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Johnson & Johnson’s single-dose COVID-19 vaccine candidate begins phase 3 trial – Global News

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Johnson & Johnson is beginning a huge final study to try to prove if a single-dose COVID-19 vaccine can protect against the virus.

The study starting Wednesday will be one of the world’s largest coronavirus vaccine studies so far, testing the shot in 60,000 volunteers in the U.S., South Africa, Argentina, Brazil, Chile, Colombia, Mexico and Peru.

A handful of other vaccines in the U.S. — including shots made by Moderna Inc. and Pfizer Inc. — and others in other countries are already in final-stage testing. Hopes are high that answers about at least one candidate being tested in the U.S. could come by year’s end, maybe sooner.

U.S. health officials insist the race for a vaccine isn’t cutting corners.

Read more:
9 drugmaker executives testing coronavirus vaccines pledge safety, high standards

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“We want to do everything we can without sacrificing safety or efficacy — we’re not going to do that — to make sure that we end up with vaccines that are going to save lives,” Dr. Francis Collins, director of the National Institutes of Health, told reporters.

But many vaccine specialists question whether the Food and Drug Administration will stick to that goal under intense pressure from the Trump administration. President Donald Trump has consistently presented a faster timeline for a new vaccine than experts say is adequate to fully test the candidates.

Meanwhile, testing of still another experimental vaccine, made by AstraZeneca, remains on hold in the U.S. as officials examine a safety question, even though studies have resumed in other countries.

Earlier this week, Vice-President Mike Pence urged state governors to “do your part to build public confidence that it will be a safe and effective vaccine.”






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Coronavirus: Trump says his administration expects vaccines for every American by April


Coronavirus: Trump says his administration expects vaccines for every American by April

And Dr. Anthony Fauci, the top U.S. infectious disease expert, added in the call to governors that he is confident in “a tried and true process” that has checks and balances built in, including an independent board evaluating the progress of each vaccine trial, as well as “the integrity of the FDA.”

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A recording of the call was provided to The Associated Press.

Senators were scheduled to question FDA Commissioner Stephen Hahn, Fauci and other administration officials later Wednesday about the pandemic response.

Even if the FDA were to allow emergency use of a vaccine by year’s end, supplies would be limited and given first to vulnerable groups such as health workers. Most Americans aren’t likely to receive a vaccine until sometime next year.

Read more:
Canada to join global coronavirus vaccine procurement program

The Centers for Disease Control and Prevention wants states to get ready now to roll out vaccinations, which will present enormous logistical challenges. On Wednesday the CDC was set to announce distribution of $200 million in congressionally approved funds to help begin setting up operations.

Health and Human Services Secretary Alex Azar said the COVID-19 vaccine campaign will build on longstanding co-operation between the federal government and the states on immunizations.

J&J’s vaccine is made with slightly different technology than others in late-stage testing, modeled on an Ebola vaccine the company created. Unlike the other three vaccines that started late-stage testing in the U.S., it requires only one shot, not two. Despite a later start to testing than some of its competitors, Dr. Paul Stoffels, J&J’s chief scientific officer, told reporters that the study was large enough to yield answers possibly by early next year.

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Associated Press writers Lauran Neergaard and Ricardo Alonso-Zaldivar contributed to this report.

© 2020 The Canadian Press

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Jack Ma Becomes Richer Than Walmart Heirs With Mega Ant IPO – Yahoo Canada Finance

