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Could contact tracing bring the US out of lockdown? – Vox.com

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South Korea and the United States reported their first cases of Covid-19 on the same day. Yet while most Americans remain under stay-at-home orders, many in South Korea are doing what seems unthinkable in the US — returning to their offices.

South Korea has often been touted as rolling out one of the best national responses to the coronavirus, and the country’s approach has been comprehensive. All passengers that arrive at Incheon Airport — South Korea’s hub for international flights — receive mandatory temperature checks and must download the country’s coronavirus app, where they report any changes in their symptoms (or lack thereof) every single day.

This app is an important part of South Korea’s effort at contact tracing: the effort to find and notify every person who comes in contact with someone who tests positive for Covid-19. And a few weeks ago, Apple and Google announced that they were developing software that would enable contact tracing apps in the US. How might this technology change the trajectory of the US coronavirus crisis?

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In this episode of Reset, host Arielle Duhaime-Ross talks with Stat News reporter Sharon Begley about how digital contact tracing is our best hope of emerging from lockdown, and why we didn’t start working on it sooner.

A lightly edited transcript of their conversation follows.

Subscribe to Reset wherever you get your podcasts, including Apple Podcasts, Google Podcasts, Spotify, and Stitcher. You can check out our guide to news of the coronavirus outbreak here and listen to other Vox podcasts on the topic here.


Arielle Duhaime-Ross

There are a lot of ways in which the US has been sort of playing catch-up in its response to the pandemic. Is that the case with contact tracing?

Sharon Begley

It is the case with contact tracing for the basic reason that experts in contact tracing, and also in infectious disease, have forever believed and argued that contact tracing does not work with a respiratory disease. And the reason experts told us that contact tracing would not work with respiratory diseases is that respiratory diseases spread too easily — air is a lot easier to come into contact with than someone else’s blood — and that they also spread too quickly. So from the get-go, this country has not even attempted to do serious contact tracing. We didn’t try it in the first cases in the state of Washington. We didn’t try it after cases appeared in California, [we] certainly have not tried it since cases appeared on the East Coast. And in addition, contact tracing is immensely laborious. You need an army of thousands of people to do it.

Arielle Duhaime-Ross

But right now, contact tracing is being touted as one of the ways that we’ll eventually be able to sort of reopen the country. Why are we seeing this shift in the way that people are talking about this?

Sharon Begley

Because of what happened in other countries. In South Korea, in particular, in Singapore, both of which had very, very early cases, not surprising given their proximity to China, that’s what they did. Those countries did contact tracing. It worked. And suddenly that opened the eyes of experts who said, no, no, it could never be done.

Arielle Duhaime-Ross

So wait, does that completely change the way that we look at respiratory illnesses like this?

Sharon Begley

It really does. You know, just as with the recognition that face masks actually can help, all sorts of assumptions about respiratory diseases are being rewritten and, in fact, overturned as a result of what we’re seeing in this pandemic.

Arielle Duhaime-Ross

Okay, so, in all the plans that we are seeing to reopen the country, to reopen the United States, how important is contact tracing going to be?

Sharon Begley

Everybody who has looked at this — academics, officials in other countries — say that this will be the only way that the country can be reopened, that we can have an exit from the very strict social distancing [and] physical distancing that we’ve had for the last month and a half. You know, whether it’s the governors talking about how to figure this out, testing and contact tracing is at the center of all of those plans. And the sequence is, test, in other words, you have to identify people who carry the virus, trace their contacts, you isolate people, and you hope that works.

Arielle Duhaime-Ross

I can’t help but notice that you’re not talking about antibody testing. You’re not talking about vaccines. I guess that’s sort of surprising, probably for a lot of people hearing this, that contact tracing and not these future things that we’re hoping will happen will be central to this approach.

Sharon Begley

You know, the reason I’m not emphasizing vaccines now is because there’s not going to be a vaccine in this calendar year. As far as serology testing, [that is], the blood tests that identify if somebody has antibodies to this coronavirus, that absolutely can play a role in reopening the economy. But, you know, let’s look at the numbers. … The country has some 350 million people. If you’re only going to let go back to life, back to work, people who have survived their Covid-19 infection, that’s not going to give you the numbers that you need. The reason you need testing and contact tracing is that you want a whole lot more people to be able to go back to their stores and their workplaces and their factories and be able to safely ride the subway and all of those things. So it can’t be only the blood tests for the antibodies.

