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Cross-Canada lab network tracking COVID-19 mutations – CBC.ca

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A network of laboratories across Canada is studying mutations in the genetic footprint of COVID-19 to track patterns of transmission across the country and internationally. 

Led by the Public Health Agency of Canada’s National Microbiology Laboratory, along with Genome Canada, the research is working to identify as many genetic sequences as possible. 

The goal is to understand which sequences are circulating in Canada and compare those to others around the world. 

“Monitoring interprovincial or international spread of the virus will become increasingly important as public health measures are slowly lifted and cross-border travel resumes,” said Natalie Mohamed, a spokesperson for the Public Health Agency of Canada, in a written response to questions.

“Genetic variants may also impact the sensitivity and performance of the current COVID-19 diagnostic methods. By comparing viral genome sequences, we will be able to monitor the spread of these established lineages in Canada.”

The agency said most genetic mutations in the virus are “silent,” meaning they do not modify the virus’s function or make it more dangerous. However, these genetic differences can be used to identify different variations that form a lineage, with a common ancestor and descendents.

Identifying source of new cases

Understanding the variations circulating in Canada will help to identify the source of new cases as travel restrictions are lifted.  

It can also help identify links between cases when investigating outbreaks, which is particularly useful when contact tracing is not available or inconclusive.

The agency said it is too early to tell whether Canada has distinct virus lineages. 

It said monitoring of viral and genetic variants will be key to ensuring the effectiveness of any vaccines and treatments, and can help make sure testing for the virus is accurate. 

“We need to continuously monitor their effectiveness, otherwise we risk missing positive cases,” Mohamed said in reference to testing methods.

The research is being carried out through the Canadian COVID-19 Genomics Network (CanCOGen), a consortium of public health and academic institutions, hospitals and large Canadian sequencing centres. 

The project has been funded for two years with $40 million from the federal government, announced in April. 

“We are already submitting our virus sequence data to the public domain databases and will make study findings available to the public as they become available,” said Mohamed. 

Individual virus sequences submitted to open source databases

Although the findings will be released at a later date, the data itself is being shared to open-source databases, like the NextStrain website, as it is generated. 

A spokesperson from the Roy Romanow Lab in Saskatchewan said mutations shown on NextStrain, such as one identified in that province, are “extremely small.” 

“The majority of these changes happen randomly and do not affect the virus in any way,” it said. 

“It’s important to note that currently none of the mutations have been shown to increase infectivity.” 

It said coronaviruses mutate very slowly compared to viruses like influenza or HIV.

The National Microbiology Lab has centres in Winnipeg, Man., Guelph, Ont., St. Hyacinthe, Que. and Lethbridge, Alta. 

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Langford, Heim lead Rangers to wild 13-8 win over Blue Jays

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ARLINGTON, Texas (AP) — Rookie Wyatt Langford homered, doubled twice and became the first Texas player this season to reach base five times, struggling Jonah Heim delivered a two-run single to break a sixth-inning tie and the Rangers beat the Toronto Blue Jays 13-8 on Tuesday night.

Leody Taveras also had a homer among his three hits for the Rangers.

Langford, who also walked twice, has 12 homers and 25 doubles this season. He is hitting .345 in September.

“I think it’s really important to finish on a strong note,” Langford said. “I’m just going to keep trying to do that.”

Heim was 1-for-34 in September before he lined a single to right field off Tommy Nance (0-2) to score Adolis García and Nathaniel Lowe, giving Texas a 9-7 lead. Heim went to the plate hitting .212 with 53 RBIs after being voted an All-Star starter last season with a career-best 95 RBIs. He added a double in the eighth ahead of Taveras’ homer during a three-run inning.

Texas had 13 hits and left 13 men on. It was the Rangers’ highest-scoring game since a 15-8 win at Oakland on May 7.

Matt Festa (5-1) pitched 1 1/3 scoreless innings to earn the win, giving him a 5-0 record in 13 appearances with the Rangers after being granted free agency by the New York Mets on July 7.

Nathan Eovaldi, a star of Texas’ 2023 run to the franchise’s first World Series championship, had his worst start of the year in what could have been his final home start with the Rangers. Eovaldi, who will be a free agent next season, allowed 11 hits (the most of his two seasons with Texas) and seven runs (tied for the most).

