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Interview with Dr. Ziyad Al-Aly on the COVID pandemic and Long COVID

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This is the first part of a two-part interview.

Soon after the COVID-19 pandemic began to sicken millions of people, complaints of post-viral syndromes afflicting those who had recovered from the acute bout of infection began to appear on social media, and then in the popular press. At first these reports were anecdotal, but in May 2020, Elisa Perego, an archaeologist at University College London, created the term “Long COVID” as a hashtag on Twitter.

There remains no consensus definition of the disease due to the multi-factorial, and as of yet not fully understood, pathophysiological process that causes the multitude of symptoms associated with Long COVID.

The World Health Organization (WHO) established a clinical case definition for Long COVID in October 2021 based on its understanding at the time, with the caveat that as new evidence emerged on the consequences of COVID-19 infection, there would be changes in the clinical definition to diagnose the condition.

The WHO wrote:

Post COVID-19 condition occurs in individuals with a history of probable or confirmed SARS-CoV-2 infection, usually three months from the onset of COVID-19 with symptoms that last for at least two months and cannot be explained by an alternative diagnosis. Common symptoms include fatigue, shortness of breath, cognitive dysfunction but also others and generally have an impact on everyday functioning. Symptoms may be new onset following initial recovery from an acute COVID-19 episode or persist from the initial illness. Symptoms may also fluctuate or relapse over time.

The British National Institute for Health and Care Excellence (NICE) and the US National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC) have provided clinical criteria for post-COVID conditions that qualify as Long COVID. As of September 2022, the CDC estimated that 7.5 percent of US adults (15.6 million) were experiencing ongoing symptoms three or more months after their initial infection.

A recent published study in the Lancet synthesized the global evidence on the prevalence of persistent symptoms in a general post-COVID population and found that on average at least 45 percent of COVID survivors, regardless of the clinical course of their illness, went on to experience one unresolved symptom four months out. More than one-quarter complained of persistent fatigue. Among the hospitalized cohort, imaging and pulmonary studies revealed abnormalities and impaired functioning.

However, evidence of the impact of COVID infections on the health of the population remains sparse and a systematic analysis and study of the long-term impacts of COVID infection and reinfection remain sorely lacking.

In this regard, the studies being conducted and presented in peer-reviewed publications by Dr. Ziyad Al-Aly and his colleagues have been critical in developiing an insight into Long COVID. Dr. Al-Aly is director of the Clinical Epidemiology Center and chief of research development at the Veterans Affairs St. Louis Health Care System. Their findings underscore the dangers posed by SARS-CoV-2 infection and reinfection, regardless of vaccination status or severity of the disease after recovery from the acute phase of illness, particularly in damage to the heart, lungs and kidneys, and in metabolic diseases, neurological sequalae (after-effects) and mental health outcomes.

Dr. Ziyad Al-Aly [Photo by Dr. Ziyad Al-Aly]

Dr. Al-Aly recounted in a recent talk he gave on Long COVID that when the pandemic first hit the country, “we as a research group in St. Louis started pondering what can we do, what the hell is going on and then how do we as group of researchers and physician scientists do our part to address the challenge with the pandemic.” He added, “As clinical epidemiologists we started deliberating the best way we could contribute to the fight against COVID-19.”

Dr. Al-Aly explained that his group shifted to studying COVID-19. Out of this grew the recognition, brought forward by a coalition of patients afflicted with Long COVID, of the need to study this condition. He was surprised by the breadth of symptoms that affected so many organ systems. “This was a historic moment in the annals of medicine,” he said, “when patients came to the fore and alerted all of us scientists that something here is wrong and needs to be investigated and researched and gave the entity its name.”

But what is Long COVID, what are the true manifestations of the disease and how is it to be researched? The St. Louis group led by Al-Aly set out to address these questions in an unbiased manner, utilizing the Veterans Affairs Health System database. The group published its first report on Long COVID in Nature on April 22, 2021, titled “High-dimensional characterization of post-acute sequelae of COVID-19.” The report laid out the researchers’ extremely concerning finding that “beyond the first 30 days of illness, people with COVID-19 exhibit a higher risk of death and use of health resources.”