Arielle Duhaime-Ross

Okay, so what do we need to do to implement a successful contact tracing program for Covid-19, and what are the obstacles?

Sharon Begley

So here’s the problem. As we were saying earlier in the experts’ objection to contact tracing for a respiratory virus, it has to be done fast. On average, to identify a person’s contacts — just to identify them, let alone to track them down — takes something like 12 hours of asking, “Where were you? What were you doing? What was it like there?” So that’s an average.

Arielle Duhaime-Ross

Twelve hours is a really long time. To be clear, that’s a long interview.

Sharon Begley

That’s a long interview. Probably not sitting in one place for all that time, but going back to the person to say, “Wait, are you sure you weren’t here or there? And what about this block of time when you forgot where you were?” So it’s very time-consuming to do that with just plain old analog human beings. The estimates are that the United States would need at least 100,000 tracers, possibly as many as 300,000. And, of course, we’re going to pay these people and value them and encourage them. So, you know, you’re probably looking at … upwards of 3.6 billion … dollars just to do that. And absolutely, it’s worth it. But that’s the order of magnitude that you’re talking about in terms of effort.

Arielle Duhaime-Ross

So it sounds like doing contact tracing with human interviewers will be expensive and time-consuming. And now we’re seeing lots of attempts to automate this process with technology. So in theory, how could technology help?

Sharon Begley

The technology that’s being discussed can be basically instantaneous. The way many of these systems would work is, again, you opt-in. And the opting in means that … you would … get an alert saying, “Yes, you came into close contact with someone. We think you should now isolate yourself for 14 days.” If you can get through those two weeks without symptoms, then that casual passing by the person did not infect you. That can be done virtually, instantaneously — certainly, you know, faster than human contact tracers. And the hope is that by doing it that quickly, you can snuff out any transmission chains that might crop up.

Arielle Duhaime-Ross

Right, because to be clear, it’s not just reducing the time of that 12-hour interview. It’s also reducing the time that it takes to contact the people that the person has been in touch with by just making it automated and automatic.

Sharon Begley

A group at Oxford university in the UK did model this. And they found that if you can accelerate how quickly you find, you diagnose cases, and trace their contacts, then you can ease up on social distancing to a degree that nothing else will enable you to do.

Arielle Duhaime-Ross

So could a tech solution for contact tracing work in the US in a widespread way?

Sharon Begley

So it’s always dicey to talk about a technological fix. But in this case, again, as with so much in Covid-19, we have other countries that have shown us the way. Singapore, South Korea, they used everything from security camera footage to smartphone tracing. Israel rolled out a system like this. What’s important to remember is that success does not mean zero cases. Success means that we do not have another instance where we overwhelm our hospitals and have the horrible situations that we’ve all seen, in especially New York hospitals. Bottom line, you can have way, way less than 100 percent opt-in and still have a really good chance of catching any incipient new infections after we’re over the current wave.


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Cytiva Showcases Single-Use Mixing System at INTERPHEX 2024 – BioPharm International

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The Xcellerex magnetic mixer, single-use mixing system was designed to address challenges in large-scale mAb, vaccine, and genomic medicine manufacturing processes.

Cytiva unveiled the Xcellerex single-use magnetic mixer at INTERPHEX 2024 in New York City on April 16, 2024. The single-use mixing system was designed to combat challenges in large-scale monoclonal antibody (mAb), vaccine, and genomic medicine manufacturing processes. The mixer is offered in 2000 L and 3000 L capacities and can be configured in several ways to accommodate diverse mixing processes. Its compact size benefits facilities with space constraints or complicated installation of large-scale consumables.

According to the company, minor leaks may cause significant delays and losses. “When dealing with a 3000 L batch of cell culture media, the estimated financial loss can cost between $60k to upwards of $100k” (1). The system helps prevent expensive leaks with a novel mixer biocontainer that incorporates user-centered design elements to improve durability and ease of use. The design provides enhanced safeguards and added protection from leaks that may occur during shipping, storage, and operation.

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Time taken to mix batches can inhibit product development times, specifically the challenge of mixing floating powders such as cell culture media. Current systems have underpowered impellers with circular or cubical shapes that make producing large volumes challenging, according to Cytiva. This new single-use system “has a powerful impeller that when combined with the mixer’s hexagonal shape creates a vortex, enhancing the interaction at the liquid surface. This vortex effectively pulls down the floating powders into the main body of the liquid to allow for a more efficient and shorter mixing process,” the company stated in a press release.