“I felt like early in the game they just had a few hits that found the holes, a few first-pitch base hits,” said Eovaldi, who is vested for a $20 million player option with Texas for 2025. “I think at the end of the day I just need to do a better job of executing my pitches.”

Eovaldi took a 7-3 lead into the fifth inning after the Rangers scored five unearned runs in the fourth. The Jays then scored four runs to knock out Eovaldi after 4 2/3 innings.

Six of the seven runs scored against Toronto starter Chris Bassitt in 3 2/3 innings were unearned. Bassitt had a throwing error during Texas’ two-run third inning.

“We didn’t help ourselves defensively, taking care of the ball to secure some outs,” Blue Jays manager John Schneider said.

The Blue Jays’ Vladimir Guerrero Jr. had a double and two singles, his most hits in a game since having four on Sept. 3. Guerrero is hitting .384 since the All-Star break.

TRAINER’S ROOM

Blue Jays: SS Bo Bichette (calf) was activated and played for the first time since July 19, going 2 for 5 with an RBI. … OF Daulton Varsho (shoulder) was placed on the 10-day injured list and will have rotator cuff surgery … INF Will Wagner (knee inflammation) was placed on the 60-day list.

UP NEXT

Rangers: LHP Chad Bradford (5-3, 3.97 ERA) will pitch Wednesday night’s game on extended five days’ rest after allowing career highs in hits (nine), runs (eight) and home runs (three) in 3 2/3 innings losing at Arizona on Sept. 14.

Blue Jays: RHP Bowden Francis (8-4, 3.50) has had two no-hitters get away in the ninth inning this season, including in his previous start against the New York Mets on Sept. 11. Francis is the first major-leaguer to have that happen since Rangers Hall of Famer Nolan Ryan in 1989.

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Billie Jean King set to earn another honor with the Congressional Gold Medal

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WASHINGTON (AP) — Billie Jean King will become the first individual female athlete to be awarded the Congressional Gold Medal.

Reps. Brian Fitzpatrick of Pennsylvania and Mikie Sherrill of New Jersey announced Tuesday that their bipartisan legislation had passed the House of Representatives and would be sent to President Joe Biden for his signature.

The bill to honor King, the tennis Hall of Famer and activist, had already passed unanimously in the Senate.

Sherrill, a Democrat, said in a statement that King’s “lifetime of advocacy and hard work changed the landscape for women and girls on the court, in the classroom, and the workplace.”

The bill was introduced last September on the 50th anniversary of King’s victory over Bobby Riggs in the “Battle of the Sexes,” still the most-watched tennis match of all-time. The medal, awarded by Congress for distinguished achievements and contributions to society, has previously been given to athletes including baseball players Jackie Robinson and Roberto Clemente, and golfers Jack Nicklaus, Byron Nelson and Arnold Palmer.

King had already been awarded the Presidential Medal of Freedom in 2009. Fitzpatrick, a Republican, says she has “broken barriers, led uncharted paths, and inspired countless people to stand proudly with courage and conviction in the fight for what is right.”

___

AP tennis:

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Account tweaks for young Instagram users ‘minimum’ expected by B.C., David Eby says

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SURREY, B.C. – Premier David Eby says new account control measures for young Instagram users introduced Tuesday by social media giant Meta are the “minimum” expected of tech companies to keep kids safe online.

The parent company of Instagram says users in Canada and elsewhere under 18 will have their accounts set to private by default starting Tuesday, restricting who can send messages, among other parental controls and settings.

Speaking at an unrelated event Tuesday, Eby says the province began talks with social media companies after threatening legislation that would put big tech companies on the hook for “significant potential damages” if they were found negligent in failing to keep kids safe from online predators.

Eby says the case of Carson Cleland, a 12-year-old from Prince George, B.C., who took his own life last year after being targeted by a predator on Snapchat, was “horrific and totally preventable.”

He says social media apps are “nothing special,” and should be held to the same child safety standards as anyone who operates a place that invites young people, whether it’s an amusement park, a playground or an online platform.

In a progress report released Tuesday about the province’s engagement with big tech companies including Google, Meta, TikTok, Spapchat and X, formerly known as Twitter, the provincial government says the companies are implementing changes, including a “trusted flagger” option to quickly remove intimate images.

— With files from The Associated Press

This report by The Canadian Press was first published Sept. 17, 2024

The Canadian Press. All rights reserved.



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