Updated: July 8, 2020 7:48:00 am
Coronavirus (Covid-19) Vaccine Latest Update: China’s Sinovac Biotech has become the latest company to start Phase III trials of its coronavirus vaccine candidate in Brazil following a fast-track approval by regulators last week.
So far, the vaccine candidates being developed by AstraZeneca-University of Oxford and China National Pharmaceutical Group (Sinopharm) are the only other jabs in late-stage trials. Moderna also plans to start its late-stage trial this month.
According to the World Health Organisation (WHO), there are 19 vaccine candidates currently in the clinical evaluation as of July 6. India’s own vaccine development efforts has gained pace, with Bharat Biotech planning to complete enrollment of Phase I trial participants by July 13 for its candidate Covaxin.
However, amid the race for a Covid-19 vaccine, top US infectious disease expert Anthony Fauci has cautioned that a shot to protect against the infection won’t work like the measles vaccine, which lasts throughout a person’s lifetime.
“You can assume that we’ll get protection at least to take us through this cycle. We may need a boost to continue the protection, but right now we don’t know how long it lasts,” Bloomberg quoted Fauci as saying.
Coronavirus (Covid-19) vaccine latest updates, status check
💉 Sinovac Biotech coronavirus vaccine status
Nearly five months after it initiated the development of a vaccine candidate, China’s Sinovac Biotech has started Phase III trials in Brazil. Sinovac will dose nearly 9,000 healthcare professionals working in Covid-19 specialised facilities, Reuters reported.
The study will be done in partnership with Brazilian vaccine producer the Instituto Butantan. Simultaneously, Sinovac is also preparing a coronavirus vaccine plant, which it hopes will be ready this year and capable of making up to 100 million shots a year.
Phase I and Phase II trials typically test the safety of a drug before it enters Phase III trials that test its efficacy.
💉 Moderna coronavirus vaccine status
Moderna Inc, which was supposed to start phase III trials of its experimental mRNA-1273 Covid-19 vaccine on July 9, has delayed it for an indefinite period of time, a news report said.
The trial, part of the US government’s Operation Warp Speed, will involve 30,000 patients. In its June update, Moderna said the primary objective of the trial was to assess the ability of the vaccine to prevent symptomatic Covid-19 disease.
A report by STAT News said Moderna was making changes to the trial’s protocol, which has pushed back the expected start date. However, CEO Stephane Bancel told CNBC the drugmaker still intended to start the trial in July.
Covaxin, which has been cleared for Phase-I and Phase-II trials by the Drug Controller General of India, will be tested on more than 1,000 people in the two phases, Bloomberg reported. Jointly developed by ICMR and Bharat Biotech India Limited, Covaxin will be tested on 375 people in Phase I trial and on 750 people in the next phase. The company has set July 13 as the final date of enrollment for the trials.
Meanwhile, the process of conducting clinical trials for Covaxin began on Tuesday at the Nizams Institute of Medical Sciences (NIMS) in Hyderabad.
An investigator who is part of the trial said “immunogenicity” – the ability to provoke an immune reaction – will be the key aspect to be examined and which will decide if the trial can move from Phase I to II. Another investigator said the first phase was likely to take “at least three months”.
Covaxin is an “inactivated” vaccine — one made by using particles of the SARS-CoV-2 that were killed, making them unable to infect or replicate. Injecting particular doses of these particles builds immunity by helping the body create antibodies against the dead virus.
💉 GSK-Sanofi coronavirus vaccine status
Human trials of the Covid-19 vaccine candidate being jointly developed by Sanofi and GlaxoSmithKline is set to begin in September. Sanofi is working on two possible COVID-19 vaccines, one of which uses an adjuvant made by GSK to potentially boost its efficacy.
Recently, a Reuters report said Britain was close to signing a 500 million pound ($624 million) supply deal with Sanofi and GSK for 60 million doses of its vaccine. The UK government has already landed a deal with AstraZeneca for 100 million doses of their vaccine candidate.
While Sanofi is contributing S-protein Covid-19 antigen based on its recombinant DNA technology, which is also used in its seasonal flu vaccine Flublok, GSK is offering its vaccine booster AS03 for their candidate.
Source:- The Indian Express
Manitobans to get more detailed regional breakdown of COVID-19 cases this week, says minister – CBC.ca
Manitobans can expect to get more details about where new COVID-19 cases are popping up by the end of the week, but it’s not yet clear how specific that information will be.
Health Minister Cameron Friesen said Monday the province will begin releasing more “nuanced” geographical breakdowns of where new cases emerge beginning later this week — a significant shift since the virus arrived in the province five months ago
Up until now, the province has generally only identified the regional health authority of new cases, occasionally offering more pointed information depending on the public health risk in those areas.
Moving forward those regions will be split down into finer zones or districts, said Friesen.
The impetus for the shift is that the province knows more now than it did in March when the coronavirus officially arrived in Manitoba, he said.
“We don’t think there’s any benefit in someone knowing that someone has COVID-19 that lives four blocks down from you or down the street, but it’s this balancing act of providing good information in a timely way to Manitobans and then of course on the other side making sure there isn’t a negative effect from over-identification.”
Another change that’s on the way is linked to hard-hit communities, said Manitoba’s chief public health officer.
Dr. Brent Roussin suggested that if things get out of control, certain communities in particular could see a return to past restrictions.
“As we move forward our approach is to not have widespread restrictions, take a much more surgical approach as any restrictions are required,” said Dr. Brent Roussin.
