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How scientists aim to make a safe COVID-19 vaccine in record time – CBC.ca

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Vaccine development normally takes years, if not decades. But scientific teams around the world are aiming to develop a COVID-19 vaccine in 12 to 18 months.

Prof. Gary Kobinger is part of a team at Laval University that is trying to do that, and he thinks it can be done without skipping any steps in the process or compromising safety.

“I believe it’s possible,” said Kobinger, a professor of microbiology and infectious diseases who helped develop a vaccine for Ebola. “You just need to put the effort into it.”

That, and, he acknowledged, “a lot of money.”

But how? Here are some of the things that are being done differently during the development of a COVID-19 vaccine to speed up the process.

Flexible clinical trials

Normally, once it’s been shown effective in preclinical animal trials, a vaccine needs to go through three stages of human clinical trials that are run one after another. They can take years to complete.

With COVID-19, vaccine developers are allowed to run trials in parallel. That is, Phase 2 can begin once early results from Phase 1 look promising, and so on, speeding up the process.

However, researchers note that each phase still must be run to its full length — typically six months for Phase 1, for example.

In this photo released by the University of Oxford, samples from coronavirus vaccine trials are handled inside the Oxford Vaccine Group laboratory in June. Scientific teams around the world are aiming to develop a COVID-19 vaccine in 12 to 18 months. (John Cairns, University of Oxford/The Associated Press)

In addition, vaccine developers are allowed to do what’s called adaptive design. They can create a plan to modify their trials depending on the results, said Lakshmi Krishnan, acting vice-president for life sciences at the National Research Council Canada.

For example if volunteers aren’t responding to a low dose, you can give them a slightly different dose or a second dose — if that was in your plan.

“You cannot do this on the fly,” Krishnan said. 

The adaptive design of Canadian trials needs to be approved by Health Canada, she said, and the department may request to see data more often in order to be able to approve — or not approve — further stages of the trial.

Advance manufacturing

Typically, doses of a vaccine aren’t manufactured on a large scale until the vaccine has been approved. 

“Manufacturing is a laborious process and it can take many years to produce sufficient doses of vaccine,” Krishnan said, noting that it’s also the most expensive part of the process.

With COVID-19, in some cases, manufacturers such as AstraZeneca have announced the start of production in advance of approval during early phase clinical trials, with no guarantee that the vaccine would ever make it through the other phases and get approval.

“If the vaccine is a good candidate, we don’t have to go back and do the manufacturing,” Krishnan said. “We already have the doses available.”

Prof. Gary Kobinger, who is part of a team at Laval University trying to develop a COVID-19 vaccine as quickly as possible, thinks it can be done in much less time than usual without skipping any steps in the process or compromising safety. (CBC News)

International co-operation and government financial support

Obviously, none of this would be possible without the financial support of governments around the world.

Normally, one of the reasons it takes so long to get through clinical trials is that scientists often have trouble getting the funding to move on to the next phase, said Dr. Natasha Crowcroft, director of the Centre for Vaccine Preventable Disease at the University of Toronto, in a June episode of CBC’s The Dose podcast.

Pharmaceutical companies are reluctant to invest in a product that could fail at the next stage, and are often not sure there will be a market for a vaccine even if it does work, she said.

With COVID-19, governments are pouring money into vaccine trials and advance manufacturing, thereby assuming a lot of that risk.

Many are also co-operating internationally. For example, the COVAX coalition is a collaboration pooling money from dozens of countries around the world to jump-start advance manufacturing of several vaccine candidates, including some doses that would be set aside for developing countries.

Krishnan said international sharing of information as vaccine development progresses is also speeding things up: “You are leveraging the knowledge that is being generated in order to inform and accelerate your design.”

Cells are counted through a microscope in the laboratory at Imperial College in London on July 30. The institution is one of more than a hundred teams around the world working on the development of a COVID-19 vaccine. (Kirsty Wigglesworth/The Associated Press)

Accelerated government approvals?

Kobinger says “the critical time” in COVID-19 vaccine development will be once the last stage of clinical trials has been completed and the data has been submitted to regulatory agencies, “because they will be under extreme pressure to make a decision. And of course, their main concern will be safety.”

