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China's virus death toll surpasses SARS but new cases fall – SooToday

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BEIJING — China’s virus death toll rose by 89 on Sunday to 811, passing the number of fatalities in the 2002-2003 SARS epidemic, but fewer new cases were reported in a possible sign its spread may be slowing as other nations stepped up efforts to block the disease.

Some 2,656 new virus cases were reported in the 24 hours ending at midnight Saturday, most of them in the central province of Hubei, where the first patients fell sick in December. That was down by about 20% from the 3,399 new cases reported in the previous 24-hour period.

“That means the joint control mechanism of different regions and the strict prevention and control measures have worked,” a spokesman for the National Health Commission, Mi Feng, said at a news conference.

Also Sunday, new cases were reported in Japan, South Korea, Vietnam, Malaysia and Spain.

More than 360 cases have been confirmed outside mainland China.

“Dramatic reductions” in the spread should begin this month if containment works, said Dr. Ian Lipkin, director of Columbia University’s Center for Infection and Immunity. He assisted the World Health Organization and Chinese authorities during the outbreak of SARS, or severe acute respiratory syndrome.

Warmer weather will reduce the virus’s ability to spread and bring people out of enclosed spaces where it is transmitted more easily, Lipkin said in an online news conference. However, he said, if new cases spike as people return to work after the Lunar New Year holiday, which was extended to reduce the risk of spreading the virus, then “we’ll know we’re in trouble.”

The fatality toll passed the 774 people believed to have died of SARS, another viral outbreak that originated in China. The total of 37,198 confirmed cases of the new virus vastly exceeds the 8,098 sickened by SARS.

The latest developments:

JAPAN, SOUTH KOREA, VIETNAM, MALAYSIA, SPAIN REPORT NEW CASES

Six more cases were reported in Japan among 3,700 passengers and crew aboard the quarantined cruise ship Diamond Princess.

South Korea reported a new case in a 73-year-old woman whose relatives visited Guangdong province in southern China, raising its total to 27. The Korea Centers for Disease Control and Prevention said the family members, a 51-year-old South Korean man and a 37-year-old Chinese woman, were confirmed infected later Sunday.

Vietnam reported its 14th case. The Health Ministry said she is a 55-year-old woman in Vinh Phuc province, northwest of Hanoi, where six earlier patients were found to be infected.

Malaysia reported its 17th case. The 65-year-old woman’s son-in-law was diagnosed earlier with the virus.

Spain confirmed its second case in Mallorca, a popular vacation island in the Mediterranean. The first case was a German tourist diagnosed a week ago in the Canary Islands off northwest Africa.

HONG KONG RELEASES QUARANTINED CRUISE SHIP

The 1,800 passengers and 1,800 crew members of the cruise ship Dream World were released from quarantine after Hong Kong authorities said tests of the crew found no infections.

The ship was isolated after eight mainland Chinese passengers were diagnosed with the disease last month.

Port official Leung Yiu-hon said some passengers with symptoms tested negative but there was no need to test all of them because they had no contact with the infected Chinese passengers.

Meanwhile, Hong Kong began enforcing a 14-day quarantine for arrivals from mainland China. The territory’s chief executive, Carrie Lam, has refused demands by some hospital workers and others to seal the border completely.

WUHAN OPENS NEW HOSPITAL, FARMERS PROMISED SUPPORT

A 1,500-bed hospital built in two weeks in Wuhan, the city at the centre of the outbreak, accepted its first patients on Saturday, the government announced. Another 1,000-bed hospital built in 10 days opened last week.

The government of the city of 11 million people said it would begin carrying out twice-daily disinfection of hospitals, markets, public toilets and other facilities starting Sunday.

The government of the surrounding province of Hubei it will pay subsidies to farmers, other food producers and supermarkets and give tax breaks to companies that donate to anti-virus work, the official Xinhua news agency said. It said the government will subsidize overtime for employees of companies making medical supplies.

China’s leaders are trying to keep food flowing to crowded cities despite anti-disease controls and to quell fears of possible shortages and price spikes following panic buying after most access to Wuhan and nearby cities was cut off.

Two more flights from Wuhan carrying American citizens, permanent residents and close relatives landed in the United States, the State Department said. A spokesman said more than 800 Americans have been evacuated from Wuhan.

