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Canadian doctors urge caution on repurposing malaria medication to fight COVID-19 – CBC.ca

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Canada’s top public health doctor warned against using malaria medication to treat COVID-19 on Monday, after U.S. President Donald Trump touted the option during a recent news conference.

People have taken chloroquine to prevent and treat malaria for decades. A related medication called hydroxychloroquine is mainly used to treat inflammatory disorders such as rheumatoid arthritis and lupus.

There are currently no approved treatments or vaccines for COVID-19. People in more than 180 countries have been sickened by the respiratory illness caused by a coronavirus humans have no immunity against.  

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Last week, Trump told reporters hydroxychloroquine had shown “very, very encouraging early results.” But Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, was also quick to say that officials are trying to strike a balance between making the potential therapy available to physicians to use on seriously ill COVID-19 patients on an emergency basis while ensuring it is truly safe and effective through clinical trials. 

On Monday, Dr. Theresa Tam, Canada’s chief public health officer, added her own cautions.

“My message is that you should not take medication without the scientific evidence,” Tam said. “It can be quite dangerous. These drugs are not without side-effects. In fact, there are quite significant side-effects.”

The World Health Organization (WHO) is running a research network called Solidarity that has identified a “vast suite of potential drug therapies and combinations” that could be repurposed to treat COVID-19.

Tam said part of Canada’s participation in the network includes making sure patients will receive drugs in the most scientific and safest way possible. 

Dr. Theresa Tam, Canada’s chief public health officer, leaves a news conference Monday after cautioning against taking medications touted for COVID-19 treatment that aren’t backed up by solid scientific evidence. (Blair Gable/Reuters)

Dr. David Juurlink, head of clinical pharmacology and toxicology at Toronto’s Sunnybrook Health Sciences Centre, is writing a review on the safety of chloroquine and hydroxychloroquine. 

Trump suggested using hydroxychloroquine together with an antibiotic based on the results of a small study by French researchers. 

Juurlink said that study involving just 36 patients is the extent of the human research so far on using hydroxychloroquine and azithromycin as a treatment for COVID-19 — research with “so many holes you could drive a truck through it,” he said. 

Normally, an antibiotic is never recommended to treat a virus. But the antibiotic and antimarlarial combination has off-target effects beyond what it was designed to do, infectious disease experts say.

Juurlink said he’s concerned about possible toxic overdoses from chloroquine and hydroxychloroquine and side-effects such as:

  • Irregular heartbeat.
  • Low blood sugar.
  • Mood changes and psychosis.

“These are not drugs to be toyed with,” Juurlink said.

The only way to tell if a treatment really works is to randomly assign a large number of patients to either take it or a placebo. Even then, rarer side-effects may not crop up until years later, once more people have taken the medication.

In the U.S. and Canada, doctors and pharmacists said hoarding hydroxychloroquine for COVID-19 could hurt others, such as those who take the drug long term to keep chronic inflammatory diseases like lupus under control.

Pharmaceutical companies in Canada and worldwide are donating hydroxychloroquine to help medical researchers collect high-quality data on the safety and effectiveness of using the medication to treat COVID-19.

Trial to protect hospital staff

Dr. Kevin Kain is an infectious disease physician at Toronto General Hospital, where he’s part of a team of researchers designing a randomized placebo-controlled trial into the safety and efficacy of using hydroxychloroquine prophylactically to prevent COVID-19 infection. Their goal is to protect front-line health-care workers in emergency departments and intensive care by preventing the infection from taking root. 

“This seems like the appropriate, high-risk group to establish that it works,” Kain said. “Right now, people are using it without good evidence. I was around long enough to remember SARS, where a number of treatments were tried without appropriate trials, and in retrospect, a lot of those things actually caused harm.”

An undated electron microscope image shows SARS-CoV-2, the virus that causes COVID-19, orange, emerging from the surface of cells, green, cultured in the lab. Chloroquine seems to facilitate entry of zinc to kill the virus. (NIAID-RML via AP/The Canadian Press)

In the lab, chloroquine works by suppressing the growth of coronaviruses such as SARS and  SARS-CoV-2, the virus that causes COVID-19, the French researchers said.

“It isn’t entirely clear, but there’s intriguing evidence that if you can get high levels of a mineral called zinc … inside a cell that’s infected, it will inhibit replication of coronaviruses,” Kain said. “Taking a lot of zinc by mouth doesn’t do this because getting zinc into a cell is tightly regulated. Chloroquine seems to facilitate it getting into the cell.”

Elsewhere in the world, Doctors Without Borders is preparing to treat patients with COVID-19, potentially with chloroquine or hydroxychloroquine. The medical charity operates in more than 70 countries.

Jason Nickerson, humanitarian affairs adviser for Doctors Without Borders in Ottawa, said if a treatment stops the severe illness from COVID-19, then it would be incredibly beneficial, particularly in countries with less resourced health systems.

“How do we get these new technologies, once they’re developed, to patients in all countries, everywhere?”

He called on governments worldwide to apply policies to ensure technologies like drugs that are developed with public funds remain affordable and globally accessible, since in a pandemic, the virus needs to be stamped out everywhere to protect people everywhere. 

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It's possible to rely on plant proteins without sacrificing training gains, new studies say – The Globe and Mail

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At the 1936 Olympics in Berlin, a scientist named Paul Schenk surveyed the eating habits of top athletes from around the world. The Canadians reported plowing through more than 800 grams of meat per day on average; the Americans were downing more than two litres of milk daily.

While there have been plenty of changes in sports nutrition since then, the belief that meat and dairy are the best fuel for building muscle persists. These days, though, a growing number of athletes are interested in reducing or eliminating their reliance on animal proteins, for environmental, ethical or health reasons. A pair of new studies bolsters the case that it’s possible to rely on plant proteins without sacrificing training gains, as long as you pick your proteins carefully.

