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COVID Increases Risk Of Mental Health Disorders – The ASEAN Post

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Having COVID-19 puts people at a significantly increased chance of developing new mental health conditions, potentially adding to existing crises of suicide and overdoses, according to new research looking at millions of health records in the United States (US) over the course of a year.

The long-term effects of having COVID are still being discovered, and among them is an increased chance of being diagnosed with mental health disorders. They include depression, anxiety, stress and an increased risk of substance use disorders, cognitive decline, and sleep problems – a marked difference from others who also endured the stress of the pandemic but weren’t diagnosed with the virus.

“This is basically telling us that millions and millions of people in the US infected with COVID are developing mental health problems,” said Ziyad Al-Aly, chief of research and development at the VA St Louis Healthcare System and senior author of the paper. “That makes us a nation in distress.”

The higher risk of mental health disorders, including suicidal ideation and opioid use, is particularly concerning, he said.

“This is really almost a perfect storm that is brewing in front of our eyes – for another opioid epidemic two or three years down the road, for another suicide crisis two or three years down the road,” Al-Aly added.

These unfolding crises are “quite a big concern”, said James Jackson, director of behavioural health at Vanderbilt University’s ICU Recovery Center, who was not involved with this study. He is also seeing patients whose previous conditions, including anxiety, depression and opioid use disorder, worsened during the pandemic.

Research like this shows the clear need to follow patients in the weeks and months after even mild COVID diagnoses and to seek quick treatment for any emerging disorders, the experts said. “If we apply attention to it now and nip it in the bud, we could literally save lives,” Al-Aly said.

More than 18 percent of COVID patients developed mental health problems, compared with 12 percent of those who did not have COVID, according to the study published on Wednesday.

The study followed more than 153,000 patients who tested positive for COVID in the Veterans Affairs health system between March 2020 and January 2021, and compared them with other health records: to 5.8 million people who did not test positive in that time, but lived through the same stresses of the pandemic, and with 5.6 million patients seen before the pandemic.

Among all patients who developed new mental health problems during the pandemic, the COVID patients were significantly more likely to develop cognitive problems (80 percent), sleep disorders (41 percent), depression (39 percent), stress (38 percent), anxiety (35 percent) and opioid use disorder (34 percent), compared with those who didn’t have COVID.

The study looked only at patients with no history of mental health diagnoses in the past two years. It compared those hospitalized for COVID versus other illnesses, and compared outcomes to thousands of flu cases. The study also adjusted for factors like demographics, other health conditions and other factors.

The results were all clear: COVID has a marked effect on mental health.

Those with more severe cases of COVID, especially those who need to be hospitalized, tend to be at higher risk. But even those with mild or asymptomatic cases were more likely to receive mental health diagnoses.

“People who were hospitalized had it worse, but the risk in non-hospitalized [patients] is significant and absolutely not trivial – and that represents the majority of people in the US and the world,” Al-Aly said.

The study did have some limitations: most of those analysed were older white men. But controlling for race, gender and age found no changes in risk.

The coronavirus can be found in the brain, other studies have shown. “We can actually see the virus in the amygdala, in the hippocampus – the very centres responsible for regulating our moods, regulating our emotions,” Al-Aly said.

The study adds to other research showing that “mental health issues are a huge concern” after COVID, Jackson said. And the results line up with what he sees among patients.

“We’re learning that COVID may be even more problematic and more impactful than we thought,” Jackson said.

Early treatment of patients facing new or additional mental health challenges after COVID can make a crucial difference, the experts said.

“The idea here is to identify patients’ data early to hopefully reduce this from becoming a much larger problem down the road,” Al-Aly said. “If you leave a disease unattended, it only gets worse.”

But the longer the virus continues circulating, the more long-term problems it may create – adding even greater pressure to health systems.

“The wave of people with mental health disorders is going to be hitting the clinics in the next year or two or three, as a result of COVID and as a result of the pandemic,” Al-Aly said.

And many mental health practitioners don’t accept insurance, creating a large stumbling block for patients, while others have long waiting lists.

“This is a gigantic problem, and I’m not really sure what we’re going to do about it,” Jackson said. “The needs are vastly greater than the resources.”

Jackson has set up peer support groups to offer counselling to patients dealing with long COVID – brain fog, cognitive impairment, memory problems, feelings of inadequacy. The groups are held on Zoom, so patients can join from all over the country.

“We need to pay attention to the long-term consequences of COVID,” Al-Aly said. “If we only pay attention to the short-term consequences, the first 30 days or the first 90 days, we really, really are missing the larger picture.

