Does microdosing magic mushrooms help people with mental health issues? Science is trying to find out | Canada News Media
Connect with us

Health

Does microdosing magic mushrooms help people with mental health issues? Science is trying to find out

Published

 on

WARNING: This story contains mentions of suicide

“Microdosing saved my life,” says Andrina Stan.

Stan, 35, works as an integrated therapist in Toronto and has struggled with her mental health at times. Stan says she believes it was psilocybin, the psychoactive ingredient found in magic mushrooms, that helped her turn her life around.

“In December 2020 I found myself in the middle of this living space, curled up in a ball,” she explains. “It was a very dark space. So I was contemplating suicide.”

Stan says she tried different therapies but nothing really helped until she found magic mushrooms — which are illegal to produce, possess and sell in Canada without special permission.

“I’m not sure that I would still be here if it weren’t for microdosing,” Stan says.

Andrina Stan said she believes microdosing psilocybin saved her life. ‘I’m not sure that I would still be here if it weren’t for microdosing.’ (Nick Purdon/CBC)

Stan has been microdosing psilocybin for three years.

She says she is aware that using that psilocybin can pose health risks, and deciding to microdose is not something she took lightly.

“I think that there’s a bit of a craze with psychedelics, and I know a lot of people, especially people my age, they just think it’s a fun thing to do,” she says. “I don’t see it as something that you should just pick up and try.”

What microdosing psilocybin allowed her to do, Stan says, is work through her issues. “It slowly brings that pain up so you can safely deal with it.”

Stan’s experience with microdosing psilocybin is a powerful anecdotal story, but what does the science say about the practice as a potential mental health treatment?

First clinical trial into microdosing psilocybin

Neuroscientist Rotem Petranker kneels in front of a safe in a nondescript medical building in midtown Toronto. He punches a code into the safe, opens it and takes out a bottle of pills. There’s a security camera attached to the wall nearby.

When your clinical trial involves an illegal substance like psilocybin, this is how the drugs are stored.

Through the University of Toronto, Petranker is leading the first clinical trial examining the effects of microdosing psilocybin on major depressive disorder.

And when your trial is the first of its kind in the world, there’s another kind of responsibility, Petranker says.

We’re taking it very seriously, because we are setting the foundation for what will hopefully be decades more of research,” he says.  “We need the foundation to be solid.”

Rotem Petranker, the director of the Canadian Centre for Psychedelic Science, holds a bottle of placebo pills used in the world’s first trial of microdosing psilocybin for major depressive disorder. The trial is being funded by the University of Toronto. (Nick Purdon/CBC)

There are 20 participants in Petranker’s eight-week trial, and each suffers from clinical depression. Once a week they either get a microdose of psilocybin or a placebo, and then Petranker and his team put them through a series of tests to determine if they experience an improvement in their mood.

Zeina Beidas, the lead research assistant, says microdosing is so trendy right now that many people in the general public simply believe it works.

“This is just a bunch of people with personal experiences that said, ‘Oh, yeah, this works for me,'” Beidas says. “So now everyone thinks microdosing helps with depression, but actually there’s no research, there’s no systematic controlled research.”

Due to the way the trial is structured, Petranker doesn’t know who is taking psilocybin and who was given a placebo. And while he doesn’t have any concrete findings yet, he has some initial observations.

“I’ve been seeing people getting better. A lot of people have gotten a lot better,” he says.

“Some people were having a hard time getting out of bed in the morning or even holding a job. And by the end of the trial, they no longer meet criteria for major depressive disorder. So that’s a very dramatic shift.”

Zeina Beidas is the lead research assistant on the clinical trial into microdosing psilocybin. She said microdosing is very trendy right now, even though there is no definitive science to prove it works. (Nick Purdon/CBC)

Still, Petranker cautions that people shouldn’t get too excited just yet.

It’s a small study over a short period of time, and it hasn’t been peer reviewed yet. Also, he explains because the trial dose is so low, many participants can’t tell if they’ve taken psilocybin or a placebo.

“And so because they don’t know what they’ve taken, but they come in with a lot of expectations and hopes, it’s possible that just because of those hopes and because they come into the lab and they feel like they’re doing something for themselves already, this affects their depression in very profound ways,” Petranker says.