This was one of the first investigations into the long-term consequences of COVID infection, underscoring the dangers posed to the population beyond just the initial phase of infection. And the damage inflicted by the infection affected multiple organ systems, regardless of disease severity or age of the person. Perhaps most fundamentally, the report posed concretely the harmful relationship between communicable diseases and their potential consequences for population health despite the oft-repeated and scientifically unproven notion that the exposure of children and young adults to germs is good for them.

Dr. Al-Aly kindly accepted our invitation for an interview to discuss his work and the COVID pandemic.

* * * *

Benjamin Mateus [BM]: Good afternoon, Dr. Al-Aly. I hope you are doing well.

Ziyad Al-Aly [ZA]: Yes, thank you. Delighted to be here.

BM: Thank you for taking the interview, Dr. Al-Aly. Your time is valuable. I have several questions for you but first I’d like to begin by asking you to tell us who you are, what you do, and your interest in Long COVID.

ZA: I’m Ziyad Al-Aly. I’m a clinical epidemiologist at Washington University School of Medicine, and the chief of research and development at the Veterans Affairs (VA) St. Louis Health Care System. And I direct the clinical epidemiology center here at the St. Louis VA.

Very early in the pandemic, we started seeing reports from patients and patient advocacy groups about patients who developed various symptoms after their acute COVID illness had resolved. Clinically, we were also seeing people coming back with lingering symptoms after what we all thought at the time was just an acute infection that if it resolves, it resolves completely in most people and does not really result in any post-acute or chronic sequelae.

But we started receiving those reports and that sort of launched us on a trajectory to understand what’s going on with these patients. That led us to the characterization of Long COVID and on a pathway to try to understand the post-acute and long-term consequences of SARS-CoV-2 infection.

BM: Historically, we know that viral infections can lead to post-acute syndromes. Was there any thought at the beginning of the pandemic that this was a possibility, or were people just not aware of these or considering these issues? Maybe you can touch on these points?

ZA: Sure. I think hindsight is always 20-20. Now it’s very clear to us that many viruses in human history have resulted in long-term consequences. But I have to also admit that we as a medical community or the community of medical professionals and people who deal with chronic disease and infectious diseases have generally actually ignored the idea that viruses can result in long-term consequences.

When initially SARS-CoV-2 hit I don’t think it was at the forefront of our minds. At least it wasn’t on my mind, although knowing, even dating back to the flu pandemics in the early decades of the 20th century, that flu also resulted in some long-term consequences in some individuals who were infected with the influenza virus. Still, I don’t think that [clinical insight] was sufficiently hardwired in our minds when the pandemic hit. And I think that’s really a lesson learned that we ignored the post-viral condition for the past century. So, when the COVID-19 pandemic hit, we had to relearn all of this [the hard way].

Now, fast forward. Hindsight is 20-20. But what we’re ultimately trying to tell people is that infections with viruses can lead to adverse long-term health consequences—debility and health manifestation in people. This is a major concern, along with mortality.

SARS-CoV-2 is unique and at the same time not unique. It is unique because of its novelty at this moment. It’s really the virus of the moment. But it’s not unique in the sense it’s not the only virus in the world that can lead to long-term sequelae. We have had to almost rediscover this field in the wake of the early days of the pandemic.

And I think an important lesson to take going forward from all this is that we must recognize that pandemics are going to happen. These are one of the certainties of life. Pandemics are going to keep happening and there are going to be pandemics down the road, and we must recognize that pandemics are not only cause acute events, but they could in some instances lead to long-term serious manifestations, which can have enormous consequences not only on health outcomes, but potentially on the economy and societal well-being, given the extent of infections we are witnessing.

All this means, going forward, is that we must think about how to learn from this pandemic and be prepared for the next one. One key step is to evolve our data systems—our data systems need to be able to capture all this information needed to help us assess the toll of post-acute and long-term effects of emerging infectious diseases and build on our collective knowledge. Our medical and health systems need to be able to address the ramifications of mass casualties like we witnessed. And our science needs to be able to anticipate all this and deal with it more proactively. I think that all those are all lessons that we need to learn now, so we don’t really keep repeating those mistakes.

