How the first Canadian COVID-19 vaccine trial will work - CTV News | Canada News Media
Connect with us

News

How the first Canadian COVID-19 vaccine trial will work – CTV News

Published

 on


TORONTO —
Saturday’s announcement that Health Canada has given the green light to a clinical trial for a potential COVID-19 vaccine is welcome news, but there is still a long way to go before any possible treatment becomes a reality.

“Under normal conditions, those types of studies … can take five to seven years. It’s a very long process,” Dr. Scott Halperin told CTV News Channel on Sunday.

Halperin is the director of the Canadian Center for Vaccinology at Dalhousie University in Halifax, which has been approved to begin trials of the vaccine candidate known as Ad5-nCoV.

He said that due to the nature of the COVID-19 pandemic, his team will carry out tests “in a more accelerated fashion, without sacrificing any safety,” by not waiting for full results from one stage of their research before moving on to the next.

“What we want to do is find a vaccine that’s well-tolerated by individuals, and that has a good immune response – and then make sure that it works,” he said.

Like most clinical trials, this one will be carried out in three phases.

In the first phase, which Halperin said will require up to 100 volunteer participants, the researchers’ focus will be less about how the vaccine candidate fights the virus than how humans respond to it in general.

“Volunteers will receive a dose of the vaccine, and they’ll be monitored very closely to see the safety of the vaccine, how well it’s tolerated and whether it generates a good immune response to the vaccine,” Halperin said.

The volunteers, who in this phase will all be between the ages of 18 and 55, will be given a dose of the vaccine and regular blood tests to track their progress over a six-month period. They will also have to keep track of and record any symptoms they may exhibit.

If preliminary data suggests the potential vaccine is safe for humans, the test will move into its second phase, for which hundreds more volunteers of all ages will be needed, without waiting for the full six-month testing period to finish.

These volunteers will still be watched closely for any signs that the vaccine candidate may not be as safe as believed – but there will also be more attention paid to exactly how the body responds to it, such as whether it generates an antibody.

The third and final phase will be the largest of all, requiring thousands of volunteers. It will aim squarely at the biggest question of all: Does the vaccine candidate prevent COVID-19 infection?

“The vaccine is given, and then we wait to see whether people who, when they come in contact with the virus under natural conditions, whether they’re protected compared to somebody who just received a placebo immunization,” Halperin said.

The Dalhousie team won’t only be relying on their own results as they investigate the potential vaccine. Ad5-nCoV was developed in China, where human trials have already entered the second phase. CanSino Biologics, the Chinese company behind the vaccine candidate, has been working with the Canadian government to bring the Canadian trial to fruition.

Jason Kindrachuk, an expert in emerging viruses at the University of Manitoba in Winnipeg, described Saturday’s announcement as “amazingly exciting news,” especially as it is still unknown what toll the novel coronavirus may take on the human body over the long-term.

“We are still in such a big learning phase right now,” he told CTV News Channel on Saturday.

“If we get to a point where we find out that protection doesn’t last for years … the vaccine is what we’re going to rely on to defeat this virus.”

With files from The Canadian Press

Let’s block ads! (Why?)



Source link

News

Statistics Canada reports wholesale sales higher in July

Published

 on

OTTAWA – Statistics Canada says wholesale sales, excluding petroleum, petroleum products, and other hydrocarbons and excluding oilseed and grain, rose 0.4 per cent to $82.7 billion in July.

The increase came as sales in the miscellaneous subsector gained three per cent to reach $10.5 billion in July, helped by strength in the agriculture supplies industry group, which rose 9.2 per cent.

The food, beverage and tobacco subsector added 1.7 per cent to total $15 billion in July.

The personal and household goods subsector fell 2.5 per cent to $12.1 billion.

In volume terms, overall wholesale sales rose 0.5 per cent in July.

Statistics Canada started including oilseed and grain as well as the petroleum and petroleum products subsector as part of wholesale trade last year, but is excluding the data from monthly analysis until there is enough historical data.

This report by The Canadian Press was first published Sept. 13, 2024.

