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How close are we to a coronavirus vaccine?

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Millions of dollars and hundreds of hours of researchers’ time have been invested in the hunt for a vaccine for the novel coronavirus.

It’s paying off – experts say we could see the first vaccines approved by the end of 2020, but there’s still a lot of questions that need to be answered before you roll up your sleeve. These include how well it works, which shot we use, and who gets first crack at the new vaccine.

Where research stands

In late July, some manufacturers announced promising early results. A vaccine candidate developed by researchers at Oxford University in the U.K. appeared to cause an immune response with minimal side effects. A joint Canadian and Chinese project also announced that they were moving forward with further testing, after seeing some success.

 

According to the World Health Organization, there are currently 165 vaccine candidates being studied worldwide. Five of those are in Stage 3 clinical trials – typically the last stage, after which the vaccine could be approved if it shows positive results.

One of those, by the company Moderna, is now being tested in thousands of people across the U.S., in a trial that started Monday.

“I think it’s pretty exciting that a number of vaccines have moved on to this phase,” said Dr. Manish Sadarangani, an assistant professor at the University of British Columbia and director of the Vaccine Evaluation Centre at B.C. Children’s Hospital.

“I think it’s actually incredible to think that, given that normally vaccine development takes 10 to 15 years at least, that we’ve done several years’ worth of development in the space of a few months.”

Manufacturers were able to move so quickly in part because they’re building upon other vaccines, he said. “It’s not quite plug-and-play,” he said, but manufacturers were able to take existing vaccines and swap out a few pieces to try to match them to the SARS-CoV-2 virus rather than starting from scratch.

While some experts have said it will take longer, others like Craig Jenne, an associate professor in microbiology, immunology and infectious diseases at the University of Calgary, believe it’s possible.

 

“I do believe that we will see one and maybe even two vaccines approved both by the FDA and by the European Regulatory Agency before the end of the calendar year,” he said.

“That doesn’t mean that January 1st we can get vaccinated.”

Safe and effective

Health Canada will want to review safety data itself and approve a vaccine on its own judgment, rather than just applying “a rubber stamp” to whatever the U.S. approves, Jenne said. This will take some time.

Sadarangani doesn’t believe there is any reason to be concerned about the speed of the research. “I think, to be honest, the follow up of participants in the trials has been very rigorous. These are people who are followed up very closely to look for side effects,” he said.

COVID-19 vaccines will still have to provide safety and efficacy data the same way as any other vaccine in order to be approved, he said. This includes monitoring for side effects even after it hits the market, as there might be very specific groups of people who experience side effects from the shot, which weren’t identified in trials.

The vaccine won’t necessarily be 100 per cent effective in preventing COVID-19 either.

“The WHO has set the bar at 50 per cent,” said Dr. Brian Ward, an infectious diseases professor at Montreal’s McGill University and medical director of Medicago, a Canadian vaccine manufacturer that is working on its own vaccine candidate.

“A vaccine that is 50 per cent effective will be considered a good enough vaccine to move forward.”

The measles vaccine, considered an extremely effective vaccine, is about 97 per cent effective with two doses, the CDC says. The flu shot varies between 40 to 60 per cent.

Even a partially effective vaccine would allow us to get back to something closer to pre-pandemic life, Ward said. There’s another advantage too: it’s likely that even if the shot doesn’t fully protect someone, it will still drastically cut down the chance of severe illness if they do catch the virus.

This happens with the flu shot, he said, where your symptoms are likely reduced, even if it doesn’t always keep you from catching the flu. “If we can reduce SARS coronavirus to being like the other human coronaviruses where it’s like a cold, that would also be certainly good enough.”

Getting the shot

Even after a shot is approved, it could still take a while before it’s generally available, experts say.

First of all, there are likely to be several vaccine formulations that get approved, said Jenne, who also holds a Canada Research Chair.

 

“As an immunologist, I very much hope that we get more than one answer,” he said.

Having several different vaccines would be a good thing, he said, as some might be more suited to give to vulnerable populations like people with pre-existing conditions or the elderly. It’s also possible that an individual might be able to get even better immunity by taking several shots.

The other reason we need many different vaccines approved worldwide, or at least made worldwide, comes down to manufacturing capacity, Ward said.

“Almost all of the vaccines that are in clinical trials are testing two doses, and most of them are likely to need two doses based on animal data to date. So that means that if we’re going to vaccinate the world at 7.8 billion people, we’re going to need 15.6 billion doses of vaccine.”

Even the pharmaceutical giants are only talking about producing 500 million doses per year, meaning it would take years to vaccinate everyone unless there are many different vaccines being made, he said.

Some countries, such as the U.S., have already made deals with pharmaceutical companies to secure supplies of an eventual vaccine, leaving smaller countries like Canada further down the list.

“If you’re talking about trying to vaccinate huge numbers of people across the globe, then I think the timeline is going to be a bit longer,” Sadarangani said.

“I don’t think it’s going to be a one-off: suddenly there’s a vaccine and everyone’s going go and get it the next week.

“I think it’s going to be a sequential thing where there’s decisions that need to be made about how to prioritize the use of the vaccines, and who should get the vaccine first, who’s at the highest risk of getting severe disease. And then who gets it in subsequent production batches.”

 

Source: – Global News

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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