“We’re tapping into our differentiated portfolio to solve a wide range of challenges for our customers. Our new magnetic mixing system is flexible and capable of meeting the many demands and constraints during buffer and cell culture media preparation,” said Amanda Halford, president, Bioprocess at Cytiva in the release. “By reimagining the design, we’ve tackled some of the biggest obstacles to downtime.”

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Cytiva is also working to advance messenger RNA (mRNA) manufacturing. In an interview with Pharmaceutical Technology EuropeTM , Scott Ripley, general manager, Nucleic Acid Therapeutics and Precision Nanosystems at Cytiva, discussed technology that enables the “democratization” of mRNA manufacturing (2). Many mRNA therapies and other types of genetic medicines in clinical development are designed to be delivered with the help of lipid nanoparticles. One such platform is Cytiva’s Precision Nanosystems NanoAssemblr microfluidic-based nanoparticle manufacturing platform, which enables the development of genetic medicines with potentially increased stability, efficacy, yield, and quality of non-viral genetic medicines, according to Ripley.

Ripley was enthusiastic about this platform’s ability to “democratize” the good manufacturing practice (GMP) manufacturing aspects for advanced therapies, while managing to cope with the increased molecular diversity of the molecules being handled.

“For example,” Ripley says, “the mRNA platform is unique in that, on one end of the spectrum, it is vaccinating the planet, on the other end, it’s personalized cancer vaccines.”

Reference

1. Cytiva. Cytiva Unveils Latest Innovation for Large Scale Mab, Vaccine, and Advanced Therapy Manufacturing Processes–The Xcellerex Compact Single-Use Magnetic Mixing System. Press Release. April 16, 2024.
2. Spivey, C. Democratizing GMP Manufacturing for the New Therapeutic Pipeline. PharmTech.com. Nov. 21, 2023.

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Nintendo Indie World Showcase April 2024 – Every Announcement, Game Reveal & Trailer – Nintendo Life

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Image: Nintendo Life

Nintendo’s April 2024 Indie World Showcase was a 20-minute presentation of games from independent developers coming to Switch sometime in 2024, with several previously announced games getting release dates.

It was a fairly low-key showcase overall, although there were definitely some choice nuggets in there.

Below you’ll find the video of the full Indie World Showcase April 2024 presentation, plus every individual game announcement with a trailer, a date, and a link to our more detailed coverage.

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Nintendo Indie World Showcase April 2024 – The Whole Presentation

First, the presentation itself if you want the whole thing:

Every Switch Game Announcement & Update

And now every trailer for every game from the April 2024 Indie World Showcase, plus some blurb and a link to our coverage if there is one:

Little Kitty, Big City – 9th May 2024

Will you make your way home or will you explore what the big city has to offer first? I mean, getting home is obviously your main priority. Obviously. Well, it’s one of your priorities. Maybe more of a guideline… It’s definitely on your To-Do list somewhere! But first? Exploration!

Yars Rising – 2024

Play as the young hacker, Emi Kimura, as she starts to uncover the dark secrets of mysterious corporation, Qotech. In this brand new side-scrolling Metroidvania from acclaimed developers, WayForward, take the Yars universe to a whole new level and unlock something hiding deep inside of you.

Refind Self: The Personality Test Game – Summer 2024

Games can really show someone’s personality, don’t you think? By way of a simple exploration-based adventure, this data-science game analyzes your actions to estimate your personality.

Sticky Business – 17th August 2024

Sticky Business is a creative relaxing 2D game developed by Spellgarden Games. Players will create stickers, pack orders, and listen to the stories of customers. Sticky Business is available now for Nintendo Switch, Mac, and PC alongside its DLC.

Antonblast – 12th November 2024

ANTONBLAST is an explosive, action-packed retro platformer featuring a destructive twist to classic gameplay and a lovingly hand-animated pixel aesthetic inspired by the Game Boy Advance, blown up and reimagined for the modern era!

Silky smooth 60fps action platforming and explosive escapes combine in a bombastic adventure. Blast through buildings, fight your demons, and explore wonky worlds in ANTONBLAST!

Valley Peaks – 2024

The mountains are calling! In this ribbiting first-person climbing platformer, each mountain is like a puzzle, and it’s your job to make your way to the top of every ridge to place radio towers for the froggy inhabitants of Valley Peaks.

