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Indian-origin neurologist's UK study to revolutionise dementia diagnosis – The Tribune India

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PTI

London, April 6

An Indian-origin neurologist is part of a world-class research team in the UK that has been awarded a major grant this week to build on recent breakthroughs in potential dementia blood tests and generate the evidence needed for them to be used more widely in the next five years.

Dr Ashvini Keshavan, Senior Clinical Research and Honorary Consultant Neurologist Fellow at University College London (UCL), is part of the team that will focus on the most promising biomarker for Alzheimer’s disease called p-tau217. A second team made up of researchers from the Universities of Oxford and Cambridge will test various proteins to detect a variety of dementia-causing diseases.

Both teams will recruit participants from sites spread across the UK with the hope of its cost-effective rollout on the National Health Service (NHS) over time.

“Proteins that underpin various dementia-causing diseases, and particularly Alzheimer’s disease, which is the commonest cause of dementia worldwide, are now detectable in blood,” said Dr Keshavan.

“The two studies that have been awarded funding by the Blood Biomarker Challenge grant are both seeking to implement blood tests in real world settings in the UK, to see if blood tests will prove useful in confirming the presence or absence of these diseases in people who have early dementia or mild but progressive cognitive problems. We want to ensure that our research will reflect the UK’s ethnic and socioeconomic diversity and are aiming to broaden access to these tests, as the current gold standard tests to confirm the presence of these diseases are currently not accessible to most UK patients because they are either expensive or invasive,” she explains.

The Blood Biomarker Challenge is a multi-million-pound award given by Alzheimer’s Society, Alzheimer’s Research UK, the UK’s National Institute for Health and Research and Gates Ventures and includes funds raised by players of People’s Postcode Lottery.

The UCL-led study is called ADAPT and will focus on plasma p-tau217 – a blood marker of Alzheimer’s disease – and will answer the question of whether knowledge of this test result can improve rates of Alzheimer’s diagnosis in conjunction with standard memory clinic assessments. The second study is called READ-OUT, which aims to test various proteins, including novel or less well-established ones, to detect a variety of dementia-causing diseases.

“If our research shows that these tests are clinically useful, and cost-effective, we would be able to contribute to the case for them becoming a part of the standard of care offered in the UK. This would have the potential for individuals to receive earlier diagnoses of their specific dementia-causing disease,” said Dr Keshavan.

Such a breakthrough would be particularly important for ensuring patients are given the right post-diagnostic support and treatment for symptoms.

“An early, accurate diagnosis of Alzheimer’s disease is already important, allowing people to access appropriate care and medications. If, as we hope, new treatments that can slow down Alzheimer’s disease become available soon, then this will be vital. This would pave the way for fair and equitable access to new and potentially life-changing treatments to all who might benefit,” added Professor Jonathan Schott, Alzheimer’s Research UK Chief Medical Officer and Dr Keshavan’s UCL colleague on the research.

Currently, people are usually diagnosed with dementia using memory tests and brain scans. These are less accurate than “gold standard” tests like PET scans or lumbar punctures, which can confirm what type of dementia they have. However, only 2 per cent of people can access these specialist tests.

In recent years, a number of different blood tests that can diagnose Alzheimer’s disease and other causes of dementia have shown very promising results in research settings. But they have yet to be tested widely in clinical settings in the UK.

Dr Vanessa Raymont, Associate Director, Dementias Platform UK, and Senior Clinical Researcher, University of Oxford, said: “There was previously a feeling that this was just another part of aging, but now we’re seeing that people want to know more about their condition and they want a diagnosis as it helps them access the support they need.

“Both my parents lived with dementia so I know first-hand the devastation this disease causes, and how a timely and accurate diagnosis can benefit people and their families.” Blood tests are seen as part of the answer to addressing the dementia conundrum as they’re quick, easy to administer and cheaper than current, more complex tests.

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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