“And so this might be the placebo effect in action.”

To know more definitively, Petranker says he would need to extend the clinical trial by six months and recruit 20 to 30 more participants. The trial has been funded by the University of Toronto, but Petranker says more funding would be needed to keep it going.

“This research is important, because people are already microdosing in droves,” Petranker says.

“So the science is far behind what the actual practices in real life are. It’s extremely important to see whether microdosing is effective and also whether microdosing is safe.”

Selling magic mushrooms

Even though there’s no hard scientific proof, some Canadians are buying into the practice of microdosing psilocybin anyway. Magic mushrooms are readily available on the internet and there are a growing number of bricks-and-mortar dispensaries in cities across the country.

Mush Luv is one of them. Its first store opened in April of 2023 in downtown Toronto. The company quickly expanded to two stores and plans to open a third.

Mush Luv has a “head of outreach,” but because the stores sell illegal products he uses an alias – Bezo West. There’s no single type of person who comes to the store looking to microdose magic mushrooms, West says.

“It goes from your regular, you know, construction worker, it could be a person in finance in the office,” he says. “It could be an elderly couple, maybe who just want to add a little bit of vibrancy to their day.”

Bezo West does public outreach for Mush Luv, a mushroom dispensary with two stores in Toronto. He says business is good and the company plans to open a third store soon. (Nick Purdon/CBC)

West says a lot of the demand is from people who say they are looking for help with their mental health problems.

“I have seen so many people, personally, come in being like, ‘Oh, I’m on antidepressants. I don’t want to be on this anymore, these aren’t working for me. I’d rather go get mushrooms instead of going to take antidepressants.”

The magic mushroom products Mush Luv sells are illegal in Canada. And while it hasn’t been raided, police have pressed charges at similar dispensaries across the country.

When asked if it worries him that he works in an illegal store, West smiles.

“I feel like I’m doing a little bit of God’s work,” he says. “Just helping people find a path to whatever helps with them. You know – it genuinely makes me feel happy.”

West doesn’t think psilocybin should be illegal. He says he believes that every Canadian should have the right to safe, equitable, regulated access to the drug.

“I genuinely think it’s going to go straight to where cannabis is. We’re right there in that process. So it’s very interesting times,” West says.

A serious warning

Dr. Ishrat Husain is a psychiatrist at the Centre for Addiction and Mental health in Toronto. He’s been studying psilocybin as a potential treatment for certain mental health conditions for several years.

He’s aware of how popular microdosing magic mushrooms has become – and how little science there is to back up the practice.

“There’s no evidence to support the benefits of microdosing,” he says.

Dr. Ishrat Husein is the lead investigator in a clinical trial commissioned by Health Canada to test whether psilocybin could be a viable treatment for some mental health conditions. He is also hoping to learn if psilocybin needs to induce a psychedelic trip to have therapeutic benefits. (Nick Purdon/CBC)

Dr. Husain says people should be careful if they get psilocybin online or at a dispensary, because he stresses it’s impossible to know where the mushrooms come from or how strong they might be.

“People who self-medicate with psychedelic drugs like psilocybin may in fact damage their mental health,” he warns.

“I work in the CAMH (Centre for Addiction and Mental Health) emergency department. Anecdotally, I see young people in particular coming in after using powerful hallucinogenic drugs like psilocybin, and leading to really, really negative mental health outcomes, like even a psychotic episode.”

Dr. Husain says his concerns extend to microdosing.

“Although theoretically the risk may be lower with lower doses of the drug, we just simply don’t know whether that’s the case, because there have been no studies in people with mental health problems taking microdoses of these substances.”

Andrina Stan, who graduated with a degree in psychology from the University of Toronto, continues to use psilocybin, but she urges others thinking of microdosing to do it safely.

“You should inform yourself. And you should definitely speak to professionals before, during and after. It’s not something to joke about or to do for fun.”


If you or someone you know is struggling, here’s where to get help:

 

Source link

Continue Reading

Health

Health Canada approves updated Moderna COVID-19 vaccine

Published

 on

 

TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

These people say they got listeria after drinking recalled plant-based milks

Published

 on

 

TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

Source link

Continue Reading

Health

B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

Published

 on

 

VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

Source link

Continue Reading

Trending

Exit mobile version