BUDAPEST, Hungary — Hungary’s prime minister says a deal to purchase Chinese coronavirus vaccines could be concluded as early as Friday, which would make Hungary the first country in the European Union to purchase a vaccine from China. Prime Minister Viktor Orban said on public radio that his government is monitoring the use of a vaccine developed by Chinese state-owned company Sinopharm in neighbouring Serbia, which became the first European country to administer the drug after it received 1 million doses earlier this month. Hungary’s drug regulator has not yet approved the Sinopharm vaccine. But a decree ordered by the government on Thursday streamlined the approval procedure by allowing any vaccine that had been administered to at least 1 million people to be used in Hungary. Orban said he would personally choose to be inoculated with the Sinopharm vaccine since he trusted it the most. Hungary last week was the first EU member to approve the Russian Sputnik V vaccine, and has ordered doses to treat 1 million people over the next three months. Orban has been critical of the EU’s vaccine procurement program and insisted that countries that pursue their own vaccine agreements are faring better. ___ COPENHAGEN, Denmark — Denmark has extended restrictions that close food shops, except for grocery stores and pharmacies, schools and public gatherings of more than five people for another three weeks until the end of February. Prime Minister Mette Frederiksen said “we have seen how quickly the new mutation can get things out of control. Therefore, we cannot relax the restrictions. Even when we get vaccinated more, we must proceed cautiously.” Cafes and restaurants remain closed but can still sell takeout food. Gyms, public libraries, beauty parlours and hairdressers also will remain shut until Feb. 28. Advice to avoid non-essential travel — including business trips — outside of Denmark also was extended to the end of February, with Foreign Minister Jeppe Kofod saying it was “an important element in the effort to control the spread of infection as the mutations of coronavirus occur in several countries.” ___ TOKYO — Japan’s minister in charge of the coronavirus vaccine rollout warned the public against scams in which callers ask for payments to reserve inoculation slots. Taro Kono, minister for administrative affairs, stressed the innoculations that begin next month are free. “We want to make sure our message is getting relayed,” says Kono, acknowledging such attempts may grow. Local government offices have been deluged with inquiries about vaccine-related telephone calls wanting cash or personal information, he says. Cases of COVID-19 infections have been growing recently, and there have been more than 5,000 confirmed deaths so far. ___ BEIJING — New cases of local transmission in China are continuing to fall with just 36 announced on Friday, as the country’s annual Lunar New Year travel push gets underway. Authorities have taken a variety measures to discourage travel this season and far few Chinese appear willing to make the trip, even though it might be their only chance to return home and see family all year. The northeastern province of Heilongjiang reported the largest number of new cases, 21, over the past 24 hours, followed by Jilin province just to the south. The capital Beijing and its surrounding province of Hebei both reported one new case each. Also Friday, inspectors from the World Health Organization began day two of a fact-finding tour in the central Chinese city of Wuhan clusters of the virus were first detected in late 2019. The mission has become politically charged, as China seeks to avoid blame for alleged missteps in its early response to the outbreak. A major question is where the Chinese side will allow the researchers to go and talk to during the visit. ___ The Associated Press

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