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Gut Microbiome Changes May Warn of Colorectal Cancer – Everyday Health

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People who go on to develop precancerous colon polyps have significant variations in the type and diversity of bacteria in their gut microbiome compared with healthy people, according to new research presented at UEG Week 2023, the annual conference of United European Gastroenterology.

These changes can be detected before the polyps become colorectal cancer, says lead author Ranko Gacesa, PhD, researcher and professor at University Medical Center in Groningen, Netherlands. “If these findings are confirmed, this means that looking at the gut microbiota could improve on current noninvasive fecal tests used to detect and prevent colorectal polyps and cancer,” he says.

How Does This Study Build on Earlier Research?

Prior research has found that certain strains of bacteria and the compounds those bacteria make inside the gut are associated with higher or lower risks of colorectal cancer, according to the American Institute for Cancer Research. But which comes first — that is, whether microbiome changes alter the course of the cancer or if the cancer results in microbiome changes — isn’t completely understood.

Lower Gut Diversity Linked With Precancerous Polyps

To investigate the connection between different bacteria found in the gut and precancerous colon polyps, researchers linked data from over 8,000 participants from the Dutch Microbiome Project with the Dutch nationwide pathology database to identify all recorded cases of colonic biopsies from the last 50 years.

Researchers analyzed the gut microbiomes of people who developed precancerous colorectal lesions before fecal sampling between 2000 and 2015 (214 people), as well as those who developed lesions after fecal sampling between 2015 and 2022 (305 people). Then they compared those gut microbiome findings with the microbiomes of people with normal colonoscopy findings (202 people) and the general population.

Investigators found that individuals with precancerous lesions had reduced gut bacteria diversity compared with healthy individuals.

It’s Still Unclear Why Certain People Have ‘Bad’ Microbes in the Gut

These findings make sense given that, in general, higher microbiome diversity is generally considered to be an indicator of “good” gut health and lower diversity as less desirable, says Dr. Gacesca. “This is based on studies which identified that patients with certain diseases such as inflammatory bowel disease [IBD] have reduced microbiome diversity in the gut,” he says.

Colorectal Polyps Typically Take 5 to 10 Years to Develop

The large number of subjects in the study and the lengthy follow up — researchers were able to follow participants for decades — are both important strengths of this study, says Suneel Kamath, MD, a hematologist and medical oncologist and assistant professor of medicine at Cleveland Clinic in Ohio, who was not involved in the research.

“Following participants for a relatively long period is especially important with colorectal cancer studies because it’s often a 5- to 10-year process to go from a normal colon to a polyp forming, and then forming cancer, and so you really need a pretty substantial period of follow up,” he says.

Bacterial Species Associated With Potential Risk of Colorectal Cancer

“It is known from previous studies that some of the species we identified are linked to the development of colorectal lesions that are potentially genotoxic,” says Gacesca, meaning they cause mutations in cells which may lead to cancer. “For example, Bacteroides fragilis is known to produce toxin which can contribute to chronic low-grade inflammation, and chronic gut inflammation is likely to be genotoxic/carcinogenic,” he adds.

“Another example is Akkermensia species which can degrade gut mucus and thus reduce the capability of the organism to defend against pathogens, again leading to chronic inflammation and potentially cancer,” he says.

Additionally, the analysis found that the bacterial species from the family Lachnospiracea and the genera Roseburia and Eubacterium were linked with the future development of lesions.

But researchers still don’t know why certain people have these “bad” microbes in their guts, says Gacesca. “And there is no clear consensus on the effectiveness of microbiome-altering therapies,” he adds.

Could Probiotics and Prebiotics Help Prevent Colorectal Cancer?

If confirmed, these findings could be used to help point the way to microbiome-targeted therapies, such as fecal microbiome transplants and probiotics and prebiotics. “This would require extensive testing to demonstrate that such probiotics have expected effect,” says Gacesca.

The work of creating these therapies is ongoing, and it is likely we will see advances in the near to mid-term future.

“What’s challenging in the field right now is that which bacteria end up being significant — or not significant — can really vary a lot across different studies. One in particular, Fusobacterium nucleatum, which is a bacterium that exists in the mouth, has been associated with increased risk of a lot of different cancers, including colorectal cancer. I was a little surprised to see that it wasn’t called out specifically in this study,” says Dr. Kamath.

A paper on the growing evidence for a link between Fusobacterium nucleatum and colorectal cancer risk was published in the November 2022 issue of Frontiers in Cellular and Infection Microbiology.

The finding that Roseburia was associated with the development of precancerous polyps was also surprising, says Kamath. “It’s been linked to helping with blood sugar control and weight loss and so it’s often associated with positive factors,” he says.

These conflicting findings highlight the relative newness of so much research on the microbiome and its role in cancer. It is a burgeoning field, says Kamath. “We need a lot more studies to really prove what’s truly going on here,” he adds.

Colorectal Cancer the Third Most Common Cancer

Not including skin cancers, colorectal cancer is the third most common cancer in both men and women in the United States, according to the American Cancer Society. It’s estimated that there will be more than 150,000 new cases of colon and rectal cancers in the United States this year.

It’s recommended that people who are at average risk start regular screening at age 45, either with a stool-based test or a visual exam such as a colonoscopy or virtual colonoscopy.

Risk factors for colorectal cancer include age, heath history, and genetic vulnerabilities, as well as lifestyle-related factors including having overweight or obesity, lack of physical activity, a diet high in processed meats and red meat, smoking, and heavy alcohol use, per the society.

Should You Seek Out Probiotics to Prevent Colorectal Cancer?

Right now, there isn’t enough solid evidence to recommend certain probiotics to reduce the risk of colorectal cancer, says Kamath.

He suggests focusing on known risk factors such as achieving and maintaining a healthy weight. “In the United States, the lack of microbial diversity and poor gut health is driven by overweight and obesity. As we continue to get more data on colorectal cancer concern, that’s increasingly the most concerning risk factor,” he says.

He recommends the Mediterranean diet to his patients who want to reduce their risk. “I’m a big fan of that way of eating, focusing on lean meats, fatty fish, beans, legumes, nuts, fresh fruit, and leafy green vegetables, and limiting processed foods,” he says.

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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