That stage can take years — four years in the case of the Ebola vaccine that Kobinger helped develop.

But he thinks the approval process can be compressed by increasing the number of staff in regulatory agencies involved in reviewing the data.

Governments can also use emergency orders to distribute vaccines prior to full approval in the case of an event such as a pandemic. For example, in 2009, Health Canada used an interim order to approve an H1N1 vaccine based on clinical trial data in Europe, even though clinical trials the Canadian version of the vaccine using the same adjuvant had only just started that same week in Canada.

In this April 11, 2020, photo released by Xinhua News Agency, staff members check and clean equipment at a vaccine production plant of SinoPharm in Beijing. In many cases, doses of COVID-19 vaccine candidates are being manufactured in large quantities before clinical trials are even complete. (Zhang Yuwei/Xinhua via AP)

Krishnan is confident that regulation for a new COVID-19 vaccine will be no less rigorous than usual.

“We can be assured that there will certainly be an oversight and that safety will be kept as the first consideration in any vaccine that is approved,” she said. “So I think we have to trust that system.”

Regulators will continue to monitor the safety of any of the vaccines as they’re rolled out to the larger population after they’re approved, she added.

While COVID-19 is a special emergency case, both Krishnan and Kobinger think what’s being done now could speed up the development for future vaccines.

Krishnan noted that vaccine manufacturers, clinical trial investigators and governments are working hard together.

“Those alliances will hopefully set us up for the future to actually do these types of studies in an accelerated fashion.”

Kobinger said up until now, we’ve relied heavily on old vaccines and vaccine technology.

“This is going to open a new era of vaccinations with safer vaccines, better vaccines and faster vaccines in terms of production,” he added. “I think people will benefit for decades to come.”

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The #1 Skill I Look For When Hiring

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File this column under “for what it’s worth.”

“Communication is one of the most important skills you require for a successful life.” — Catherine Pulsifer, author.

I’m one hundred percent in agreement with Pulsifer, which is why my evaluation of candidates begins with their writing skills. If a candidate’s writing skills and verbal communication skills, which I’ll assess when interviewing, aren’t well above average, I’ll pass on them regardless of their skills and experience.

 

Why?

 

Because business is fundamentally about getting other people to do things—getting employees to be productive, getting customers to buy your products or services, and getting vendors to agree to a counteroffer price. In business, as in life in general, you can’t make anything happen without effective communication; this is especially true when job searching when your writing is often an employer’s first impression of you.

 

Think of all the writing you engage in during a job search (resumes, cover letters, emails, texts) and all your other writing (LinkedIn profile, as well as posts and comments, blogs, articles, tweets, etc.) employers will read when they Google you to determine if you’re interview-worthy.

 

With so much of our communication today taking place via writing (email, text, collaboration platforms such as Microsoft Teams, Slack, ClickUp, WhatsApp and Rocket.Chat), the importance of proficient writing skills can’t be overstated.

 

When assessing a candidate’s writing skills, you probably think I’m looking for grammar and spelling errors. Although error-free writing is important—it shows professionalism and attention to detail—it’s not the primary reason I look at a candidate’s writing skills.

 

The way someone writes reveals how they think.

 

  • Clear writing = Clear thinking
  • Structured paragraphs = Structured mind
  • Impactful sentences = Impactful ideas

 

Effective writing isn’t about using sophisticated vocabulary. Hemingway demonstrated that deceptively simple, stripped-down prose can captivate readers. Effective writing takes intricate thoughts and presents them in a way that makes the reader think, “Damn! Why didn’t I see it that way?” A good writer is a dead giveaway for a good thinker. More than ever, the business world needs “good thinkers.”