The Canadian Press. All rights reserved.



Source link

Continue Reading

News

Dolphins’ Tua Tagovailoa sustains third concussion of his career after hitting head on turf

Published

 on

MIAMI GARDENS, Fla. (AP) — Miami Dolphins quarterback Tua Tagovailoa sustained a concussion for the third time in his NFL career, leaving his team’s game Thursday night against Buffalo after running into defensive back Damar Hamlin and hitting the back of his head against the turf.

Tagovailoa remained down for about two minutes before getting to his feet and walking to the sideline after the play in the third quarter. He made his way to the tunnel not long afterward, looking into the stands before smiling and departing toward the locker room.

The Dolphins needed almost no time before announcing it was a concussion. The team said he had two during the 2022 season, and Tagovailoa was diagnosed with another concussion when he was a college player at Alabama.

Dolphins coach Mike McDaniel said Tagovailoa would get “proper procedural evaluation” and “appropriate care” on Friday.

“The furthest thing from my mind is, ‘What is the timeline?’ We just need to evaluate and just worry about my teammate, like the rest of the guys are,” McDaniel said. “We’ll get more information tomorrow and take it day by day from here.”

Some players saw Tagovailoa in the locker room after the game and said they were encouraged. Tagovailoa spoke with some players and then went home after the game, McDaniel said.

“I have a lot of love for Tua, built a great relationship with him,” said quarterback Skylar Thompson, who replaced Tagovailoa after the injury. “You care about the person more than the player and everybody in the organization would say the same thing. Just really praying for Tua and hopefully everything will come out all right.”

Tagovailoa signed a four-year, $212 million extension before this season — a deal that makes him one of the highest-paid players in the NFL — and was the NFL’s leading passer in Week 1 this season. Tagovailoa left with the Dolphins trailing 31-10, and that was the final score.

“If you know Tua outside of football, you can’t help but feel for him,” Bills quarterback Josh Allen said on Amazon following the game. “He’s a great football player but he’s an even greater human being. He’s one of the best humans on the planet. I’ve got a lot of love for him and I’m just praying for him and his family, hoping everything’s OK. But it’s tough, man. This game of football that we play, it’s got its highs and it’s got its lows — and this is one of the lows.”

Tagovailoa’s college years and first three NFL seasons were marred by injury, though he positioned himself for a big pay bump with an injury-free and productive 2023 as he led the Dolphins into the playoffs. He threw for 29 touchdowns and a league-best 4,624 yards last year.

When, or if, he can come back this season is anyone’s guess. Tagovailoa said in April 2023 that the concussions he had in the 2022 season left him contemplating his playing future. “I think I considered it for a time,” he said then, when asked if he considered stepping away from the game to protect himself.

McDaniel said it’s not his place to say if Tagovailoa should return to football. “He’ll be evaluated and we’ll have conversations and progress as appropriate,” McDaniel said.

Tagovailoa was hurt Thursday on a fourth-down keeper with about 4:30 left in the third. He went straight ahead into Hamlin and did not slide, leading with his right shoulder instead.

Hamlin was the player who suffered a cardiac arrest after making a tackle during a Monday night game in January 2023 at Cincinnati, causing the NFL to suspend a pivotal game that quickly lost significance in the aftermath of a scary scene that unfolded in front of a national television audience.

Tagovailoa wound up on his back, both his hands in the air and Bills players immediately pointed at him as if to suggest there was an injury. Dolphins center Aaron Brewer quickly did the same, waving to the sideline.

Tagovailoa appeared to be making a fist with his right hand as he lay on the ground. It was movement consistent with something that is referred to as the “fencing response,” which can be common after a traumatic brain injury.

Tagovailoa eventually got to his feet. McDaniel grabbed the side of his quarterback’s head and gave him a kiss on the cheek as Tagovailoa departed. Thompson came into the game to take Tagovailoa’s spot.

“I love Tua on and off the football field,” Bills edge Von Miller said. “I’m a huge fan of him. I can empathize and sympathize with him because I’ve been there. I wish him the best.”

