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Coronavirus in California US

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California officials said this week that they had bolstered efforts to confront the growing threat of the coronavirus, declaring that they were prepared and pursuing aggressive measures to thwart its spread.

Gov. Gavin Newsom said on Thursday that the state had pushed for improved and expanded testing, urging federal officials to alter a testing protocol that he considered “inadequate” to address the situation California faces. He also said officials were actively monitoring people who might have come into contact with the pathogen.

California has had more coronavirus cases than any other state and has also been the nucleus of quarantine efforts in the United States. The sense of concern became more heightened after officials confirmed what is believed to be the first documented case of community transmission, in Solano County.

The governor sought to strike a delicate note by quelling fears over the virus while acknowledging the seriousness of the situation. He told residents that the overall number of cases remained low and that the state government was well positioned to keep it that way.

“We have been in constant contact with federal agencies,” Mr. Newsom, a Democrat, said in a news conference on Thursday. “We have history and expertise in this space. We are not overreacting, but nor are we underreacting to the understandable anxiety that many people have as it relates to this novel virus.”

Mr. Newsom has resisted declaring a state of emergency, a step taken by some local officials largely in an effort to muster public health resources. But there are worries about the economic fallout, with events having already been changed or canceled. Both Facebook and Microsoft said they were pulling out of conferences scheduled for March and May.

Thirty-three people have tested positive for the virus in California, said Dr. Sonia Angell, the director of the California Department of Public Health. Out of that group, 24 were from repatriation flights, seven were related to the patients’ travel and one had contracted it from an infected spouse. The most recent case was the one involving community transmission, which was reported in Solano County.

Mr. Newsom said five people had moved out of the state after testing positive. In addition, at least 8,400 people who have returned from overseas are being monitored in 49 jurisdictions.

One confirmed coronavirus case that cropped up in Solano County, between San Francisco and Sacramento, is especially worrisome to health officials. The patient had not had contact with anyone known to be infected, and had not traveled recently to a country where the virus is known to be in circulation.

The Centers for Disease Control and Prevention said it was the first such case reported in the United States, and it raised the possibility that someone who is asymptomatic may be carrying the virus and infecting others without knowing it.

The Coronavirus Outbreak

  • Answers to your most common questions:

    Updated Feb. 26, 2020

    • What is a coronavirus?
      It is a novel virus named for the crownlike spikes that protrude from its surface. The coronavirus can infect both animals and people and can cause a range of respiratory illnesses from the common cold to more dangerous conditions like Severe Acute Respiratory Syndrome, or SARS.
    • How do I keep myself and others safe?
      Washing your hands frequently is the most important thing you can do, along with staying at home when you’re sick.
    • What if I’m traveling?
      The C.D.C. haswarned older and at-risk travelers to avoid Japan, Italy and Iran. The agency also has advised against all nonessential travel to South Korea and China.
    • Where has the virus spread?
      The virus, which originated in Wuhan, China, has sickened more than 80,000 people in at least 33 countries, including Italy, Iran and South Korea.
    • How contagious is the virus?
      According to preliminary research, it seems moderately infectious, similar to SARS, and is probably transmitted through sneezes, coughs and contaminated surfaces. Scientists have estimated that each infected person could spread it to somewhere between 1.5 and 3.5 people without effective containment measures.
    • Who is working to contain the virus?
      World Health Organization officials have been working with officials in China, where growth has slowed. But this week, as confirmed cases spiked on two continents, experts warned that the world was not ready for a major outbreak.

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The patient, a woman, became ill and was first treated in a hospital in Vacaville, then transferred to the UC Davis Medical Center. Doctors there suspected coronavirus and requested a test. But the C.D.C. did not perform the test for days, because it was restricting testing to sick people known to have been exposed to the virus. The day after her case was confirmed, the C.D.C. broadened its criteria to allow testing of people like her who appear to be ill from coronavirus but have no known point of exposure.

Solano County is also the location of Travis Air Force Base, where many Americans who were infected in Asia have been quarantined.

A government whistle-blower has filed a complaint saying that the federal health officials sent to interact with quarantined people at the base were not given proper training or protective gear, were not monitored or tested, and were allowed to move freely around and off the base — practices that potentially could have spread the virus into the community. The Department of Health and Human Services said it was looking into the complaint.

Similar things may have happened at Marine Corps Air Station Miramar near San Diego, another base where American coronavirus evacuees from Asia were taken to be quarantined, according to a person with direct knowledge of the efforts there.

California officials said on Thursday that the C.D.C. had promised to vastly expand the state’s ability to test patients for the coronavirus. Mr. Newsom repeatedly said the previous system had been “inadequate” to keep the virus from spreading.

Mr. Newsom said the director of the C.D.C. had promised him that physicians would have a much greater ability to test patients who were showing symptoms of the infection, changes the governor said “can’t happen soon enough.”

“Testing protocols have been a point of frustration for many of us,” Mr. Newsom said, referring to health officials in California and governors of other states. State officials said California had just 200 testing kits left.

Even as the governor resisted declaring a statewide emergency, officials in San Francisco and Orange County announced they were taking that step. But officials in both places stressed that the move was less an acknowledgment of an active crisis and more about mobilizing the resources to prevent one.

“This declaration of emergency is all about preparedness,” San Francisco’s mayor, London Breed, told reporters on Wednesday.

Nichole Quick, the health officer for Orange County, said the formal declaration there would enable local officials to be “more nimble and flexible” in their response.

“This is a rapidly evolving situation,” Ms. Quick said on Wednesday, according to The Orange County Register, which reported that there had been one confirmed case of the virus in the county.

State officials planned to move people infected with the virus to a state-owned facility in Costa Mesa, a city of more than 100,000 in Orange County. But city leaders are fighting to keep them out.

