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Israeli study finds Pfizer vaccine 85% effective after first shot – Al Jazeera English

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Researchers say a longer follow-up is required to understand the effect of one shot to inform second dose delay policy.

A new study on healthcare workers in Israel has found that one shot of a two-dose vaccine produced by Pfizer-BioNTech is 85 percent effective, heightening the debate over the possibility of spacing out doses.

The Lancet medical journal published on Thursday the results of the study based on more than 9,000 health care workers from the Sheba Medical Center, an Israeli research hospital, showing a drop by 85 percent of staff presenting COVID-19 symptoms after a period of 15 to 28 days after the first dose.

The overall reduction of infections, including asymptomatic cases detected by testing, was 75 percent.

The reductions of infections “provide support of delaying the second dose in countries facing vaccine shortages and scarce resources, so as to allow higher population coverage with a single dose,” read the report.

However, it added that a longer follow-up is required to assess the long-term effect of a single shot to “inform a second dose delay policy”.

Sheba epidemiologist Gili Regev-Yochay cautioned that the cohort studied at the hospital was “mostly young and healthy”.

Unlike Pfizer-BioNTech’s own clinical trial, “we don’t have many (staff) here aged over 65,” she told reporters. But she also noted that the Sheba study took place during a surge in COVID-19 infections in Israel, which flooded hospitals with new cases.

Pfizer declined to comment on the data, saying in a statement it was doing its own analysis of “the vaccine’s real-world effectiveness in several locations worldwide, including Israel”.

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Pfizer said it hopes to use Israeli data to look at the potential of the vaccine to protect against COVID-19 arising from emerging variants. Israel has become a real-world test laboratory since it has signed an agreement with Pfizer, promising to share vast troves of medical data with the international drug giant in exchange for the continued flow of its vaccine.

The Israeli study comes a day after Canadian researchers suggested that the second Pfizer-BioNTech dose be delayed given the high level of protection from the first shot in order to increase the number of people getting vaccinated.

Their research showed efficacy of 92.6 percent after the first dose, based on an analysis of the documents submitted by the drugmaker from its late-stage human trials to the United States Food and Drug Administration (FDA) in December.

The results from the Sheba Medical Center add to another laboratory study in Israel at the Rambam Health Care Campus where 91 percent of 1,800 health workers reportedly developed antibodies 21 days after receiving the first dose and before getting the second one.

The FDA said in December data from those trials showed that the vaccine began conferring some protection to recipients before they received the second shot, but more data would be needed to assess the potential of a single-dose shot.

Pfizer has said alternative dosing regimens of the vaccine have not been evaluated yet and that the decision resided with health authorities.

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Roots sees room for expansion in activewear, reports $5.2M Q2 loss and sales drop

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TORONTO – Roots Corp. may have built its brand on all things comfy and cosy, but its CEO says activewear is now “really becoming a core part” of the brand.

The category, which at Roots spans leggings, tracksuits, sports bras and bike shorts, has seen such sustained double-digit growth that Meghan Roach plans to make it a key part of the business’ future.

“It’s an area … you will see us continue to expand upon,” she told analysts on a Friday call.

The Toronto-based retailer’s push into activewear has taken shape over many years and included several turns as the official designer and supplier of Team Canada’s Olympic uniform.

But consumers have had plenty of choice when it comes to workout gear and other apparel suited to their sporting needs. On top of the slew of athletic brands like Nike and Adidas, shoppers have also gravitated toward Lululemon Athletica Inc., Alo and Vuori, ramping up competition in the activewear category.

Roach feels Roots’ toehold in the category stems from the fit, feel and following its merchandise has cultivated.

“Our product really resonates with (shoppers) because you can wear it through multiple different use cases and occasions,” she said.

“We’ve been seeing customers come back again and again for some of these core products in our activewear collection.”

Her remarks came the same day as Roots revealed it lost $5.2 million in its latest quarter compared with a loss of $5.3 million in the same quarter last year.

The company said the second-quarter loss amounted to 13 cents per diluted share for the quarter ended Aug. 3, the same as a year earlier.

In presenting the results, Roach reminded analysts that the first half of the year is usually “seasonally small,” representing just 30 per cent of the company’s annual sales.

Sales for the second quarter totalled $47.7 million, down from $49.4 million in the same quarter last year.

The move lower came as direct-to-consumer sales amounted to $36.4 million, down from $37.1 million a year earlier, as comparable sales edged down 0.2 per cent.

The numbers reflect the fact that Roots continued to grapple with inventory challenges in the company’s Cooper fleece line that first cropped up in its previous quarter.

Roots recently began to use artificial intelligence to assist with daily inventory replenishments and said more tools helping with allocation will go live in the next quarter.

Beyond that time period, the company intends to keep exploring AI and renovate more of its stores.

It will also re-evaluate its design ranks.

Roots announced Friday that chief product officer Karuna Scheinfeld has stepped down.

Rather than fill the role, the company plans to hire senior level design talent with international experience in the outdoor and activewear sectors who will take on tasks previously done by the chief product officer.

This report by The Canadian Press was first published Sept. 13, 2024.

Companies in this story: (TSX:ROOT)

The Canadian Press. All rights reserved.

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Talks on today over HandyDART strike affecting vulnerable people in Metro Vancouver

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VANCOUVER – Mediated talks between the union representing HandyDART workers in Metro Vancouver and its employer, Transdev, are set to resume today as a strike that has stopped most services drags into a second week.

No timeline has been set for the length of the negotiations, but Joe McCann, president of the Amalgamated Transit Union Local 1724, says they are willing to stay there as long as it takes, even if talks drag on all night.

About 600 employees of the door-to-door transit service for people unable to navigate the conventional transit system have been on strike since last Tuesday, pausing service for all but essential medical trips.

Hundreds of drivers rallied outside TransLink’s head office earlier this week, calling for the transportation provider to intervene in the dispute with Transdev, which was contracted to oversee HandyDART service.

Transdev said earlier this week that it will provide a reply to the union’s latest proposal on Thursday.

A statement from the company said it “strongly believes” that their employees deserve fair wages, and that a fair contract “must balance the needs of their employees, clients and taxpayers.”

This report by The Canadian Press was first published Sept. 12, 2024.

The Canadian Press. All rights reserved.

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Transat AT reports $39.9M Q3 loss compared with $57.3M profit a year earlier

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MONTREAL – Travel company Transat AT Inc. reported a loss in its latest quarter compared with a profit a year earlier as its revenue edged lower.

The parent company of Air Transat says it lost $39.9 million or $1.03 per diluted share in its quarter ended July 31.

The result compared with a profit of $57.3 million or $1.49 per diluted share a year earlier.

Revenue in what was the company’s third quarter totalled $736.2 million, down from $746.3 million in the same quarter last year.

On an adjusted basis, Transat says it lost $1.10 per share in its latest quarter compared with an adjusted profit of $1.10 per share a year earlier.

Transat chief executive Annick Guérard says demand for leisure travel remains healthy, as evidenced by higher traffic, but consumers are increasingly price conscious given the current economic uncertainty.

This report by The Canadian Press was first published Sept. 12, 2024.

Companies in this story: (TSX:TRZ)

The Canadian Press. All rights reserved.

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