 

Therefore, when I come across a candidate who’s a good writer, hence a good thinker, I know they’re likely to be able to write:

 

  • Emails that don’t get deleted immediately and are responded to
  • Simple, concise, and unambiguous instructions
  • Pitches that are likely to get read
  • Social media content that stops thumbs
  • Human-sounding website copy
  • Persuasively, while attuned to the reader’s possible sensitivities

 

Now, let’s talk about the elephant in the room: AI, which job seekers are using en masse. Earlier this year, I wrote that AI’s ability to hyper-increase an employee’s productivity—AI is still in its infancy; we’ve seen nothing yet—in certain professions, such as writing, sales and marketing, computer programming, office and admin, and customer service, makes it a “fewer employees needed” tool, which understandably greatly appeals to employers. In my opinion, the recent layoffs aren’t related to the economy; they’re due to employers adopting AI. Additionally, companies are trying to balance investing in AI with cost-cutting measures. CEOs who’ve previously said, “Our people are everything,” have arguably created today’s job market by obsessively focusing on AI to gain competitive advantages and reduce their largest expense, their payroll.

 

It wouldn’t be a stretch to assume that most AI usage involves generating written content, content that’s obvious to me, and likely to you as well, to have been written by AI. However, here’s the twist: I don’t particularly care.

 

Why?

 

Because the fundamental skill I’m looking for is the ability to organize thoughts and communicate effectively. What I care about is whether the candidate can take AI-generated content and transform it into something uniquely valuable. If they can, they’re demonstrating the skills of being a good thinker and communicator. It’s like being a great DJ; anyone can push play, but it takes skill to read a room and mix music that gets people pumped.

 

Using AI requires prompting effectively, which requires good writing skills to write clear and precise instructions that guide the AI to produce desired outcomes. Prompting AI effectively requires understanding structure, flow and impact. You need to know how to shape raw information, such as milestones throughout your career when you achieved quantitative results, into a compelling narrative.

So, what’s the best way to gain and enhance your writing skills? As with any skill, you’ve got to work at it.

Two rules guide my writing:

 

  • Use strong verbs and nouns instead of relying on adverbs, such as “She dashed to the store.” instead of “She ran quickly to the store.” or “He whispered to the child.” instead of “He spoke softly to the child.”
  • Avoid using long words when a shorter one will do, such as “use” instead of “utilize” or “ask” instead of “inquire.” As attention spans get shorter, I aim for clarity, simplicity and, most importantly, brevity in my writing.

 

Don’t just string words together; learn to organize your thoughts, think critically, and communicate clearly. Solid writing skills will significantly set you apart from your competition, giving you an advantage in your job search and career.

_____________________________________________________________________

 

Nick Kossovan, a well-seasoned veteran of the corporate landscape, offers “unsweetened” job search advice. You can send Nick your questions to artoffindingwork@gmail.com.

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Politics likely pushed Air Canada toward deal with ‘unheard of’ gains for pilots

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MONTREAL – Politics, public opinion and salary hikes south of the border helped push Air Canada toward a deal that secures major pay gains for pilots, experts say.

Hammered out over the weekend, the would-be agreement includes a cumulative wage hike of nearly 42 per cent over four years — an enormous bump by historical standards — according to one source who was not authorized to speak publicly on the matter. The previous 10-year contract granted increases of just two per cent annually.

The federal government’s stated unwillingness to step in paved the way for a deal, noted John Gradek, after Prime Minister Justin Trudeau made it plain the two sides should hash one out themselves.

“Public opinion basically pressed the federal cabinet, including the prime minister, to keep their hands clear of negotiations and looking at imposing a settlement,” said Gradek, who teaches aviation management at McGill University.

After late-night talks at a hotel near Toronto’s Pearson airport, the country’s biggest airline and the union representing 5,200-plus aviators announced early Sunday morning they had reached a tentative agreement, averting a strike that would have grounded flights and affected some 110,000 passengers daily.

The relative precariousness of the Liberal minority government as well as a push to appear more pro-labour underlay the prime minister’s hands-off approach to the negotiations.

Trudeau said Friday the government would not step in to fix the impasse — unlike during a massive railway work stoppage last month and a strike by WestJet mechanics over the Canada Day long weekend that workers claimed road roughshod over their constitutional right to collective bargaining. Trudeau said the government respects the right to strike and would only intervene if it became apparent no negotiated deal was possible.

