COVID infections may give more potent immunity than vaccines – but that doesn’t mean you should try to catch it - Devdiscourse | Canada News Media
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COVID infections may give more potent immunity than vaccines – but that doesn’t mean you should try to catch it – Devdiscourse

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By Charlotte Thalin, Karolinska Institutet Solna (Sweden), Sep 7 (The Conversation) Israel was way ahead of the rest of the world when it came to COVID vaccination, so it’s not surprising that data from this corner of the Mediterranean causes a lot of excitement – it’s a glimpse into the future.

Indeed, this happened recently when researchers at Maccabi Healthcare Services in Tel Aviv released a preprint (a study that is yet to be reviewed by other experts) suggesting people who had been infected with COVID had greater protection than vaccinated people against becoming reinfected with the delta variant. Unfortunately, some took this to mean that getting COVID is a better idea than getting vaccinated.

First, the possibility that a COVID infection leads to longer-lived immunity than vaccination is not far-fetched. Infection exposes our immune system to several viral proteins, whereas the most commonly used COVID vaccines introduce a single antigen: the spike protein. This results in a more directed but also a more restricted immune response than after infection.

Although people who have had COVID can get reinfected, naturally acquired immunity continues to evolve over time and antibodies remain detectable for longer than was first anticipated. New evidence suggests that immunity following both severe and mild infection protects against both symptomatic and asymptomatic reinfection.

However, apart from the danger of drawing conclusions from data that other scientists have not yet reviewed, it is also crucial to put the data in the right context. Although the study draws attention to the potency of naturally acquired immunity, it does not consider the risks involved in achieving natural immunity through infection. Nor does it cast a shadow on vaccine-generated immunity.

In fact, the benefit of vaccination is not even addressed in the study since unvaccinated people without prior infection were not included for comparison. The low rate of COVID-related hospitalisations among vaccinated participants (eight out of 16,000) would probably be strikingly lower than among non-vaccinated people without prior infection, but this group was not included in the analyses.

A common reason to remain unvaccinated is the misconception that waiting for natural immunity by choosing infection over vaccination is an option. But infection-acquired immunity may come at a heavy cost.

Indeed, apart from the overt risks of severe illness or death, several recent studies show that otherwise healthy people who have recovered from COVID have a substantially increased risk of longer-term serious health problems, including myocarditis (inflammation of the heart muscle), blood clots and stroke, compared to vaccinated people. And the most rigorous safety monitoring in US history has shown that COVID vaccines are safe and effective.

With cases surging globally and deaths driven by the delta variant, waiting for infection – and risking long-term health problems, severe illness and death – to achieve immunity to the very same infection is as fruitless as it is dangerous.

Hybrid immunity The Israeli preprint does, however, shed light on our increasing understanding of the potent immunity induced by getting the vaccine after having COVID – so-called hybrid immunity. Several studies show a substantial boost in both antibody and T-cell responses to vaccine in people with previous COVID infection.

A recent report from the US Centers for Disease Control and Prevention showed that people who’d recovered from COVID and were later vaccinated had half the risk of reinfection compared with unvaccinated people who’d previously had COVID. So it’s still worth getting the vaccine, even if you have previously had COVID.

The effective immune booster following the combination of natural immunity and a single subsequent vaccine jab also raises the question of whether one dose is enough for people who have had COVID. Several studies report that immune responses to a single dose of either the Pfizer or AstraZeneca vaccine exceed those after two doses in people without prior infection.

Several countries, such as France, Italy and Germany, therefore now recommend a single dose for people with a previous COVID infection. And infection without vaccination is recognised as immunity for the current Israeli green pass rules.

Although directing boosters to people who have not been infected may make the most of limited vaccine supplies, personalised schedules and exemptions from vaccine mandates may be logistically tricky in the midst of a pandemic. Antibody screening before vaccination is time-consuming and expensive, and it introduces practical challenges in identifying those who have or haven’t previously had COVID. These exemptions could slow vaccine rollout rather than speed it up.

As unprecedented research efforts deliver knowledge about our immune responses to COVID infection and vaccination on a daily basis, we must critically view the data together with all the facts that relate to it. We are far from bringing the pandemic to an end, and the potential risks of being infected are unquestionable. Our priority should be to slow transmission and get vaccines to those who remain unvaccinated and need them the most. To avoid vaccination, wait for infection and hope for natural immunity makes little sense. (The Conversation) AMS

(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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