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Canadian government announces deal with two leading COVID-19 vaccine candidates – Brockville Recorder and Times

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The government announced Wednesday it had placed orders with Pfizer and Moderna, two companies with candidates in the third and final stage of trials

Brazilian pediatric doctor Monica Levi, a volunteer who received a potential COVID-19 vaccine, works at the Specialized Clinic in Infectious and Parasitic Diseases and Immunizations (CEDIPI), in Sao Paulo, Brazil, on July 24, 2020.

NELSON ALMEIDA/AFP via Getty Images

OTTAWA – Following the lead of other countries, the federal government has purchased early access to two of the leading candidates for a COVID-19 vaccine.

The government announced Wednesday they had placed orders with Pfizer and Moderna, two of the companies with candidates in the third and final stage of clinical trials for COVID-19 vaccines, which could be ready by the end of the year.

Procurement Minister Anita Anand said she was pleased to have reached deals that will give Canadians access to the vaccines, provided they are successful, in 2021.

“We are extremely pleased to be among the first countries to establish these agreements,” she said.

Anand said the government has secured millions of doses, but didn’t specify exactly how many, what they would cost or when in 2021 they would be delivered. Anand said the government will make those details public in time, but for now it can’t because of ongoing negotiations with other suppliers.

“Canada is pursuing agreements with a number of international and domestic companies to guarantee a supply base of potential vaccine,” she said. “We owe it to Canadians to explore every options for vaccines.”

She said the government is negotiating secure orders with options to get millions more doses. The government has also placed orders for millions of syringes, alcohol swabs and other equipment for a mass vaccination campaign when a vaccine is ready.

Moderna and Pfizer’s vaccines are both in the third and final stage of clinical trials. Assuming those trials are successful, Pfizer, which is partnering with another company called BioNTech said it can produce up to 100 million doses of its vaccine this year and another 1.3 billion in 2021.

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Moderna has also entered into a series of partnerships to be able to manufacture one billion doses of its vaccine per year.

Both vaccines are messenger ribonucleic acid or mRNA vaccines, which essentially trick the body into making spike proteins, similar to the spike proteins that allow COVID-19 to infect cells. Once those spike proteins are there, the body’s own immune system can learn to attack them, preventing infection.

Canada is not the first country to strike a deal for one of these vaccines. The U.S. government secured a deal in mid July with Pfizer to provide up to 100 million doses for $1.95 billion, with an option to provide 500 million more doses.

In June, a European consortium made up of France, Germany, the Netherlands and Italy has a deal with AstraZeneca, which is manufacturing the Oxford University vaccine, to provide up to 400 million doses.

The U.S., U.K. and India also have deals struck for the Oxford vaccine and the company said it believes it could make up to two billion doses spread across several countries.

The whole process of making better vaccines has been accelerated by this pandemic

Conservative MP Matt Jeneroux said getting to the table finally is a welcome move, but he is worried the government waited too long and Canada is now at the back of the line.

“Finally, Canada’s decided to realize that vaccines are an important component of recovery, however we’re months behind the other countries,” he said. “It’s frustrating to see that this government continues to be months behind the rest of the world.”

Immunologist and University of Toronto professor Tania Watts had been concerned about Canada’s lack of purchase agreements, but she said she is pleased with Wednesday’s announcement.

“We don’t know what they’re negotiating in detail — how many doses and when they will get them — but I think those are among the front runners,” she said.

She said the mRNA process both companies are using allows for mass production and with the billions of doses they say they can make, Canada should still be able to get some.

“Even though a lot of other countries have ordered them, I think it is a safe bet that there will be some for Canada.”

She said the government should also invest in Canadian vaccines and production capability, which could have a lasting legacy after the pandemic.

“The whole process of making better vaccines has been accelerated by this pandemic and we found ourselves without much manufacturing capability, without a pipeline from discovery and yet we have very good scientists.”

Finally, Canada’s decided to realize that vaccines are an important component of recovery

The government did announce $56 million in funding to Variation Biotechnologies Inc, a Canadian firm that is developing a COVID-19 vaccine. The funding will help the company move into clinical trials.

Dr. Zain Chagla, a specialist in infectious diseases and an assistant professor at McMaster University, said the vaccine purchase announcement is a good step forward. The two companies’ mRNA technology is new, but he said it’s also very promising

“There has never been a vaccine used in humankind that is mRNA targeted. It’s using the building blocks of the viral proteins to manufacture those proteins internally and then use that to provoke an immune response.”

Chagla said the technology may be new, but the science behind it is solid and holds great promise not just for this pandemic, but for other viruses moving forward.

“This is the proof of principle,” he said. “If this works it is a big win for humanity.”

David Fisman, a professor of epidemiology at the University of Toronto’s Dalla Lana School of Public Health, said both vaccines have proven themselves in early trials and hold a lot of promise.

He said unlike with other vaccines that require growing a virus, the mRNA technology is manufactured more easily and can be scaled up quickly.

“You are basically just making a chemical, just like any other pharmaceutical,” he said.

He said the vaccine mimics functions the body already does and appears safe.

“It is a very elegant approach and there is no reason to be concerned about it,” he said.

He also applauded the government for getting eggs in more than one basket, because he said there could be unexpected issues that prevent a vaccine from being successful.

“Industrial scale manufacturing can have unexpected problems.”

Canada’s chief public health officer Dr. Theresa Tam said Tuesday she was optimistic about the vaccine research underway, but she cautioned not to allow the promise of a future vaccine to cloud the need for public health measures now.

“We can’t at this stage put all of our focus in the hopes this is the silver bullet solution,” she said. “It is a very important solution if we get a safe and effective vaccine but I would say the public health measures that we have in place, the personal daily measures that we take are going to have to continue.”

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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