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China looks to recovered to develop effective COVID-19 treatments – Al Jazeera English

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Chengdu, China – As the deadly coronavirus spreads to every continent except Antarctica and the death toll climbs above 3,000, scientists and doctors around the world are rushing to find a way to cure the disease, COVID-19, before it infects more people and poses an even bigger challenge to global health.

The progress made by the Chinese health workers in treating the disease offers hope: more than half the patients in China where the outbreak first originated late last year have reportedly been discharged, reducing the remaining number of confirmed cases to less than 35,000.

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China has been touting the recovery rate and offering to provide medical help to other countries in need. Foreign Minister Wang Yi called his counterparts in the hard-hit countries of Italy and Iran at the weekend to offer assistance.

Most of those who have recovered only suffered mild symptoms of the disease, but the mortality rate among the elderly and those whose infection progresses to the critical stage remains high.

That remains a significant challenge for medical workers treating COVID-19 patients, according to a doctor working at one of the leading hospitals in Wuhan who requested anonymity because the hospital management had banned its medics from talking to the media.

The overall mortality rate among the infected is approximately 2.3 percent in China. However, according to a study on early samples that was published in The Lancet, a UK-based medical journallast week the disease killed 61.5 percent of the critically ill.

“The normal procedure of treating pneumonia, such as using ventilators, putting the patients on antiviral and antibacterial treatment and using steroids, has been proven relatively ineffective in treating patients reaching the last stage of the disease,” the doctor told Al Jazeera.

A picture made available by the National Institutes of Health (NIH) shows a transmission electron microscope image of SARS-CoV-2 – also known as 2019-nCoV, the virus that causes COVID-19 – isolated from a patient in the USA. Doctors in China say the virus does not respond to traditional pneumonia treatments [NIAID- RML/National Institutes of Health via EPA]

“The unsatisfactory supply of ECMO machines and effective drugs contributed to the high mortality rate,” the doctor continued, referring to the machine that provides cardiac and respiratory support to patients whose heart and lungs are failing.

Stopping disease progression

Such concerns have been echoed by China’s National Health Commission.

Officials have stressed the importance of reducing the mortality rate among those who are more severely affected, usually people who are older or who have existing health problems such as heart disease, diabetes and high blood pressure.

“One of the main things we are trying to do at this moment is to reduce the number of patients whose conditions progress to the critically ill stage and improve the survival rate of those who have already reached that stage,” said the doctor. “To do this, we need to understand which drugs would be helpful.”

There are, so far, 293 clinical trials on various existing drugs’ ability to fight off the novel coronavirus, according to the latest data on Chinese Clinical Trial Registry. Despite the usual logic of “more trials, better chance of success,” some experts have voiced concern over the sheer number of trials and how that might actually impede the research process.

“Frankly, it’s a bit ridiculous that so many clinical trials are continuing, especially given the fact that the drugs used in some trials have practically no possibility of being effective in treating this disease,” a doctor at a leading research institute in Beijing who requested anonymity told Al Jazeera.

“Consequently, it leaves less room for trials that actually have a shot at effectively treating the patients and indirectly slows down the process of finding an actual cure.”

Although there are currently no drugs that have allowed scientists to conclusively determine their efficacy against the disease, among all the 293 drugs or combination of drugs being tested, one has stood out: Remdesivir, an antiviral drug produced by the US-based pharmaceutical company Gilead Sciences and aimed at fighting the Ebola virus.

“There is only one drug right now that we think may have real efficacy and that’s Remdesivir,” the World Health Organization or WHO Assistant Director-General Bruce Aylward said at a press briefing in Beijing after visiting the outbreak’s epicentre in Wuhan.

The drug made its debut in the fight against COVID-19 at the beginning of last month when a paper reporting that Remdesivir was used in the treatment of the first discharged case in the US was published in The New England Journal of Medicine.

Two days later, the China-Japan Friendship Hospital in Wuhan also started its clinical trial and the outcome is expected in April, which could offer doctors a more definite answer to the medicine’s efficacy.

Plasma donations

Gilead also announced on February 26 the initiation of two Phase 3 clinical studies to evaluate the drug’s safety and efficacy, which would include 1,000 infected adults.

Researchers around the world are working to find effective treatments and vaccines as the coronavirus spreads to nearly all continents of the world [Matteo Corner/EPA] 

Apart from Remdesivir, doctors in China are also putting a few other contenders into clinical trials, including chloroquine phosphate, an anti-malaria drug, after finding “apparent efficacy” in the treatment of COVID-19. Earlier, anti-HIV drugs, such as Lopinavir or Arbidor, were also included in China’s diagnosis and treatment plan, which has been updated six times since the outbreak began.

None of these drugs has yet been proved to be universally applicable to every patient battling the novel coronavirus.

This problem also extends to the plasma extracted from the donated blood of those who have recovered. Earlier this month, doctors confirmed the usage of the plasma had had some use in fighting the disease, but experts remain cautious. 

“Any drug or supplement options only constitute part of the entire treatment plan, so the idea of injecting the plasma to the patients yielding immediate results can only be seen in movies,” said Dr Zhang Wenhong, the leader of a medical team sent from Shanghai to Wuhan to help tackle the outbreak. “The result is limited, and the usage of plasma will probably reduce the time needed to treat the disease from five to 10 days to three to five days.”

Other are also cautious on treatments, preferring to wait until the outcome of the trials is known.

“It’s unclear how effective these drugs will be and whether we need some new drugs to effectively curb the progression of the disease, so only clinical trials can tell,” said Dr David Ho, a prominent Columbia University professor who made significant contributions to the development of anti-HIV/AIDS drugs.

Apart from making use of existing drugs, the development of a vaccine has also been put under the spotlight since a group of scientists in Shanghai first released the viral genome of the virus early in January.

Finding a vaccine

Despite a concerted effort from across the globe, experts believe it will take at least a year for any vaccine to be available to the general public.

Moderna, a biotech company based in the US, is leading the global race and released the first batch of a vaccine against the novel coronavirus for human use on February 24. In a statement, the company said the vials of mRNA-1273, the official name for the vaccine, had been shipped to the National Institute of Allergy and Infectious Diseases (NIAID) to be used in the Phase 1 study in the US.

The clinical trials will first take place at a research centre in Seattle among 45 volunteers and are expected to run 13 months with the main objective being to detect if the vaccine will trigger an immune system response and whether it is safe.

After Phase 1, clinical trials to actually test the vaccine’s ability to resist the novel coronavirus will take place. 

“The earliest efficacy trial will take an additional six to eight months, so although it is the fastest we have gone from getting the sequence of the virus to a trial, it still would not be applicable to the current epidemic unless this goes on for another year or year and a half,” Anthony Fauci, the director of NIAID, said at a news conference held by US President Donald Trump last week.

In addition to the long process of developing a vaccine from scratch, researchers also voiced concern over its fate: many suspect its development could be halted if the outbreak begins to taper off, as happened with SARS, the last large outbreak to originate in China.

“We never had a chance to test the SARS vaccines because there was no need to continue the development at that time,” Dr Zhong Nanshan, a leading pulmonary disease expert in China, said. “However, I do think it’s important to continue the effort in this case because of the fast-spreading nature of the virus and the subsequent unpredictability on how long this epidemic will last.”

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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