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McMaster lab to screen for rare antibody that causes blood clots after AstraZeneca vaccine – CBC.ca

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A team of doctors at Hamilton’s McMaster University is preparing to test blood samples from across Canada in search of a rare type of clot linked to the Astra-Zeneca COVID-19 vaccine.

There have been no cases of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) in Canada, but there have been cases in Europe. Since those cases, Canada’s National Advisory Committee on Immunization (NACI) has recommended pausing administration of the AstraZeneca COVID-19 vaccine to those under age 55.

The McMaster team is preparing to screen blood samples of Canadian patients who may have had VIPIT.

In the meantime, clinical hematologist Meneka Pai, among doctors involved in the McMaster testing, says she likes the idea of pausing the vaccine for “more study” into its safety.

“Ten days ago, we didn’t know that this condition existed, so things are moving really fast,” Pai told CBC News. 

Dr. Menaka Pai, a clinical hematologist at McMaster University Menaka Pai and a member of Ontario’s COVID-19 Science Advisory Table, says ‘things are moving fast’ when it comes to vaccine-related findings. (Submitted by Menaka Pai)

“I think when things are moving so fast, just taking this brief pause [allows us to] figure out what’s going on … gather more data, tighten up those estimations and continue doing surveillance in Canada to make sure we’re not seeing these cases.”

When a blood clot occurs, the flow of blood stops, said Pai. 

“In many blood clots, it’s platelets, little sticky cells — they basically turn on and they form a jam. If you get a blood clot, it stops healthy blood from flowing to the area. And it actually stops deoxygenated blood from draining, so there’s a problem with flowing in and flowing out,” said Pai.

“In VIPIT, what happens is that patients get the vaccine, and then it seems that four to 20 days later, their body makes a molecule called an antibody and that antibody actually attacks the person’s own platelets. These platelets switch on and they get sticky. Now you have these sticky cells and they start to form clots.

“So the real key with VIPIT is there’s this predisposing factor of the vaccine, and then the immune response revs up, and then four to 20 days later, we see this very dangerous antibody forming,” the hematologist said.

More women than men, but why?

Pai, who is also a member of Ontario’s COVID-19 Science Advisory Table, said while there have been no vaccine-induced VIPIT cases in Canada, the majority of them elsewhere involved people under 55, and more often women.

But Pai said it’s not known if this is a predisposition, because countries in Europe preferentially gave the AstraZeneca vaccine to younger people and health-care workers. There are more women in the latter group.

“We don’t know if it’s true that it’s women under age 55 who are very at-risk, or is it just because this is who got the AstraZeneca vaccine in the countries that are reporting? So, we’re waiting on data,” she said.

“Is the U.K. going to tell us something different, because they vaccinated older people? We’re sort of keeping our ears open but right now.”

Dr. Donald Arnold, medical director of the Platelet Immunology Laboratory at McMaster University, says the school’s lab is ‘very equipped’ to do special testing for platelet disorders. (Submitted by Jessica Clarke)

Dr. Donald Arnold, medical director of the Platelet Immunology Laborotory at McMaster, said preliminary reports from Europe show people who develop VIPIT had “very positive tests in what’s called platelet activation assays.”

He said the McMaster lab is “very equipped” to do those tests. The lab runs specialized tests for different types of platelet disorders, including screening for Heparin-induced thrombocytopenia (HIT).

Know the risks

People with HIT sometimes develop a low platelet count and blood clots.

“As it turned out, this vaccine-induced syndrome called VIPIT is very similar to Heparin-induced thrombocytopenia and the testing is quite similar as well,” Arnold told CBC News.

“We’re the only reference lab in Canada that does this whole battery of testing. It has, up until now, been a fairly niche area and not a common test that’s been required although it had its own place in medicine, looking for this type of disorder called HIT.”

Arnold said the lab is offering “confirmatory testing” for anyone in Canada suspected of developing vaccine-induced VIPIT.

“I think what really has to happen with this vaccine is people who get it, and doctors who are giving it or overseeing it, have to be aware that this is a potential risk and know what signs and symptoms to look out for.”

Symptoms include headaches and seizures

Arnold added: “If a person does end up presenting with some of those signs and symptoms, they should be investigated with routine tests first and then a consultation with a hematologist should happen.

“If there is still a suspicion that this could be a real case of vaccine-induced VIPIT, then they should send the sample to us to do the confirmation.” The lab will be able to detect VIPIT in two or three days. 

An advisory issued by the Ontario COVID-19 Science Advisory Table says VIPIT symptoms include:

  • Persistent and severe headaches.
  • Seizures.
  • Blurred vision.
  • Shortness of breath.
  • Chest or abdominal pain.
  • Redness in a limb.

“We just want to give clinicians and Canadians the best information on how to detect this and treat this — that’s the goal of the science table,” said Pai.