A plane evacuating more than 200 people from Wuhan landed Sunday in Britain. British officials said the flight, the country’s second evacuation plane, brought back 105 British citizens and family members, as well as 95 European citizens and family members. The passengers will be quarantined at a hotel for 14 days.

A charter flight carrying Filipinos from Wuhan arrived in the Philippines. The 29 adults and one infant will be quarantined for 14 days. At least 56 Filipinos initially planned to join the flight home, but some changed their mind and others feared they couldn’t immediately return to their jobs and lives in Hubei due to travel restrictions, officials said.

Elsewhere in China, the industrial metropolis of Chongqing in the southwest told residential communities to close their gates and check visitors for fever. The government said the spread of the virus through “family gatherings” had been reported in Chongqing but gave no details.

FRANCE CLOSES SCHOOLS, ITALIAN STUDENTS RETURNING FROM CHINA TOLD TO STAY HOME

France closed two schools and tried to reassure vacationers in the Alps after five Britons contracted the virus at a ski resort.

France stepped up a travel alert, recommending against all visits to China except for “imperative reasons.”

Italy recommended students returning from China stay home from school for two weeks after the government reported three cases.

WORLD HEALTH ORGANIZATION SENDING EXPERTS

The WHO director-general said it will send experts to China starting Monday or Tuesday.

Asked whether that will include members of the U.S. Centers for Disease Control and Prevention, Tedros Adhanom Ghebreyesus replied, “We hope so.”

___

Associated Press writers Eileen Ng in Kuala Lumpur, Malaysia; Hyung-jin Kim in Seoul, South Korea; Yves Dam Van in Hanoi, Vietnam; Yuri Kayegama in Tokyo and Barry Hatton in Lisbon contributed to this report.

Joe McDonald, The Associated Press























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Delivering new services ‘complicated,’ Freeland says of planned dental care program

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OTTAWA — The government is working hard to meet its end-of-year deadline to deliver dental-care coverage to kids, the deputy prime minister said Tuesday, but added providing new services is “complicated.”

The Liberals agreed to offer dental coverage to low- and middle-income children by the end of the year as part of their confidence and supply deal with the New Democrats to keep the minority government from toppling before 2025.

Several groups have raised concerns about the very tight deadline, and four sources close to the program say the government is working on a temporary solution to give money directly to qualifying families while it comes up with a permanent program.

“As we experienced, for example, in rolling out child-care agreements across the country, delivering new services to Canadians is complicated,” Freeland said when asked about the stopgap plan at a news conference in Toronto.

“I think Canadians understand that.”

Freeland did not confirm or deny the government’s immediate plans but said the Liberals are committed to the dental-care program, and it’s a commitment she’s “happy to make.”

The government could pursue dental-care deals that resemble the ones it made with provinces to lower the cost of child care, in which it offered provincial governments money to administer their programs under a prescribed set of criteria. However, that route is looking increasingly unlikely.

Federal officials have also canvassed dental-health experts about other approaches. The government could contract out a national program to a private insurance firm or have federal public servants take on the work.

“Kids should not have their teeth get rotten just because their parents don’t have enough money to pay for them to go see a dentist, I think it’s as simple as that,” Freeland said.

The Liberals set aside $5.3 billion over five years to fully implement the program. They hope to start with children under the age of 12 with an annual household income of less than $90,000.

Last week NDP Leader Jagmeet Singh said he was confident the dental-care program would come together by the end of the year, as outlined in the agreement with the Liberals.

Freeland said the government is working “very, very hard” to make good on the promise to the NDP. The Liberals risk the NDP walking away from the supply and confidence agreement entirely if they don’t.

This report by The Canadian Press was first published Aug. 9, 2022.

 

Laura Osman, The Canadian Press

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Top commander defends military’s vaccine requirement, says ‘tweak’ in the works

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OTTAWA — Canada’s top military commander said he will “tweak” the vaccine mandate for the Armed Forces in the next few weeks but defended vaccine requirements as necessary to keep the military ready to respond to any emergency.

“This is an institution that’s unlike any other because we do have to be operationally ready, we are the nation’s insurance policy,” chief of the defence staff Gen. Wayne Eyre told The Canadian Press in an interview.

“We have to go into dangerous locations and close confined quarters, we have to deploy overseas, where there’s potentially an increased threat with the pandemic. We also don’t know the trajectory of this pandemic, where it’s going to go into the future.”

When Eyre ordered all troops vaccinated against COVID-19 last October, he said it was to both protect the force and “demonstrate leadership” as the Liberal government adopted vaccine mandates across the federal public service.