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The Canadian Press

Fitting finale: Dodgers win title, lose Turner to COVID-19

ARLINGTON, Texas — No dogpile, no champagne and a mask on nearly every face — the Los Angeles Dodgers celebrated their first World Series title since 1988 in a manner no one could have imagined prior to the coronavirus pandemic.They started the party without Justin Turner, too, after their red-headed star received a positive COVID-19 test in the middle of their clinching victory.Turner was removed from Los Angeles’ 3-1 victory over the Tampa Bay Rays in Game 6 on Tuesday night after registering Major League Baseball’s first positive test in 59 days and wasn’t initially on the field as the Dodgers enjoyed the spoils of a title earned during a most unusual season.He returned about an hour after the game, hugging longtime teammate Clayton Kershaw and sitting front-and-centre for a team photo next to manager Dave Roberts with his mask pulled down under his bushy beard.“Thanks to everyone reaching out!,” Turner said on Twitter. “I feel great, no symptoms at all. Just experienced every emotion you can possibly imagine. Can’t believe I couldn’t be out there to celebrate with my guys! So proud of this team & unbelievably happy for the City of LA.”Major League Baseball insulated post-season teams in neutral-site bubbles after travelling them across the country during a shortened 60-game season. Turner was the first player since the playoffs began to be flagged for the coronavirus.MLB received Turner’s Monday sample from the Sports Medicine Research and Testing Laboratory in Utah in the bottom of the second inning, when lab president Dr. Daniel Eichner called deputy commissioner Dan Halem, who was in New York, a person familiar with the call said, speaking to The Associated Press on condition of anonymity because details were not released.Eichner told Halem the result was inconclusive. MLB receives many inconclusive results, so Halem told Eichner to run Tuesday’s pregame sample from Turner. That result came back positive in the sixth inning, the person said.Halem called Chris Young, MLB’s senior vice-president of baseball operations, who was in Manfred’s box at Globe Life Field, then called Dodgers president of baseball operations Andrew Friedman. Friedman notified the dugout or clubhouse, and Turner was removed from the game after the seventh inning.The 35-year-old Turner has been a staple in the Dodgers’ lineup for seven of their eight consecutive NL West titles. A late-blooming slugger who helped reshape the game by succeeding with an upper-cut swing, Turner is LA’s career leader with 12 post-season home runs, including a pair in this Series, in which he hit .364 and also played stellar defence.“It’s gut-wrenching,” World Series MVP Corey Seager said. “If I could switch places with him right now, I would. That’s just not right.”Commissioner Rob Manfred confirmed Turner’s positive test moments after presenting the World Series trophy to Los Angeles — a jarring reminder of all that’s been different in this season where the perennially favoured Dodgers finally broke through.Mookie Betts, who came to the Dodgers to make a World Series difference, had a mad dash to home plate in the sixth inning to put Los Angeles over the top.The end of a frustrating championship drought for LA — and perhaps just the start for Betts and the Dodgers, whose seventh World Series title was their sixth since leaving Brooklyn to the West Coast in 1958.“I had a crazy feeling that came to fruition,” Roberts said. “It’s just a special group of players, organization, all that we’ve kind of overcome.”Betts bolted from third for the go-ahead run on Seager’s infield grounder, then led off the eighth with a punctuating homer.“It was absolutely phenomenal. This team was incredible,” said Seager, also the NLCS MVP who had franchise records with his eight homers and 20 RBIs this post-season. “We never stopped. We were ready to go as soon as the bell was called. Once it did, we kept rolling. You can’t say enough about what we did this season.”Kershaw was warming in the bullpen when Julio Urías struck out Willy Adames to end it and ran alongside teammates to celebrate in the infield, later joined by family who had been in the bubble with them in North Texas.Players were handed face masks as they gathered, although many of their embraces came mask-free even after Turner’s positive test.The Dodgers had played 5,014 regular season games and were in their 114th post-season game since Orel Hershiser struck out Oakland’s Tony Phillips for the final out of the World Series in 1988, the same year Kershaw — the three-time NL Cy Young Award winner who won Games 1 and 5 of this Series — was born in nearby Dallas.Los Angeles had come up short in the World Series twice in the previous three years. Betts was on the other side two years ago and homered in the clinching Game 5 for the Boston Red Sox, who before this season traded the 2018 AL MVP to the Dodgers. They later gave him a $365 million, 12-year deal that goes until he turns 40 in 2032.Betts’ 3.2-second sprint was just enough to beat the throw by first baseman Ji-Man Choi, pushing Los Angeles ahead 2-1 moments after Rays manager Kevin Cash pulled ace left-hander Blake Snell despite a dominant performance over 5 1/3 innings.“I’m not exactly sure why,” Betts said when asked about the move. “I’m not going to ask any questions. He was pitching a great game.”Snell struck out nine — including the first time all season that Betts, Seager and Turner each struck out in their first two at-bats. But the 2018 AL Cy Young Award winner didn’t see the top three batters in the Dodgers lineup a third time.“The only motive was the lineup the Dodgers feature is as potent as any team in the league,” Rays manager Kevin Cash said. “Mookie coming around for the third time through, I value that. I totally respect and understand the questions that come with it. They’re not easy decisions.”The Dodgers leadoff hitter had a .531 OPS against lefties this season, compared to 1.061 versus right-handers.Randy Arozarena, the powerful Tampa Bay rookie, extended his post-season record with his 10th homer in the first off rookie right-hander Tony Gonsolin, the first of seven Dodgers pitchers. The Rays never got another runner past second base as LA’s bullpen gave reliever-reliant Tampa Bay a taste of its own medicine while allowing only two hits and no walks over 7 1/3 innings.About 2 1/2 weeks after the Lakers won the NBA title while finishing their season in the NBA bubble in Orlando, Florida, the Dodgers gave Los Angeles another championship in this year when the novel coronavirus pandemic has delayed, shortened and moved around sports seasons.The MLB season didn’t start until late July and was abbreviated for the shortest regular season since 1878. And the expanded post-season, with 16 teams making it instead of 10, almost went the full distance.It ended when Urías got the last two out Tampa Bay batters on called third strikes — the 15th and 16 Ks by the Rays, with catcher Austin Barnes stuffing the last pitch in his back pocket. Along with the 11 strikeouts by the Dodgers, it was the most combined strikeouts in a nine-inning World Series game.Chants of “M-V-P!, M-V-P!” broke out when Betts hit his double in the sixth off reliever Nick Anderson, who allowed runs in seven consecutive relief appearances, the longest streak in MLB post-season history.Those chants got even louder — even with the a limited crowd of 11,437 — when Betts went deep on an 0-2 pitch by hard-throwing right-hander Pete Fairbanks.There were plenty of fans in Dodgers blue at the new $1.2 billion home of the Texas Rangers, the stadium with the retractable roof where they played 16 games over three weeks. And the roof was closed for the final one, with misty conditions and a game-time temperature of 39 degrees outside.Los Angeles was home team for the final game of the season, like in the 2017 World Series when the Houston Astros won Game 7 at Dodger Stadium, and two years ago against the Red Sox.“This year has been crazy, but no matter what, we’ll look back on this and we’re World Series champs. To get to say that and get to be part of that, it’s so special no matter what,” Kershaw said. “The only thing that may have made it better would be to be at Dodger Stadium.”___AP Baseball Writer Ronald Blum contributed to this report.___More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_SportsStephen Hawkins, The Associated Press

