Halifax lab team to conduct first Canadian trials for possible COVID-19 vaccine - Terrace Standard | Canada News Media
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Halifax lab team to conduct first Canadian trials for possible COVID-19 vaccine – Terrace Standard

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The first Canadian clinical trials for a possible COVID-19 vaccine will be conducted by a Halifax research team that also was involved in trials that eventually led to a vaccine for the Ebola virus.

Health Canada has approved trials that will be conducted at the Canadian Centre for Vaccinology at Dalhousie University.

The centre’s director, Dr. Scott Halperin, says the lab was one of several in Canada and the U.S. whose work starting in 2014 eventually saw an “emergency release” of an Ebola vaccine that was used in West Africa before a third phase of clinical trials had been completed.

Halperin said each lab did slightly different studies in order to get the right type of information before quickly moving to the second phase and then the third.

“The Phase 1 studies were done and within six months the data were available and the phase three studies were started in West Africa which then helped to actually stop the epidemic,” he said in an interview.

Halperin said it’s possible the same emergency release could happen in Canada with a potential COVID-19 vaccine if it shows potential and is deemed safe, expediting a process that usually takes a number of years to complete — anywhere from five to seven years under normal circumstances.

“That would be something that Health Canada and the Canadian government would have to decide whether they wanted to do that. But it is certainly one of the options in the tool kit of things they can do to expedite the process if this or any other vaccine is looking promising.”

READ MORE: First clinical trial for potential COVID-19 vaccine in Canada approved: Trudeau

Halperin pointed out that despite its early use during testing, the Ebola vaccine wasn’t actually licensed as a regular marketed vaccine until late last year.

However, he cautions there’s much work to be done before a COVID-19 vaccine could be approved for use.

The Halifax researchers will be following up work by Chinese manufacturer CanSino Biologics, which is already conducting human clinical trials for the vaccine.

Halperin said the first phase trial should be underway within the next three weeks once final approval is given by the centre’s research ethics board.

Phase 1 will involve fewer than 100 healthy volunteers between the ages of 18 and 55 who will be followed over the next six months.

“We want to make sure that the vaccine is safe first in younger individuals before we go into people who may be at higher risk,” Halperin said.

The participants are given a dose of the vaccine and are clinically monitored through a series of blood tests. They are also asked to record their symptoms in a diary so the researchers can have even more information.

“We collect any type of symptoms they might have whether they think it’s related to the vaccine or not,” said Halperin.

Each participant will make between nine and 13 visits to the centre during the first phase of the study.

If the initial test group shows a safe immune response to the vaccine, Halperin said researchers will quickly transition into an expanded second phase study before the first phase is even completed.

That would involve hundreds of people of all ages, including those aged 65 to 85, and would be administered by several other research centres across the country that are part of the Canadian Immunization Research Network.

Halperin said the network was set up by the federal government in 2009 as part of the response to the H1N1 pandemic. He said the intent was to create the necessary infrastructure to respond rapidly to an emergency and to do early phase clinical trials so vaccines would be available in Canada.

“This is a good test of that (network),” Halperin said of clinical trials that will be the first of “many more to come.”

Keith Doucette, The Canadian Press


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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

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