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Covid-19 roundup: Booster protection against hospitalization drops after 3 months – The Daily Briefing

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The shortest known time between coronavirus infections is 20 days, the omicron subvariant BA.2.12.1 is gaining prevalence in the United States, and more in this week’s roundup of Covid-19 news.

Your top resources on the Covid-19 vaccines

  • Moderna on Thursday asked FDA to authorize its Covid-19 vaccine for children under 6. Based on clinical trial data, the company’s vaccine for children, which consists of two 25-microgram doses, was 51% effective against symptomatic infection for children between 6 months and 2 years and 37% effective for children ages 2 to 6. In addition to its vaccine for children under 6, Moderna has also requested FDA authorize its vaccine for children ages 6 to 11 and adolescents ages 12 to 17, with a spokesperson saying the company would complete its data submission for these groups in the next two weeks. During a Senate oversight heating, Peter Marks, who oversees vaccine regulation for FDA, suggested the agency might consider Moderna’s applications for children under 18 as a whole rather than individually. Separately, Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said FDA may review children vaccine data from Moderna and Pfizer-BioNTech simultaneously to directly compare the two vaccines and not “confuse people.” According to the New York Times, federal regulators are unlikely to review Moderna’s application before June, when FDA’s outside advisory panel is scheduled to meet on vaccines for young children. (LaFraniere, New York Times, 4/28; Doherty, Axios, 4/28; AP/Modern Healthcare, 4/28; LaFraniere, New York Times, 4/26)
  • FDA on Monday expanded its approval for the IV antiviral Veklury, also known as remdesivir, to children under 12, making it the first Covid-19 treatment approved for this age group. According to MedPage Today, Veklury is now approved for use in children as young as 28 days who weigh at least three kilograms. The drug may be used for either hospitalized patients or those at risk of severe outcomes. “As COVID-19 can cause severe illness in children, some of whom do not currently have a vaccination option, there continues to be a need for safe and effective COVID-19 treatment options for this population,” said Patrizia Cavazzoni, director of the FDA’s Center for Drug Evaluation and Research. “Today’s approval of the first COVID-19 therapeutic for this population demonstrates the agency’s commitment to that need.” (Chen, Axios, 4/25; Reuters, 4/25; Walker, MedPage Today, 4/25)
  • Booster protection against hospitalization from Covid-19 declines after three months, according to a new Kaiser Permanente study published in The Lancet Respiratory Medicine. For the study, researchers analyzed Kaiser Permanente patient records between December 2021 and Feb. 6, 2022. In total, there were 11,123 hospital admissions or ED visits, and all patients included in the analysis had received at least three doses of the Pfizer-BioNTech vaccine. Overall, the researchers found that a booster dose was 80% to 90% protective against hospital admissions and ED visits caused by both the delta and omicron variants during the first three months of receiving it. However, after three months, protection against hospitalization from omicron decreased to 55%, while protection against ED visits decreased to 53%. “Pfizer BioNTech COVID-19 booster doses significantly improve protection against omicron, although that protection seems to wane after three months against emergency room visits, and even for hospitalization,” said Sara Tartof, an epidemiologist in Kaiser Permanente’s department of research and evaluation and the study’s lead author. “Trends in waning against delta-related outcomes were generally similar to omicron but with higher effectiveness at each time point than those seen for omicron.” (Carbajal, Becker’s Hospital Review, 4/25)
  • The shortest known time between separate coronavirus infections is 20 days, according to a case report presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). According to researchers, a 31-year-old female health care worker in Spain first tested positive for Covid-19 on a PCR test on Dec. 20, 2021. She was fully vaccinated and had received a booster dose 12 days earlier. After this positive test, the patient, who was asymptomatic, self-isolated for 10 days before returning to work. Then, on Jan. 10, 2022, just 20 days after her original positive test, the patient began feeling unwell and tested positive on another PCR test. According to whole genome sequencing, there had been two different coronavirus variants, with the first being delta in December and the second being omicron in January. “This case highlights the potential of the omicron variant to evade the previous immunity acquired either from a natural infection with other variants or from vaccines,” said Gemma Recio, one of the study’s authors. “In other words, people who have had COVID-19 cannot assume they are protected against reinfection, even if they have been fully vaccinated.” (Gleeson, Becker’s Hospital Review, 4/21; ECCMID press release, 4/20)
  • Pfizer and BioNTech on Tuesday requested FDA authorize a booster dose of their Covid-19 vaccine for children ages 5 to 11. In an announcement, Pfizer said data from a Phase 2/3 trial indicated children in that group saw a “strong immune response” after receiving a booster dose six months after their primary vaccine series. If authorized, the dose would be the first booster available to children under 12. However, some health experts said a third dose may not be necessary for children at this point. “It may be that over time, those two doses don’t protect against serious illness, in which case one could reasonably [receive] a third dose,” said Paul Offit, who leads the Vaccine Education Center at Children’s Hospital at Philadelphia. “But for right now, protection against serious illness appears to be holding up.” In addition, it is not clear how much demand there will be for booster doses in this age group, according to NPR. Currently, CDC data shows that only 28.4% of children ages 5 to 11 are fully vaccinated, and only around 35% have received an initial dose. (Chen, Axios, 4/26; Stein, “Shots,” NPR, 4/26; Choi, The Hill, 4/26)
  • According to CDC data, the prevalence of the omicron subvariant BA.2 is decreasing in the United States as a new subvariant continues to spread. For the week ending April 23, BA.2 made up 68.1% of all new Covid-19 cases, down from 74.9% the week ending April 9. In comparison, the subvariant BA.2.12.1 made up 28.7% of new Covid-19 cases the week ending April 23, up from 13.7% the week ending April 9. Researchers estimate BA.2.12.1 has a 27% growth advantage over BA.2, which is already more transmissible than the original omicron BA.1 variant. BA.2.12.1, as well as a related subvariant BA.2.12, are currently driving a surge in Covid-19 cases in New York. Based on HHS data, Covid-19 cases nationwide have increased 53% over the past two weeks as of April 25. (Bean, Becker’s Hospital Review, 4/26)

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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