But I think we have also to be honest with ourselves that none of this was… I don’t think collectively here in the United States or anywhere in the world that we had that sort of front and center on our minds when the pandemic hit.

BM: Has anybody ever compared the post-viral syndromes between SARS-CoV-1 and SARS-CoV-2?

ZA: No, not to my knowledge. I think that this is really to your point, Benjamin, is that we haven’t really invested in or thought sufficiently about the post-viral condition to fully characterize different viruses and their long-term consequences, nor do comparative analyses to try to understand similarities and differences in the long-term adverse health consequences of different viruses—the disease processes at play.

So, what are the consequences of SARS-CoV-1, SARS-CoV-2, and MERS? What about Ebola and post-polio? And post flu? And we draw quite a bit of comparison to COVID versus flu, but I also have to admit, what are the five-year outcomes of COVID versus flu? Does anybody know the answer? It’s not known. Look, the flu has been around a very long time, meaning we should know these things, but we don’t. It’s been around for more than a hundred years, but we’ve also ignored it for more than a hundred years.

Dr. Al-Aly at his desk [Photo by Dr. Ziyad Al-Aly]

And as a result, when you ignore something, you don’t have a lot of knowledge about it. So going back to your question of SARS-CoV-1 and SARS-CoV2, there isn’t a whole lot of data out there that can give us a full view for a comparative analysis or the long-term consequences of one versus the other.

BM: Regarding ME/CFS—myalgic encephalomyelitis/chronic fatigue syndrome—is there a better understanding now that this may be a post-viral syndrome that has manifested in a blanket name for this disease, whose pathophysiological mechanisms are poorly understood?

ZA: There are many hypotheses on ME/CFS, which has been talked about for more than 30 years. But it has been substantially underfunded and therefore not sufficiently studied. One of the hypotheses of the pathobiology of ME/CFS is that it’s initially triggered… or the initiating event is a viral infection.

So, what is the virus that initiates ME/CFS still needs to be clarified. But many of those patients, when they are eventually diagnosed with the condition, when they track back the origins of their symptomatology, in a lot of these patients the triggering event is an upper respiratory tract infection or some sort of an infection with fever that only lasted a few days or just symptoms of a cough, some shortness of breath and sore throat for a few days… what we generally classify broadly under the umbrella of an upper respiratory tract infection or the symptomatology that overlaps substantially or what we commonly refer to as upper respiratory tract infection. It’s at least clear from those data that that maybe the triggering event is a viral infection.

But I also caveat that by saying that the science on that is not definitive. The identity of that virus has not been pinned down. Still, all of this speaks to the notion that we are talking about, that these entities may have a viral origin and they could be broadly classified under the post-viral illness category, or more appropriately called an infection-associated chronic illness. That’s the term that most people prefer to use. There are different terminologies, and the field is still nascent and evolving but presently the most accepted term is infection-associated chronic illnesses.

However, those baskets of conditions, including ME/CFS, have not been sufficiently studied for us to sit and have a conversation without the data being available to review. The short answer is that we don’t really know conclusively if ME/CFS is initiated by a virus and then which virus. But plausibly, there are hypotheses suggesting that may be the case.

BM: Which raises the topic that has captured the attention of the mainstream press and social media, that is, the pseudo-scientific construct of immunity debt. Additionally, many people, whether they’re politically reactionary or they just don’t know, think that getting infected is somehow good for building your immunity. Within the confines of long COVID and these post viral acute syndromes, what would you tell someone who raises those issues?

ZA: Sure. I hear that a lot and I hear people saying that “a cold never really killed anyone!” And it is true that getting a cold doesn’t really kill anyone [immediately]. But I would like to ask the question, “Does a person who gets, between the ages of 20 and 50, if they get five colds and another person with the same characteristics gets 20 colds, do they have the same risk of cardiovascular outcomes or neurologic outcomes?”

And the answer to that is that we don’t really know. People trivialize infections because they don’t really see immediately the [long-term] consequences of infections. That’s not only true for SARS-CoV-2, but also for a lot of other infections. Even going back to the mildest infection that people generally try to trivialize—the common cold —but we don’t really know what repeat infection means for the life of a person, though we should. Are those people who have more colds at higher risk of long-term disease?

