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Feeling vexed by long COVID? Treatment may soon be available – North Shore News

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Grace Parraga’s phone has been ringing off the hook since Tuesday with calls from long COVID patients from across Canada, the U.S. and the U.K. 

Parraga is the lead researcher of a new study that’s identified a minuscule abnormality in the lungs of long COVID patients that can contribute to the prolonged breathing difficulty they may experience post-infection.

Following the announcement of their findings, Parraga said people have been reaching out to her, excitedly seeking further clarification on their long COVID symptoms. Parraga, a professor at Western University’s Schulich School of Medicine and Dentistry and Tier 1 Canada Research Chair in Lung Imaging, said the response has been very humbling.

“We do this as scientists with the hope of helping people,” she said.

Human lungs, the organ under examination in this research, pack 2,400 kilometres of airways within them, Parraga explained. Stretched out across Canada, those airways would be long enough to start in Vancouver and reach all the way to Thunder Bay.

“That’s what’s packed inside of you to allow you to live,” Parraga said.

At the end of those airways are 500 million air sacs. When you inhale, oxygen moves into those tiny air sacs and hops onto your red blood cells. As you exhale, carbon dioxide hops off of those cells and is sent out of your body.

Using a very high spatial resolution MRI method, the research team was able to measure the function at the tip of those 500 million air sacs.

What they found, is an abnormally low red blood cell signal in the lungs of these long COVID patients that’s affecting their ability to breathe.

Parraga said it’s likely the lungs’ blood vessel tree is blocked by tiny, microscopic clots.

“That’s something that you can’t see with chest X-rays or CT scans, or any other method,” she said.

The study was conducted at five centres across Ontario that house this specific MRI technology and observed 34 long COVID patients.

Parraga said her team is now focusing on translating their work to other centres across Canada that also have this technology, such as BC Children’s Hospital and St. Paul’s Hospital in Vancouver.

Long-awaited evidence

Until now, Parraga said long COVID has been a vexing infection to have. Standard clinical tests are unable to pick up on this tiny piece of evidence that indicates something is wrong.

“Folks [with long COVID] look normal. The chest X-ray looks normal, the CT scan looks normal,” she said. 

“This is the first evidence that something is not normal.”

The study’s findings serve as a relief, Parraga said. As researchers, she said it’s encouraging to find something that they understand and is consistent with their previous understanding of lung infections.

“If you’re not feeling well, you can’t walk to the mailbox and think straight, you do start to wonder if it’s in your head,” she said. “I think that physicians were concerned and that really started us on this hunt.”

Parraga said she thinks the study is providing people with hope, knowing that this abnormality is something physicians can understand and treat.

Next steps: treatment

The discovery is only the first step in the journey to treating long COVID patients experiencing difficulty breathing. Following the release of the study, Parraga said her focus is now shifting to determine the why and how factors of the infection.

“We’ve identified the what, the where, and the when. [Now], the clinical folks are going to be using that information to target treatments,” she said.

Parraga said she plans to continue following the study’s participants “for as long as they want to come to the lab.” With their participation, she hopes to answer questions such as why certain people are susceptible to long COVID and what’s going to happen to these patients in the long term. 

In the meantime, Parraga and her team are taking a moment to reflect upon their success in a unique way, after sharing their results with the study’s participants.

“We created a word cloud from their emails back to us… [with] words like understanding, thank you, congratulations, thoughtful,” she said. “It was very humbling and fulfilling to see that.”

“That’s why we do this. To help people.”

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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