COVID-19 roundup: Flu may be linked with coronavirus spread, RA drug could aid recovery | Daily Sabah - Daily Sabah | Canada News Media
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COVID-19 roundup: Flu may be linked with coronavirus spread, RA drug could aid recovery | Daily Sabah – Daily Sabah

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This week’s roundup of some of the latest scientific studies on the coronavirus and efforts to find treatments and vaccines for COVID-19 investigates the possible link between influenza outbreaks and the spread of the coronavirus, newly discovered proteins SARS-CoV-2 has that may be responsible for immune triggers and how other drugs can be utilized in the fight against this infectious disease.

Flu may be linked to coronavirus spread

Influenza outbreaks may be linked with the spread of COVID-19 infections, according to a European study.

The researchers created a mathematical model of transmission of the coronavirus in Belgium, Italy, Norway and Spain. It calculates that higher rates of influenza infections would be associated with increased coronavirus transmission in each of the countries, Matthieu Domenech de Celles of the Max Planck Institute for Infection Biology in Berlin told Reuters. He said the estimates, published Wednesday on the medical website medRxiv in advance of peer review, align with earlier research.

In Italy, he noted, higher rates of flu vaccination have been linked with lower rates of death from COVID-19. Also, he said, a U.S. study of nearly 11,700 people tested for COVID-19 found that those who had flu vaccines were less likely to have a positive test.

None of these studies proves that flu vaccines affect the spread of COVID-19 or an individual’s risk for it, and other factors might explain the associations. Still, de Celles said, in advance of “the upcoming ‘twindemic'” of seasonal flu and COVID-19 in the northern hemisphere, “our results suggest the need to increase vaccination against influenza,” which may not only reduce the burden of influenza but also limit COVID-19 cases. (Here’s why you should consider having a flu shot this year)

Rheumatoid arthritis drug found to aid COVID-19 recovery

Hospitalized COVID-19 patients being treated with Gilead Sciences Inc.’s antiviral medication remdesivir recovered about a day sooner, on average, if they also received Eli Lilly and Co.’s rheumatoid arthritis drug baricitinib, clinical trial investigators found.

The trial, sponsored by the U.S. National Institute of Allergy and Infectious Diseases (NIAID), included more than 1,000 patients. The study also showed that compared to patients who did not receive the arthritis drug, those who did had better outcomes at 15 days after they enrolled in the trial. Based on the data, Lilly plans to discuss the potential for emergency-use authorization with the U.S. Food and Drug Administration (FDA). The company announced the results of the so-called ACTT-2 trial in a news release Monday. The results have not been formally published yet.

Experts tell when to test for COVID-19 antibodies

COVID-19 antibody tests – so-called serology tests – are widely available, but evidence of their usefulness is limited, the Infectious Diseases Society of America said as it unveiled new guidelines published earlier this month in the journal Clinical Infectious Diseases.

Antibodies to the coronavirus do not show up in the blood for quite a while after someone becomes infected, so serology tests are unreliable for diagnosing COVID-19 unless a patient has been sick for weeks, according to the guidelines.

The panel of authors, led by Dr. Kimberly Hanson of the University of Utah, listed three instances in which a test for antibodies to the coronavirus would be warranted. The first one is when doctors strongly suspect a patient has COVID-19 but gold-standard diagnostic PCR molecular tests that look for genetic components of the virus have been negative and at least two weeks have passed since the onset of symptoms.

The second is when a child has signs and symptoms of multisystem inflammatory syndrome, a life-threatening condition that has been linked with previous coronavirus infection. The third is when public health officials conduct so-called serosurveillance studies to track the proportion of the population that has been exposed to the virus.

Newly discovered coronavirus proteins may be immune triggers

Scientists have discovered 23 previously unknown proteins made by the coronavirus, including four that might be triggering patients’ immune system to act – or in some cases, to overreact – and cause severe illness.

For the most part, proteins in this new virus have been identified based on computational predictions and similarities with other coronaviruses. But these researchers took a different approach.

By tracking protein-producing “machines” in cells called ribosomes, they were able to map exactly which parts of the genetic code of the virus were being translated into proteins, study co-leader Yaara Finkel of the Weizmann Institute of Science in Israel told Reuters. Most of the newly discovered proteins probably have regulatory functions in the virus – that is, they help keep it active – except for the four “full-fledged proteins” that might be alerting the immune system to the presence of a foreign invader, Finkel and colleagues wrote in a study published in the journal Nature on Wednesday.

More work is required to determine the roles these proteins play in infection, Finkel said, but that knowledge could “lead to a better understanding of the progression of the infection, as well as better ways of either treating COVID-19 or preventing the dangerous immune over-response.”

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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