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Does microdosing magic mushrooms help people with mental health issues? Science is trying to find out

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WARNING: This story contains mentions of suicide

“Microdosing saved my life,” says Andrina Stan.

Stan, 35, works as an integrated therapist in Toronto and has struggled with her mental health at times. Stan says she believes it was psilocybin, the psychoactive ingredient found in magic mushrooms, that helped her turn her life around.

“In December 2020 I found myself in the middle of this living space, curled up in a ball,” she explains. “It was a very dark space. So I was contemplating suicide.”

Stan says she tried different therapies but nothing really helped until she found magic mushrooms — which are illegal to produce, possess and sell in Canada without special permission.

“I’m not sure that I would still be here if it weren’t for microdosing,” Stan says.

Andrina Stan said she believes microdosing psilocybin saved her life. ‘I’m not sure that I would still be here if it weren’t for microdosing.’ (Nick Purdon/CBC)

Stan has been microdosing psilocybin for three years.

She says she is aware that using that psilocybin can pose health risks, and deciding to microdose is not something she took lightly.

“I think that there’s a bit of a craze with psychedelics, and I know a lot of people, especially people my age, they just think it’s a fun thing to do,” she says. “I don’t see it as something that you should just pick up and try.”

What microdosing psilocybin allowed her to do, Stan says, is work through her issues. “It slowly brings that pain up so you can safely deal with it.”

Stan’s experience with microdosing psilocybin is a powerful anecdotal story, but what does the science say about the practice as a potential mental health treatment?

First clinical trial into microdosing psilocybin

Neuroscientist Rotem Petranker kneels in front of a safe in a nondescript medical building in midtown Toronto. He punches a code into the safe, opens it and takes out a bottle of pills. There’s a security camera attached to the wall nearby.

When your clinical trial involves an illegal substance like psilocybin, this is how the drugs are stored.

Through the University of Toronto, Petranker is leading the first clinical trial examining the effects of microdosing psilocybin on major depressive disorder.

And when your trial is the first of its kind in the world, there’s another kind of responsibility, Petranker says.

We’re taking it very seriously, because we are setting the foundation for what will hopefully be decades more of research,” he says.  “We need the foundation to be solid.”

Rotem Petranker, the director of the Canadian Centre for Psychedelic Science, holds a bottle of placebo pills used in the world’s first trial of microdosing psilocybin for major depressive disorder. The trial is being funded by the University of Toronto. (Nick Purdon/CBC)

There are 20 participants in Petranker’s eight-week trial, and each suffers from clinical depression. Once a week they either get a microdose of psilocybin or a placebo, and then Petranker and his team put them through a series of tests to determine if they experience an improvement in their mood.

Zeina Beidas, the lead research assistant, says microdosing is so trendy right now that many people in the general public simply believe it works.

“This is just a bunch of people with personal experiences that said, ‘Oh, yeah, this works for me,'” Beidas says. “So now everyone thinks microdosing helps with depression, but actually there’s no research, there’s no systematic controlled research.”

Due to the way the trial is structured, Petranker doesn’t know who is taking psilocybin and who was given a placebo. And while he doesn’t have any concrete findings yet, he has some initial observations.

“I’ve been seeing people getting better. A lot of people have gotten a lot better,” he says.

“Some people were having a hard time getting out of bed in the morning or even holding a job. And by the end of the trial, they no longer meet criteria for major depressive disorder. So that’s a very dramatic shift.”

Zeina Beidas is the lead research assistant on the clinical trial into microdosing psilocybin. She said microdosing is very trendy right now, even though there is no definitive science to prove it works. (Nick Purdon/CBC)

Still, Petranker cautions that people shouldn’t get too excited just yet.

It’s a small study over a short period of time, and it hasn’t been peer reviewed yet. Also, he explains because the trial dose is so low, many participants can’t tell if they’ve taken psilocybin or a placebo.

“And so because they don’t know what they’ve taken, but they come in with a lot of expectations and hopes, it’s possible that just because of those hopes and because they come into the lab and they feel like they’re doing something for themselves already, this affects their depression in very profound ways,” Petranker says.