Lorelei and the Laser Eyes – 16th May 2024

A woman, summoned by an eccentric man to participate in a project in an old hotel somewhere in central Europe, becomes embroiled in a game of illusions, increasingly dangerous and surreal.
Now you are invited to fall into the same rabbit hole, in a non-linear mystery with an immense amount of handcrafted puzzles, constantly presenting you with new riddles to solve, each leading you closer to deciphering the enigma of Lorelei and the Laser Eyes.

Europa – 2024

On the moon Europa, a lush terraformed paradise in Jupiter’s shadow, an android named Zee sets out in search of answers. Run, glide and fly across the landscape, solve mysteries in the ruins of a fallen utopia, and discover the story of the last human alive.

TMNT: Splintered Fate – July 2024

Join the Teenage Mutant Ninja Turtles as they rescue Splinter from the clutches of the Foot Clan amidst chaos in NYC. Experience fast-paced, roguelike action with unique powers for each Turtle. Team up with friends for co-op gameplay, explore iconic locations, and face classic TMNT foes. Don’t miss the adrenaline-packed adventure in this FIGHT, ADAPT, REPEAT portal loop! Subscribe now for updates and get ready to restore peace to the city!

Cat Quest III – 8th August 2024

Ahoy, ye brave buccaneers and fearless feline adventurers!
Prepare to weigh anchor on August 8th as Cat Quest III hoists its sails! 🏴‍☠️😸 Embark on a voyage through the Purribean and clash swords with the notorious Pi-rats. There is no better way to celebrate International Cat Day.

Take command of yer own sea vessel, meow-ster the waves, and plunder yer way through this swashbucklin’ catventure! Join forces with yer matey for local co-op play, and together, turn the tides of fate!

Will ye be the one to discover the mythical North Star? Set paw on the path to glory!

stitch. – Today (17th April 2024)

Stitch. is a casual puzzle game with embroidery on a numbered grid. The main objective is to fill in the levels’ areas with no gaps to complete Hoops.

Stitch. lets you create beautiful embroidery patterns, by solving levels and Hoops of various difficulties and sizes. It’s easy to learn, but hard to master!

Stitch up all the beautiful landscapes, plants, animals, objects, and more.

BZZZT – Summer 2024

Become a tiny ZX8000 robot and begin your journey through a beautiful, pixel-art world inspired by games iconic to the platformer genre. Follow a surprising story, upgrade your skills, beat challenging levels, and compete with other players for the fastest speedrun!

SCHiM – 18th July 2024

Embark on a playful journey in SCHiM and get ready to jump from shadow to shadow. This 3D platformer integrates light, shadow, and animation into its gameplay.
Interact with the shadows you visit in a colorful environment and be part of the stories that unfold. Every object, living being, and thing has a “schim”. You play as a schim who becomes separated. Can you make it back to your human and help others along the way?

Animal Well – 9th May

Hatch from your flower and spelunk through the beautiful and sometimes haunting world of ANIMAL WELL, a pixelated action-exploration game rendered in intricate audio and visual detail. Encounter lively creatures small and large, helpful and ominous as you discover unconventional upgrades and unravel the well’s secrets. This is a truly unique experience that can make you laugh in fear, surprise, or delight.

Duck Detective: The Secret Salami – 23rd May 2024

Solving crime is no walk in the pond. You are a down-on-his-luck detective who also happens to be a duck. Use your powers of de-duck-tion to inspect evidence, fill in the blanks, and bust the case wide open, in a narrative mystery adventure where nothing is quite as it seems.

Another Crab’s Treasure – 25th April 2024

In a vibrant undersea kingdom on the verge of collapse, a hermit crab embarks on a treasure hunt to buy back his repossessed shell. The second game from AGGRO CRAB.

SteamWorld Heist II – 8th August 2024

Get ready to join Captain Leeway and set sail on the Great Sea in this turn-based strategy game. Bullets ricochet with deadly precision as you go on heists to find epic loot, whilst trying to figure out just what is causing the water crisis. Put together your rag-tag Steambot crew and sail across the sea to uncover the mysteries that surround you!


Let us know below what you thought of the latest Indie World Showcase by voting in the polls below and dropping us a comment.

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Aaron Sluchinski adds Kyle Doering to lineup for next season – Sportsnet.ca

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