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‘Don’t bring this upon yourself’: Toronto COVID-19 survivor’s message to unvaccinated individuals – Global News

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As Mary Dalianis reflects on the last five months, including the devastating loss of her mother, the COVID-19 survivor becomes overwhelmed with emotion.

“I’m not going to break down and cry, I promised myself, but I hate to have lost her that way due to COVID-19 because my mom was medically stable. She had her challenges, but she didn’t have to die that way,” said Dalianis, wiping tears from her eyes.

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The family contracted COVID-19 in March, possibly from a local supermarket, though the exact point of exposure is unconfirmed.

Dalianis’ mother was about to be vaccinated when she became ill, though she herself was not yet eligible.

Read more:
Toronto COVID-19 survivor says ‘dying alone’ was her greatest fear

“Unfortunately she went into the hospital before thenmy mom had a very high fever, she would lose her balance, she would fall so the ambulance was called. Then two days later, I went with the same high fever. I couldn’t walk. I couldn’t talk. I had pneumonia in the beginning. But they later diagnosed me as well with COVID-19,” recalled Dalianis.

Her own symptoms worsened quickly and she was intubated in the ICU at Toronto Western Hospital.

“I believe I was getting maximum oxygen. I had sepsis, I had lung abscesses, necrotizing pneumonia, which is the worst kind of pneumonia you can get, a pulmonary embolism … And I had clots in my legs,” she said.

While attached to a ventilator, Dalianis was unaware her mother had died of the virus.

“My aunt came up and told me that my mom passed away and I was shocked. I don’t remember anything in ICU, only going under, that’s it,” she said.

Read more:
‘I’m scared’: Toronto COVID-19 survivor who defied odds updates recovery, expresses fear

The hardest part of the five-month long ordeal, said Dalianis, was not getting the opportunity to say goodbye to her mother.

“The hardest news I ever had to receive was the death of my mom. She was a very special lady, very special lady,” she said.

After being released from hospital, Dalianis spent weeks at Bridgepoint Health undergoing intensive rehabilitation to learn to walk and talk again.

Just last month, she was finally able to return home.

They worked hard with me and I was able to walk within a month and a half. I gained back my mobility, my brain, walking, talking — doing everything I did before in life a little slower, but I’m much better now and getting stronger each day,” she said.

Read more:
‘I’ll live to see another day’: COVID-19 survivor describes effects of virus 8 months later

As Ontarians get ready to show proof of vaccination to enter certain businesses and public spaces, Dalianis said she is hopeful more people who have yet to get the vaccine will now access it.

She herself is double vaccinated.

“I urge you from the bottom of my heart, [as] someone who has suffered a great loss, my mom, and I regained my health, please do not go through what I did,” said Dalianis.

“I went through a lot of heartache, pain and emotional trauma. Don’t bring this upon yourself. Get vaccinated.”

Dalianis credited Dr. Abdu Sharkawy, infectious diseases specialist at the University Health Network, with saving her life.

“He’s my hero because he fought along with my friends in ICU … they fought hard and through the grace of God, they saved me,” she said.

Read more:
‘Miraculous’: Ontario man’s COVID-19 recovery inspires health-care workers

“I remember the first time I laid eyes on her, I thought, ‘Oh, my goodness,’ what she had gone through being so sick in the intensive care unit, how serious the complications were with respect to her COVID pneumonia, the clots that she endured afterwards, the sepsis and the serious life-threatening organ dysfunction that she went through, and she looked like she should have really been left for dead,” recalled Sharkawy.

He said he was amazed when suddenly one day “she just came to life.”

“She literally started talking and started smiling and started interacting and engaging,” he said, adding, “this is the reason we practice medicine, is to be able to see people emerge from the depths of despair and medical distress and to rise above it and to show us the resilience and strength and really the grace and humility that it takes to get through these difficulties.”

Sharkawy said he hopes people hear Dalianis’ message and heed the warning.

“COVID-19 isn’t going away. The pandemic might end very soon, hopefully, but the disease isn’t going away entirely,” Sharkawy said.

“We’ve got to do whatever we can to continue to spread a message that’s going to keep people safe, prevent them from being unnecessarily exposed, or if they’re exposed, immunized and vaccinated so that they can defend themselves and keep themselves and the rest of their communities healthy.”

© 2021 Global News, a division of Corus Entertainment Inc.

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Aaron Sluchinski adds Kyle Doering to lineup for next season – The Grand Slam of Curling

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Aaron Sluchinski’s team announced Wednesday on social media that Kyle Doering has joined the club for next season.

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Sluchinski was searching for a new player after second Kerr Drummond stepped back from competitive curling late last month. The Airdrie, Alta., team also includes third Jeremy Harty and lead Dylan Webster.

Sluchinski had a breakout season, winning the Boston Pizza Cup to represent Alberta at the Montana’s Brier for the first time and also competed in three Grand Slam of Curling events. The team finished 16th in the world rankings and seventh among Canadian clubs.

Doering has spent the past two years playing with Edmonton’s Karsten Sturmay and was also on the lookout for a new squad after his skip announced his departure from competitive curling.

Winnipegger Doering earned a silver medal at the world men’s curling championship earlier this month as the alternate on Team Canada, skipped by Brad Gushue.

Doering captured the Canadian junior title and a world junior bronze medal in 2016 playing with skip Matt Dunstone.

The Canadian men’s curling landscape has seen several shifts in recent days. Brendan Bottcher’s teammates announced Tuesday they were looking for a new skip and Reid Carruthers’ team revealed Wednesday it has parted ways with skip Brad Jacobs.

Skip Glenn Howard also announced his retirement Tuesday.

Meanwhile, skip John Epping unveiled his new team last week, featuring third Tanner Horgan, second Jacob Horgan and lead Ian McMillan.