“And so this might be the placebo effect in action.”

To know more definitively, Petranker says he would need to extend the clinical trial by six months and recruit 20 to 30 more participants. The trial has been funded by the University of Toronto, but Petranker says more funding would be needed to keep it going.

“This research is important, because people are already microdosing in droves,” Petranker says.

“So the science is far behind what the actual practices in real life are. It’s extremely important to see whether microdosing is effective and also whether microdosing is safe.”

Selling magic mushrooms

Even though there’s no hard scientific proof, some Canadians are buying into the practice of microdosing psilocybin anyway. Magic mushrooms are readily available on the internet and there are a growing number of bricks-and-mortar dispensaries in cities across the country.

Mush Luv is one of them. Its first store opened in April of 2023 in downtown Toronto. The company quickly expanded to two stores and plans to open a third.

Mush Luv has a “head of outreach,” but because the stores sell illegal products he uses an alias – Bezo West. There’s no single type of person who comes to the store looking to microdose magic mushrooms, West says.

“It goes from your regular, you know, construction worker, it could be a person in finance in the office,” he says. “It could be an elderly couple, maybe who just want to add a little bit of vibrancy to their day.”

Bezo West does public outreach for Mush Luv, a mushroom dispensary with two stores in Toronto. He says business is good and the company plans to open a third store soon. (Nick Purdon/CBC)

West says a lot of the demand is from people who say they are looking for help with their mental health problems.

“I have seen so many people, personally, come in being like, ‘Oh, I’m on antidepressants. I don’t want to be on this anymore, these aren’t working for me. I’d rather go get mushrooms instead of going to take antidepressants.”

The magic mushroom products Mush Luv sells are illegal in Canada. And while it hasn’t been raided, police have pressed charges at similar dispensaries across the country.

When asked if it worries him that he works in an illegal store, West smiles.

“I feel like I’m doing a little bit of God’s work,” he says. “Just helping people find a path to whatever helps with them. You know – it genuinely makes me feel happy.”

West doesn’t think psilocybin should be illegal. He says he believes that every Canadian should have the right to safe, equitable, regulated access to the drug.

“I genuinely think it’s going to go straight to where cannabis is. We’re right there in that process. So it’s very interesting times,” West says.

A serious warning

Dr. Ishrat Husain is a psychiatrist at the Centre for Addiction and Mental health in Toronto. He’s been studying psilocybin as a potential treatment for certain mental health conditions for several years.

He’s aware of how popular microdosing magic mushrooms has become – and how little science there is to back up the practice.

“There’s no evidence to support the benefits of microdosing,” he says.

Dr. Ishrat Husein is the lead investigator in a clinical trial commissioned by Health Canada to test whether psilocybin could be a viable treatment for some mental health conditions. He is also hoping to learn if psilocybin needs to induce a psychedelic trip to have therapeutic benefits. (Nick Purdon/CBC)

Dr. Husain says people should be careful if they get psilocybin online or at a dispensary, because he stresses it’s impossible to know where the mushrooms come from or how strong they might be.

“People who self-medicate with psychedelic drugs like psilocybin may in fact damage their mental health,” he warns.

“I work in the CAMH (Centre for Addiction and Mental Health) emergency department. Anecdotally, I see young people in particular coming in after using powerful hallucinogenic drugs like psilocybin, and leading to really, really negative mental health outcomes, like even a psychotic episode.”

Dr. Husain says his concerns extend to microdosing.

“Although theoretically the risk may be lower with lower doses of the drug, we just simply don’t know whether that’s the case, because there have been no studies in people with mental health problems taking microdoses of these substances.”

Andrina Stan, who graduated with a degree in psychology from the University of Toronto, continues to use psilocybin, but she urges others thinking of microdosing to do it safely.

“You should inform yourself. And you should definitely speak to professionals before, during and after. It’s not something to joke about or to do for fun.”


If you or someone you know is struggling, here’s where to get help:

 

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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