The authorities in California selected the site after the Defense Department informed them that patients who tested positive for the virus could no longer stay at Travis Air Force Base.

Federal officials had planned to move the patients to a government facility in Alabama, court documents said, but officials in California thought that moving the group, most of them said to be residents of the state, would be detrimental to their health and well-being.

Instead, state officials said the people would be moved from the base in Solano County to the facility in Southern California, where they would remain in isolation while recovering.

But the decision touched off a legal fight with Costa Mesa. A federal judge issued a temporary restraining order to stop the move. The judge said she would reconsider the issue after state and federal authorities provide more details about how they plan to protect the health of the community, as well as the people with the coronavirus. The judge set a hearing for March 2.

“This is a new one in terms of claiming a right not to have infectious disease introduced into your community,” said Polly Price, a professor of law and global public health at Emory University. Although cities and towns once claimed “an absolute right” to guard against disease, she said, state-level control over isolation and quarantine has been the norm for more than a century.

Blair Zong, 33, was among hundreds of Americans who were evacuated on flights arranged by the U.S. government and have had to wait through mandatory 14-day quarantines on military bases.

Ms. Zong, who lives in San Jose, Calif., was visiting her mother and grandparents in Wuhan, China, where she grew up, when the coronavirus outbreak became an epidemic.

She agreed to keep a daily journal of her time in quarantine at Marine Corps Air Station Miramar in San Diego.

Reporting was contributed by Patrick J. Lyons, Sean Plambeck, Roni Caryn Rabin, Farah Stockman, Louis Keene, Emily Cochrane, Margot Sanger-Katz and Noah Weiland.

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Whooping cough is at a decade-high level in US

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MILWAUKEE (AP) — Whooping cough is at its highest level in a decade for this time of year, U.S. health officials reported Thursday.

There have been 18,506 cases of whooping cough reported so far, the Centers for Disease Control and Prevention said. That’s the most at this point in the year since 2014, when cases topped 21,800.

The increase is not unexpected — whooping cough peaks every three to five years, health experts said. And the numbers indicate a return to levels before the coronavirus pandemic, when whooping cough and other contagious illnesses plummeted.

Still, the tally has some state health officials concerned, including those in Wisconsin, where there have been about 1,000 cases so far this year, compared to a total of 51 last year.

Nationwide, CDC has reported that kindergarten vaccination rates dipped last year and vaccine exemptions are at an all-time high. Thursday, it released state figures, showing that about 86% of kindergartners in Wisconsin got the whooping cough vaccine, compared to more than 92% nationally.

Whooping cough, also called pertussis, usually starts out like a cold, with a runny nose and other common symptoms, before turning into a prolonged cough. It is treated with antibiotics. Whooping cough used to be very common until a vaccine was introduced in the 1950s, which is now part of routine childhood vaccinations. It is in a shot along with tetanus and diphtheria vaccines. The combo shot is recommended for adults every 10 years.

“They used to call it the 100-day cough because it literally lasts for 100 days,” said Joyce Knestrick, a family nurse practitioner in Wheeling, West Virginia.

Whooping cough is usually seen mostly in infants and young children, who can develop serious complications. That’s why the vaccine is recommended during pregnancy, to pass along protection to the newborn, and for those who spend a lot of time with infants.

But public health workers say outbreaks this year are hitting older kids and teens. In Pennsylvania, most outbreaks have been in middle school, high school and college settings, an official said. Nearly all the cases in Douglas County, Nebraska, are schoolkids and teens, said Justin Frederick, deputy director of the health department.

That includes his own teenage daughter.

“It’s a horrible disease. She still wakes up — after being treated with her antibiotics — in a panic because she’s coughing so much she can’t breathe,” he said.

It’s important to get tested and treated with antibiotics early, said Dr. Kris Bryant, who specializes in pediatric infectious diseases at Norton Children’s in Louisville, Kentucky. People exposed to the bacteria can also take antibiotics to stop the spread.

“Pertussis is worth preventing,” Bryant said. “The good news is that we have safe and effective vaccines.”

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AP data journalist Kasturi Pananjady contributed to this report.

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The Associated Press Health and Science Department receives support from the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

The Canadian Press. All rights reserved.

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Scientists show how sperm and egg come together like a key in a lock

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How a sperm and egg fuse together has long been a mystery.

New research by scientists in Austria provides tantalizing clues, showing fertilization works like a lock and key across the animal kingdom, from fish to people.

“We discovered this mechanism that’s really fundamental across all vertebrates as far as we can tell,” said co-author Andrea Pauli at the Research Institute of Molecular Pathology in Vienna.

The team found that three proteins on the sperm join to form a sort of key that unlocks the egg, allowing the sperm to attach. Their findings, drawn from studies in zebrafish, mice, and human cells, show how this process has persisted over millions of years of evolution. Results were published Thursday in the journal Cell.

Scientists had previously known about two proteins, one on the surface of the sperm and another on the egg’s membrane. Working with international collaborators, Pauli’s lab used Google DeepMind’s artificial intelligence tool AlphaFold — whose developers were awarded a Nobel Prize earlier this month — to help them identify a new protein that allows the first molecular connection between sperm and egg. They also demonstrated how it functions in living things.

It wasn’t previously known how the proteins “worked together as a team in order to allow sperm and egg to recognize each other,” Pauli said.

Scientists still don’t know how the sperm actually gets inside the egg after it attaches and hope to delve into that next.

Eventually, Pauli said, such work could help other scientists understand infertility better or develop new birth control methods.

The work provides targets for the development of male contraceptives in particular, said David Greenstein, a genetics and cell biology expert at the University of Minnesota who was not involved in the study.

The latest study “also underscores the importance of this year’s Nobel Prize in chemistry,” he said in an email.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

The Canadian Press. All rights reserved.

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