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Cenovus-Husky deal to result in upward of 2150 layoffs – CTV Toronto

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CALGARY —
Officials with Cenovus Energy confirm the acquisition of Husky Energy will result in the elimination of between 20 and 25 per cent of the staff of the combined company.

Together, the companies currently have 8,600 employees and contractors, which means between 1,720 and 2,150 layoffs are planned.

According to Cenovus, the majority of the staffing cuts will occur in Calgary.

Cenovus announced it had purchased Husky on the weekend through a $3.8 billion share transaction. The deal is expected to be finalized in 2021.

Following the announcement of planned cuts at the combine company, Energy Minister Sonya Savage says there’s still reason for optimism regarding Alberta’s energy sector.

“Those who wish to see Canada’s energy sector shut down entirely will no doubt opportunistically seize upon today’s news,” said Savage in a statement. “But projections show continued global demand for fossil fuels well into the future. We believe that Canada should not cede that market to countries like Russia and Saudi Arabia. 

“As companies across the globe navigate unprecedented economic times, job restructurings are an unfortunate reality of weathering the storm. 

“As part of Alberta’s Recovery Plan, the Government focused on ensuring that the oil and gas sector is in a strong position for recovery, while also diversifying the economy to create new jobs.”

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'Already struggling' Calgary downtown core will be hit hard by job cuts from Cenovus-Husky merger – National Post

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“It’s an unfortunate thing, because, the timing being such, the pandemic has affected everyone in Calgary and certainly in Alberta,” Ball said. “For non-profits it means there’s been an increase in the demands for their services.”

It’s especially acute for the cultural non-profits, most of which are based downtown, she said.

“Of course people working downtown creates a vibrancy 5 to 7 and 7 beyond for bars and restaurants and also live in-person events and so the arts sector is tied to, in some ways, the vitality of the downtown core.”

Still, in spite of the doom and gloom, there are bright spots: On Monday, Suncor announced it would be relocating employees at its branch offices in the Toronto area to Calgary, essentially bringing 700 positions to Calgary.

“Yesterday, Suncor’s leadership spoke with our Downstream employees and let them know that over the course of 2021, we’d be moving our Downstream head office from Mississauga and Oakville to Calgary,” Suncor spokesperson Sneh Seetal said in an email.

Nenshi said that Suncor moving people to the city is good news, evidence of the city’s appealing real-estate market, compared to overheated business markets such as Toronto, something he hopes will bring even more business to the city.

“That’s really the pitch that we’re making to a lot of firms,” said Nenshi.

Woolley, for his part, also remains optimistic: “There is hope, I am a hopeful, optimistic Calgarian, I believe in our city, but it really does speak to the importance of us taking a look at economic diversification,” said Woolley.

With files from Geoffrey Morgan

• Email: tdawson@postmedia.com | Twitter:

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