Health Canada greenlights another COVID-19 vaccine candidate for human trials - CTV News | Canada News Media
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Health Canada greenlights another COVID-19 vaccine candidate for human trials – CTV News

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TORONTO —
A Saskatchewan-developed COVID-19 vaccine candidate is the latest to be approved for human trials in Canada, and could be ready by the end of 2021, its backers say.

The vaccine candidate is one of two being developed by the Vaccine and Infectious Disease Organization (VIDO) at the University of Saskatchewan.

VIDO reported Tuesday that it has received authorization from Health Canada to begin a Phase 1 clinical trial through the Canadian Center for Vaccinology in Halifax.

Participants will be recruited shortly, VIDO said, with vaccinations starting in January. Volker Gerdts, director and CEO of VIDO, said in a statement that if the three-phase trials prove successful, VIDO’s vaccine candidate could be ready for use by late 2021.

Both of VIDO’s potential vaccines are what are known as protein subunit vaccines, meaning they are created out of specific parts of a dead germ, rather than a live virus or an entire dead germ. Subunit vaccines are often used to protect against hepatitis B, human papillomavirus, whooping cough and shingles, among other viruses and diseases.

Most of the leading vaccines in the race to stop COVID-19 are based on either viral vector or RNA technology. However, VIDO is not alone in developing a subunit vaccine. According to the World Health Organization, 18 of the 61 vaccine candidates that have reached the clinical trial stage are based on protein subunits – including the ones developed by Novavax and Sanofi, for which Canada has reserved 76 million doses and 72 million doses respectively.

Subunit vaccines are typically much simpler to mass-produce than RNA or viral vector vaccines, and do not require ultra-cold storage.

While dozens of potential treatments to mitigate or negate the effects of COVID-19 are in the midst of clinical trials in Canada, only a handful of vaccine candidates have been approved for trials.

In addition to the new VIDO trial, the list includes a vaccine candidate from Quebec-City based Medicago, which entered a combined Phase 2 and 3 trial this month after reporting successful results in early testing. The company said its vaccine candidate, which is unusual in that it is derived from “virus-like particles” found in plants, provoked an antibody response in 100 per cent of the trial subjects.

Toronto’s University Health Network is currently recruiting front-line workers in Ontario to test a potential COVID-19 vaccine that is also the subject of ongoing trials in Australia, Germany, the United Kingdom and the Netherlands. Rounding out the list is CanSino’s Ad5-nCoV, which was approved in the spring to much fanfare but has been at a standstill since, because the promised shipments of the vaccine candidate from China never materialized.

Gerdts, who is leading the development of VIDO’s vaccine candidate, said it is important for the ongoing trials to continue, even though some vaccines developed outside Canada are closer to approval – and in the case of Pfizer’s vaccine, have already been approved here.

“COVID-19 is not going to go away,” he said.

“To have sustainable long-term vaccine access, I think it’s important for Canada to continue on with its own vaccines.”

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Canada’s Denis Shapovalov wins Belgrade Open for his second ATP Tour title

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BELGRADE, Serbia – Canada’s Denis Shapovalov is back in the winner’s circle.

The 25-year-old Shapovalov beat Serbia’s Hamad Medjedovic 6-4, 6-4 in the Belgrade Open final on Saturday.

It’s Shapovalov’s second ATP Tour title after winning the Stockholm Open in 2019. He is the first Canadian to win an ATP Tour-level title this season.

His last appearance in a tournament final was in Vienna in 2022.

Shapovalov missed the second half of last season due to injury and spent most of this year regaining his best level of play.

He came through qualifying in Belgrade and dropped just one set on his way to winning the trophy.

Shapovalov’s best results this season were at ATP 500 events in Washington and Basel, where he reached the quarterfinals.

Medjedovic was playing in his first-ever ATP Tour final.

The 21-year-old, who won the Next Gen ATP Finals presented by PIF title last year, ends 2024 holding a 9-8 tour-level record on the season.

This report by The Canadian Press was first published Nov. 9, 2024.

The Canadian Press. All rights reserved.



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Talks to resume in B.C. port dispute in bid to end multi-day lockout

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VANCOUVER – Contract negotiations resume today in Vancouver in a labour dispute that has paralyzed container cargo shipping at British Columbia’s ports since Monday.

The BC Maritime Employers Association and International Longshore and Warehouse Union Local 514 are scheduled to meet for the next three days in mediated talks to try to break a deadlock in negotiations.

The union, which represents more than 700 longshore supervisors at ports, including Vancouver, Prince Rupert and Nanaimo, has been without a contract since March last year.

