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Cancer patients and survivors gather to talk about the future of ‘precision medicine’

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HALIFAX — Robin McGee has been living with stage four colorectal cancer for the past 13 years — a remarkable feat given the seriousness of her condition.

On Wednesday, the 62-year-old Nova Scotia resident travelled to Halifax, where she and 30 other cancer patients and survivors from nine provinces talked to researchers about their experiences with something called precision medicine. It’s an approach tailoring treatment for individual patients, taking into account the genetic make-up of each tumour and the personal characteristics of each patient.

For McGee, this data-driven approach to cancer research and treatment has been life-changing.

“My cancer was like a freight train, and this precision medicine slammed on the brakes,” she said in an interview after taking part in a series of discussions organized by the Terry Fox Marathon of Hope Cancer Centres Network. “It’s prevented very serious pain and disability.”

McGee said she had run out of treatment options paid for by the province. At her own expense, she arranged to have her tumour subjected to a genomic analysis, which would tell her about its mutations. The results pointed to an unusual therapy: a drug typically used to treat other forms of cancer.

After purchasing the drug in Bangladesh, she started treatment in July with her oncologist’s approval.

“My cancer blood markers have plummeted, showing I was responding (to the medication),” she said. “If we could make cancer treatment … responsive to individual biomarkers of mutations, as in my case, we’d save a lot more lives.”

When the cancer centres network was established in 2019, it brought together Canada’s leading cancer hospitals and research universities for the first time. The organization has been described as the “Team Canada of cancer research.”

With advanced research focused on finding harmful genetic mutations, the network has been hard at work sorting harmful mutations from benign ones by compiling genetic profile data from patients across Canada.

In the past, this kind of data sharing was hindered by provinces’ reluctance to transmit sensitive health information across borders. The network now provides a secure platform.

“We are building Canada’s most comprehensive resource when it comes to cancer,” said Robin Urquhart, co-leader of the Atlantic Cancer Consortium, which is part of the network.

“It includes clinical data and genomic data from patients across the country. That allows us to do a lot of things, like identifying different markers in blood that can detect cancer earlier …. (Precision medicine) is about being able to match every cancer patient to the best treatment possible.”

Urquhart said the meetings in Halifax marked the first time researchers within the network gathered with cancer patients, survivors and caregivers to talk about the future of precision medicine.

“This group has come together … to help guide our work,” said Urquhart, an associate professor in the department of community health and epidemiology at Dalhousie University in Halifax. “We want to make sure that the work we’re doing aligns with what patients want.”

Urquhart said she wanted to learn from patients and their relatives about their experiences with precision medicine and what might prevent some from taking part.

“They have the biggest stake in this data,” she said.

As for McGee, she has no doubt about its value.

“It is the wave of the future,” she said. “The miracles of today can be the standard of care tomorrow.”

This report by The Canadian Press was first published Nov. 16, 2023.

Michael MacDonald, The Canadian Press

 

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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