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How the technology used to make COVID-19 vaccines could improve flu shots – CBC.ca

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The Dose21:56What’s the latest in flu vaccines?

Some experts fear this year’s flu season will be severe – especially with the pandemic still raging in many parts of Canada. Dr. Brian Goldman speaks with Dr. Susy Hota, Medical Director for Infection Prevention and Control at University Health Network in Toronto, about the latest developments in flu vaccines. 21:56

With flu season fast approaching, people who haven’t been vaccinated against COVID-19 or qualify for a third dose can safely get shots to protect them against both illnesses in the same visit, say health experts.

They anticipate that in the future, by applying the latest advances in mRNA technology, it may be possible to vaccinate a person against COVID-19 and the seasonal flu with a single vaccine. 

That’s because vaccine developers have been working on developing influenza vaccines using mRNA technology, the kind used in the Pfizer-BioNTech and Moderna COVID-19 vaccines, since before the pandemic, said Susy Hota, medical director of infection prevention and control at the University Health Network in Toronto. 

Several are already at the clinical trial stage.

No COVID-19 and flu combo vaccine is that far along. 

Hota says it would be incredibly convenient to leverage mRNA technology to better protect people against the flu.  

“What the future may hold is having one single, combined vaccine that addresses multiple infections that circulate at the same time. So that could be COVID 19 and influenza,” she told Dr. Brian Goldman, host of CBC Radio’s The Dose podcast.

“We’re not there yet. But wouldn’t that be nice, coming in for your one respiratory virus injection that will cover you for that season?” 

People get flu shots in Calgary last October. The vaccinations are available at pharmacies and primary care offices. (Leah Hennel/Alberta Health Services)

Flu viruses mutate frequently as they circulate around the world, Hota said. By the time scientists see what strains are taking off in the Southern Hemisphere and predict what to put in flu vaccines for people in the Northern Hemisphere, there could be mismatches.

On average, flu vaccines are about 40 to 60 per cent effective in protecting you from infection, Hota said. 

Since people infected with flu are at higher risk for having heart attacks and other cardiac problems than the general population, flu vaccinations save lives, she said.

“If we were to see too many COVID-19 and influenza patients coming to our hospitals, that could paralyze the system,” she said.

Speed is of the essence to beat flu

Vaccine makers are trying to catch up with the mutating virus so that what’s in their vials better matches the flu strains we might encounter from others who are coughing or perhaps talking a bit too close. 

That’s where mRNA technology comes in. Experts say perhaps they could observe flu activity worldwide for a longer period and then take advantage of the speed of mRNA vaccine manufacturing to add circulating flu strains to vaccines in time to better protect the public.

Dr. Susy Hota says getting two jabs at the same time to protect against COVID-19 and the flu is well worth it. (Craig Chivers/CBC)

Scott Halperin, a pediatric infectious diseases specialist and professor at Dalhousie University in Halifax, leads clinical trials for influenza and other vaccines at the Canadian Centre for Vaccinology in Halifax.

He says mRNA technology could likely accelerate the manufacturing of flu vaccines compared with the time-consuming approach of growing the virus in chicken eggs that’s used today.

At least three companies say they’re starting Phase 1 human safety trials of mRNA flu-only vaccines to check if the side-effects mirror those from conventional flu vaccines, such as a sore arm or fever. 

To eventually combine COVID-19 and flu protection in one jab, researchers first need to test that mRNA technology can be applied safely and effectively to influenza viruses. 

New technology brings better immunity

Moderna and Pfizer’s mRNA vaccines for COVID-19 include the genetic instructions to make a modified spike protein from the virus. Once the vaccine is injected into the body, human cells use the instructions to make copies of the spike protein for the immune system to learn to recognize.

WATCH | Flu shots recommended amid COVID’s 4th wave:

Doctors urging flu shots to prevent further health-care strain

10 days ago

Canadians are being urged to get flu shots as soon as possible because doctors expect the flu season to be much worse than last year, when there were very few cases. They want to avoid further strain on the health-care system already struggling with COVID-19. 3:30

For the three mRNA seasonal influenza vaccines in clinical trials now, companies need to show that combining flu strains this way doesn’t lessen the effectiveness of the immune response before regulators like Health Canada consider approval.

Alyson Kelvin, a scientist at the Vaccine and Infectious Disease Organization (VIDO) at the University of Saskatchewan, has spent years studying different influenza vaccines and also works on COVID-19 vaccine candidates.

“It seems that we do have this nice, broader immunity from mRNA vaccine technology,” Kelvin said. “Could you somehow target more than one influenza strain at once?”

Even if the answer is yes, Kelvin said, it’s a leap to go from using one spike protein from SARS-CoV-2, the coronavirus that causes COVID-19, to also covering four circulating influenza virus strains, as the current flu shots do, with a single shot.

“It’s exciting, but I think that we need to really complete the investigation,” Kelvin said. The all-in-one flu and COVID-19 vaccination studies haven’t reached clinical trials in humans, which normally take years to complete.

Researchers recognize that better strategies are needed to vaccinate against flu to achieve more protective responses, she said. 

Until then, public health officials hope people will continue wearing masks where necessary and washing their hands to protect against all of the pathogens that sicken people of all ages during respiratory virus season.

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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