“They felt that they really didn’t want to try for a third attempt at intervention and basically said, ‘Let’s let the airline decide how they want to deal with this one,'” said Gradek.

“Air Canada ran out of support as the week wore on, and by the time they got to Friday night, Saturday morning, there was nothing left for them to do but to basically try to get a deal set up and accepted by ALPA (Air Line Pilots Association).”

Trudeau’s government was also unlikely to consider back-to-work legislation after the NDP tore up its agreement to support the Liberal minority in Parliament, Gradek said. Conservative Leader Pierre Poilievre, whose party has traditionally toed a more pro-business line, also said last week that Tories “stand with the pilots” and swore off “pre-empting” the negotiations.

Air Canada CEO Michael Rousseau had asked Ottawa on Thursday to impose binding arbitration pre-emptively — “before any travel disruption starts” — if talks failed. Backed by business leaders, he’d hoped for an effective repeat of the Conservatives’ move to head off a strike in 2012 by legislating Air Canada pilots and ground crew to stick to their posts before any work stoppage could start.

The request may have fallen flat, however. Gradek said he believes there was less anxiety over the fallout from an airline strike than from the countrywide railway shutdown.

He also speculated that public frustration over thousands of cancelled flights would have flowed toward Air Canada rather than Ottawa, prompting the carrier to concede to a deal yielding “unheard of” gains for employees.

“It really was a total collapse of the Air Canada bargaining position,” he said.

Pilots are slated to vote in the coming weeks on the four-year contract.

Last year, pilots at Delta Air Lines, United Airlines and American Airlines secured agreements that included four-year pay boosts ranging from 34 per cent to 40 per cent, ramping up pressure on other carriers to raise wages.

After more than a year of bargaining, Air Canada put forward an offer in August centred around a 30 per cent wage hike over four years.

But the final deal, should union members approve it, grants a 26 per cent increase in the first year alone, retroactive to September 2023, according to the source. Three wage bumps of four per cent would follow in 2024 through 2026.

Passengers may wind up shouldering some of that financial load, one expert noted.

“At the end of the day, it’s all us consumers who are paying,” said Barry Prentice, who heads the University of Manitoba’s transport institute.

Higher fares may be mitigated by the persistence of budget carrier Flair Airlines and the rapid expansion of Porter Airlines — a growing Air Canada rival — as well as waning demand for leisure trips. Corporate travel also remains below pre-COVID-19 levels.

Air Canada said Sunday the tentative contract “recognizes the contributions and professionalism of Air Canada’s pilot group, while providing a framework for the future growth of the airline.”

The union issued a statement saying that, if ratified, the agreement will generate about $1.9 billion of additional value for Air Canada pilots over the course of the deal.

Meanwhile, labour tension with cabin crew looms on the horizon. Air Canada is poised to kick off negotiations with the union representing more than 10,000 flight attendants this year before the contract expires on March 31.

This report by The Canadian Press was first published Sept. 16, 2024.

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Federal $500M bailout for Muskrat Falls power delays to keep N.S. rate hikes in check

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HALIFAX – Ottawa is negotiating a $500-million bailout for Nova Scotia’s privately owned electric utility, saying the money will be used to prevent a big spike in electricity rates.

Federal Natural Resources Minister Jonathan Wilkinson made the announcement today in Halifax, saying Nova Scotia Power Inc. needs the money to cover higher costs resulting from the delayed delivery of electricity from the Muskrat Falls hydroelectric plant in Labrador.

Wilkinson says that without the money, the subsidiary of Emera Inc. would have had to increase rates by 19 per cent over “the short term.”

Nova Scotia Power CEO Peter Gregg says the deal, once approved by the province’s energy regulator, will keep rate increases limited “to be around the rate of inflation,” as costs are spread over a number of years.

The utility helped pay for construction of an underwater transmission link between Newfoundland and Nova Scotia, but the Muskrat Falls project has not been consistent in delivering electricity over the past five years.

Those delays forced Nova Scotia Power to spend more on generating its own electricity.

This report by The Canadian Press was first published Sept. 16, 2024.

The Canadian Press. All rights reserved.

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