BM: These are important questions and in the context of the pandemic not inconsequential.

ZA: And I would posit, based on some of the evidence we have obtained from our studies, I would hypothesize that the person who gets more infections actually has a higher risk of long-term outcomes, even with a cold.

People trivialize these things without really knowing that there are phases of infection, and it may be true that in the acute phase, if you’re only observing for a few days after an upper respiratory tract infection with a common cold and they quickly bounce back and seemingly on the surface there is no real damage, we can’t be certain on the long-term impact it will have on their health.

We really don’t know, but this is really what we need: more understanding of repeat infections.

Now, with SARS-CoV-2, we know because we’ve done some work to characterize these risks between one, two or three infections. And it is abundantly clear that the people who got hit twice or three times with COVID have it worse compared to those with only one prior infection, both in the acute phase and the long-term phase or post-acute viral phase.

So I think that this idea that infections provide you with immunity and that’s going to shield you and it’s going to totally offset the long-term cost of an infection is bizarre to me. It’s too simplistic and wishful thinking. I wish this was true—to be a kid in a candy store trying to imagine life like that. It would be nice to get one infection that would immunize us from subsequent infections and carry no further risk—it would be wonderful, but that’s simply not the case at all, at least for SARS-CoV-2.

BM: Just one more question along this line before circling back to something you mentioned earlier. What is the latest hypothesis around the mechanism behind post-COVID syndrome? Is it the persistence of the virus? Is it immune dysregulation? Is it a vasculitis and micro-thrombi?

ZA: Brilliant question, Benjamin. But the short answer is we still don’t definitely know with absolute certainty. There are multiple hypotheses and many interesting experimental works that are being done by researchers throughout the world on this question.

One central hypothesis suggests the idea of viral persistence in “immune-privileged sites.” And when we say viral persistent, it doesn’t mean the whole virus but fragments of the viral RNA or proteins that reside in immune-privileged sites that provoke chronic inflammation. That hypothesis is plausible, but it still remains in the realm of a hypothesis, meaning it would still need to be supported with evidence or refuted with evidence. That’s what hypotheses are—a line of thinking that would need to be tested experimentally and clinically to validate whether it’s true or false. In other words, we would conclude that a certain hypothesis is not valid based on A, B, C, D, and E evidence.

At this point, I still classify viral persistence under the umbrella of a hypothesis. And there are a lot of other hypotheses that have been presented. One of them, as you pointed out, is immune dysregulation. Another revolves around the idea of a microbiome dysbiosis. This idea that within us, within the human body, there are more bacteria than human cells. And with viral infections, these microbiomes are disturbed, causing “microbiome dysbiosis,” which then provokes a state of ill health or disease. Again, all of those are hypotheses.

I also have to say that they’re not necessarily mutually exclusive. The idea there could be immune dysfunction does not really exclude the possibility that viral persistence or microbiome dysbiosis is causing chronic inflammation or a state of disease.

When we speak about Long COVID, and we both have studied it and thought about it deeply, to know it’s not really one thing. At the end of the day, it’s unlikely to be one thing. We can certainly classify it under the broad umbrella of post-acute illness or post-viral illness. That would be correct. But I think we have to be reluctant to oversimplify a complex condition like that and make it one thing. It’s unlikely to be just one thing.

When I speak to the “lay press” I give the example of our conception of cancer a hundred years ago, when we lumped all cancers under one category—this is tumor outgrowth or this is cancer—but we now know that there are more than 800 types of malignancies and all have different genomic signatures and different responses to treatment, and so on.

In that sense, the field of Long-COVID [and post-acute viral syndromes] is really that nascent or that embryonic in the sense that maybe ultimately, over time, we’ll recognize Long COVID type A, type B, and type C with different manifestations, different responses to treatment, and also different pathophysiology on different mechanisms, meaning, that some of it, maybe Type A, is driven by viral persistence, but type B is driven by microbiome dysbiosis.

The field is nascent or embryonic, which means we have to have an open-minded approach to it and learn from the evidence and adjust our thinking accordingly.

 

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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