The public service vaccine mandate was suspended in June but the military one persists, a fact that has heightened criticism of the military’s policy.

The Department of National Defence said more than 98 per cent of Canadian troops complied with the order. Defence Minister Anita Anand was briefed in June that 1,137 remained unvaccinated.

Those who refuse vaccination face the risk of forced removal from the military. The department says 241 unvaccinated troops have been ousted with disciplinary measures initiated against hundreds more.

Eyre said he is trying to find the “sweet spot” between the military’s medical, legal, operational and ethical requirements.

“We need to maintain our operational viability going forward,” he said. “So over the course of the next number of weeks, we will tweak the policy, we’ll put out something amended. But we also need to realize that this is a dynamic environment, and things can change, the trajectory of the pandemic can change. So we’ve got to maintain that flexibility as well.”

He added that not only has the military been called upon to assist in communities across Canada that have been hit by the pandemic, but that vaccine requirements still exist in many allied and foreign nations and militaries.

The U.S. military still requires all troops to be vaccinated as do some NATO facilities and bases.

“There are going to be operational requirements where to operate with allies, (vaccination) is going to be essential,” he said. “But as we go forward, the options are being developed looking at those four factors that I talked about and finding the right balance.”

Eyre’s comments appear to contradict a draft copy of a revised vaccine policy obtained by the Ottawa Citizen last month, which suggested vaccine requirements for military personnel would be lifted.

The draft document, which officials say has not been approved by Eyre, said military personnel as well as new recruits would no longer have to attest to their vaccination status.

The document also noted potential legal difficulties ahead to deal with people who were kicked out of the military because of the vaccine mandate, suggesting they could be forced to apply for re-enrolment.

By contrast, other unvaccinated federal public servants were put on leave without pay but allowed to return to their jobs when the mandate was suspended.

The military mandate was unsuccessfully challenged several times in Federal Court, most recently last month.

Phillip Millar, the London, Ont.-based lawyer who appeared before the court to seek an injunction on behalf of unvaccinated service members, said the court ultimately decided it couldn’t rule on the issue until the new policy was released.

Millar, who is also representing James Topp, an army reservist charged with publicly speaking out against federal vaccine mandates while wearing his uniform, said he was disappointed with the decision given the lack of timeline for the new policy.

“The military is deliberately dragging its feet on this new direction because it just wants to kick people out,” Millar alleged, adding: “It’s obviously a political policy, not an operational policy.”

Eyre would not say whether Armed Forces members are still being kicked out, or whether such releases have been suspended pending the results of his review.

The Defence Department says there have been more than 9,500 cases of COVID-19 among military personnel, including 113 active cases as of Aug. 1. It did not say whether there have been any deaths associated with the illness.

This report by The Canadian Press was first published Aug. 9, 2022.

 

Lee Berthiaume, The Canadian Press

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Double mRNA COVID-19 vaccination found to increase SARS-CoV-2 variant recognition – News-Medical.Net

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In a recent study posted to the bioRxiv* preprint server, researchers evaluated the impact of double BNT162b2 messenger ribonucleic acid (mRNA) vaccination in recognition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoCs).

Study: Double-dose mRNA vaccination to SARS-CoV-2 progressively increases recognition of variants-of-concern by Spike RBD-specific memory B cells. Image Credit: CKA/Shutterstock

Background

Studies have reported that double coronavirus disease 2019 (COVID-19) vaccinations generate high titers of SARS-CoV-2 S-targeted antibodies (Ab), Bmem and T lymphocytes; however, VoCs with SARS-CoV-2 S receptor-binding domain (RBD) mutations can evade humoral immune responses.

Booster doses have been reported to enhance VoC recognition by Abs; however, it is not clear whether VoC recognition is enhanced due to higher Ab titers or due to the increased capacity of Ab binding to S RBDs.

About the study

In the present study, researchers evaluated the benefit of double BNT162b2 vaccinations on SARS-CoV-2 VoC recognition.

Healthy and SARS-CoV-2- naïve persons (n=30) without immunological or hematological diseases were enrolled in the study to assess their peripheral blood B-lymphocyte subsets between February and June 2021.  Samples were obtained before the BNT162b2 vaccination, after three weeks of the first vaccination, and four weeks following the second vaccination.