“The pandemic itself caught the US unprepared, and we’re going to be caught unprepared again for long COVID,” Al-Aly said. “The reality is that COVID is producing long-term consequences, and we cannot just wish it away or sweep it under the rug or not deal with it.”

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Whooping cough is at a decade-high level in US

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MILWAUKEE (AP) — Whooping cough is at its highest level in a decade for this time of year, U.S. health officials reported Thursday.

There have been 18,506 cases of whooping cough reported so far, the Centers for Disease Control and Prevention said. That’s the most at this point in the year since 2014, when cases topped 21,800.

The increase is not unexpected — whooping cough peaks every three to five years, health experts said. And the numbers indicate a return to levels before the coronavirus pandemic, when whooping cough and other contagious illnesses plummeted.

Still, the tally has some state health officials concerned, including those in Wisconsin, where there have been about 1,000 cases so far this year, compared to a total of 51 last year.

Nationwide, CDC has reported that kindergarten vaccination rates dipped last year and vaccine exemptions are at an all-time high. Thursday, it released state figures, showing that about 86% of kindergartners in Wisconsin got the whooping cough vaccine, compared to more than 92% nationally.

Whooping cough, also called pertussis, usually starts out like a cold, with a runny nose and other common symptoms, before turning into a prolonged cough. It is treated with antibiotics. Whooping cough used to be very common until a vaccine was introduced in the 1950s, which is now part of routine childhood vaccinations. It is in a shot along with tetanus and diphtheria vaccines. The combo shot is recommended for adults every 10 years.

“They used to call it the 100-day cough because it literally lasts for 100 days,” said Joyce Knestrick, a family nurse practitioner in Wheeling, West Virginia.

Whooping cough is usually seen mostly in infants and young children, who can develop serious complications. That’s why the vaccine is recommended during pregnancy, to pass along protection to the newborn, and for those who spend a lot of time with infants.

But public health workers say outbreaks this year are hitting older kids and teens. In Pennsylvania, most outbreaks have been in middle school, high school and college settings, an official said. Nearly all the cases in Douglas County, Nebraska, are schoolkids and teens, said Justin Frederick, deputy director of the health department.

That includes his own teenage daughter.

“It’s a horrible disease. She still wakes up — after being treated with her antibiotics — in a panic because she’s coughing so much she can’t breathe,” he said.

It’s important to get tested and treated with antibiotics early, said Dr. Kris Bryant, who specializes in pediatric infectious diseases at Norton Children’s in Louisville, Kentucky. People exposed to the bacteria can also take antibiotics to stop the spread.

“Pertussis is worth preventing,” Bryant said. “The good news is that we have safe and effective vaccines.”

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AP data journalist Kasturi Pananjady contributed to this report.

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The Associated Press Health and Science Department receives support from the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

The Canadian Press. All rights reserved.

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Scientists show how sperm and egg come together like a key in a lock

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How a sperm and egg fuse together has long been a mystery.

New research by scientists in Austria provides tantalizing clues, showing fertilization works like a lock and key across the animal kingdom, from fish to people.

“We discovered this mechanism that’s really fundamental across all vertebrates as far as we can tell,” said co-author Andrea Pauli at the Research Institute of Molecular Pathology in Vienna.

The team found that three proteins on the sperm join to form a sort of key that unlocks the egg, allowing the sperm to attach. Their findings, drawn from studies in zebrafish, mice, and human cells, show how this process has persisted over millions of years of evolution. Results were published Thursday in the journal Cell.

Scientists had previously known about two proteins, one on the surface of the sperm and another on the egg’s membrane. Working with international collaborators, Pauli’s lab used Google DeepMind’s artificial intelligence tool AlphaFold — whose developers were awarded a Nobel Prize earlier this month — to help them identify a new protein that allows the first molecular connection between sperm and egg. They also demonstrated how it functions in living things.

It wasn’t previously known how the proteins “worked together as a team in order to allow sperm and egg to recognize each other,” Pauli said.

Scientists still don’t know how the sperm actually gets inside the egg after it attaches and hope to delve into that next.

Eventually, Pauli said, such work could help other scientists understand infertility better or develop new birth control methods.

The work provides targets for the development of male contraceptives in particular, said David Greenstein, a genetics and cell biology expert at the University of Minnesota who was not involved in the study.

The latest study “also underscores the importance of this year’s Nobel Prize in chemistry,” he said in an email.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

The Canadian Press. All rights reserved.

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