Cure for Baldness Could Be Linked to Hairy Moles, Study Finds | Canada News Media
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Cure for Baldness Could Be Linked to Hairy Moles, Study Finds

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Hair loss is a common issue, with baldness affecting an estimated 80 million people in the U.S. But despite how common it is, there is no cure for baldness…yet. Now, researchers think they may have found one.

A new study published in the journal Nature analyzed genetic mouse models of nevi (aka moles) and found that two molecules—osteopontin and CD44—are responsible for hair growth that can happen inside moles. These moles tend to have robust hair growth of long, thick hairs, the scientists pointed out.

Osteopontin “causes normally dormant and diminutive hair follicles to activate their stem cells for robust growth of long and thick hairs,” study co-author Maksim Plikus, Ph.D., a professor of developmental and cell biology at University of California, Irvine, said in a statement. “Senescent cells [which make up moles] are typically viewed as detrimental to regeneration and are thought to drive the aging process as they accumulate in tissues throughout the body, but our research clearly shows that cellular senescence has a positive side to it,” he adds.

The researchers also conducted mouse models where osteopontin or CD44 were removed from genes and found that the moles had significantly slower hair growth. (The also confirmed the impact of osteopontin on hair growth by analyzing samples of hairy moles collected from people.)

The researchers also suggested in the study that osteopontin could be needled into the scalp of people with hair loss to reawaken hair follicles that have gone dormant.

The researchers concluded in the study that their findings identify senescent cells as “an attractive therapeutic target in regenerative disorders.”

“Our decision to study this phenomenon stemmed from an intriguing observation in human hairy nevi, where we noticed an abundance of excessive hair growth emerging from hyperpigmented skin,” says lead study author Xiaojie Wang, Ph.D., a postdoctoral fellow at University of California, Irvine. “We set out to understand why hair growth tends to be more pronounced in dark skin and which specific genes play a role in regulating this process.”

Obviously, there’s a lot that needs to happen to bridge the gap between discovering that molecules found in hairy moles help grow long, thick hairs, and creating a cure for baldness, but dermatologists say the early findings are promising.

What do dermatologists think of the potential cure for baldness?

Dermatologists say the latest findings are promising. “Regenerative medicine is the wave of the future,” says Joshua Zeichner, M.D., director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City. “The use of stem cells and growth factors to stimulate natural activity of our skin has already been shown to fight the signs of aging.”

Hair thinning is a “significant concern for millions of Americans,” Dr. Zeichner points out. “While we have treatments that can help, none have yet proven to be the silver bullet,” he says. “The discovery that osteopontin induces hair growth could be a major breakthrough for those suffering from thinning hair.”

Gary Goldenberg, M.D., a board-certified dermatologist practicing in New York City, agrees. “Hair follicles are one of the few cells in the body that have stem cells. Activating of follicular stem cells could potentially help restore hair and increase the number of follicles in the scalp,” he explains. “In fact, some of the current modalities—platelet rich plasma, stem cells, or exosomes injections—try to activate and turn on follicular stem cells in order to grow new follicles.”

Dr. Goldenberg says the findings are “all very exciting and could give a real boost to patients with hair loss.”

“I find this new development regarding the role of osteopontin in hair growth quite intriguing,” says Ife J. Rodney, M.D., founding director of Eternal Dermatology Aesthetics and professor of dermatology at Howard University and George Washington University. “Until now, osteopontin was not recognized as a molecule associated with hair growth, so this study opens up new possibilities for potential hair loss treatments.”

While the findings are early, Dr. Rodney says they have big implications. “The fact that osteopontin, when injected or overexpressed, can induce robust hair growth in mice is promising,” she says. “It suggests that manipulating the levels of this molecule in the scalp could potentially stimulate dormant hair follicles and promote hair regrowth in individuals experiencing hair loss.”

But Dr. Zeichner says that there is a lot that needs to happen to see if this is a good treatment option for baldness. “The next step will be to see how well it works in a clinical setting, where it is actually used on the scalps of patients,” he says. “It’s always exciting to learn about the latest innovations, but there’s a difference between what works in the test tube and what actually works in humans.”

Dr. Zeichner says he’s “cautiously optimistic” about whether this will lead to a cure for baldness.

Wang says the research team plans to continue to study osteopontin and its impact on balding.

What causes hair loss?

There are several causes of hair loss. However, the most common form is hereditary hair loss, aka androgenic alopecia. Hereditary hair loss is inherited and causes hair follicles—which hair grows out of—to shrink and, eventually, to stop growing hair, per the American Academy of Dermatology (AAD).

This usually shows up as overall thinning or a widening part in women and a receding hairline or bald spot at the top of the head in men.

Other causes of hair loss include aging, alopecia areata (a disease that develops when the body’s immune system attacks hair follicles), cancer treatment, childbirth, and hairstyles that pull on your scalp, the AAD says.

What treatments are currently available for hair loss?

There is no cure for balding, but there are treatments available. Those can include over-the-counter options like minoxidil (Rogaine), red light therapy caps, and vitamin supplements, Dr. Zeichner says.

“I recommend the Revian red cap, which emits a dual wavelength of red and orange light to enhance production of nitric oxide and improve delivery of oxygen and nutrients to the hair follicles,” Dr. Zeichner says. “Supplements, like Nutrafol and Viviscal have become the leaders in the vitamin category, with significant clinical data supporting their use.”

You can also visit your dermatologist for in-office procedures, including platelet rich plasma therapy. “In this procedure, your own blood is drawn and processed, isolating growth factors which are injected into thinning hair follicles,” Dr. Zeichner says. “You can think of it like fertilizer for your hair follicles.”

Prescription medications like oral finasteride and oral minoxidil “are commonly used and effective,” Dr. Zeichner says.

If you’re experiencing hair loss and it bothers you, Dr. Goldenberg says it’s important to check in with a dermatologist. “Don’t wait. See your dermatologist right away,” he says. “Many of today’s treatments can slow down and even stop hair loss. But it’s a lot more difficult to regrow hair once it’s gone.”

Korin Miller is a freelance writer specializing in general wellness, sexual health and relationships, and lifestyle trends, with work appearing in Men’s Health, Women’s Health, Self, Glamour, and more. She has a master’s degree from American University, lives by the beach, and hopes to own a teacup pig and taco truck one day.

 

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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