Serum memory B lymphocytes (Bmem) counts and Ab titers were assessed using recombinant SARS-CoV-2 spike (S) protein RBDs of the Wuhan, Gamma, and Delta strains. Neutralizing Ab (NAb) titers were evaluated using 293T-ACE2 cells and SARS-CoV-2 pseudotyped viral assays. Further, the nature of RBD-targeted Bmem was examined based on the expression of cluster of differentiation (CD) 21, 27, and 71.

Enzyme-linked immunosorbent assays (ELISA) were performed to evaluate variant-specific S RBD antibody titers and the serum dilution needed for preventing 50% SARS-CoV-2 entry (ID50) values were ascertained. Flow cytometry (FC) was performed to evaluate Bmem counts. Immunoglobulin G (IgG) titers against SARS-CoV-2 nucleocapsid (N) protein RBD and S RBD were evaluated before and post the first and second BNT162b2 vaccination.

Results

In total, 28, 30, and 30 samples were obtained pre-vaccination, after three weeks of the first dose and after four weeks of the second dose, respectively. All the participants remained SARS-CoV-2-naïve throughout the study without anti-SARS-CoV-2 N antibodies. Most participants (n=22) induced NAbs after the first vaccination, and the NAb titers after the second vaccination had IC50 values >100.

Double BNT162b2 vaccination generated robust NAb responses among all study participants. Immunoglobulin G+ (IgG+) and IgM+ RBD-targeted Bmem were generated after the first vaccination, and IgG1+ Bmem counts increased after the second vaccination. Most RBD-targeted Bmem showed binding with Delta and/or Gamma VoCs, which increased significantly after the second vaccination.

The RBD-targeted Bmem compartment comprised mainly IgG1+ or IgM+ cells, and contrastingly, the total Bmem compartment comprised more IgG2+ cells and fewer IgG1+ cells compared to the RBD-targeted Bmem compartment.

After the second vaccination dose, RBD-targeted IgG1, 2 and 3-expressing Bmem populations expanded significantly, although the total Bmem lymphocyte compartment was unaltered.

The number of RBD-targeted IgG+ Bmem correlated positively with RBD-targeted serum IgG post first and second vaccinations. While two subsets of IgM+ Bmem lymphocytes (CD27+ IgM+ and CD27+ IgM+ IgD+) proportionally decreased after the second vaccination dose, the absolute cell counts were identical to those observed post the first vaccine dose. Taken together, BNT162b2 vaccinations particularly affected the antigen-targeted Bmem lymphocyte counts, and the production of IgG1-expressing Bmem lymphocytes was boosted after the second BNT162b2 vaccination.

CD27 was expressed by 95% of anti-RBD and IgG-expressing Bmem lymphocytes, the proportion of which did not differ between the initial and subsequent BNT162b2 vaccination. After the first vaccine dose, 15% of anti-RBD Bmem lymphocytes were CD21lo, the proportion of which was marginally but significantly lower (reduced to 10%) after four weeks of the second vaccination.

CD71 was expressed by 10% of anti-RBD Bmem lymphocytes after the first and second vaccination. In the total population of Bmem lymphocytes, the results after the first and second vaccination did not differ significantly, denoting the Bmem compartment stability. After four weeks of vaccination, anti-RBD Bmem lymphocytes exhibited a nature and resting Bmem lymphocyte immunophenotype.

Anti-Wuhan S RBD- IgG titers exhibited partial recognition of the Beta, Gamma and Delta VoCs with more prominent reductions for Gamma and Beta VoCs than for the Delta VoC. The second vaccine BNT162b2 dose significantly enhanced anti-Wuhan RBD antibody binding to Gamma and Beta VoCs; however, the neutralization potency of vaccine-induced NAbs against Gamma and Beta was lesser than for Delta.

Delta RBD and Gamma RBD were recognized by 50% and 70% of RBD-targeted Bmem lymphocytes after the first and second vaccinations, respectively, and the increase in VoC-recognizing Bmem counts was largely due to elevated IgG1+ Bmem counts.

Conclusion

Overall, the study findings showed that the second BNT162b2 vaccination elevated NAb titers and SARS-CoV-2 RBD-targeted Bmem counts and that double BNT162b2 vaccination was especially needed for Delta and Gamma VoC recognition. The findings indicated that the second vaccine dose improved S RBD-targeted Bmem counts and the Bmem affinity to overcome VoC mutations.

*Important notice

bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

Journal reference:

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