How plants can play a role in the future of fighting COVID, RSV and even the common cold | Canada News Media
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How plants can play a role in the future of fighting COVID, RSV and even the common cold

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Inside a greenhouse perched atop a University of Ottawa building, there are hundreds of plants that are part of a vaccine revolution offering hope for an end to the pandemic.

A team of scientists at uOttawa, led by virologist Marc-André Langlois in collaboration with biologist Allyson MacLean, is aiming to create something new — a plant-based mucosal vaccine that people could spray into their nostrils to boost their protection against COVID-19.Langlois pictures people picking up the nasal vaccine from a drug store and taking it home to top-up their COVID-19 defences to prevent infection.

The Nicotiana benthamiana plants growing in the university greenhouse — weeds in their native Australia — work as a vaccine bio-factory to produce viral proteins that act as antigens to create an immune response against COVID-19.

The nasal vaccine would act as a booster for those who have already received an mRNA COVID vaccine or have been infected, said Langlois, a professor in the faculty of medicine at the university and executive director of the Coronavirus Variants Rapid Response Network.

“We are aiming to capitalize on the fact that most people will have received prior vaccines or had an infection and acquired immunity.”Work on the prototype nasal spray vaccine is still in the early stages, but preliminary results have successfully boosted antibody protection in mice previously given mRNA COVID-19 vaccines. The next step is to challenge mice with the virus to see if the vaccine confers protection.

Eventually, studies in humans are needed to further develop a potential plant-based mucosal vaccine, which would require additional funding, said Langlois.

Marc-André Langlois and Allyson MacLean, uOttawa researchers, are working on a nasal COVID booster vaccine that is plant based. Photo by Jean Levac /Postmedia

Scientists at McMaster University in Hamilton are further along in developing a mucosal vaccine for COVID-19.

The McMaster mucosal vaccine has demonstrated broad, long-lasting protection against the original strain of SARS-CoV-2 as well as variants of concern. It is currently being tested in healthy adults who already received two doses of a COVID mRNA vaccine.

Why, at this point in the pandemic, with highly successful mRNA and other vaccines widely available, are Canadian researchers working to develop new mucosal vaccines against COVID-19? And why should people care?Because mucosal vaccines hold the hope of ending the pandemic, according to uOttawa epidemiologist Raywat Deonandan.

Mucosal vaccines — which work by blocking infection where the virus enters the body in areas such as the mouth and nose — have the potential to prevent infections and transmission of COVID-19. That is something existing intramuscular vaccines, which produce neutralizing antibodies that circulate throughout the body, cannot do very well. Mucosal vaccines are typically sprayed in the nostrils or the mouth while traditional vaccines are injected.

“We don’t want to be mildly sick. We don’t want to be sick at all,” says Langlois.“These (mucosal) vaccines are focused on completely blocking infection.” That goes for COVID-19 as well as all respiratory virus infections, including RSV and the common cold, he said.

Current COVID-19 vaccines administered via needles, produced within months of pandemic declarations, were approved for emergency use based on proof that they could prevent severe disease and deaths, which they did. They did not entirely stop infection or transmission.

With COVID-19 transmission continuing at high levels, Deonandan said the possibilities of mucosal vaccines are exciting.

Dr. Raywat Deonandan is an epidemiologist, author, journalist and global health specialist. Photo by ERROL MCGIHON /Postmedia

In the best-case scenario, they could end the pandemic, he said. “I think in the end it depends on what they end up looking like. But that is the hope.”

Not only do they have the potential to stop transmission, preventing further infections and mutations, but they are also potentially longer lasting than current intramuscular vaccines, whose immunity can wane within months.Because mucosal vaccines can be delivered through the mouth and nose, they can be self-administered, making delivery significantly easier and cheaper, something that is crucial in parts of the world with fewer resources. They also do away with the need for injections.

Deonandan sees them as the next generation of COVID-19 vaccines, but notes there has been a lack of enthusiasm by governments and drug companies about underwriting the financial risk, as they did with the first-generation of vaccines.

Other countries, including India, are using mucosal COVID-19 vaccines. But none have been approved in Canada.The mucosal vaccine research at uOttawa is to develop a prototype, Langlois said. Where it goes from there depends on funding. “Right now it is limited, until we make a strong case that it is effective and then we can increase our team size to move things along faster.

“There are still very large gaps in knowledge in what makes a good antigen for a mucosal vaccines,” said Langlois. “We are decades behind the standard intramuscular vaccines in terms of our understanding of what makes a good mucosal vaccine.

Mucosal vaccines in general are relatively new and research to make effective vaccines is ongoing, said Langlois. It is important work toward making Canada more self-sufficient when it comes to vaccine development and production, he said.

“Canada needs much higher sovereignty over vaccine production and bio-manufacturing of drugs. We are highly reliant on foreign industry. That has been a lesson of the pandemic.”
OTTAWA – March 02, 2023 – Marc-André Langlois and Allyson MacLean, uOttawa researchers, are working on a nasal covid booster vaccine that is plant based. Assignment 138797 Photo by Jean Levac/Ottawa Citizen Photo by Jean Levac /Postmedia

The goal of Canada becoming less reliant on foreign industry was delivered a blow last month when Medicago, a plant-based COVID-19 vaccine manufacturer, shut down its operations in Quebec after its sole shareholder decided to no longer invest in the company. Medicago’s COVID-19 vaccines had been approved by Health Canada but the World Health Organization initially rejected the vaccine because of its ties to tobacco company Phillip Morris.

MacLean, an assistant professor in the department of biology at the university and the biologist collaborating with Langlois, called it a big loss for Canada in the burgeoning field of biopharming — the use of plants to produce pharmaceuticals.

It is more reason for Canada to continue investing in research, she said.The work at uOttawa is pushing the boundaries of vaccine research.

“Not only are we trying to develop a mucosal vaccine, we are trying to do it in plants,” said MacLean.

There is still work to be done to get plants to produce similar amounts of viral proteins as eggs or animal cells, which are used more commonly in vaccine production, MacLean said. But the advantages of using plants are numerous. Among them, plant-based vaccines are inexpensive and quick to produce and contamination is less likely than with vaccines produced in eggs and animal cells.

“Plants are dead cheap to work with; you need soil, you need a bit of fertilizer, you need sun and water, and that’s it,” said MacLean.

Marc-André Langlois and Allyson MacLean. Photo by Jean Levac /Postmedia

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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