Cheap antidepressant shows promise; virus can infect inner ear | Canada News Media
Connect with us

Health

Cheap antidepressant shows promise; virus can infect inner ear

Published

 on

The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that have yet to be certified by peer review.

Cheap antidepressant shows promise against COVID-19

Fluvoxamine, an inexpensive antidepressant, might help keep patients with COVID-19 from developing severe disease, according to a new study published in The Lancet Global Health https://www.sciencedirect.com/science/article/pii/S2214109X21004484 on Wednesday. Researchers in Brazil recruited nearly 1,500 COVID-19 patients at high risk for complications and randomly assigned half of them to receive fluvoxamine by mouth for 10 days. Everyone received standard COVID-19 treatments. Over the next month, 11% of the fluvoxamine group needed at least six hours of emergency care or were hospitalized, compared to 16% of patients who did not get fluvoxamine, and fewer fluvoxamine patients died, the researchers. The researchers suspect the drug is helping by limiting the ability of the virus to cause inflammation. However, more research is needed to determine the impact of fluvoxamine because “composite outcomes” – where a variety of results are lumped together for analysis – are unreliable, according to an editorial https://www.sciencedirect.com/science/article/pii/S2214109X21005015 by Otavio Berwanger of Hospital Israelita Albert Einstein in Sao Paulo.

Reinfection odds higher for unvaccinated COVID-19 survivors

While SARS-CoV-2 infection induces antibodies that protect against reinfection, those antibodies may not protect as well as vaccine-induced antibodies, according to a study of hospitalized adults who displayed COVID-like symptoms. Of 6,328 patients who were vaccinated in the previous three to six months, 5.1% were confirmed to have COVID-19. That compared to 8.7% of 1,020 patients who had contracted the virus in the last three to six months but who had not opted to get vaccinated. After accounting for risk factors, the odds of a COVID-19 diagnosis were more than five-fold higher for the unvaccinated survivors, researchers reported on Friday in the CDC’s Morbidity and Mortality Weekly Report https://www.cdc.gov/mmwr/volumes/70/wr/mm7044e1.htm. “All eligible persons should be vaccinated against COVID-19 as soon as possible, including unvaccinated persons previously infected with SARS-CoV-2,” they said.

Ear infection by virus may explain hearing, balance problems

The coronavirus can infect cells of the inner ear, researchers found in a study that may help explain the balance problems, hearing loss and tinnitus, or ringing in the ears experienced by some COVID-19 patients. Using cellular models of the human ear, plus samples of inner ear tissues from mice and humans, researchers found that inner ear cells “have the molecular machinery to allow SARS-CoV-2 entry” and that the virus can indeed infect those cells, according to a report published on Friday in Communications Medicine https://go.nature.com/3k99DMX by the team from MIT and Massachusetts Eye and Ear Hospital in Boston. The virus might enter the ears via the eustachian tube, which connects the nose to the ear, or it might travel via nerves that carry smells from the nose to brain and from there via nerves that connect to the inner ear, the authors speculate. They hope now to use their human cellular models to test possible treatments for inner ear infections caused by SARS-CoV-2 and other viruses.

CDC, FDA tally side effects from 300 million vaccines

Safety data from nearly 300 million doses of COVID-19 mRNA vaccines administered in the first six months of the U.S. vaccination program show the majority of reported adverse events were mild and brief, researchers from the U.S. Centers for Disease Control and Prevention and the U.S. Food and Drug Administration said this week. Between mid-December 2020 and mid-June this year, more than 298 million doses of the vaccines from Pfizer/BioNTech and Moderna were administered, the researchers reported on Thursday on medRxiv https://www.medrxiv.org/content/10.1101/2021.10.26.21265261v2 ahead of peer review. The Vaccine Adverse Event Reporting System (VAERS) received more than 340,000 reports of side effects, of which 6.6% were serious but not deadly and 1.3% were fatal. Among roughly 8 million users of the CDC’s v-safe app, which surveys people about their COVID-19 vaccination experiences, more than half reported some kind of reaction, usually one day after the injection, and more often after the second dose, but fewer than 1% reported seeking medical care. “Based on the most current information,” the report concludes, serious side effects of the vaccines “are rare.”

Click for a Reuters graphic https://tmsnrt.rs/3c7R3Bl on vaccines in development.

 

(Reporting by Nancy Lapid; Editing by Tiffany Wu)

Health

Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

Published

 on

 

The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

Published

 on

 

HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

Published

 on

 

ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Trending

Exit mobile version