The latest talks come after employers locked out workers in response to what it said was “strike activity” by union members.

The start of the lockout was then followed by several days of no engagement between the two parties, prompting federal Labour Minister Steven MacKinnon to speak with leaders on both sides, asking them to restart talks.

MacKinnon had said that the talks were “progressing at an insufficient pace, indicating a concerning absence of urgency from the parties involved” — a sentiment echoed by several business groups across Canada.

In a joint letter, more than 100 organizations, including the Canadian Chamber of Commerce, Business Council of Canada and associations representing industries from automotive and fertilizer to retail and mining, urged the government to do whatever it takes to end the work stoppage.

“While we acknowledge efforts to continue with mediation, parties have not been able to come to a negotiated agreement,” the letter says. “So, the federal government must take decisive action, using every tool at its disposal to resolve this dispute and limit the damage caused by this disruption.

“We simply cannot afford to once again put Canadian businesses at risk, which in turn puts Canadian livelihoods at risk.”

In the meantime, the union says it has filed a complaint to the Canada Industrial Relations Board against the employers, alleging the association threatened to pull existing conditions out of the last contract in direct contact with its members.

“The BCMEA is trying to undermine the union by attempting to turn members against its democratically elected leadership and bargaining committee — despite the fact that the BCMEA knows full well we received a 96 per cent mandate to take job action if needed,” union president Frank Morena said in a statement.

The employers have responded by calling the complaint “another meritless claim,” adding the final offer to the union that includes a 19.2 per cent wage increase over a four-year term remains on the table.

“The final offer has been on the table for over a week and represents a fair and balanced proposal for employees, and if accepted would end this dispute,” the employers’ statement says. “The offer does not require any concessions from the union.”

The union says the offer does not address the key issue of staffing requirement at the terminals as the port introduces more automation to cargo loading and unloading, which could potentially require fewer workers to operate than older systems.

The Port of Vancouver is the largest in Canada and has seen a number of labour disruptions, including two instances involving the rail and grain storage sectors earlier this year.

A 13-day strike by another group of workers at the port last year resulted in the disruption of a significant amount of shipping and trade.

This report by The Canadian Press was first published Nov. 9, 2024.

The Canadian Press. All rights reserved.



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The Royal Canadian Legion turns to Amazon for annual poppy campaign boost

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The Royal Canadian Legion says a new partnership with e-commerce giant Amazon is helping boost its veterans’ fund, and will hopefully expand its donor base in the digital world.

Since the Oct. 25 launch of its Amazon.ca storefront, the legion says it has received nearly 10,000 orders for poppies.

Online shoppers can order lapel poppies on Amazon in exchange for donations or buy items such as “We Remember” lawn signs, Remembrance Day pins and other accessories, with all proceeds going to the legion’s Poppy Trust Fund for Canadian veterans and their families.

Nujma Bond, the legion’s national spokesperson, said the organization sees this move as keeping up with modern purchasing habits.

“As the world around us evolves we have been looking at different ways to distribute poppies and to make it easier for people to access them,” she said in an interview.

“This is definitely a way to reach a wider number of Canadians of all ages. And certainly younger Canadians are much more active on the web, on social media in general, so we’re also engaging in that way.”

Al Plume, a member of a legion branch in Trenton, Ont., said the online store can also help with outreach to veterans who are far from home.

“For veterans that are overseas and are away, (or) can’t get to a store they can order them online, it’s Amazon.” Plume said.

Plume spent 35 years in the military with the Royal Engineers, and retired eight years ago. He said making sure veterans are looked after is his passion.

“I’ve seen the struggles that our veterans have had with Veterans Affairs … and that’s why I got involved, with making sure that the people get to them and help the veterans with their paperwork.”

But the message about the Amazon storefront didn’t appear to reach all of the legion’s locations, with volunteers at Branch 179 on Vancouver’s Commercial Drive saying they hadn’t heard about the online push.

Holly Paddon, the branch’s poppy campaign co-ordinator and bartender, said the Amazon partnership never came up in meetings with other legion volunteers and officials.

“I work at the legion, I work with the Vancouver poppy office and I go to the meetings for the Vancouver poppy campaign — which includes all the legions in Vancouver — and not once has this been mentioned,” she said.

Paddon said the initiative is a great idea, but she would like to have known more about it.

The legion also sells a larger collection of items at poppystore.ca.

This report by The Canadian Press was first published Nov. 9, 2024.

The Canadian Press. All rights reserved.



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