The standard objection to plant proteins is that they don’t have the right mix of essential amino acids needed to assemble new muscle fibres. Unlike animal proteins, most plant proteins are missing or low in at least one essential amino acid.

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In particular, there’s one specific amino acid, leucine, that seems to play a special role in triggering the synthesis of new muscle. It’s particularly abundant in whey, one of the two proteins (along with casein) found in milk. That’s why whey protein is the powdered beverage of choice in gyms around the world, backed by decades of convincing research, which was often funded by the dairy industry.

But one of the reasons whey looks so good may be that we haven’t fully explored the alternatives. A 2018 study by Luc van Loon of the University of Maastricht in the Netherlands, for example, tested nine vegetable proteins including wheat, hemp, soy, brown rice, pea and corn. To their surprise, they found that corn protein contains 13.5 per cent leucine – even more than whey.

Based on that insight, van Loon decided to pit corn against milk in a direct test of muscle protein synthesis. Volunteers consumed 30 grams of one of the proteins; a series of blood tests and muscle biopsies were collected over the next five hours to determine how much of the ingested protein was being turned into new muscle fibres. The results, which appeared in the journal Amino Acids, were straightforward: Despite all the hype about whey, there was no discernible difference between them.

A second study, this one published in Medicine & Science in Sports & Exercise by a team led by Benjamin Wall of the University of Exeter in Britain, had similar findings. Instead of corn, it used a mix of 40 per cent pea, 40 per cent brown rice and 20 per cent canola proteins. Since different plants have different amino acids profiles, mixing complementary proteins has long been suggested as a way overcoming the deficiencies of any single plant protein. Sure enough, the protein blend triggered just as much new muscle synthesis as whey.

On the surface, the message from these studies is straightforward: Plant proteins are – or at least can be – as effective as even the best animal proteins for supporting muscle growth. There are a few caveats to consider, though. One is that the studies used isolated protein powders rather than whole foods. You would need nearly nine cobs of corn to get the 30 grams of protein used in van Loon’s study, compared to just three-and-a-half cups of milk.

Another is that plants are generally harder to digest, meaning that not all the amino acids will be usable. That may not be a problem for healthy young adults consuming 30 grams of protein at once, which is enough to trigger a near-maximal muscle response. But for older people, who tend to have blunted muscle-building responses to protein, or in situations where you’re getting a smaller dose of protein, the details of protein quality may become more important.

Of course, the effectiveness of plant proteins won’t be news to notable plant-based athletes such as ultrarunner Scott Jurek or basketball star Chris Paul – but it’s encouraging to see the science finally begin to catch up.

Alex Hutchinson is the author of Endure: Mind, Body, and the Curiously Elastic Limits of Human Performance. Follow him on Threads @sweat_science.

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See how chicken farmers are trying to stop the spread of bird flu – Fox 46 Charlotte

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CLOVER, S.C. (QUEEN CITY NEWS) — Poultry farmers across the Carolinas aren’t taking any chances.  Many are turning to strict protocols as another wave of bird flu continues to threaten the chicken population across the country. 

Since 2022, it is estimated more than 90 million birds have either died from the virus or were killed to prevent further spread in the U.S. 

“We try to make them the happiest as possible. We always say a happy chicken is a tasty chicken,” owner of Eden Farms Adam Shumate said. 

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With their happiness in mid, Shumate also wants to keep his chickens alive and healthy. On his farm in Clover, he has implemented protocols to minimize a potential bird flu outbreak.  

“We want to be prepared,” he said. “We feel like the things that we can do to prevent it first is the best case because we don’t want to start from scratch with a whole new flock.”  

Because bird flu is commonly spread through bird droppings, Shumate is limiting the number of people coming into contact with his flocks. He says this would minimize the chances of someone walking onto the property with bird droppings on the bottoms of their shoes. 

On top of monitoring the chickens closely, Shumate and his staff are constantly cleaning their equipment, including what they wear on their feet.   

“We have specific shoes that are just for working with the flock and for when we are taking care of them,” Shumate said. 

Other farmers, like Holly Burrell, haven’t let a visitor step foot near her hens in Gastonia for more than two years. 

No visitors or outside cars are welcomed, and her chickens are separated in what she calls “tent cities.” 

“We don’t want to do that because we want them to live their best life,” Burrell said in a 2022 interview with Queen City News. 

Recently, health officials have detected bird flu in other animals like seals, squirrels and dolphins. 

Earlier this month, bird flu was detected in one of the state’s dairy cow herds. While concerning, state health officials say the overall risk to the general public remains low. 

“I’ve not heard of any cases, zero cases of people being affected by this virus associated with food consumption, milk consumption with egg consumption… any of these products we’re getting from farm animals is not really been associated with any human risk at this point,” said Dr. Michael Martin, director of the Veterinary Division at the N.C. Department of Agriculture and Consumer Services. 

As of March 28, at least 80 birds in North Carolina were detected with the virus. Back in York County, Shumate says it all starts with the individual farms. 

“When it comes to wildlife and things that that, there is only so much that you can do is be observant,” Shumate said. “Keep a healthy flock that way they can find off the infections that may come about.” 

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CFIA Monitoring for Avian Influenza in Canadian Dairy Cattle After US Discoveries – Morning Ag Clips –

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From the field to your inbox, the Weekend Edition of the Morning Ag Clips features stories, trends, and unique perspectives from the farming community. This laid-back edition is great for anyone looking for a fun weekend read.

Morning Ag Clips. All ag. All the time.

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