He said health officials don’t yet have anything too specific in mind. He didn’t share a possible timeline for region-specific restrictions.
But Roussin made the comments Monday after announcing 16 new cases and addressing a cluster in Brandon that has soared to at least 64.
Most of the active cases are in Prairie Mountain and Southern health regions.
There are early signs of community spread in Brandon, which is when health officials are unable to confirm where someone got the virus, but most of the clusters cases have a known source, he said.
That’s why Brandon hasn’t been hit with restrictions — yet.
“We’re certainly talking about Brandon where we see this cluster,” he said. “That area should be taking extra caution.”
Roussin acknowledged increasing enforcement is an option but he would prefer to see businesses, organizations and individual take actions now to prevent that.
“By messaging, by things that Manitobans have learned, this is our opportunity to live with the virus, not shut things down,” he said.
“It shouldn’t be necessary to have to enforce these things to protect the health of Manitobans, but we will.”
B.C. records 131 new COVID-19 cases over three days, as active cases surge past 400 – Global News
Health officials reported 131 new cases of COVID-19 in B.C. over the past three days and no new deaths.
There were 50 cases from Friday to Saturday, 37 cases Saturday to Sunday, and 44 from Sunday to Monday.
The number of active cases in the province jumped from 386 on Friday to 445, an increase of just over 15 per cent.
B.C. health officials to provide latest on COVD-19 curve
There are 4,065 confirmed cases of the disease in B.C. Of those, 3,425 patients have fully recovered, or about 84 per cent.
B.C.’s death toll from COVID-19 remains at 195 as the province has not recorded a death related to the virus since July 31.
Nine COVID-19 patients are in hospital, a decrease of two since Friday. Three of those patients are in intensive care, a decrease of one.
The province says 1,765 people are in self-isolation.
Health officials have repeatedly warned B.C. residents as more COVID-19 cases emerge from large social gatherings.
Three Vancouver police officers and two Vancouver police patrols are in isolation after breaking up an out-of-control party with more than 100 people attending, Ralph Kaisers, president of the Vancouver Police Union, said on social media on Friday.
Global BC political panel: August 9
Kaisers told Global News the party took place in an apartment in downtown Vancouver in late July.
Between 16 to 20 officers are in self-isolation as a result, Kaisers said.
In addition, hundreds of people are now self-isolating following a house party in North Vancouver.
“The numbers of contacts related to that are in the 400 range,” B.C. provincial health officer Dr. Bonnie Henry said on Thursday.
People under the age of 40 make up a disproportionately large number of coronavirus cases in the Okanagan and throughout the wider Interior Health region, according to statistics from the BC Centre for Disease Control.
Forty-seven per cent of diagnosed cases in the Interior Health region involve people aged 20 to 40, compared to a provincial average of 34 per cent for the same age demographic.
The rise in coronavirus cases among young people is related to private parties in and around Kelowna, B.C., over the Canada Day long weekend, health officials have said.
— With files from Amy Judd and Shelby Thom
© 2020 Global News, a division of Corus Entertainment Inc.
Manitoba announces 16 more cases of COVID-19 on Monday – CTV News Winnipeg
Provincial health officials announced there are 16 new cases of COVID-19 in Manitoba.
Dr. Brent Roussin, the province’s chief provincial health officer, made the announcement Monday afternoon.
There have been 558 cases in Manitoba since early March.
Of the new cases announced, 11 are from the Prairie Mountain Health Region and five are from the Southern Health Region.
In the Prairie Mountain Health Region, one case is a male between the ages of 10 and 19, one is a woman in her 20s, four are men in their 30s, three are men in their 40s, one is a man in his 50s and one is a woman in her 70s.
In the Southern Health Region, one case is a woman in her 30s, another is a woman in her 40s, two cases are men in their 40s and one is a man in his 50s.
Roussin said many of the new cases are connected to a cluster of cases in Brandon, which currently totals 64. He said most are connected to close contacts but a small amount is being considered community transmission.
He also mentioned there are 22 cases of COVID-19 connected to a business in Brandon.
“These cases are self-isolating and contact tracing is underway to determine close contacts,” said Roussin. “The company is going beyond public health recommendations and is having a larger number of workers self-isolating than what was recommended.”
There are currently six people in hospital, three of which are in intensive care.
There are 196 active cases, and 354 people have recovered from the virus.
The death toll remains at eight.
Roussin said the current positivity rate is 1.59 per cent.
On Sunday, 1,364 tests were performed, bringing the total number of tests to 103,782 since early February.
Roussin said it is important for people who get tested to do so 24 hours after symptoms develop and not to wait.
“What we found was a number of our cases being tested many, many days after symptom onset. So by the time we were connecting with contacts, some of those contacts are already symptomatic.”
‘LACK OF CLARITY’
Following the health announcement, Manitoba NDP MLA Uzoma Asagwara, who is the critic for Health, Seniors, and Active Living, said there continues to be a “lack of clarity” when it comes to the information being released.
“Now what we are seeing is a reactive tendency that is not benefitting Manitobans. So, we are seeing these case numbers increase, we’re seeing clusters happening, we’re seeing obvious community transmission now at this point, and we are seeing a hesitation from the government to act quickly and act clearly,” said Asagwara.
They said situations in the province, like not closing the Maple Leaf plant or not mandating masks yet, shows the government is not using a proactive approach.
Asagwara said the government needs to get back to the house and put forward legislation that will help Manitobans worry less during this pandemic, such as implementing paid sick leave, which Asagwara said would help mitigate the risk of Manitobans contracting the virus.
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