TORONTO —
A Saskatchewan-developed COVID-19 vaccine candidate is the latest to be approved for human trials in Canada, and could be ready by the end of 2021, its backers say.
The vaccine candidate is one of two being developed by the Vaccine and Infectious Disease Organization (VIDO) at the University of Saskatchewan.
VIDO reported Tuesday that it has received authorization from Health Canada to begin a Phase 1 clinical trial through the Canadian Center for Vaccinology in Halifax.
Participants will be recruited shortly, VIDO said, with vaccinations starting in January. Volker Gerdts, director and CEO of VIDO, said in a statement that if the three-phase trials prove successful, VIDO’s vaccine candidate could be ready for use by late 2021.
Both of VIDO’s potential vaccines are what are known as protein subunit vaccines, meaning they are created out of specific parts of a dead germ, rather than a live virus or an entire dead germ. Subunit vaccines are often used to protect against hepatitis B, human papillomavirus, whooping cough and shingles, among other viruses and diseases.
Most of the leading vaccines in the race to stop COVID-19 are based on either viral vector or RNA technology. However, VIDO is not alone in developing a subunit vaccine. According to the World Health Organization, 18 of the 61 vaccine candidates that have reached the clinical trial stage are based on protein subunits – including the ones developed by Novavax and Sanofi, for which Canada has reserved 76 million doses and 72 million doses respectively.
Subunit vaccines are typically much simpler to mass-produce than RNA or viral vector vaccines, and do not require ultra-cold storage.
While dozens of potential treatments to mitigate or negate the effects of COVID-19 are in the midst of clinical trials in Canada, only a handful of vaccine candidates have been approved for trials.
In addition to the new VIDO trial, the list includes a vaccine candidate from Quebec-City based Medicago, which entered a combined Phase 2 and 3 trial this month after reporting successful results in early testing. The company said its vaccine candidate, which is unusual in that it is derived from “virus-like particles” found in plants, provoked an antibody response in 100 per cent of the trial subjects.
Toronto’s University Health Network is currently recruiting front-line workers in Ontario to test a potential COVID-19 vaccine that is also the subject of ongoing trials in Australia, Germany, the United Kingdom and the Netherlands. Rounding out the list is CanSino’s Ad5-nCoV, which was approved in the spring to much fanfare but has been at a standstill since, because the promised shipments of the vaccine candidate from China never materialized.
Gerdts, who is leading the development of VIDO’s vaccine candidate, said it is important for the ongoing trials to continue, even though some vaccines developed outside Canada are closer to approval – and in the case of Pfizer’s vaccine, have already been approved here.
“COVID-19 is not going to go away,” he said.
“To have sustainable long-term vaccine access, I think it’s important for Canada to continue on with its own vaccines.”
NEW GLASGOW, N.S. – Police in New Glasgow, N.S., say a 44-year-old woman faces fraud charges after funds went missing from the Pictou East Progressive Conservative Association.
New Glasgow Regional Police began the investigation on Oct. 7, after Nova Scotia Premier Tim Houston reported that an undisclosed amount of money had gone missing from his riding association’s account.
Police allege that a volunteer who was acting as treasurer had withdrawn funds from the association’s account between 2016 and 2024.
The force says it arrested Tara Amanda Cohoon at her Pictou County, N.S., residence on Oct. 11.
They say investigators seized mobile electronic devices, bank records and cash during a search of the home.
Cohoon has since been released and is to appear in Pictou provincial court on Dec. 2 to face charges of forgery, uttering a forged document, theft over $5,000 and fraud over $5,000.
Police say their investigation remains ongoing.
Houston revealed the investigation to reporters on Oct. 9, saying he felt an “incredible level of betrayal” over the matter.
The premier also said a volunteer he had known for many years had been dismissed from the association and the party.
This report by The Canadian Press was first published Oct. 23, 2024.
PICTOU, N.S. – A Nova Scotia excavation company has been fined $80,000 after a worker died when scaffolding collapsed on one of its job sites.
In a decision released Wednesday, a Nova Scotia provincial court judge in Pictou, N.S., found the failure by Blaine MacLane Excavation Ltd. to ensure scaffolding was properly installed led to the 2020 death of Jeff MacDonald, a self-employed electrician.
The sentence was delivered after the excavation company was earlier found guilty of an infraction under the province’s Occupational Health and Safety Act.
Judge Bryna Hatt said in her decision she found the company “failed in its duty” to ensure that pins essential to the scaffolding’s stability were present at the work site.
Her decision said MacDonald was near the top of the structure when it collapsed on Dec. 9, 2020, though the exact height is unknown.
The judge said that though the excavation company did not own the scaffolding present on its job site, there was no evidence the company took steps to prevent injury, which is required under legislation.
MacDonald’s widow testified during the trial that she found her husband’s body at the job site after he didn’t pick up their children as planned and she couldn’t get in touch with him over the phone.
Julie MacDonald described in her testimony how she knew her husband had died upon finding him due to her nursing training, and that she waited alone in the dark for emergency responders to arrive after calling for help.
“My words cannot express how tragic this accident was for her, the children, and their extended family,” Hatt wrote in the sentencing decision.
“No financial penalty will undo the damage and harm that has been done, or adequately represent the loss of Mr. MacDonald to his family, friends, and our community.”
In addition to the $80,000 fine, the New Glasgow-based company must also pay a victim-fine surcharge of $12,000 and provide $8,000 worth of community service to non-profits in Pictou County.
This report by The Canadian Press was first published Oct. 23, 2024.
ST. JOHN’S, N.L. – Investigators found the remains of a 77-year-old American man on Wednesday at the scene of a fire that destroyed a hotel in western Newfoundland on the weekend.
Eugene Earl Spoon, a guest at the hotel, was visiting Newfoundland from Kansas. His remains were found Wednesday morning during a search of the debris left behind after the fire tore through the Driftwood Inn in Deer Lake, N.L., on Saturday, the RCMP said in a news release.
“RCMP (Newfoundland and Labrador) extends condolences to the family and friends of the missing man,” the news release said.
Spoon was last seen Friday evening in the community of about 4,800 people in western Newfoundland. The fire broke out early Saturday morning, the day Spoon was reported missing.
Several crews from the area fought the flames for about 16 hours before the final hot spot was put out, and police said Wednesday that investigators are still going through the debris.
Meanwhile, the provincial Progressive Conservative Opposition reiterated its call for a wider review of what happened.
“Serious questions have been raised about the fire, and the people deserve answers,” Tony Wakeham, the party’s leader, said in a news release Wednesday. “A thorough investigation must be conducted to determine the cause and prevent such tragedies in the future.”
The party has said it spoke to people who escaped the burning hotel, and they said alarm and sprinkler systems did not seem to have been activated during the fire. However, Stephen Rowsell, the Deer Lake fire chief, has said there were alarms going off when crews first arrived.
This report by The Canadian Press was first published Oct. 23, 2024.