“We’re not making vaccine policy. We’re here to tell people we know what this is, we know how to treat it, if it happens you’re going to be ready to give the patient really good care.”

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Roots sees room for expansion in activewear, reports $5.2M Q2 loss and sales drop

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TORONTO – Roots Corp. may have built its brand on all things comfy and cosy, but its CEO says activewear is now “really becoming a core part” of the brand.

The category, which at Roots spans leggings, tracksuits, sports bras and bike shorts, has seen such sustained double-digit growth that Meghan Roach plans to make it a key part of the business’ future.

“It’s an area … you will see us continue to expand upon,” she told analysts on a Friday call.

The Toronto-based retailer’s push into activewear has taken shape over many years and included several turns as the official designer and supplier of Team Canada’s Olympic uniform.

But consumers have had plenty of choice when it comes to workout gear and other apparel suited to their sporting needs. On top of the slew of athletic brands like Nike and Adidas, shoppers have also gravitated toward Lululemon Athletica Inc., Alo and Vuori, ramping up competition in the activewear category.

Roach feels Roots’ toehold in the category stems from the fit, feel and following its merchandise has cultivated.

“Our product really resonates with (shoppers) because you can wear it through multiple different use cases and occasions,” she said.

“We’ve been seeing customers come back again and again for some of these core products in our activewear collection.”

Her remarks came the same day as Roots revealed it lost $5.2 million in its latest quarter compared with a loss of $5.3 million in the same quarter last year.

The company said the second-quarter loss amounted to 13 cents per diluted share for the quarter ended Aug. 3, the same as a year earlier.

In presenting the results, Roach reminded analysts that the first half of the year is usually “seasonally small,” representing just 30 per cent of the company’s annual sales.

Sales for the second quarter totalled $47.7 million, down from $49.4 million in the same quarter last year.

The move lower came as direct-to-consumer sales amounted to $36.4 million, down from $37.1 million a year earlier, as comparable sales edged down 0.2 per cent.

The numbers reflect the fact that Roots continued to grapple with inventory challenges in the company’s Cooper fleece line that first cropped up in its previous quarter.

Roots recently began to use artificial intelligence to assist with daily inventory replenishments and said more tools helping with allocation will go live in the next quarter.

Beyond that time period, the company intends to keep exploring AI and renovate more of its stores.

It will also re-evaluate its design ranks.

Roots announced Friday that chief product officer Karuna Scheinfeld has stepped down.

Rather than fill the role, the company plans to hire senior level design talent with international experience in the outdoor and activewear sectors who will take on tasks previously done by the chief product officer.

This report by The Canadian Press was first published Sept. 13, 2024.

Companies in this story: (TSX:ROOT)

The Canadian Press. All rights reserved.

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Talks on today over HandyDART strike affecting vulnerable people in Metro Vancouver

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VANCOUVER – Mediated talks between the union representing HandyDART workers in Metro Vancouver and its employer, Transdev, are set to resume today as a strike that has stopped most services drags into a second week.

No timeline has been set for the length of the negotiations, but Joe McCann, president of the Amalgamated Transit Union Local 1724, says they are willing to stay there as long as it takes, even if talks drag on all night.

About 600 employees of the door-to-door transit service for people unable to navigate the conventional transit system have been on strike since last Tuesday, pausing service for all but essential medical trips.

Hundreds of drivers rallied outside TransLink’s head office earlier this week, calling for the transportation provider to intervene in the dispute with Transdev, which was contracted to oversee HandyDART service.

Transdev said earlier this week that it will provide a reply to the union’s latest proposal on Thursday.

A statement from the company said it “strongly believes” that their employees deserve fair wages, and that a fair contract “must balance the needs of their employees, clients and taxpayers.”

This report by The Canadian Press was first published Sept. 12, 2024.

The Canadian Press. All rights reserved.

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Transat AT reports $39.9M Q3 loss compared with $57.3M profit a year earlier

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MONTREAL – Travel company Transat AT Inc. reported a loss in its latest quarter compared with a profit a year earlier as its revenue edged lower.

The parent company of Air Transat says it lost $39.9 million or $1.03 per diluted share in its quarter ended July 31.

The result compared with a profit of $57.3 million or $1.49 per diluted share a year earlier.

Revenue in what was the company’s third quarter totalled $736.2 million, down from $746.3 million in the same quarter last year.

On an adjusted basis, Transat says it lost $1.10 per share in its latest quarter compared with an adjusted profit of $1.10 per share a year earlier.

Transat chief executive Annick Guérard says demand for leisure travel remains healthy, as evidenced by higher traffic, but consumers are increasingly price conscious given the current economic uncertainty.

This report by The Canadian Press was first published Sept. 12, 2024.

Companies in this story: (TSX:TRZ)

The Canadian Press. All rights reserved.

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