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Moderna coronavirus vaccine displays 'promising' final results in posted Phase 1 examine – CA News Ottawa

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These early outcomes, revealed in the New England Journal of Medicine on Tuesday, confirmed that the vaccine labored to set off an immune response with delicate facet effects — exhaustion, chills, headache, muscle discomfort, agony at the injection web site — becoming the initial US vaccine prospect to publish success in a peer-reviewed medical journal

The vaccine is anticipated to get started later this thirty day period a significant Phase 3 trial — the ultimate trial stage just before regulators take into account regardless of whether to make the vaccine out there.

Moderna observed in a push release on Tuesday that, if all goes well in future reports, “the Firm remains on observe to be capable to provide roughly 500 million doses per 12 months, and maybe up to 1 billion doses for every 12 months, starting in 2021.”

“We thought the immune responses glimpse promising, but we really don’t know regardless of whether the stages we’re seeing would really protect from an infection. It is really genuinely tough to know that till you do the precise efficacy trial,” she claimed. “So we are laying the groundwork for the demo that will give those people answers.”

Moderna expects to start the firm’s most significant examine nonetheless of its Covid-19 vaccine applicant mRNA-1237 on July 27, according to aspects released separately on Tuesday. It really is envisioned to be the 1st in the United States to begin Section 3 trials.

For now, the new analyze “furnished details speedily that could be used to ascertain what dose to go forward with Section 2 and Section 3 trials. Which is a critically important decision to make and so owning that details obtainable so shortly after the vaccine trial was initiated is pretty impressive,” Jackson said.

A Section 1 research typically scientific tests a tiny selection of men and women and focuses on no matter if a vaccine is safe and sound and elicits an immune response.

In Section 2, the scientific review is expanded and the vaccine is specified to men and women who have traits — this sort of as age and physical wellbeing — very similar to those people for whom the new vaccine is meant, in accordance to the US Centers for Sickness Regulate and Prevention. In Stage 3, the vaccine is given to 1000’s of men and women and tested for efficacy and once again for basic safety.

‘We want to know regardless of whether the vaccine is protected and effective’

The Phase 1 review provided 45 balanced grown ups, ages 18 to 55, who gained two vaccinations of the mRNA-1237 vaccine prospect 28 times apart. Some of the volunteers enrolled in the trial at Kaiser Permanente in Seattle and other individuals at Emory University in Atlanta.

The volunteers have been divided into groups where by they either been given the vaccine at a dose of 25, 100 or 250 micrograms. They received their first vaccination involving March 16 and April 14.

“The initial dose kind of sets the immune process up, it can be called priming,” Jackson reported. “So that when you then administer the exact matter again, there is a booster reaction. There is an augmented reaction. So we did not believe that one particular vaccination would be ample to get the degree of response that we wanted to see.”

The scientists located “no trial-limiting security considerations” immediately after volunteers been given their two doses of vaccine, but there were being some delicate to average facet outcomes, these types of as some soreness at the injection web-site, and there were being extra of all those the better the dose of the vaccine.

Soon after the initially vaccination, adverse activities were noted by five contributors in the 25-microgram team, 10 in the 100-microgram team, and 8 in the 250-microgram team. Then right after the second vaccination, this sort of events occurred in 7 of 13 members in the 25-microgram team, all 15 in the 100-microgram team, and all 14 in the 250-microgram team, with a few of those individuals reporting “one particular or much more intense activities,” in accordance to the examine.

The most usually documented systemic adverse events subsequent next vaccination at the 100-microgram dose have been exhaustion, between 80% chills, among the 80% headache, among the 60% and myalgia or muscle mass discomfort, between 53% all of which were being transient and delicate or average in severity, as noted in Moderna’s push launch.

The research information also showed that the vaccine induced an antibody reaction. Antibodies are the proteins the body makes to fight an infection.

Exclusively, all members developed neutralizing antibodies to the virus at degrees related to these noticed in men and women who’ve by natural means recovered from Covid-19, in accordance to the research. Neutralizing antibodies bind to the virus, disabling it from attacking human cells.

The scientists calculated two types of immune responses, Jackson reported.

“Those two forms of responses assistance every single other. We know that the antibodies are remaining generated and it appears that there is operate right after vaccination that serves to block the means of the virus to enter cells. So it neutralizes the action of the virus,” she stated.

But far more investigation is needed.

“What do we seriously want to know? We want to know regardless of whether the vaccine is safe and successful, that’s what we want to know,” explained Dr. Paul Offit, a member of the NIH panel that’s setting a framework for vaccine scientific studies in the United States, who was not involved in the new study.

With the analyze, “we know that it is secure in 45 folks, which is not going to be the 20 million people today or 200 million men and women who are likely to get it in this article in the United States,” explained Offit, who is also director of the Vaccine Schooling Heart and an attending health practitioner in the Division of Infectious Diseases at Children’s Clinic of Philadelphia.

“So we know that it would not have a really common facet outcome problem, which is what we know,” he mentioned. “Then we don’t know anything at all about efficacy, which is what we seriously want to know. Is this vaccine going to function? The only way to know that is to do a so-identified as Period 3 demo.”

Moderna expects to start off substantial US Covid-19 vaccine trial in late July

Effects from the Stage 1 examine can help guidebook what the Stage 3 study appears to be like.

“These Stage 1 information show that vaccination with mRNA-1273 elicits a sturdy immune response across all dose degrees and obviously support the option of 100 μg in a prime and raise routine as the optimal dose for the Phase 3 review,” Dr. Tal Zaks, chief medical officer of Moderna, mentioned in the firm’s press launch on Tuesday.

“We look forward to starting our Stage 3 study of mRNA-1273 to reveal our vaccine’s potential to substantially decrease the danger of COVID-19 condition,” he stated.

For the Period 3 analyze, researchers program to enroll 30,000 adult members, including men and women whose destinations or instances put them at superior-risk of an infection. 1 group will be injected with 100 micrograms of the vaccine on working day 1 and all over again on day 29. A next group will be injected with two doses of a placebo for comparison.

Fourteen times right after the individuals get their second dose, the researchers will be searching at no matter whether they create Covid-19. The participants will be adopted for two a long time soon after obtaining their 2nd dose.

The study will be done at 87 locations throughout the United States.

Moderna’s vaccine prospect is one particular of 23 in medical trials around the world, according to the Environment Health Firm.

All round, “the security and immunogenicity details in this preliminary report are promising, and they support ongoing development of this vaccine. On the other hand, we will have to bear in brain the complexity of vaccine enhancement and the do the job continue to to be carried out right before Covid-19 vaccines are commonly available,” Dr. Penny Heaton, chief govt officer of the Monthly bill and Melinda Gates Basis, wrote in an editorial accompanying the Stage 1 research in the New England Journal of Drugs on Tuesday.

“Accelerating the progress of Covid-19 vaccine candidates past period 1 depends on continued parallel monitoring of actions and fulsome sources. The world has now witnessed the compression of 6 many years of do the job into 6 months,” Heaton wrote. “Can the vaccine multiverse do it yet again, main to a fact of a safe, efficacious Covid-19 vaccine for the most susceptible in the subsequent 6?”

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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