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New EV features for Google Maps have arrived. Here’s how to use them. – The Washington Post

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Google has announced new features in its Maps app designed to help electric car drivers find a charge.

The updates include a tool to help drivers find nearby chargers with real-time information about availability and charging speed, the ability to find charging stops on longer road trips and more detailed instructions about how to find chargers within parking lots and garages.

Google expects to start rolling out these features “in the coming months,” according to a blog post. Some will come first to people who drive a car that comes with “Google Built-in,” the company’s driver-assistance software. Google updated its other route-finding app, Waze, with information on EV chargers last month.

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The update addresses one of Americans’ top concerns about owning an electric vehicle: finding a place to charge. Range anxiety remains a significant barrier for EV sales — especially for drivers who don’t own a house. Among people who don’t drive an EV, roughly half say they think finding a place to charge would be “extremely” or “very” difficult, according to a 2023 Washington Post-University of Maryland poll.

EVs make up roughly 7 percent of new U.S. car sales, which some experts believe is a tipping point at which electric cars will quickly become popular and take over the market. But lately, the EV market appears to be cooling off. Sales slowed in the first quarter of this year.

In addition to building more charging stations, companies can make driving an EV easier by building apps that help drivers find chargers, said Stephanie Valdez Streaty, director of Industry Insights at Cox Automotive. “That could be really helpful with mitigating some of those concerns about charging anxiety,” she said.

Find available EV charging stations

For electric-car drivers who need a last-minute charge, Google is developing a feature that can find nearby chargers with updated information about how many ports are available and their charging speed. The company says this feature will eventually be available to all drivers but will be available first for drivers with Google Built-in.

Plan a road trip with EV charging stops

The Maps update will allow EV owners with Google Built-in to plan where they can power up when taking long trips with multiple stops, such as a cross-country road trip. The feature will access information about your car’s battery life to suggest the best places to charge up.

The company also announced a search feature that allows travelers to look for hotels with electric car chargers.

Locate hard-to-find EV charging stations

Some EV chargers are tucked in hard-to-find corners of parking garages. The Maps update will crowdsource information from Google reviewers to generate more detailed instructions about how to get to a charger. According to the company’s blog post, the instructions might read something like, “Enter the underground parking lot and follow the signs toward the exit. Just before exiting, turn right.”

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Cytiva Showcases Single-Use Mixing System at INTERPHEX 2024 – BioPharm International

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The Xcellerex magnetic mixer, single-use mixing system was designed to address challenges in large-scale mAb, vaccine, and genomic medicine manufacturing processes.

Cytiva unveiled the Xcellerex single-use magnetic mixer at INTERPHEX 2024 in New York City on April 16, 2024. The single-use mixing system was designed to combat challenges in large-scale monoclonal antibody (mAb), vaccine, and genomic medicine manufacturing processes. The mixer is offered in 2000 L and 3000 L capacities and can be configured in several ways to accommodate diverse mixing processes. Its compact size benefits facilities with space constraints or complicated installation of large-scale consumables.

According to the company, minor leaks may cause significant delays and losses. “When dealing with a 3000 L batch of cell culture media, the estimated financial loss can cost between $60k to upwards of $100k” (1). The system helps prevent expensive leaks with a novel mixer biocontainer that incorporates user-centered design elements to improve durability and ease of use. The design provides enhanced safeguards and added protection from leaks that may occur during shipping, storage, and operation.

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Time taken to mix batches can inhibit product development times, specifically the challenge of mixing floating powders such as cell culture media. Current systems have underpowered impellers with circular or cubical shapes that make producing large volumes challenging, according to Cytiva. This new single-use system “has a powerful impeller that when combined with the mixer’s hexagonal shape creates a vortex, enhancing the interaction at the liquid surface. This vortex effectively pulls down the floating powders into the main body of the liquid to allow for a more efficient and shorter mixing process,” the company stated in a press release.

“We’re tapping into our differentiated portfolio to solve a wide range of challenges for our customers. Our new magnetic mixing system is flexible and capable of meeting the many demands and constraints during buffer and cell culture media preparation,” said Amanda Halford, president, Bioprocess at Cytiva in the release. “By reimagining the design, we’ve tackled some of the biggest obstacles to downtime.”

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Cytiva is also working to advance messenger RNA (mRNA) manufacturing. In an interview with Pharmaceutical Technology EuropeTM , Scott Ripley, general manager, Nucleic Acid Therapeutics and Precision Nanosystems at Cytiva, discussed technology that enables the “democratization” of mRNA manufacturing (2). Many mRNA therapies and other types of genetic medicines in clinical development are designed to be delivered with the help of lipid nanoparticles. One such platform is Cytiva’s Precision Nanosystems NanoAssemblr microfluidic-based nanoparticle manufacturing platform, which enables the development of genetic medicines with potentially increased stability, efficacy, yield, and quality of non-viral genetic medicines, according to Ripley.

Ripley was enthusiastic about this platform’s ability to “democratize” the good manufacturing practice (GMP) manufacturing aspects for advanced therapies, while managing to cope with the increased molecular diversity of the molecules being handled.

“For example,” Ripley says, “the mRNA platform is unique in that, on one end of the spectrum, it is vaccinating the planet, on the other end, it’s personalized cancer vaccines.”

Reference

1. Cytiva. Cytiva Unveils Latest Innovation for Large Scale Mab, Vaccine, and Advanced Therapy Manufacturing Processes–The Xcellerex Compact Single-Use Magnetic Mixing System. Press Release. April 16, 2024.
2. Spivey, C. Democratizing GMP Manufacturing for the New Therapeutic Pipeline. PharmTech.com. Nov. 21, 2023.

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