Tagovailoa’s history with concussions — and how he has since worked to avoid them — is a huge part of the story of his career, and now comes to the forefront once again.

He had at least two concussions during the 2022 season. He was hurt in a Week 3 game against Buffalo and cleared concussion protocol, though he appeared disoriented on that play but returned to the game.

The NFL later changed its concussion protocol to mandate that if a player shows possible concussion symptoms — including a lack of balance or stability — he must sit out the rest of the game.

Less than a week later, in a Thursday night game at Cincinnati, Tagovailoa was concussed on a scary hit that briefly knocked him unconscious and led to him being taken off the field on a stretcher.

His second known concussion of that season came in a December game against Green Bay, and he didn’t play for the rest of the 2022 season. After that, Tagovailoa began studying ways where he may be able to fall more safely and protect himself against further injury — including studying jiu-jitsu.

“I’m not worried about anything that’s out of my hands,” McDaniel said. “I’m just worried about the human being.”

___

AP NFL:



Source link

Continue Reading

News

David Beckham among soccer dignitaries attending ex-England coach Sven-Goran Eriksson’s funeral

Published

 on

TORSBY, Sweden (AP) — David Beckham and former England coach Roy Hodgson were among the soccer dignitaries who attended the funeral of Sven-Goran Eriksson on Friday in the Swedish manager’s small hometown of Torsby.

Eriksson’s wooden coffin was covered in white flowers and surrounded by six tall candles and other floral wreaths as the ceremony began inside the 600-seat Fryksande church.

“It is a day of grief but also a day of thankfulness,” the priest, Ingela Älvskog, told those in attendance.

Beckham, who arrived by private jet on Thursday, greeted Eriksson’s 95-year-old father Sven and other family members with hugs inside the church before the funeral started.

Eriksson became England’s first foreign-born coach when he led the national team from 2001-06, and made Beckham his captain.

Eriksson, who also won trophies at club level in Italy, Portugal and Sweden, died on Aug. 26 at the age of 76, eight months after he revealed he had been diagnosed with pancreatic cancer and had at most one year to live.

Some 200 seats in the neo-Gothic church from 1898 were reserved for his family, friends and players from his career in the football world, according to his agent. The remaining seats were open for the public, according to Eriksson’s wish, with a big screen set up outside the church where hundreds more gathered to watch the ceremony. The funeral was also broadcast live on some Swedish media websites.

The wooden coffin was wheeled in by pallbearers at the church Friday morning as fog wrapped Torsby — a town of about 4,000 people located about 310 kilometers (193 miles) west of Stockholm. Next to the casket was a photo of Eriksson on a small table. The floral wreaths included ones sent by FIFA and Lazio, the Italian team that Eriksson led to the Serie A title in 2000.

The ceremony began with somber piano and organ music, but later took on a more upbeat note with Swedish singer Charlotta Birgersson performing Elton John’s song “Candle In The Wind” and then “My Way” in a duet with Johan Birgersson, who later intoned the popular Italian song “Volare” after the family had gathered around the casket to lay flowers.

Beckham also visited Eriksson in Sweden in June to say goodbye. Others attending the funeral included the Swedish coach’s longtime partner Nancy Dell’Olio. Eriksson’s agent had said that guests from England, Italy and Spain were expected.

After the funeral, the casket was carried out of the church by eight men to the hearse. The guests then walked in a procession accompanying the coffin to a nearby museum where speeches and eulogies to the coach fondly known as “Svennis” were planned on an outdoor stage. A brass band played during the procession through Torsby, including the tune “You never walk alone” from the musical “Carousel” which has become the anthem of Liverpool, the club Eriksson supported since childhood.

The local soccer club Torsby IF, where Eriksson started his career in the 1960s, wrote on its webpage that “you also showed your greatness by always being yourself, the caring Svennis who talked to everyone and took the time, for big and small, asking how things were and how the football was going. We will miss you.”

___

AP soccer:

The Canadian Press. All rights reserved.



Source link

Continue Reading

Trending

Exit mobile version