Health
FDA Approved Drugs Show Promise Against COVID-19 – WebMD
TUESDAY, March 24, 2020 (HealthDay News) — Two new studies each suggest that dozens of drugs already approved for use in the United States may prove effective against the new coronavirus.
“Repurposing these FDA-approved drugs could be a fast way to get treatment to patients who otherwise have no option,” explained the co-author of one of the studies, Dr. Hesham Sadek. He’s professor in the departments of internal medicine, molecular biology and biophysics at UT Southwestern Medical Center, in Houston.
However, experts stressed that this research is still in its early stages, so people shouldn’t try any of the drugs now to prevent or treat COVID-19.
Right now, “there is no specific medicine recommended to prevent or treat the new coronavirus,” according to the World Health Organization (WHO). “Some specific treatments are under investigation, and will be tested through clinical trials,” the WHO said, according to the Washington Post.
As COVID-19, the illness caused by the new coronavirus, sickens hundreds of thousands worldwide, the race is on to find a drug that might help save severely ill patients.
But even with rapid government approval, it could take months to develop new drugs from scratch that might be effective against the virus, Sadek explained in a UT Southwestern news release.
That led his team to conduct computer modeling studies on certain drugs already approved by the U.S. Food and Drug Administration, to assess their potential in combating the coronavirus.
The results showed that the most promising drugs included several antiviral drugs — including Darunavir, Nelfinavir, and Saquinavir — and several other types of drugs, including: the ACE inhibitor Moexipril; the chemotherapy drugs Daunorubicin and Mitoxantrone; the painkiller Metamizole; the antihistamine Bepotastine; and the antimalarial drug Atovaquone.
Another promising candidate is the cholesterol-lowering statin rosuvastatin, which is sold under the brand name Crestor. It’s already taken by millions of patients around the world to lower their cholesterol, is safe, inexpensive and readily available, Sadek noted.
The results were published March 19 on a pre-print server called ChemRxiv; they have not yet been subject to peer review.
Health
RCMP warn about benzodiazepine-laced fentanyl tied to overdose in Alberta – Edmonton Journal
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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.
The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.
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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.
The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.
Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”
From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.
Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.
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Health
CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture
The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.
Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.
The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.
Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.
As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.
This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.
Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.
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Health
Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star
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Canada has seen a concerning rise in measles cases in the first months of 2024.
By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.
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